• The Korean Society of Law and Medicine
• /
• v.11 no.1
• /
• pp.271-296
• /
• 2010

Objective: Poisonous Medicinal herbs can be considered as a risk factor to public health unless they are prescribed by Doctor of traditional Korean medicine. The proper method to manage them should be prepared to prevent risk factors caused by misuse and abuse of the poisonous medicinal herbs and enhance public health. Methods: In this dissertation (paper), the definition, scope, management status, data about pharmacology and toxicity and media release regarding adverse reaction were understood after organizing documents, laws and regulations concerning poisonous medicinal herbs. Also, management methods are suggested by analyzing related examples and regulations in China, Japan and Hong Kong, where the use of herbal medicine is general. Results: Methods for items for poisonous medicinal herbs, safety information management, management based on standardization of traditional processing methodology and reorganization and revision of related laws and regulations are established. Conclusion: Proper laws and regulations are not yet established to manage poisonous medicinal herbs in Korea. In this regard, it is urgent to establish laws and regulations which can apply independently. The purpose of the laws and regulations should be to enhance management of poisonous medicinal herbs and prevent incidence of addiction and death, improving the public health.

• Applied Biological Chemistry
• /
• v.47 no.1
• /
• pp.1-16
• /
• 2004

The purpose of this paper is to review the occurrence, analytical methods and reduction methods of aflatoxins in foods. Aflatoxins are produced by the secondary metabolism of various fungal species and have the highest toxicity among mycotoxins. Due to their toxicity including carcinogenic activity, aflatoxins affect not only the health of humans ana animals but also the economics of agriculture and food. As a food-importing country, because aflatoxins could contaminate raw commodities and foodstuffs, there should be inspection on the exposure and the regulation of risk assessment as a food safety measure. In addition, studies on rapid analytical methods and reduction of toxicity by various processes for aflatoxins should be carried out in conjunction with those of the risk assessment of aflatoxins.

• Journal of Korea Society of Digital Industry and Information Management
• /
• v.16 no.2
• /
• pp.95-104
• /
• 2020

Bribery is one of the world's most destructive and challenging issues. Yet despite efforts on national and international levels to tackle bribery, it remains a significant issue. Recognizing this, ISO has developed a new standard to help organizations fight bribery and promote an ethical business culture, which is "ISO 37001 - Anti-bribery Management Systems" in 2016. ISO 37001 can provide the tools and systems to greatly reduce the risk and help organizations deal with it effectively if it does arise. It is a flexible tool, which can be adapted according to the size and nature of the organization and the bribery risk it faces. After enforcing the Improper Solicitation and Graft Act, Korean government standardized ISO 37001, one of the Business Ethics of Global Standard, harmonizing International Standards into Korean Industrial Standards (KS) in 2017. It is meaningful in that Korean companies have localized regulation which applies to global standard anti-bribery management systems. Only about 100 organizations, however, have adopted ISO 37001 so far. The primary purpose of this paper is to examine the expectation and awareness of ISO 37001. Results show that still many organizations lack of awareness of ISO 37001 and it is implicated that much promotion and education will be necessary. This study has originality and value in that it can provide the guidelines for activation of ISO 37001.

• Clinical and Experimental Pediatrics
• /
• v.52 no.12
• /
• pp.1321-1326
• /
• 2009

Prevalence of obesity in Korean children and adolescents has dramatically increased since the last 10-20 years. It is important to initiate prevention efforts early in childhood because prevalence of obesity in adolescence is the strongest predictor of its prevalence in adulthood. Intrauterine life, infancy, and preschool years may comprise the critical periods that are essential for the long-term regulation of energy balance therefore, obesity-prevention strategies should be initiated in utero and continued throughout childhood and adolescence. Families with high-risk children should be provided early education about maintaining normal weight. Encouraging physical activity and, especially, avoiding inactivity, are key challenges in the prevention of future obesity. Schools should be primarily involved in educating parents to discourage their children from excessively watching TV or playing computer games and eating unhealthy snacks and food. The involvement of medical practitioners is also important, especially, in the case of obese parents, obesity prevention strategies should be promoted from the first visit of pregnant women to the physicians. Health professionals can also be involved in obesity prevention because they are ideally equipped to identify young children at risk of obesity. Community and nation-wide efforts to increase awareness and promote environments that encourage physical activity and healthy nutrition are required.

• Environmental Analysis Health and Toxicology
• /
• v.29
• /
• pp.9.1-9.3
• /
• 2014

Diesel exhaust particles (DEP) contain elemental carbon, organic compounds including Polyaromatic hydrocarbons (PAHs), metals, and other trace compounds. Diesel exhaust is complex mixture of thousands of chemicals. Over forty air contaminants are recognized as toxicants, such as carcinogens. Most diesel exhaust particles have aerodynamic diameters falling within a range of 0.1 to $0.25{\mu}m$. DEP was classified as a definite human carcinogen (group 1) by the International Agency for Research on Cancer at 2012 based on recently sufficient epidemiological evidence for lung cancer. Significant decreases in DEP and other diesel exhaust constituents will not be evident immediately, and outworn diesel car having longer mileage still threatens health of people in spite of recent remarkable development in diesel engine technology. Policy change in South Korea, such as introduction of diesel taxi, may raise health risk of air pollution in metropolitan area with these limitations of diesel engine. To protect people against DEP in South Korea, progressive strategies are needed, including disallowance of diesel taxi, more strict regulation of diesel engine emission, obligatory diesel particulate filter attachment in outworn diesel car, and close monitoring about health effects of DEP.

