• 부동산연구
• /
• 제24권1호
• /
• pp.77-90
• /
• 2014

전 국토에 대한 난개발을 방지할 목적으로 2002년부터 시행되고 있는 토지개발허가제는 재산권 제한의 한 유형으로서 의의가 있지만, 전통적으로 이해하고 있는 토지소유권의 내용에 대한 수정도 불가피하게 하고 있다. 그리고 토지의 개발금지를 해제하는 것은 토지개발의 자유를 회복하는 데 그치는 것이 아니라 토지개발권을 형성하는 원인으로 해석될 수 있으며 이를 물권(物權)으로 발전시켜야 한다는 것이 이 논문의 취지이다. 개발행위허가를 재산권 제한의 한 유형이라는 점에서 보면 헌법상 그 제한의 근거와 보상요부 문제가 발생하게 된다. 그러나 그 제한은 개발행위허가를 통하여 회복되거나 완화될 수 있으므로 보상 문제가 해소될 수 있다. 개발행위허가제에 의해 토지개발권은 토지소유권에서 분리되어 공유화되었으며, 토지소유권은 이제 토지의 현상이용권만 남아 있고 장래의 현상변경권은 원칙적으로 가지고 있지 못하므로 전통적인 토지소유권 개념의 수정을 불가피하게 하고 있는 것이다. 토지개발허가제는 토지소유권의 권능에서 개발권을 독자적인 권리로 분리할 수 있는 성질이 있어야만 그 정당성이 부여될 수 있다. 만약 이러한 성질이 없다면 토지개발허가제는 토지개발권의 사회적 필요성을 충족하지 못하고 토지소유권 제한이론의 범주에서 그 논의를 벗어나지 못할 수 있다. 현행 "민법"이나 토지규제법 체계 하에서 토지 개발권을 물권으로 일반화하기는 여러 가지 어려움과 한계가 있을 것으로 보인다. 따라서 사회법이념의 토지기본법을 제정하여 재산권이나 물권이론에서 토지권 이론을 특성화하고, 이곳에서 토지개발허가제나 개발권 이론을 독자적 체계적으로 연구 발전시켜야 할 것으로 생각된다.

• 의료법학
• /
• 제10권1호
• /
• pp.39-75
• /
• 2009

The development of the biomedical science and technology has extended an argument about a status in constitutional law of unborn human life and a protection of the potential human life to that of an embryo and a gamete beyond a fetus. This argument has been focused on whether we should provide unborn or potential human life with human dignity and the right to life that are guaranteed by the constitutional law altogether or separately. If the right to life is given to unborn or potential human life, on what grounds can we restrict this right. Those who argue for the unity of the right to life with human dignity and the inseparability of those two claims that the right to life in itself should be guaranteed absolutely. According to the constitutional law, however, any constitutional right of the human person within the protection of essential part of the right can be compared with each other and restricted with some valid reasons from the legal perspective. This measure is unavoidable in reality because one right can come into conflict with another right frequently. Since fetus and embryo are in a process of developing into the human person, it is difficult to think that they are the same with the human person. For that reason, it is hard to consider that the right to life of fetus or embryo is the same with that of the human person. However, since a fetus has a special status as a potential human person, and an embryo also has a special value as a potential fetus upon an implantation, the right to life of fetus or embryo should be judged differently according to the stage of their development. A study on a constitutional status and protection of a fetus and an embryo is essential because unborn or potential human life is the origin of human person. Therefore, we have to make much account of their right to life and seek the legal respect for their inherent value.

• Genomics & Informatics
• /
• 제5권2호
• /
• pp.41-45
• /
• 2007

Pharmacogenomics is the study that examines how genetic variations affect the ways in which people respond to drugs. The ways people respond to drugs are complex traits that are influenced by many different genes. Pharmacogenomics intends to develop rational means of optimizing drug therapy, with respect to the patients' genotype, to maximize efficacy with minimal adverse drug reactions. Pharmacogenomics has the potential to revolutionize the practice of medicine, and promises to usher in an area of personalized medicine, in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Indeed, pharmacogenomics is exploited as an essential step for target discovery and drug development in the pharmaceutical industry. The goal of the personalized medicine is to get the right dose of the right drug to the right patient at the right time. In this article, we will review the use of pharmacogenomics in drug discovery and development.

