• Biomolecules & Therapeutics
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• 제31권6호
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• pp.583-598
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• 2023

Dementia is a clinical syndrome characterized by progressive impairment of cognitive and functional abilities. As currently applied treatments for dementia can only delay the progression of dementia and cannot fundamentally cure it, much attention is being paid to reducing its incidence by preventing the associated risk factors. Cardiovascular and metabolic diseases are well-known risk factors for dementia, and many studies have attempted to prevent dementia by treating these risk factors. Growing evidence suggests that sex-based factors may play an important role in the pathogenesis of dementia. Therefore, a deeper understanding of the differences in the effects of drugs based on sex may help improve their effectiveness. In this study, we reviewed sex differences in the impact of therapeutics targeting risk factors for dementia, such as cardiovascular and metabolic diseases, to prevent the incidence and/or progression of dementia.

• Journal of Preventive Medicine and Public Health
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• 제53권1호
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• pp.56-63
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• 2020

Objectives: The objective of this study was to determine the effect of atrial fibrillation (AF) on the risk of dementia in the Korean elderly. Methods: A 10-year retrospective cohort study was conducted using the National Health Insurance Service-Senior Cohort database. We excluded those who were under 65 years of age as of January 2006 (n=46 113), those who were diagnosed with dementia between 2002 and 2005 (n=9086), and those with a history of stroke prior to AF diagnosis (n=8392). We used a Cox proportional hazards model with a time-varying covariate to determine whether AF is associated with the risk of dementia after adjusting for potential confounders. Results: In univariable Cox regression, the hazard ratio (HR) of dementia according to AF status was 1.28 (95% confidence interval [CI], 1.23 to 1.33). After adjusting for potential confounders, AF was found to increase the risk of dementia (HR, 1.12; 95% CI, 1.07 to 1.17), Alzheimer dementia (HR, 1.12; 95% CI, 1.07 to 1.17), and vascular dementia (HR, 1.10; 95% CI, 1.03 to 1.18). In patients diagnosed with AF, the incidence of dementia was lower (HR, 0.50; 95% CI, 0.47 to 0.52) in patients who were treated with oral anticoagulants. Conclusions: Investigating the potential risk factors of dementia in an aged society is important. We found a slightly higher risk of dementia in those with AF than in those without AF, and we therefore concluded that AF is a potential risk factor for dementia.

• 지역사회간호학회지
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• 제19권1호
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• pp.36-45
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• 2008

Purpose: This study was to estimate the prevalence of dementia in order to estimate the associations of dementia with its risk factors in the community elderly. Methods: The multistage random cluster sampling method was used to select the subjects. The response rate was 94.3%. For the 1st stage screening survey, the Korean-version Mini-Mental State Examination (K-MMSE) and the Bathel Index of activities of daily living (ADL) and instrumental activities of daily living (IADL) were used as primary screening tools. At the 2nd stage. diagnoses were confirmed according to the Clinical Dementia Rating Scale (CBR) and Computer Tomogram (CT). Results: Age-sex adjusted prevalence (%) [95% CI] of dementia was 6.25% [4.47-7.83] (male 4.21% [2.40-6.02]; female 8.28% [5.71-10.85]). Four statistically significant risk factors of the dementia were identified: age 70-74 (OR=1.367), age 75-79 (OR=1.712), age 80-84 (OR=2.465), age 85 over (OR=7.363) illiteracy (OR=3.827); unconsciousness after head injury (OR=3.383), and no exercise (OR=2.188). Hosmer and Lemeshow goodness-of-fit index of dementia risk model was E (legit of dementia)= -4.337+$0.312^*Age(70{\sim}74)+0.538^*Age(75{\sim}79)+0.902^*Age(80{\sim}84)+1.996^*Age$(85over)+$1.342^*$Illiteracy+$1.219^*$Unconsciousness after head trauma+$0.783^*$No exercise. We confirmed that the overall prevalence of dementia in adults aged 65 and older was 94.3%. The risk factors of dementia were explained by age, illiteracy unconsciousness after head trauma and no exercise. Conclusion: These data have been used to estimate the incidence of dementia in elderly community population and to manage the possible role of risk factors as predictors of dementia.

