• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집E
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• pp.235-240
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• 2001

The CHFG (Critical Heat Flux in Gap) test results have been evaluated to quantify the critical power in hemispherical narrow gaps and a new correlation has been developed. The CHFG test results have shown that increases in the gap thickness and pressure lead to an increase in critical power. The pressure effect on the critical power was found to be much milder than predictions by CHF correlations of other researches. From the CHFG test results, a new correlation on critical power in the hemispherical gap has been developed using the non-dimensional parameters as follows: $$\frac{qCHF}{{\rho}g^hfg}{\cdot}4\sqrt{\frac{{\rho}_g^2}{g{\sigma}{\Delta}{\rho}}=\frac{0.1042}{1+0.1375({\rho}g/{\rho}l)^{0.21}(D/s)}$$ The developed correlation has been expanded to apply the spherical geometry using the Siemens/KWU's correlation.

• 한국초전도저온공학회:학술대회논문집
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• 한국초전도저온공학회 2003년도 추계학술대회 논문집
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• pp.30-34
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• 2003

For an inhomogeneous superconductor, we reveal a relation of an observed superconducting gap, $\Delta$$_{obs}$ and the intrinsic true gap, $\Delta$$_{i}$, $\Delta$$_{obs}$(equation omitted) where band filling, 0＜$\rho$<$\leq$1. $\Delta$$_{obs}$ is the effect of measurement when 0＜$\rho$＜1. The true gap is observed only when $\rho$=1. Parring symmetry analyzed by a coherence-peak shape of density of states, observed in B $i_2$S $r_2$CaC $u_2$ $O_{8}$＋$\chi$ superconductors, is s- wave.X> $O_{8}$＋$\chi$ superconductors, is s- wave. wave.

• Journal of Gastric Cancer
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• 제20권4호
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• pp.408-420
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• 2020

Purpose: Isoform 2 of tight junction protein claudin-18 (CLDN18.2) is a potential target for gastric cancer treatment. A treatment targeting CLDN18.2 has shown promising results in gastric cancer. We investigated the clinical significance of CLDN18.2 and other cell-adherens junction molecules (Rho GTPase-activating protein [RhoGAP] and E-cadherin) in metastatic diffuse-type gastric cancer (mDGC). Materials and Methods: We evaluated CLDN18.2, RhoGAP, and E-cadherin expression using two-plex immunofluorescence and quantitative data analysis of H-scores of 77 consecutive mDGC patients who received first-line platinum-based chemotherapy between March 2015 and February 2017. Results: CLDN18.2 and E-cadherin expression was significantly lower in patients with peritoneal metastasis (PM) than those without PM at the time of diagnosis (P=0.010 and 0.013, respectively), whereas it was significantly higher in patients who never developed PM from diagnosis to death than in those who did (P=0.001 and 0.003, respectively). Meanwhile, CLDN18.2 and E-cadherin expression levels were significantly higher in patients with bone metastasis than in those without bone metastasis (P=0.010 and 0.001, respectively). Moreover, we identified a positive correlation between the expression of CLDN18.2 and E-cadherin (P<0.001), RhoGAP and CLDN18.2 (P=0.004), and RhoGAP and E-cadherin (P=0.001). Conversely, CLDN18.2, RhoGAP, and E-cadherin expression was not associated with chemotherapy response and survival. Conclusions: CLDN18.2 expression was reduced in patients with PM but significantly intact in those with bone metastasis. Furthermore, CLDN18.2 expression was positively correlated with other adherens junction molecules, which is clinically associated with mDGC and PM pathogenesis.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2005년도 International Meeting on Information Displayvol.II
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• pp.878-881
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• 2005

We report a cell gap variation tolerant liquid crystal display(LCD). Since the cell gap variation of the LCD results in the variation of brightness and contrast ratio, we should control carefully the process to get the uniform cell gap. For the projector application, this is more significant and the one reason of the low yield. We observed that the brightness variation of LCD is suppressed by insertion of dielectric layer between the pixel electrode and liquid crystal.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2009년도 춘계학술대회 논문집
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• pp.1213-1217
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• 2009

The air gap between electromagnet and guiderail in an EMS-type Maglev vehicle must be maintained within an allowable deviation by controlling the voltage on the magnet. In this type of vehicle, the air gap response is strongly dependent on the structural characteristics of the elevated guideway, such as stiffness, damping and mass. For this reason, the dynamic interaction between the vehicle with electromagnets and the elevated guideway must be understood to ensure safe running. The response of the air gap to guideway characteristics such as mass, stiffness, and damping are analyzed through vehicle tests over different guideways. Through such tests, the design requirements for Maglev vehicles and elevated guideways can be established, improving levitation stability.

