• Title/Summary/Keyword: Role Models

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Suppressing breast cancer by exercise: consideration to animal models and exercise protocols

  • Lee, Jea Jun;Beak, Suji;Ahn, Sang Hyun;Moon, Byung Seok;Kim, Jisu;Lee, Kang Pa
    • Korean Journal of Exercise Nutrition
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    • v.24 no.2
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    • pp.22-29
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    • 2020
  • [Purpose] Exercise is thought to have a significant effect on chemotherapy, and previous studies have reported that exercise can increase patient survival. Thus, in this review, we aimed to summarize various animal models to analyze the effects of exercise on breast cancer. [Methods] We summarized types of breast cancer animal models from various reports and analyzed the effects of exercise on anti-cancer factors in breast cancer animal models. [Results] This review aimed to systematically investigate if exercise could aid in suppressing breast cancer. Our study includes (a) increase in survival rate through exercise; (b) the intensity of exercise should be consistent and increased; (c) a mechanism for inhibiting carcinogenesis through exercise; (d) effects of exercise on anti-cancer function. [Conclusion] This review suggested the necessity of a variety of animal models for preclinical studies prior to breast cancer clinical trials. It also provides evidence to support the view that exercise plays an important role in the prevention or treatment of breast cancer by influencing anticancer factors.

Comparing Role of Two Chemotherapy Regimens, CMF and Anthracycline-Based, on Breast Cancer Survival in the Eastern Mediterranean Region and Asia by Multivariate Mixed Effects Models: a Meta-Analysis

  • Ghanbari, Saeed;Ayatollahi, Seyyed Mohammad Taghi;Zare, Najaf
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.14
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    • pp.5655-5661
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    • 2015
  • Purpose: To assess the role of two adjuvant chemotherapy regimens, anthracycline-based and CMF on disease free survival and overall survival breast cancer patients by meta-analysis approach in Eastern Mediterranean and Asian countries to determine which is more effective and evaluate the appropriateness and efficiency of two different proposed statistical models. Materials and Methods: Survival curves were digitized and the survival proportions and times were extracted and modeled to appropriate covariates by two multivariate mixed effects models. Studies which reported disease free survival and overall survival curves for anthracycline-based or CMF as adjuvant chemotherapy that were published in English in the Eastern Mediterranean region and Asia were included in this systematic review. The two transformations of survival probabilities (Ln (-Ln(S)) and Ln(S/ (1-S))) as dependent variables were modeled by a multivariate mixed model to same covariates in order to have precise estimations with high power and appropriate interpretation of covariate effects. The analysis was carried out with SAS Proc MIXED and STATA software. Results: A total of 32 studies from the published literature were analysed, covering 4,092 patients who received anthracycline-based and 2,501 treated with CMF for the disease free survival and in order to analyze the overall survival, 13 studies reported the overall survival curves in which 2,050 cases were treated with anthracycline-based and 1,282 with CMF regimens. Conclusions: The findings illustrated that the model with dependent variable Ln (-Ln(S)) had more precise estimations of the covariate effects and showed significant difference between the effects of two adjuvant chemotherapy regimens. Anthracycline-based treatment gave better disease free survival and overall survival. As an IPD meta-analysis in the Italy the results of Angelo et al in 2011 also confirmed that anthracycline-based regimens were more effective for survival of breast cancer patients. The findings of Zare et al 2012 on disease free survival curves in Asia also provided similar evidence.

