• 제목/요약/키워드: Rheumatoid arthritis(RA)

검색결과 240건 처리시간 0.023초

Effects of phylloquinone supplementation on lipid profile in women with rheumatoid arthritis: a double blind placebo controlled study

  • Kolahi, Sousan;Gargari, Bahram Pourghassem;Abbasi, Mehran Mesgari;Jafarabadi, Mohammad Asghari;Shishavan, Neda Ghamarzad
    • Nutrition Research and Practice
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    • 제9권2호
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    • pp.186-191
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    • 2015
  • BACKGROUND/OBJECTIVES: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease which is likely attributed to an atherogenic lipid profile. Among nutritional factors vitamin K has been recently focused as a pivotal nutrient in improvement of lipid related markers. Thus, this study was designed to determine the effects of vitamin K on lipid profile in this disease. SUBJECTS/METHODS: Fifty eight patients with definitive RA were participated in the present double blind placebo controlled study. They were randomly allocated into two groups to receive vitamin $K_1$ as phylloquinone [10 mg/day] (n = 30) or placebo pills (n = 28), for eight weeks. In order to control the effects of probable confounders dietary intakes, anthropometric measurements including weight and height, clinical status using disease activity score-28 (DAS-28), physical activity and anxiety status were evaluated at baseline. Moreover, serum levels of lipid related markers including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured at baseline and at the end of intervention. RESULTS: There were no significant differences between the two groups regarding any of the baseline characteristics. After adjusting for some relevant confounders, in comparison between two groups, we observed no significant changes in lipid related markers at the end of intervention. Also, there was no significant difference between before and after intervention values within groups (P > 0.05). CONCLUSIONS: Function of vitamin $K_1$ in lipid profile modification remains still controversial. This study showed that vitamin $K_1$ has no effect on lipid profile in women with rheumatoid arthritis. Further studies with a longer follow-up are required to determine the effects of vitamin K on atherogenic lipid profile.

Caffeic Acid Phenethyl Ester Inhibits the PKC-Induced IL-6 Gene Expression in the Synoviocytes of Rheumatoid Arthritis Patients

  • Hur, Gang-Min;Hwang, Yin-Bang;Lee, Jae-Heun;Bae, So-Hyun;Park, Ji-Sun;Lee, Choong-Jae;Seok, Jeong-Ho
    • The Korean Journal of Physiology and Pharmacology
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    • 제7권6호
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    • pp.363-368
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    • 2003
  • To gain insight on the role of pro-inflammatory cytokines in the pathogenesis and treatment of rheumatoid arthritis (RA), the phorbol 12-myristate 13-acetate (PMA)-induced IL-6 gene expression and the effect of caffeic acid phenethyl ester (CAPE) on the PMA-induced IL-6 gene expression were investigated in human fibroblast-like synoviocytes (FLSs). Synovial tissue samples were obtained from rheumatoid arthritis patients, and FLSs were isolated. The cells were stimulated with PMA (100 nM) for 6 hrs to induce IL-6 gene. The cells were pretreated with CAPE (20, 50, $100{\mu}M$) prior to PMA treatment. PMA increased IL-6 RNA expression, binding activities of transcription factors ($NF-{\kappa}B$, AP-1) to IL-6 promoter, and IL-6 promoter activity. However, CAPE inhibited PMA-induced IL-6 mRNA expression in dose-dependent manner, and also inhibited the increased binding activities of transcription factors to IL-6 promoter and IL-6 promoter activity. These results suggest that CAPE might regulate PKC-mediated IL-6 expression and inflammatory reactions in RA.

The Efficacy of Shikonin on Cartilage Protection in a Mouse Model of Rheumatoid Arthritis

  • Kim, Young-Ock;Hong, Seung-Jae;Yim, Sung-Vin
    • The Korean Journal of Physiology and Pharmacology
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    • 제14권4호
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    • pp.199-204
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    • 2010
  • The potential therapeutic action of shikonin in an experimental model of rheumatoid arthritis (RA) was investigated. As a RA animal model, DBA/1J mice were immunized two times with type II collagen. After the second collagen immunization, mice were orally administered shikonin (2 mg/kg) once a day for 35 days, and the incidence, clinical score, bone mineral density (BMD), bone mineral content (BMC) and joint histopathology were evaluated. BMD in the proximal regions of the tibia largely increased in the shikonin treatment group compared with the control group. We also examined the effect of shikonin on inflammatory cytokines and cartilage protection. Shikonin treatment significantly reduced the incidence and severity of collagen-induced arthritis (CIA), markedly abrogating joint swelling and cartilage destruction. Shikonin also significantly inhibited the production of matrix metalloproteinase (MMP)-1 and up-regulated tissue inhibitors of metalloproteinase (TIMP)-1 in mice with CIA. In conclusion, shikonin exerted therapeutic effects through regulation of MMP/TIMP; these results suggest that shikonin is an outstanding candidate as a cartilage protective medicine for RA.