• The Korean Journal of Physiology and Pharmacology
• /
• v.17 no.5
• /
• pp.385-392
• /
• 2013

Vitamin D deficiency is prevalent, primarily due to limited sun exposure, which may be observed in urban areas, or as a result of modern lifestyles. Common myths about vitamin D persist, including that it is mostly obtained from the diet and is only essential for bone and mineral homeostasis. Nonetheless, advances in biomedical science suggest that vitamin D is a hormone that is integral to numerous physiologic functions in most cells and tissues. Therefore, abnormal vitamin D levels may contribute to health disturbances. A number of recent reports on potential associations between vitamin D deficiency and cardiovascular disease have highlighted its role in this system. A focus over the previous decade has been to better understand the mechanisms behind vitamin D regulation and the pathophysiology associated with suboptimal vitamin D levels. Vitamin D deficiency is highly associated with the incidence of cardiovascular diseases, even when considering other well-known risk factors. In this process, the renin-angiotensin system is disrupted, and hypertension and endothelial dysfunction contribute to the risk of cardiovascular disease. Likewise, clinical outcomes upon the normalization of vitamin D levels have been investigated in different patient populations. It makes sense that vitamin D supplementation to improve vitamin D status among vitamin D-deficient individuals could be useful without requiring a sudden lifestyle change. This manuscript provides a brief overview of vitamin D metabolism and the vitamin D receptor. It also summarizes the current clinical research relating to vitamin D supplementation and its effects on hypertension and endothelial dysfunction in cardiovascular medicine.

• International Journal of Internet, Broadcasting and Communication
• /
• v.12 no.2
• /
• pp.98-112
• /
• 2020

There is a strong connection between the diet rich in antioxidants and the decreased incidence of inflammatory bowel disease and cancerous diseases. Diets that are rich in anti-oxidants particularly include fruits and vegetables containing the high amounts of vitamin A-E, carotenoids, and minerals. The supercritical heat-treated radish extracts of the research result had an inhibitory effect on the development of aberrant crypt foci (ACF), namely, preneoplastic lesions having a potential to become cancer cells and reduced the number of the aberrant crypt foci (ACF) consisting of four or more aberrant crypts (AC) having high risk to become tumors by about half. The supercritical heat-treated radish extracts can reduce the incidence of preneoplastic lesions having a high risk of developing cancer by about 28 %. DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. Supercritical heat-treated radish extracts, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, supercritical heat-treated radish extracts treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both mitogen-activated protein kinases (MAPK) and nuclear factor-kappa B (NF-kB) signaling pathways, and prevented the apoptosis of colon. Moreover, supercritical heat-treated radish extracts administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase.

• Journal of Korean Society on Water Environment
• /
• v.21 no.4
• /
• pp.305-313
• /
• 2005

In these days, water environment is getting threatened by a variety of toxic pollutants discharged from industries. However, environmental standards and regulations in Korea may be in straitened circumstances to protect the water environment from it. Therefore, the purpose of this review is to compare the management state of the toxic substances in water environment and to present the framework for deriving water quality criteria in USA and Japan. To conserve the water environment from the toxic pollutants more efficiently, the following considerations could be suggested in standards and regulation in Korea. Firstly, there should be consistency of regulated pollutants in drinking water quality standard, water quality standards and permissible wastewater discharge standards. Secondly, in case of deriving the water quality standards, it is required to consider the conservation of the aquatic ecosystem as well as the protection of human health. Finally, it is indispensable to make risk-based approach in management of toxic pollutants in water environment.

• Journal of the Korean Society of Safety
• /
• v.32 no.5
• /
• pp.103-114
• /
• 2017

The landslide disaster damage has been increased by mountain development, leading to construction of educational facilities, medical facilities, petty industrial facilities, and large housing complexes. Therefore, effective regulation is required as an effort in urban planning solutions. For suggesting specific mitigation strategies on urban landslide, this study aims to define evaluation criteria for urban planning management of debris-flow disaster. AHP (Analytic Hierarchy Process), one of the multiple criterion decision making methods, was utilized in this study. This study makes use of 16 sub-criteria under the framework of hazard, exposure, and vulnerability, and well-planned expert survey measures their weights. The weights are also applied to evaluate each grid in urban space (min $10{\times}10m$) and classify it with red, orange, yellow, or green grade so that areas at higher risk are clearly identified. This study concludes that the suggested method is useful to support a strategies for urban planning management of debris-flow disaster, particularly in a GIS base.

• Clinical and Experimental Pediatrics
• /
• v.57 no.3
• /
• pp.101-109
• /
• 2014

The use of glucocorticoids (GCs) in the perinatal period is suspected of being associated with adverse effects on long-term neurodevelopmental outcomes for preterm infants. Repeated administration of antenatal GCs to mothers at risk of preterm birth may adversely affect fetal growth and head circumference. Fetal exposure to excess GCs during critical periods of brain development may profoundly modify the limbic system (primarily the hippocampus), resulting in long-term effects on cognition, behavior, memory, co-ordination of the autonomic nervous system, and regulation of the endocrine system later in adult life. Postnatal GC treatment for chronic lung disease in premature infants, particularly involving the use of dexamethasone, has been shown to induce neurodevelopmental impairment and increases the risk of cerebral palsy. In contrast to studies involving postnatal dexamethasone, long-term follow-up studies for hydrocortisone therapy have not revealed adverse effects on neurodevelopmental outcomes. In experimental studies on animals, GCs has been shown to impair neurogenesis, and induce neuronal apoptosis in the immature brains of newborn animals. A recent study has demonstrated that dexamethasone-induced hypomyelination may result from the apoptotic degeneration of oligodendrocyte progenitors in the immature brain. Thus, based on clinical and experimental studies, there is enough evidence to advice caution regarding the use of GCs in the perinatal period; and moreover, the potential long-term effects of GCs on brain development need to be determined.