• Korean Circulation Journal
• /
• 제48권11호
• /
• pp.1014-1024
• /
• 2018

Background and Objectives: Intense exercise (IE) induced myocardial fibrosis (MF) showed contradictory findings in human studies, making the relationship between IE and the development of MF unclear. This study aims to demonstrate exercise induced MF is associated with cardiac damage, and inflammation is essential to the development of exercise induced MF. Methods: Sprague-Dawley rats were submitted to daily 60-minutes treadmill exercise sessions at vigorous or moderate intensity, with 8-, 12-, and 16-week durations; time-matched sedentary rats served as controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum cardiac troponin I (cTnI) concentration. After completion of the exercise protocol rats were euthanized. Biventricular morphology, ultrastructure, and collagen deposition were then examined. Protein expression of interleukin $(IL)-1{\beta}$ and monocyte chemotactic protein (MCP)-1 was evaluated in both ventricles. Results: After IE, right but not left ventricle (LV) MF occurred. Serum cTnI levels increased and right ventricular damage was observed at the ultrastructure level in rats that were subjected to long-term IE. Leukocyte infiltration into the right ventricle (RV) rather than LV was observed after long-term IE. Long-term IE also increased protein expression of proinflammation factors including $IL-1{\beta}$ and MCP-1 in the RV. Conclusions: Right ventricular damage induced by long-term IE is pathological and the following inflammatory response is essential to the development of exercise induced MF.

• 기술혁신학회지
• /
• 제2권2호
• /
• pp.233-248
• /
• 1999

For the last several decades, it has been recognized that technology is a key factor in becoming an ADC and an advanced firm. So many countries and individual firms have been increasing investments on technology development. Especially LDCs including Korea choose technology transfer and transaction as an important alternative of their own technology development. To activate technology transaction and transfer, it is necessary to establish an technology transaction system, namely a Technomart that will make good connections between technology suppliers and technology buyers, and efficient functional linkages of supporting infrastructures including organizations and laws related with technology transactions. Therefore this study reviewed both the characteristics of technology transfer and transaction and a conceptual structure of a Technomart through a literature review. And then, the study analyzed the Technomart related laws including an intellectual property right, a copyright, a patent right, and electric transaction related laws. In conclusion the study proposed the development directions of the Technomart related laws.

• 한국산업보건학회지
• /
• 제17권3호
• /
• pp.203-211
• /
• 2007

This study was conducted in cut rose cultivation field in Goyang to evaluate pesticide exposure of farmers and the relationship between the exposure and work environment/method for cut rose farmers. Dermal exposure was assessed with patch (thin chromatography layer paper), cotton glove by body parts during mixing and spraying works in which pyrethroid, organophosphate, carbamate pesticide were used in 4 cut rose greenhouses located in Goyang province, checking characteristics of environment/working method at the same time. Body parts assessed were as follows ; glove : hand, patch : head, neck(front/back), chest, back, shoulder(right/left), upperarm(right/left), forearm(right/left), thigh(right/left), shin(right/left). Pesticides were analyzed using gas chromatography(NPD/FID) after extracting with ethyl acetate. Exposure amount differed according to pesticide type. But after standardizing with total net weight of pesticide sprayed, there were no significant difference among pesticides. There were significant difference in exposure amount among body parts(especially exposure amount of thigh, shin were more than the others), which means exposure happen not by pesticide dispersion in air but by contact with cut rose(leaf, branch) indirectly. Walking forward during spraying made farmers more exposed than waling backward, these results means contacts with leaves/branches made exposure happen in cut rose greenhouse also. As a result, pesticide exposure in cut rose greenhouse was related with contact of leaf/branch which pesticide remained in, which made exposure pattern (especially exposure amount) differ by body parts