폐경 후 류마티스 관절염 여성의 골량감소 판별요인 (Determinants of Reduced Bone Mass in Postmenopausal Women with Rheumatoid Arthritis)

  • 이은남
    • 재활간호학회지
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    • 제2권2호
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    • pp.193-205
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    • 1999
  • This study was carried out to identify the important risk factors for reduced bone mass of postmenopausal RA patients and to develop discriminant function which can classify postmenopausal RA patients with either reduced or normal bone mass. Through the literature review, individual characteristics such as age, body weight, height, age of menarche, duration of menopause, gravity, parity, and breast feeding period and factors of life style such as milk consumption exercise habit, alcohol intake, cigarette smoking, coffee consumpt ion , disease activity, corticosteroid therapy were identified as influencing factors of reduced bone mass in RA patients Sixty eight postmenopausal women with rheumatoid arthritis aged between 42 and 76 were selected among those who checked bone mineral density in lumbar spine and femur from october, 1998 to Apr il, 1999 at Dong-a university hospital in Pusan. Assessment of disease activity, duration of disease and corticosteroid therapy were made by the same rheumatologist and included Ritchie articular index, erythrocyte sedimentation rate, and C-reactive protein on measuring bone mineral density. Cumulative steroid dosage was calculated from the daily dosage multiplied by t h e number of days received. The information of other risk factor including health assessment score, individual characteristics and life style factors were collected by questionnaire. Bone mineral density(BMD) was measured using DXA at lumbar spine and femoral Ward's triangle. Discriminant function(regression equation) was developed for estimating the likelihood of the presence or absence of reduced bone mass. The results are as follows: Among the subjects, thirteen(19.1%) exhibited osteoporosis in lumbar spine and twenty four(35.3%) exhibited osteoporosis in femoral Ward's triangle. For lumbar spine, the variables significant were age, body weight, health assessment score, while for femoral Ward's triangle, age, body weight, duration of disease. But disease activity and corticosteroid therapy were not signigicant to distinguish reduced bone mass from normal bone mass. When the discriminant function was evaluated by comparing the observed out come with predicted out come, the discriminant function correctly classified 85.4% of patients with reduce bone mass and 63.0% of patients with normal bone mass in the lumbar spine and 100% of patients with reduced bone mass and 9.1% of patients with normal bone mass in the femoral Ward's triangle. In summary, we found that osteoporosis in postmenopausal women with RA is more evident at the femur than the lumbar spine. Also the important discriminant factors of reduced bone mass postmenopausal women with RA were age, body weight , duration of disease and health disability. In nursing situation, the efforts to improve of functional capacity of postmenopausal women with rheumatoid arthritis should be considered to prevent osteoporosis and fractures. Also we recommend those postmenopausal women with RA who are classified as a group of the reduced bone mass in the discriminant function should examine the bone mineral density to further examine the usefulness of this discriminant function.

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류마티스 관절염 환자의 자가간호역량과 가족지지, 삶의 질과의 관계 (The Relationships among Self-Care Agency, Family Support, Quality of Life in Patients with Rheumatoid Arthritis)

  • 박상연;남영화;백명화
    • 근관절건강학회지
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    • 제7권2호
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    • pp.281-293
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    • 2000
  • This study was conducted to identify the relationships among self-care agency, family support, qualify of life in patients with rheumatoid arthritis. The subjects were 120 rheumatoid arthritis patients who attended RA O.P.D. at a university hospital, located in Daegu city, from 10th of May in 1998 to 30th of July in 1998. Three structure questionnaires were administered for explore three main research variables; 소향숙's self-care agency scale, 강현숙's family support scale, and 김종임's quality of life scale of RA patien. Data analysis was conducted with SPSS program including percentage, mean, standard deviation, mean score, Pearson Correlation Coefficient, multiple regression, and Cronbach's Alpha. Results are summarized as follows; 1. The mean of RA patient's self-care agency was 136.62, the mean of family support 37.38, and the mean of qualify of life 134.41. 2. Subject's self-care agency was positively correlated with family support(r=.2446) and with quality of life(r=.4341). Subject's family support was positively correlated with quality of life(r=.2630). 3. Stepwise multiple regression was used to determine the predictors of subject's quality of life. Significant predictors for subject's quality of life were self-care agency(t=4.873 p=0.0000), family support(t=4.480 p=0.0000) and the severity of arthralgia(t=-3.838, p=0.0002). The number of joints involved and the periods of illness did not show significant contribution to subject's quality of life. Self-care agency, family support, and family support explained 40. 39% of the variance in RA patient's quality of life. Given this results, it is suggested that a repeated study to measure RA patient's self-care practice in their own life may be needed to develope and validate an optimum level of nursing intervention for RA patient with which family support will be encouraged and patient's self-care agency will be facilitated.