A RBAC Model Considering the Characteristics of the Adhocracy Organization (애드호크러시 조직의 특성을 고려한 역할기반 모델)

  • Shim, Won-Bo;Park, Seog
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.12 no.4
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    • pp.41-53
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    • 2002
  • Role Based Access Control (RBAC), which is a method, using role as an access control, has been popular with users and it is recognized as an effective method to replace the Discretionary Access Control and the Mandatory Access Control However, the existing Role Based Access Control Models have only been limited to the bureaucracy organization in which a distinctive hierarchy system was used, incorporating a stable structure and a standardized work system. Only in some parts, some access control models have been used, which supports 'Team' concept, such as Team Based Access Control Model. However, it did not incorporate the characteristics of the adhocracy organization, which is similar to the company's task force team, whose characteristics are organic, temporary, no standardized operation procedures, and many frequent changes. In this study, we have discussed the characteristics of the adhocracy organization which is different from the existing bureaucracy organization, and we have also discussed the problems related to when the existing access control models are used as the access control model for the adhocracy organization due to its characteristics. In addition, based on the problems, we have suggested an improved role based access control model for the adhocracy organization, and have come up with the solutions when any problems occur in the access control system.

A Role-Based Access Control System API Supporting External Authority Interface

  • Ma, Jin;Kim, Hyunah;Park, Minjae
    • Journal of Internet Computing and Services
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    • v.19 no.2
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    • pp.27-32
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    • 2018
  • In industries that are operating various enterprise systems, new systems are integrated and operated in accordance with each period. In particular, when a new system is to be integrated, one of the major considerations is the single sign-on part for integrating and operating the authentication. To implement this authority system using role-based access control method, an extension method for access control method is needed. Therefore, in this paper, we design an extended role-based access control model for interworking with legacy authority system and provide its APIs. The extended role-based access control model is a model in which external authority information, which holds authority information in the authority information, is added. And we describe operations that the REST Web APIs are based on these models. In this paper, the method is described in the back-end APIs and can be implemented as an operation of an extended role-based access control system based on the method.

A Role-Performer Bipartite Matrix Generation Algorithm for Human Resource Affiliations (인적 자원 소속성 분석을 위한 역할-수행자 이분 행렬 생성 알고리즘)

  • Kim, Hak-Sung
    • Journal of Digital Contents Society
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    • v.19 no.1
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    • pp.149-155
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    • 2018
  • In this paper we propose an algorithm for generating role-performer bipartite matrix for analyzing BPM-based human resource affiliations. Firstly, the proposed algorithm conducts the extraction of role-performer affiliation relationships from ICN(Infromation Contorl Net) based business process models. Then, the role-performer bipartite matrix is constructed in the final step of the algorithm. Conclusively, the bipartite matrix generated through the proposed algorithm ought to be used as the fundamental data structure for discovering the role-performer affiliation networking knowledge, and by using a variety of social network analysis techniques it enables us to acquire valuable analysis results about BPM-based human resource affiliations.

A Role-driven Security and Access Control Model for Secured Business Process Management Systems

  • Won Jae-Kang;Kim Kwang-Hoon
    • The Journal of Information Systems
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    • v.14 no.3
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    • pp.1-8
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    • 2005
  • This paper formally defines a role-driven security and access control model of a business process in order eventually to provide a theoretical basis for realizing the secured business process management systems. That is, we propose a graphical representation and formal description of the mechanism that generates a set of role-driven security and access control models from a business process modeled by the information control net(ICN) modeling methodology that is a typical business process modeling approach for defining and specifying business processes. Based upon the mechanism, we are able to design and accomplish a secured business process management system that provides an unified resource access control mechanism of the business process management engine domain's and the application domain's. Finally, we strongly believe that the secured access control policies from the role-driven security and access control model can be easily transformed into the RBAC(Role-based Access Control) model that is a standardized security technology for computer and communications systems of commercial and civilian government organizations.

