• The Journal of Korean Medicine
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• v.29 no.4
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• pp.1-12
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• 2008

Background and Objectives: Sinusitis is a common disease in the otorhinolaryngology field. It is inflammatory change of the mucous membrane which surrounds the sinus. The aim of this study was to investigate the anti-inflammatory effects of the Taklisodok-eum (TSE) extract on the mouse model with acute sinusitis induced by S. pneumoniae. Methods: Thirty six-week-old male BALB/c mice were divided into three groups: the normal group, the group inoculated with S. pneumoniae which caused allergic rhinitis (control group), and the group treated with the TSE extract after it was treated the same as the control group (sample group). Results: $NF-{\kappa}B$ activation was suppressed, and iNOS & COX-2 production were inhibited by TSE in acute sinusitis. Apoptosis was increased by TSE in acute sinusitis. The number of eosinophils in the sample group noticeably decreased when compared to the control group. In the general morphologic change, the increase of damaged respiratory ciliated epithelia & eosinophils' infiltration was lessin the sample group. Goblet cells were maintained in the sample group. MMP-9, HSP-70 and BrdU decreased in the sample group. Apocrine secretion decreased in the sample group. Conclusion: The findings in this study show that TSE reduces acute sinusitis through its anti-inflammatory effects, such as the inhibition of $NF-{\kappa}B$ activity.

• 대한상한금궤의학회지
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• v.8 no.1
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• pp.121-143
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• 2016

Objective : This study is to report 4 Eumyangyeokchahunobok-byung cases diagnosed and treated according to newly hypothesized Eumyangyeokchahunobok-byung definition based on Shanghanlun disease pattern identification diagnostic system. Methods : We analyzed 4 clinical cases diagnosed with Eumyangyeokchahunobok-byung and treated by herbal medicine, which included in Eumyangyeokchahunobok-byung chapter of Shanghanlun according to newly hypothesized definition. Results : Dermatology Life Quality Index decreased from 25 to 10 on first patient, dizziness handicap inventory decreased from 64 to 2 on second patient, dizziness handicap inventory also decreased from 56 to 2 on third patient, and fatigue severity scale decreased from 7 to 2 on fourth patient. Conclusions : Not only all the patients' chief complaints relieved but their other clinical problems such as allergic rhinitis, body pain, constipation, reflux esophagitis also improved. These results highly insist that there is quite a possibility that Eumyangyeokchahunobokbyung means various diseases caused by reversed sleep cycle.

• Journal of Integrative Natural Science
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• v.8 no.4
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• pp.273-284
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• 2015

Chemoattractant Receptor Homologous molecule expressed on Th2 cells (CRTh2) is a chemoattractant receptor with seven transmembrane helices targeted for inflammatory diseases such as asthma and allergic rhinitis. In this study, pharmacophore based Comparative Molecular Similarity Indices Analysis (CoMSIA) were performed on the series of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acids derivatives. Initially, GASP module was used for generation of pharmacophore models using five highly active compounds from the dataset. Among the generated pharmacophores, the best pharmacophore model was selected based on fitness score and was used as template for the alignment of compounds which was used for CoMSIA analysis. The best predictions were obtained utilizing steric, hydrophobic and H-bond acceptor parameters showing a $q^2$=0.559 and $r^2$=0.730. 15 test set compounds was used to investigate the predictive ability of the CoMSIA model. Contour maps suggested that presence of bulky substituents and H-bond acceptor atoms at $5^{th}$ position of benzene ring will increase the activity of the compounds. The results obtained from this study will be useful to design more potent CRTh2 antagonists.