• Animal cells and systems
• /
• 제6권3호
• /
• pp.253-261
• /
• 2002

Although cardiac distribution of specific receptors for atrial natriuretic peptide (ANP) was mainly observed in the ventricular endocardium, the modulation of ANP receptors in relation to cardiac development is not defined. The present study was undertaken to investigate ANP receptor modulation in rat during development. In the developmental stages examined (fetus, after postnatal 3-days, 1-, 2-, 3-, 4-, and 8-week-old Sprague Dawley rats) specific ANP binding sites were localized in the right and left ventricular endo-cardia by quantitative in vitro receptor autoradiography using (equation omitted)-rat ANP as labeled ligand. The specific bindings to endocardium were much higher in the right than the left ventricle. The binding affinities of ANP were much higher in the right than the left ventricular endocardium. The difference of these binding affinities among various developmental stages was not observed in the right ventricle, whereas the binding affinity in left ventricle was gradually increased with aging and reached the peak value at 8 weeks. No significant difference in maximal binding capacities of endocardial bindings was observed in the right and left ventricular endocardia during developmental stages. Also, cGMP production via activation of particulate guanylyl cyclase-coupled receptor subtypes in the ventricular membranes was gradually decreased with close relationship to aging. Therefore, the present study show that the endocardial ANP receptor is modulated with close relationship to cardiac development in the left ventricle rather than the right ventricle, and may be involved in regulating myocardial contractility in left heart.

• Journal of Chest Surgery
• /
• 제19권1호
• /
• pp.1-11
• /
• 1986

Using an experimental model of pulmonary hypertension, the effects of anticonstrictive drugs on the development of pulmonary vascular remodeling and right ventricular hypertrophy were studied. Male Sprague-Dawley rats weighing 200~250 gm were used. For the experimental model of pulmonary hypertension, a group of animal was given by a subcutaneous injection of monocrotaline on a dose of 20mg, 40mg, or 60mg per kg of body weight. After 4 weeks of injection, all animals were sacrificed. Another group of animal was given by a subcutaneous injection of monocrotaline in a dose of 40 mg per kg of body weight. The animals were sacrificed, in which they were kept alive for 1, 2, 3 and 4 weeks, respectively. For the effects of anticonstrictive drugs on the development of pulmonary vascular remodeling and right ventricular hypertrophy, the animals treated with monocrotaline were given daily by an intraperitoneal injection of phenoxybenzamine in a dose of 1.3mg/kg of body weight, and were given propranolol via their drinking water at a concentration of 400mg/liter. The animals were sacrificed after 4 weeks of administration. The hearts and lungs were examined histopathologically and morphometrically. The results obtained were summarized as follows: 1. The rats treated with monocrotaline showed an interstitial pneumonitis, medial thickening of the pulmonary small arteries and hypertrophy of the right ventricular wall. 2. The medial thickening of the pulmonary arteries in rats treated with monocrotaline was due to muscular hypertrophy and hyperplasia, and the right ventricular hypertrophy was due to hypertrophy of cardiac muscles. Both medial thickening of the pulmonary arteries and hypertrophy of right ventricular wall were more marked with time and with dose. 3. The daily intraperitoneal injection of phenoxybenzamine suppressed significantly the percentage medial thickness of pulmonary small arteries and the index of right ventricular hypertrophy in rats given a single subcutaneous injection of monocrotaline, but propranolol has shown no protective effect on the development of medial thickening of pulmonary arteries and right ventricular hypertrophy in treated with monocrotaline. The results described above suggested that monocrotaline is an alkaloid selectively inducing pulmonary hypertension and that a-adrenergic receptor is responsible for the pathogenesis of monocrotaline induced pulmonary hypertension in rat.

• Journal of Chest Surgery
• /
• 제21권1호
• /
• pp.152-157
• /
• 1988

Traumatic aorta-right ventricular shunt is an uncommon but important phenomenon due to development of irreversible cardiac dysfunction. Aorto-right ventricular shunt and aortic valvular laceration following stab wound of the chest was successfully surgically repaired in a twenty-year-old male patient. With the brief review of literatures, we describe the case.

• 한국태양에너지학회 논문집
• /
• 제25권1호
• /
• pp.65-78
• /
• 2005

The objective of this paper is to develop a automatic computation module for optimum stories in apartment buildings in order to assure the solar access right for neighboring areas. Compared to the existing solar access right analysis programs, the proposed solar access right analysis program is more improved and expanded by automating the computing process of optimum stories in apartment buildings. With the result of this research, it would be possible to furnish advanced information for an amicable settlement against the civil petition and disputes, to reduce waste of the time and money, and to improve the efficiency of solar access right analysis works.