• 대한의생명과학회지
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• 제20권2호
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• pp.49-55
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• 2014

RalBP1 is an ATP-dependent non-ABC transporter, responsible for the major transport function in many cells including many cancer cell lines, causing efflux of glutathione-electrophile conjugates of both endogenous metabolites and environmental toxins. RalBP1 is expressed in most human tissues, and is over-expressed in non-small cell lung cancer cell lines and in many other tumor types. Blockade of RalBP1 by various approaches has been shown to increase sensitivity to radiation and chemotherapeutic drugs, leading to cell apoptosis. In xenograft tumor models in mice, RalBP1 blockade or depletion results in complete and sustained regression across many cancer cell types including lung cancer cells. In addition to its transport function, RalBP1 has many other cellular and physiological functions, based on its domain structure which includes a unique Ral-binding domain and a RhoGAP catalytic domain, as well as docking sites for multiple signaling proteins. Additionally, RalBP1 is also important for stromal cell function in tumors, as it was recently shown to be required for efficient endothelial cell function and angiogenesis in solid tumors. In this review, we discuss the cellular and physiological functions of RalBP1 in normal and lung cancer cells.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 춘계학술대회
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• pp.1927-1932
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• 2004

A 1/21.6 scaled non-heating experimental facility was prepared utilizing the results of a scaling analysis to simulate the APR1400 reactor and insulation system. The behaviors of the air bubble-induced two-phase natural circulation flow in the insulation gap were observed, and the liquid mass flow rates driven by natural circulation loop were measured by varying the injected air flow rate and distribution. As the injected air flow rates increased, the natural circulation flow rates also increased. Both the longitudinal and the latitudinal distributions of the injected air affected the natural circulation flow rates, especially, the longitudinal effect is more larger.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1637-1642
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• 2015

Background: RhoGTPase-activating proteins (RhoGAPs) regulate RhoGTPases in cells, but whether individual reactive oxygen species (ROS) regulate RhoGAPs is unknown. Our previous published papers have shown that deleted in liver cancer 1 (DLC1) inhibits cancer cell migration by its RhoGAP activity. The present study was designed to explore the role of $H_2O_2$ in regulation of DLC1. Materials and Methods: We treated cells with $H_2O_2$ for 24h and phenotypic changes were analyzed by MTT, RT-PCR, Western blotting, immunofluorescence staining and wound healing assays. Results: $H_2O_2$ downregulated cyclin D1 and cyclin E to inhibit proliferation, and upregulated BAX to induce apoptosis in MCF-7 cells. Compared with non-tumorigenic cells, $H_2O_2$ increased expression of DLC1 and reduced activity of RhoA in cancer cells. Stress fiber production and migration were also suppressed by $H_2O_2$ in MDA-MB-231 cells. Conclusions: Our study suggests that $H_2O_2$ inhibits proliferation through modulation of cell cycle and apoptosis-related genes, and inhibits migration by decreasing stress fibers via DLC1/RhoA signaling.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1992년도 하계학술대회 논문집 B
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• pp.915-917
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• 1992

This paper shows the discharge characteristics in flowing air with variation of tempearature(T) under the needle-needle gap. Flowing air duct of this investigation is circular tube. The flow at the experimental position's section is described as fully developed laminar flow. The important results obtained from this study are as follows. The ratio sparkover voltages to the Reynolds number(Re) increases with decreasing the Re. The velocity profiles can be visualized by this experimental method. The breakdown voltage ($V_{s1}$) for variation of T at 1[m/s] can be expressed by $V_{s1}$ = $K_1$(23.98$\rho$d + 6.98$\sqrt{\rho{d}}$) [kV].

• International Journal of Aeronautical and Space Sciences
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• 제17권2호
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• pp.139-148
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• 2016

The passive control methods such as horizontal and vertical fences on the lower surface of the bluff body were applied to suppress the vortex shedding and enhance the aerodynamic stability of flow. For investigating the effects of the passive control methods, wind tunnel experiments on the unsteady flow field around a bluff body near a moving ground were performed. The boundary layer and velocity profiles were measured by the Hot Wire Anemometer (HWA) system and the vortex shedding patterns and flow structures in a wake region were visualized via the Particle Image Velocimetry (PIV) system. Also, it is a measuring on moving ground condition that the experimental values of the critical gap distances, Strouhal numbers and aerodynamic force FFT analyses. Through the experiments, we found that the momentum supply due to moving ground caused the vortex shedding at the lower critical gap distance rather than that of fixed ground. The horizontal and vertical fences increase the critical gap distance and it can suppress the vortex shedding. Consequently, the stability characteristics of the bluff body near a moving ground could be effectively enhanced by the simple passive control such as the vertical fences.