• Clinical and Experimental Pediatrics
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• v.50 no.7
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• pp.606-612
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• 2007

Since the introduction of chemotherapy for the treatment of childhood leukemia more than 50 years ago, the results of childhood cancer have improved dramatically. The 5-year survival rate of disease, many of which were uniformly fatal in the prechemotherapy era, reached to more than 75%. This remarkable improvement in survival is a direct result of the incorporation of chemotherapeutics into treatment regimens that previously relied only on surgery or radiotherapy for the primary tumor. The multimodality approach, which integrates surgery and radiotherapy to control local disease with chemotherapy to eradicate systemic or metastatic disease, has become the standard approach to treating most childhood cancers. The overall improvement in outcomes in childhood solid tumors has been related to the development of multidisplinary cooperative studies that has permitted the development of well-designed tumor treatment protocols characterized by uniform staging criteria, sharing informations in pathologic classification, uniform methods for tumor markers, oncogenes, and other biologic and genetic factors. Important advances in the biologic study of cancer and its genetic basis led to a number of observations that impact directly on the management of childhood solid tumors. Identification of specific genes, oncogenes, tumor markers, and other biologic and pathologic factors plays an important role in both staging and clarifying the risk categorization of individual patients. Treatment of the patient is influenced by the recognition of specific risk factors. This knowledge has resulted in a change in the approach to care based not only on staging criteria, but also on risk-based management. This concept uses various risk factors of outcomes. Risk-based management allows for each patient to maximize survival, minimize long-term morbidity and improve the quality of life, especially for children's growth and development.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.40 no.3
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• pp.38-48
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• 2017

ISO 9001 Quality Management Systems-Requirements has been revised in 2015. It has been updated four times since its publication in 1987. It is the most widely used International Standard in the world. There are over one million companies and organizations in over 170 countries certified to ISO 9001 from an ISO survey. Organizations are supposed to be certified to this new version by late 2018. The key changes in ISO 9001:2015 are to establish a High Level Structure (HLS) and focus on Risk-Based Thinking (RBT). Risk-Based Thinking means the process approach to decide how risk is addressed in establishing the processes to improve process outputs and prevent undesirable results. It pursues process planning and controls based on risks so that organizations can improve the effectiveness of the quality management system. It maintains and manages a Quality Management System that inherently addresses risks and meets objectives. In this article we firstly attempt to explain how to understand the fundamental concept of Risk-Based Thinking which is a systematic approach to consider risks rather than treating prevention as a separate component of a Quality Management System. We comment on the detailed requirements that contain risks in ISO 9001:2015 clauses. We also summarize recent advances on the risk assessment and management in line with ISO 31000:2009 Risk Management-Principles and Guidelines. We finally propose the practical risk management procedures for implementing ISO 9001:2015 with an emphasis on RBT. This article would contribute to help quality managers and practitioners convert to ISO 9001:2015.

• Management & Information Systems Review
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• v.3
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• pp.179-199
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• 1999

Case-Based Reasoning(CBR) offers a new approach for developing knowledge based systems. In case-based approach the problem solving experience of the domain expert is encoded in the form of cases. CBR has successfully been applied to many kinds of problems such as design, planning, diagnosis and forecasting. In this paper, CBR was applied for forecasting default risk. The applied result was successful in spite of the small casebase. Generally, CBR requires large casebase. So, if the number of data was large, the result was better. But in this paper, what financial variable was more forecastable was not tested. Next, this should be tested.

• Nuclear Engineering and Technology
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• v.50 no.8
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• pp.1372-1386
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• 2018

Despite recent advances in multi-hazard analysis, the complexity and inherent nature of such problems make quantification of the landslide effect in a probabilistic safety assessment (PSA) of NPPs challenging. Therefore, in this paper, a practical approach was presented for performing an earthquake-induced landslide PSA for NPPs subject to seismic hazard. To demonstrate the effectiveness of the proposed approach, it was applied to Korean typical NPP in Korea as a numerical example. The assessment result revealed the quantitative probabilistic effects of peripheral slope failure and subsequent run-out effect on the risk of core damage frequency (CDF) of a NPP during the earthquake event. Parametric studies were conducted to demonstrate how parameters for slope, and physical relation between the slope and NPP, changed the CDF risk of the NPP. Finally, based on these results, the effective strategies were suggested to mitigate the CDF risk to the NPP resulting from the vulnerabilities inherent in adjacent slopes. The proposed approach can be expected to provide an effective framework for performing the earthquake-induced landslide PSA and decision support to increase NPP safety.