• Korean Journal of Health Education and Promotion
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• v.33 no.2
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• pp.27-37
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• 2016

Objectives: This study investigated the relationship between adolescents' suicidal ideation and their physical health conditions to contribute to lower suicide rates among adolescents. Methods: Secondary analysis of 2108 high school students of $10^{th}$ grade was conducted using the Korean Child and Youth Panel survey in 2013. The association between suicidal ideation and socio-demographic and health characteristics were analyzed using Chi-square tests and regression models. Results: Adolescents' physical health conditions were significantly related to suicidal ideation. In particular, rhinitis and various symptoms such as feeling feverish, low appetite, feeling of nausea, stomachache while studying, and sleeping problem showed statistically significant relationships with suicidal ideation (P < .05). Furthermore, the higher frequency of diseases and body symptoms increases the rate of suicidal ideation. Considering socio-economic characteristics, family structure was also important. Conclusions: Physical health condition is a major contributor to adolescent's suicidal ideation. results suggest that improving social support system for adolescents' physical health conditions across family and school may be important in suicide prevention efforts.

• Child Health Nursing Research
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• v.24 no.1
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• pp.101-108
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• 2018

Purpose: This study aimed to identify the effects of the mother-medical staff partnership on mothers' condition management ability for children with chronic allergic diseases. Methods: A total of 109 Korean mothers caring for a child with a chronic allergic diseases, identified according to the allergic march, such as food allergy, atopic dermatitis, allergic rhinitis, and allergic asthma, were recruited from the pediatric department of a general hospital in Seoul through convenience sampling. Data were collected using structured self-reported questionnaires from August 1, 2017 to October 31, 2017. and analyzed by descriptive statistics and multiple regression using SPSS version 22.0. Results: The Mother-medical staff partnership had a statistically significant effect on mothers' condition management ability for children with chronic allergic diseases (p<.05). Among the general characteristics, satisfaction with nursing services had a statistically significant effect on mothers' condition management ability (p<.05). Conclusion: In conclusion, strategies to support children with chronic allergic diseases, as well as their caregivers, should consider the mother-medical staff partnership as part of a family-centered approach.

• Journal of Acupuncture Research
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• v.24 no.1
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• pp.99-110
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• 2007

Objectives : This study was performed to evaluate a recent status of acupunctural treatment in pediatric practice. Methods: 660,893 children, who visited HAMSOA oriental clinic from January 2004 to December 2005 was screened to decide the number treated with acupuncture, the diagnosis and the type of acupuncture. In addition, the questionnaire for clinician about acupuncture therapy was performed and analysed to understand their applications. Results: The number treated with acupuncture was 69,797, 10.56%. Classified with ages, 3 months and below was 729 (1.7%), 1 year - 3 months was 5,035 (11.80%), 2 year - 1 year was 6,875 (16.10%), 3 year - 2 year was 5,540 (12.98%), 6 year - 3 year was 12.636 (31.94%) and 6 year and above was 10,876 (25.48%). The most frequent diagnosis taken acupuncture was atopic dermatitis (14.93%) and the next was rhinitis (13.80%). The most frequent type of acupuncture was laser acupuncture. The clinicians answered questionnaire agreed that acupuncture therapy is effective for pediatric disease treatment and fear about acupuncture of young patients was the most important obstacle. Conclusion : The acupuncture therapy in pediatric practice is not so frequent treatment but in increasing stage. Futhermore, in-depth research about acupuncture therapy in pediatrics is demanded.

• Journal of Environmental Health Sciences
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• v.29 no.3
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• pp.35-42
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• 2003

Nitric Oxide(NO) is produced in many organs of the body, including the lung and airways, and it is detectable in the exhaled air. The measurement of exhaled NO(eNO) provides a simple non-invasive means for measuring airway inflammation, such as asthma. We measured eNO among adult male workers to examine the distribution of eNO in healthy people and to find factors affecting eNO. We measured eNO in a sample of 921 adult workers who also performed lung function test and skin prick test. Exhaled NO was measured in a sitting posture without using a nose clip and NO free gas. NO was measured at three expiratory rates(l8; 42; 71 $m\ell$/sec) and the flow rate of 71 $m\ell$/sec was used in analysis. The average eNO concentration was 5.29 $\pm$ 2.98 ppb. The level increased with age but not significantly(P=0.0529). Exhaled NO showed positive relations to the height(P=0.0001), pollen 1 (P=0.0124), asthma history(P=0.0212), allergic rhinitis symptom(P=0.0302). Exhaled NO Concentration of smokers( 4.62 ppb) was significantly lower than that of nonsmokers(5.99 ppb; P<0.0001).