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자조관리 프로그램이 여성 류마티스 관절염 환자의 자기효능감과 삶의 질에 미치는 효과 (The Effects of a Self-management Program on Self-efficacy and Quality of Life for Korean Women with Rheumatoid Arthritis)

  • 김현지;유혜라;송미숙;현명선
    • 임상간호연구
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    • 제16권2호
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    • pp.107-116
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    • 2010
  • Purpose: The purpose of this study was to examine the effects of a self-management program on self-efficacy and quality of life for Korean women with rheumatoid arthritis. Methods: A quasi-experimental study using a nonequivalent control group pretest posttest design was used. The data were collected from July 1 to Sep. 15, 2007. Thirty one arthritis patients (15 in the experimental group and 16 in the control group) were participated in this study. A self-management program developed by Korean Society of Muscle and Joint Health in 1994 was used. The program was consisted of 6 sessions, 2 hours each and held every Friday for 6 weeks. General Self-Efficacy Scale and Quality of Life were used to test the effect of the program. Results: Hypothesis 1; "Self-efficacy in the experimental group after program would be higher than the control group" was supported. Hypothesis 2; "Quality of Life in the experimental group after program would be higher than the control group " was not supported. Conclusion: The self-management program was effective for Korean women with rheumatoid arthritis in terms of increasing self-efficacy. Therefore, to increase self-management skills and self-efficacy for female rheumatoid arthritis patients, the program can be useful.

Korean Red Ginseng exhibits no significant adverse effect on disease activity in patients with rheumatoid arthritis: a randomized, double-blind, crossover study

  • Cho, Soo-Kyung;Kim, Dam;Yoo, Dasomi;Jang, Eun Jin;Jun, Jae-Bum;Sung, Yoon-Kyoung
    • Journal of Ginseng Research
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    • 제42권2호
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    • pp.144-148
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    • 2018
  • Background: Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the impact of Korean Red Ginseng (KRG) on disease activity and safety in RA patients. Methods: A total of 80 female RA patients were randomly assigned to either the KRG (2 g/d, n = 40) treatment or placebo (n = 40) groups for 8 wk, followed by crossover to the other treatment group for an additional 8 wk. The primary outcome was the disease flare rate, defined as worsening disease activity according to the disease activity score 28 joints-erythrocyte sedimentation rate (DAS28-ESR). The secondary outcomes were development of adverse events (AEs) and patient reported outcomes. Outcomes were evaluated at baseline and 8 wk and 16 wk. The outcomes were compared using the Chi-square test. Results: Of the 80 patients, 70 completed the full study. Their mean age was 51.9 yr, and most exhibited low disease activity (mean DAS28-ESR $3.5{\pm}1.0$) at enrollment. After intervention, the flare rate was 3.7% in each group. During KRG treatment, 10 AEs were reported, while five AEs were developed with placebo; however, this difference was not statistically significant (p = 0.16). Gastrointestinal- and nervous system-related symptoms were frequent in the KRG group. Conclusion: KRG is not significantly associated with either disease flare rate or the rate of AE development in RA patients.