• Journal of Periodontal and Implant Science
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• 제50권5호
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• pp.303-312
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• 2020

Purpose: The purpose of this study was to evaluate severe periodontitis with tooth loss as a modifiable risk factor for Alzheimer dementia (AD), vascular dementia (VaD), and mixed dementia (MD) using the National Health Insurance Service-National Health Screening Retrospective Cohort database with long-term follow-up over 14 years. Methods: Multivariate Cox hazards regression analysis was applied to a longitudinal retrospective database, which was updated in 2018, to evaluate the association between severe periodontitis with few remaining teeth and dementia after adjusting for potential risk factors, including sociodemographic factors and comorbid diseases. Results: Among 514,866 individuals in South Korea, 237,940 (46.2%) participants satisfying the inclusion criteria were selected. A total of 10,115 age- and sex-matched participants with severe periodontitis and 10,115 periodontally healthy participants were randomly selected and evenly assigned. The results showed that the risks of AD (hazard ratio [HR], 1.08), VaD (HR, 1.24), and MD (HR, 1.16) were significantly higher in patients with severe periodontitis with 1-9 remaining teeth after adjustment for sociodemographic factors, anthropomorphic measurements, lifestyle factors, and comorbidities. Conclusions: Severe periodontitis with few remaining teeth (1-9) may be considered a modifiable risk factor for the development of AD, VaD, and MD in Korean adults.

• Biomolecules & Therapeutics
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• 제28권1호
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• pp.58-73
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• 2020

Sleep is an essential physiological process, especially for proper brain function through the formation of new pathways and processing information and cognition. Therefore, when sleep is insufficient, this can result in pathophysiologic conditions. Sleep deficiency is a risk factor for various conditions, including dementia, diabetes, and obesity. Recent studies have shown that there are differences in the prevalence of sleep disorders between genders. Insomnia, the most common type of sleep disorder, has been reported to have a higher incidence in females than in males. However, sex/gender differences in other sleep disorder subtypes are not thoroughly understood. Currently, increasing evidence suggests that gender issues should be considered important when prescribing medicine. Therefore, an investigation of the gender-dependent differences in sleep disorders is required. In this review, we first describe sex/gender differences not only in the prevalence of sleep disorders by category but in the efficacy of sleep medications. In addition, we summarize sex/gender differences in the impact of sleep disorders on incident dementia. This may help understand gender-dependent pathogenesis of sleep disorders and develop therapeutic strategies in men and women.

• 감성과학
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• 제12권1호
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• pp.11-18
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• 2009

본 연구의 목적은 재가치매노인에게 발생한 사고사례들의 조사를 통해 치매노인에게 위험요소로 작용 될 수 있는 요인들을 추출하고, 이를 바탕으로 치매노인 보호를 위해 고려해야 할 모니터링 요소의 결정에 필요한 기초 정보를 제공하고자 하는 것이다. 재가치매노인 55명(남자 16명, 여자 39명)을 대상으로 설문지를 이용하여 기본특성, 행동특성, 노인인지기능(Short form of Samsung Dementia Questionnaire: S-SDQ), 일상생활 수행능력(Activities of Daily Living: ADL), 사고사례를 조사하였다. 설문조사내용을 바탕으로 위험인자로 작용하는 요소들을 추출하고, 추출된 요소들의 발생빈도, 공발생빈도, 발생장소, 신체손상유무, 손상부위, 손상정도를 분석하였다. 그리고 행동특성, ADL, S-SDQ와 위험요소간의 발생빈도를 교차빈도분석을 통해 알아보았다. 분석결과 12개의 위험요소가 추출되었으며, 이 중 '나감'의 빈도가 가장 많았고, 신체적 손상이 발생한 위험요소는 넘어짐, 부딪힘, 미끄러짐, 떨어짐이었다. 공발생빈도 분석 결과, 넘어짐, 나감, 가스방화, 폭력이 다른 요인과 함께 발생하는 빈도가 높았다. 위험요소의 발생장소는 집주변이 가장 많았으며, 손상부위로는 무릎, 손상정도는 타박상이 가장 많았다. 교차빈도분석결과 위험요소의 발생빈도에 차이가 발생한 항목은 행동장애, 일상생활수행장애 그리고 ADL이였다. 행동장애와 일상생활수행장애의 정도에 따라 빈도의 차이를 보인 요인은 나감이었고, ADL의 정도에 따라 빈도의 차이를 보인 요인은 미끄러짐과 가스방화였다.