• Biomedical Science Letters
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• v.20 no.4
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• pp.244-249
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• 2014

Arazyme is a metalloprotease secreted by Aranicola proteolyticus that was previously shown to suppress cytokine expression of keratinocytes and endothelial cells and inhibit histopathological features in an atopic dermatitis-like animal model. However, the regulatory effects of arazyme in other allergic diseases have yet to be elucidated. In this study, we investigated whether arazyme is effective against neutrophil apoptosis in allergic diseases such as allergic rhinitis and asthma. Arazyme inhibited neutrophil apoptosis of normal subjects in a dose-dependent manner. However, the antiapoptotic effect of arazyme was reversed by LY294002, an inhibitor of PI3K, AKTi, an inhibitor of Akt, PD98059, an inhibitor of MEK, and BAY-11-7085, an inhibitor of NF-${\kappa}B$. Arazyme induced activation of NF-${\kappa}B$ via PI3K/Akt/ERK pathway. The anti-apoptotic effect of arazyme is associated with inhibition of cleavage of caspase 3 and caspase 9. Arazyme inhibited constitutive apoptosis of neutrophil in a dose-dependent manner in allergic subjects, and its mechanism was shown to be associated with PI3K/Akt/ERK/NF-${\kappa}B$. The results presented here improve our understanding of neutrophil apoptosis regulation and will facilitate development of drugs for treatment of allergic diseases.

• Korean Journal of Pharmacognosy
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• v.16 no.1
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• pp.18-25
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• 1985

Experimental studies were conducted to investigate for the effect of Tongkyu-tang on analgesic, antipyretic, sedative, anti-inflammatory, isolated ileum and anti-histamine actions. Tongkyu-Tang was composed of sixteen crude drugs including Astragali Radix, which has been used for the treatment of common cold, headache, rhinitis, nasal obstruction, rhincospasm, etc. The following results have been obtained; analgesic and antipyretic actions were obtained. Prolonged action against the hypnotic duration of pentobarbital were significantly noted in mice. Anti-inflammatory effects in the paw edema induced by 1% carrageenin and 1% dextran were significantly shown in rats. Spontaneous motilities of isolated ileum of mice were strongly suppressed, and contractions of isolated ileum of mice and guinea-pigs induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Antihistamine actions were noted. Considering the above experimental results, it is suggested that effects of Tongkyu-tang based on the Oriental Medical References were similarly consistent with the actual experimental results.

• Archives of Pharmacal Research
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• v.27 no.3
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• pp.346-350
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• 2004

Chitosan microspheres were prepared by ionic gelation process with sodium sulfate for nasal vaccine delivery. Bordetella Bronchiseptica Dermonecrotoxin (BBD) as a major virulence factor of a causative agent of atrophic rhinitis (AR) was loaded to the chitosan microspheres for vaccination. Morphology of BBD-loaded chitosan microspheres was observed as spherical shapes. The average particle sizes of the BBD-loaded chitosan microspheres were about $2.69$\mid${\;}\mu\textrm{m}$. More BBD was released with an increase of molecular weight of chitosan and with an increase of medium pH in vitro due to weaker intermolecular interaction between chitosan and BBD. Tumor necrosis $factor-{\alpha}{\;}(TNF{\alpha})$ and nitric oxide (NO) from RAW264.7 cells stimulated with BBD-loaded chitosan microspheres were gradually secreted, suggesting that released BBD from chitosan microspheres had immune stimulating activity of AR vaccine.