류마티스 관절염 여성의 심리사회적 적응 - 신체적 기능장애와 사회적 지지를 중심으로 - (Psychosocial Adaptation of Women with Rheumatoid Arthritis: Focusing on Physical Disability and Social Support)

  • 임승주;안경애;한인영
    • 근관절건강학회지
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    • 제11권2호
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    • pp.165-175
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    • 2004
  • Purpose: To describe the psychosocial adaptation, physical disability and social support, and to examine whether the physical disability and social support influence the psychosocial adaptation of women with Rheumatoid Arthritis(RA). Method: This survey was conducted with 102 women diagnosed as RA using a structured survey tool between April 12th and 30th 2004. Results: The Physical disability ranged from 0 to 51, the average was 9.89(${\pm}12.15$), appearing that less severe than previous studies. The social support ranged from 29 to 168, and the average was 91.73(${\pm}31.44$). The age, marital status, and monthly income were associated with patient's perceived social support. The psychosocial adaptation ranged from 77 to 186 and the average was 132.12(${\pm}24.13$). Entering physical disability and social support into the model significantly improved the prediction of psychosocial adaptation: 45.1% of the variance of psychosocial adaptation was attributed by the physical disability (Beta=-.325) and the social support (Beta=.204). Additionally, the religion (Beta=.231) and monthly income (Beta=.381) were significant predictors of the psychosocial adaptation. Conclusions: (1) Programs to improve physical disability of the clients are needed. (2) Marital status and age should be considered when the programs are developed. (3) More social support should be provided to the women with RA. (4) Adequate financial support is essential for the psychosocial adaptation of women with RA.

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Effects of Soy Bread on Cardiovascular Risk Factor, Inflammation and Oxidative Stress in Women With Active Rheumatoid Arthritis: A Randomized Double-Blind Controlled Trial

  • Afsaneh Sayyaf;Ehsan Ghaedi;Fatemeh Haidari;Elham Rajaei;Kambiz Ahmadi-engali;Bijan Helli
    • Clinical Nutrition Research
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    • 제13권1호
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    • pp.22-32
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    • 2024
  • Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disorder with widespread synovitis. Isoflavones, the main active component of soy, have been reported to have potent anti-inflammatory effects; the previous RA animal models showed the promising effect of soy supplementation. We aimed to evaluate the effect of soy bread on inflammatory markers and lipid profiles in RA patients. The present study was designed as a randomized controlled trial. RA patients were randomly allocated to obtain soy bread (n = 22) or placebo bread (n = 22) for 8 weeks. Fasting serum levels of lipid profile, total antioxidant capacity (TAC), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and DAS28 were checked. Findings showed that there were no significant differences between the two groups in physical activity and dietary intake at the beginning of the study and the end of the study. There were no significant differences between the two groups in measured lipid profile markers, including high-density lipoprotein, low-density lipoprotein, total cholesterol, triglyceride, and very low-density lipoprotein, at the end of the trial. In addition, TAC and CRP also were not significant at the end of the trial between the 2 groups (0.66 and 0.12, respectively). However, the serum levels of TNF-α reduced significantly in the soy bread group at the end of the intervention (p < 0.000) and compared with the control group (p < 0.019). Soy bread consumption only decreased circulating TNF-α serum concentration. Other outcome measures were not changed following supplementation. Future long-term, well-designed studies are needed to confirm these findings.

Anti-nociceptive effect of bee venom treatment on chronic arthritic pain in rats

  • Kwon, Young-bae;Lee, Jae-dong;Lee, Hye-jung;Han, Ho-jae;Lee, Jang-hern
    • 대한수의학회지
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    • 제39권4호
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    • pp.715-723
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    • 1999
  • Bee venom (BV) has been traditionally applied to relieve pain and to cure inflammatory diseases such as rheumatoid arthritis (RA) and neuritis. While several investigators have evaluated the anti-inflammatory effect of BV treatment, the anti-nociceptive effect of BV treatment on inflammatory pain is not reported. Therefore, we decided to evaluate the analgesic effect of BV treatment using Freund's adjuvant induced chronic arthritis model. Freund's adjuvant-induced arthritis has been used as an experimental animal model for RA in humans to assess the efficacy of the anti-inflammatory/analgesic drugs. In this study, subcutaneous BV treatment (1mg/kg/day) produced significantly reductions of symptoms related to arthritic pain (i.e. mechanical hyperalgesia and thermal hyperalgesia). The anti-nociceptive effect of BV was observed from at least 12 days after BV treatment. Furthermore, BV treatment significantly suppressed adjuvant induced Fos expression in lumbar spinal cord. We also found that local injection of BV into near the inflammatory site (especially Zusanli-acupoint) showed more potent analgesic effect on arthritic pain rather than distant injection of BV from inflammatory site (arbitrary side of back). The present study demonstrates that BV treatment has anti-nociceptive effect on arthritis induced inflammatory pain. The analgesic effect of BV on RA is probably mediated by the effect of BV itself or possible other mechanism such as counter-irritation. Furthermore, it is possible that BV acupuncture is one of the promising candidates for long-term therapy of RA.

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