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Effect of Gender Role Attitude and Work·Family Balance Perceived by Married Career Women on Life Stress : The Mediating Effect of Marital Intimacy (기혼 여성의 성역할태도, 일·가정양립, 생활스트레스 간의 관계에서 부부친밀감의 매개효과)

  • Han, Hye Rim;Lee, Ji Min
    • Human Ecology Research
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    • v.56 no.5
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    • pp.425-433
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    • 2018
  • This study investigates the effect of gender role attitude and work family balance on life stress for married career women. We also explore the mediating effect of marital intimacy on the relation between gender role attitude, work family balance, and life stress. The subjects were married women from the five year data of the Korean Longitudinal Survey of Women and Family (KLoWF). Data was analyzed by descriptive statistics, Pearson correlation, structural equational models, and Sobel test with SPSS software ver. 23.0, and Amos software ver. 23.0. The findings are as follows. First, gender role attitude had a direct effect on life stress, but work family balance had no significant effect on life stress. Second, marital intimacy mediated between gender role attitude, work family balance, and life stress. In conclusion, the results can be used as basic data to prevent life stress in married career women and increase marital intimacy.

Cyber University e-Mentoring System with Role Modeling (역할모형을 적용한 원격대학교 e-멘토링 시스템)

  • Lee, Jung-Hun;Woo, Jin-Woon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.4
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    • pp.1285-1293
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    • 2010
  • This study suggests the design and implementation of an e-mentoring system, which creates more than one role models to help adult learners of cyber university to improve their academic performance and to successfully complete their education. The benefits of this system are as following; First, automatic matching system is built in consideration of mutual requests between mentor and mentee. And the system enforces all participants to actively participate in the program by sharing ideas and to improve their academic performance with specific academic goals. Second, participants are rewarded at the end of the program for their performance by an evaluation system developed for assessing role models and participants' activities. Also, the system encourages best mentors to remain in the program and help adult learners to improve academic performance.

Semantic Role Labeling using Biaffine Average Attention Model (Biaffine Average Attention 모델을 이용한 의미역 결정)

  • Nam, Chung-Hyeon;Jang, Kyung-Sik
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.26 no.5
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    • pp.662-667
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    • 2022
  • Semantic role labeling task(SRL) is to extract predicate and arguments such as agent, patient, place, time. In the previously SRL task studies, a pipeline method extracting linguistic features of sentence has been proposed, but in this method, errors of each extraction work in the pipeline affect semantic role labeling performance. Therefore, methods using End-to-End neural network model have recently been proposed. In this paper, we propose a neural network model using the Biaffine Average Attention model for SRL task. The proposed model consists of a structure that can focus on the entire sentence information regardless of the distance between the predicate in the sentence and the arguments, instead of LSTM model that uses the surrounding information for prediction of a specific token proposed in the previous studies. For evaluation, we used F1 scores to compare two models based BERT model that proposed in existing studies using F1 scores, and found that 76.21% performance was higher than comparison models.

Updated Primer on Generative Artificial Intelligence and Large Language Models in Medical Imaging for Medical Professionals

  • Kiduk Kim;Kyungjin Cho;Ryoungwoo Jang;Sunggu Kyung;Soyoung Lee;Sungwon Ham;Edward Choi;Gil-Sun Hong;Namkug Kim
    • Korean Journal of Radiology
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    • v.25 no.3
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    • pp.224-242
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    • 2024
  • The emergence of Chat Generative Pre-trained Transformer (ChatGPT), a chatbot developed by OpenAI, has garnered interest in the application of generative artificial intelligence (AI) models in the medical field. This review summarizes different generative AI models and their potential applications in the field of medicine and explores the evolving landscape of Generative Adversarial Networks and diffusion models since the introduction of generative AI models. These models have made valuable contributions to the field of radiology. Furthermore, this review also explores the significance of synthetic data in addressing privacy concerns and augmenting data diversity and quality within the medical domain, in addition to emphasizing the role of inversion in the investigation of generative models and outlining an approach to replicate this process. We provide an overview of Large Language Models, such as GPTs and bidirectional encoder representations (BERTs), that focus on prominent representatives and discuss recent initiatives involving language-vision models in radiology, including innovative large language and vision assistant for biomedicine (LLaVa-Med), to illustrate their practical application. This comprehensive review offers insights into the wide-ranging applications of generative AI models in clinical research and emphasizes their transformative potential.