• 감성과학
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• 제10권1호
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• pp.79-86
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• 2007

치매노인의 주요 문제특성의 추출을 위해 시설에 입소해 있는 치매노인 110명을 대상으로 기본특성 조사, 인지기능 선별검사, 문제특성 설문조사를 실시하였다. 요인분석결과 총 20개의 주요 문제특성이 추출되었다. 본 연구에서는 치매노인 보호를 위해 주요 문제특성 20개의 위험순위를 결정하였다. 치매진단 및 치매환자를 접한 경험이 있는 정신보건 임상심리사 32명을 대상으로 설문조사를 실시하였다. 계층분석법을 이용하여 상대적 위험도를 분석하였고, 20개의 문제특성 전체에 대하여 위험도 서열을 정하도록 하여 위험순위를 결정하였다. 두 가지 분석 결과 모두 치매 노인의 일상생활 수행 시 기억력, 판단력, 지남력 장애와 같은 인지문제가 가장 위험한 것으로 나타났다.

• 한국노년학
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• 제38권4호
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• pp.1107-1125
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• 2018

본 연구는 치매환자와 동거하는 가족의 자살생각 위험요인과 보호요인에 따라 유형화를 하고, 각 유형집단이 자살생각에 미치는 영향을 분석하여 자살예방을 위한 실증적 기초 자료를 제시하는데 목적이 있다. 본 연구는 2013년 지역사회건강조사를 활용하여 치매환자와 동거하고 있는 가족 2,715명의 자료를 분석대상으로 하였고, 잠재계층모형분석과 이항로지스틱분석을 실시하였다. 주요분석내용은 (1) 자살생각의 위험요인과 보호요인의 유형화 (2) 유형화된 집단이 자살생각에 미치는 영향을 규명하고자 한다. 총24개의 자살생각 위험요인과 보호요인의 지표를 활용하여 잠재적 집단분석을 실시하여 '고위험-저보호요인'집단, '고위험-고보호요인'집단, '저위험-고보호요인'집단, '저위험-저보호요인'집단으로 유형화하였다. 분석 결과, '고위험-저보호요인'집단인 경우 자살생각이 가장 높았고, 유의하게 자살생각을 가지는 것으로 나타났다. 결과에 기반한 실천적 함의와 과제를 제시하였다.

• 한국융합학회논문지
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• 제9권8호
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• pp.265-272
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• 2018

본 연구는 독거노인의 치매 위험인자 보유상태가 인지기능 저하에 미치는 영향요인임을 알아보기 위한 서술적 조사 연구이다. 지역사회에 거주하는 독거노인 143명을 대상으로 치매 위험인자를 파악하기 위한 간이 설문지, 노인우울척도, 치매선별용 간이정신상태 검사를 실시하였다. 연구결과, 독거노인의 인지기능에 영향을 미치는 주요 요인은 무학과 초졸 이하의 학력, 연령, 우울상태, 흡연, 여가활동, 성별 순으로 나타났다. 향후 독거노인을 대상으로 치매예방 전략을 마련하기 위해서는 인지기능에 부정적인 영향을 주는 요인을 파악하여 인지건강에 도움을 줄 수 있는 생활습관의 변화와 다각적인 관리방안을 모색해야할 필요성이 있다.

• International Journal of Contents
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• 제17권4호
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• pp.46-51
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• 2021

This pilot study examined the contribution of citizen science approach to the datification of factors influencing the progress of cognitive health of the older adults. Newspapers were reviewed and FGIs of field workers at a Day Care Center gathered relevant data from citizen. Two questions were put forward; whether new factors are drawn from citizen knowledge; if yes, whether they represent a new type of data. 'Aesal', personality of the older adults with dementia is noted as a new dementia affecting factor. The data on personality also present a new challenge for scientific measurement. The relationship between personality or psychology of the older adults and the risk of getting dementia has been a research field for a long time, yet the impact of personality on the progress of dementia has not been examined scientifically. Because of communication difficulties with the older adults with dementia, new types of indicators and new ways of measurements thus need to be developed.