• Journal of Navigation and Port Research
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• v.33 no.4
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• pp.255-261
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• 2009

Prediction of the stability for ships is very complex in reality. In this paper, risk based approach is applied to predict the probability of capsize for a certified ship, which is effected by the forces of sea especially the wave loading Safety assessment and risk analysis process are also applied for the probabilistic prediction of stability for ships. The probability of shipsencountering different waves at sea is calculated by the existed statistics data and risk based models. Finally, ship capsizing probability is calculated according to single degree of freedom(SDF) rolling differential equation and basin erosion theory of nonlinear dynamics. Calculation results show that the survival probabilities of ship excited by the forces of the seas, especially in the beam seas status, can be predicted by the risk based method.

• Proceedings of the Korean Nuclear Society Conference
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• 1998.05a
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• pp.838-843
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• 1998

Risk importance measures are widely wed to rank risk contributors in risk-based applications. Typically, Fussell-Vesely (F-V) importance and risk achievement worth (RAW) are used in the component importance raking for the reliability centered maintenance (RCM) analysis of safety system in nuclear power plants (NPPs). This study was performed as part of feasibility study on RCM for domestic NPPs, which is focused on the component importance ranking approach the maintenance recommendation. The approach of modulizing faulting tree basic events was applied in the simplification process of the PSA model and the validity of the approach was evaluated As a result of the case study, this paper included the importance and the maintenance recommendations for the safety-related equipments associated with safety injection and containment spray in large loss of coolant accident sequences.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.39-40
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• 2015

As international construction market increases, the importance of risk management in international construction project is emphasized. Unfortunately, current risk management practice does not sufficiently deal with project risks. Although a lot of risk analysis techniques have been introduced, most of them focus on project's external unexpected risks such as country conditions and owner's financial standing. However, because those external risks are difficult to manage and take preemptive action, we need to concentrate on project inherent risks. Based on this premise, this paper proposes a project-oriented risk mining approach which could detect and extract project risk factors automatically before they are materialized. This study presents a methodology regarding how to extract potential risks which exist in owner's project requirements and project tender documents using state of the art data analysis method such as text mining. The project-oriented risk mining approach is expected to effectively reflect project characteristics to the project risk management and could provide construction firms with valuable business intelligence.

• Journal of IKEEE
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• v.23 no.4
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• pp.1150-1156
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• 2019

This paper explores a model-free value-based approach for solving survival gridworld problem. Survival gridworld problem opens up a challenge involving taking risks to gain better rewards. Classic value-based approach in model-free reinforcement learning assumes minimal risk decisions. The proposed method involves a hybrid on-policy and off-policy updates to experience roll-outs using a modified Q-based update equation that introduces a parametric linear rectifier and motivational discount. The significance of this approach is it allows model-free training of agents that take into account risk factors and motivated exploration to gain better path decisions. Experimentations suggest that the proposed method achieved better exploration and path selection resulting to higher episode scores than classic off-policy and on-policy Q-based updates.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.2
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• pp.89-97
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• 2020

This study was conducted to examine how independent audit firms in Vietnam understand and use risk based audit approach (RBAA) in audit practice. To answer the research questions, the researchers used primary and secondary data collected from 2018 to 2019. The results from the interview survey showed that audit firms were aware of the advantages of adopting RBAA. However, RBAA is practiced to a moderate extent by audit firms in Vietnam. Big 4 audit firms use RBAA more popularly than Non-Big 4 audit firms. The causes of the difference are the disadvantages of adopting RBAA and client's characteristics such as relevant guideline, audit fees, auditors' knowledge and experience. Besides, the study investigated factors impacting on the RBAA adoption by distributing a questionnaire to 246 auditors of 126 audit firms in Vietnam. A set of statistical appropriate methods where used through SPSS software version 22.0. The results indicated that there were six factors influencing RBAA adoption including: Auditor's ability, Technological development, Audit fees, auditors' motivation, Audit time and client's risk. Of which, auditor's ability and technological development are factors that have the most significant and positive impacts on the adoption of RBAA. Additional implications were argued in the final section of this study.

• Journal of Korea Water Resources Association
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• v.56 no.8
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• pp.521-528
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• 2023

An approach for producing a rip current risk index using the rip current likelihood distribution obtained through the FUNWAVE simulations was applied to a rip current forecast system. The approach originally developed for an observation-based real-time rip current warning system was utilized with wave forecast data instead of observations for the rip current forecast system. The availability of the present approach was checked by comparing the observation-based rip current risk index and the wave forecast-based rip current risk index of the Haeundae Beach in 2021.