• 생약학회지
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• 제15권4호
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• pp.176-178
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• 1984

From the leaves of Zizyphus jujuba (Rhamnaceae), rutin and isoquercitrin were isolated and characterized by chemical and spectral analysis.

• 생약학회지
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• 제20권3호
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• pp.149-153
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• 1989

The presence of saponin, terpenoid, steroid, anthraquinone and flavonoid were screened with the usual test methods in forty five(sixty four parts) Korean plants belonging to Urticaceae, Celastraceae, Rhamnaceae, Sterculiceae and Rubiaceae. Plants were extracted with methanol and fractionated with hexane, chloroform, ethyl acetate and butanol. Each fraction was tested for the components. The result showed that in saponin test, 21 plants were positive and 11 plants were weak positive; in terpenoid and steroid test, 26 plants were strong positive; in anthraquinone test, 20 plants strong positive; in flavonoid test, 31 plants were positive and 9 plants were weak positive.

• 한국자원식물학회지
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• 제37권1호
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• pp.1-10
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• 2024

본 연구에서는 국내 자생하고 있는 갈매나무과 식물 13종에 대한 부위별(잎, 가지, 열매) 물 추출물의 NO 생성능을 통하여 면역증진 활성을 측정하여 기능성을 검토하였다. 망개나무, 헛개나무, 까마귀베개, 산황나무, 갈매나무, 참갈매나무, 상동나무 등에서 50% 이상 NO 생성능을 보여줌으로써 대식세포 활성화를 검증하였다. 또한 PCR 전기영동을 통하여 면역증진과 관련된 cytokine인 iNOS, COX-2, IL-1β, IL-6, TNF-α의 발현을 확인하였다. 본 연구를 통해 갈매나무과 분류군들의 부위별 NO 생성능, mRNA 발현 등과 같은 면역 활성에 대한 과학적 근거를 제시할 수 있었고, 이는 면역증진 관련 소재 발굴 및 제품 개발에 기초자료로 활용할 수 있을 것으로 판단된다.

• Archives of Pharmacal Research
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• 제14권2호
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• pp.99-102
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• 1991

A hight performance liquid chromatographic methods was developed for the seperation and determination of seven alkaloids in "sanjoin" (the seeds of Zizyphus jujuba Rhamnaceae), a plant with potent sedative activity. A reverse phase system of Lichrosorb RP-Select B column and 0.05 M potassium phosphate buffer (pH = 3.5)-acetonitrile with gradient elution was employed. Two known alkaloids, juzirine and lysicamine, were newly isolated fom "sanjoin"."sanjoin".oin&".ot;.

• 생약학회지
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• 제20권2호
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• pp.83-87
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• 1989

The alkaloids of thirty five Korean plants which belong to Rhamnaceae, Sterculiaceae, Celastracea, Urticaceae and Rubiaceae were screened. Plant was extracted and solvent fractionated to yield ether soluble alkaloidal fraction and butanol soluble fraction. Each fraction was subjected to alkaloidal test by Dragendorff's reaction. The result showed eighteen plants strong positive, fourteen weak and six negative to alkaloidal test.

• Journal of Plant Biotechnology
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• 제47권3호
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• pp.254-259
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• 2020

본 연구에서는 국내 자생하고 있는 갈매나무과 식물 13종(망개나무, 먹넌출, 헛개나무, 갯대추나무, 까마귀베개, 산황나무, 갈매나무, 털갈매나무, 돌갈매나무, 참갈매나무, 짝자래나무, 상동나무, 묏대추나무)에 대한 결실기 부위별(잎, 가지, 열매) 39점 70% ethanol 추출물의 총 페놀 및 플라보노이드 함량을 측정하고, ABTS 라디칼 소거능과 DPPH 전자 공여능 이용한 항산화 활성 및 NO 생성 억제력을 통한 항염증 활성을 측정하여 기능성 검토하였다. 총 페놀 및 플라보노이드 함량은 망개나무, 상동나무, 묏대추나무 추출물에서 높게 나타났다. 망개나무, 갯대추나무, 까마귀베개, 상동나무 추출물에서 높은 ABTS 라디칼 소거능을 보였고, 망개나무, 상동나무 추출물에서 약 80% 이상의 DPPH 전자공여능을 보였다. 또한, 망개나무, 먹넌출, 갯대추나무, 상동나무, 묏대추나무 등에서 50% 이상의 NO 생성 억제력을 보였다. 이러한 결과를 통하여 갈매나무과 식물의 이용 부위별 다양한 기능성을 검토하였고, 천연 항산화제 및 NO생성 억제를 통한 과도한 면역반응 완화 소재 개발 가능성을 확인하였다.

• Archives of Pharmacal Research
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• 제10권4호
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• pp.208-211
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• 1987

Sedative activity of Zizyphi fructus was evaluated by potentiation of hexobarbital-induced hypnosis test and its active principles have been characterized as nornuciferine and lysicamine. A new cyclopeptide alkaloid, daechucyclopeptide-1 was isolated together with zizyphusine.

• 약학회지
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• 제40권4호
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• pp.394-399
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• 1996

As a series of the studies on the specific and indigenous plants of Mt. Halla, the constituents from stem of Rhamnus taquetii (Rhamnaceae) were investigated. From the water fraction of the MeOH extract, a new flavonol glycoside, kaempferide-3-O-${\alpha}$-L-rhamnopyranosyl(1->3)-${\alpha}$-L-rhamnopyranosyl(1-6)-${\beta}$-D-galactopyranoside, was isolated with three known compounds, quercetin, quercetin-3-methylether, kaempferol, by column chromatographic separation using Amberlite XAD-2, ODS-gel and Sephadex LH-20 and elucidated physico-chemical evidences($^1H-NMR,\;^{13}C-NMR$,IR, EI-Mass, FAB-Mass, and G.C.),respectively.

• Archives of Pharmacal Research
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• 제12권4호
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• pp.263-268
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• 1989

From the seeds of Zizyphus vulgaris var. spinosus, aporphine alkaloids : nuciferine, N-methylasimilobine, nornuciferine, norisocorydine, caaverine and tetrahydro benzylisoquinoline alkaloid : (+) coclaurine were isolated and identified. Zyzyphusine, a new quaternary aporphinium alkaloid form butanol soluble fraction was isolated and characterized by spectral data.

• Archives of Pharmacal Research
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• 제10권4호
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• pp.203-207
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• 1987

Sedative principles of the seeds of Zizyphus vulgaris var. sphinosus have been characterized as sanjoinine-A (frangufoline), nuciferine and their congeners. Also, heat treatment of sanjoinine-A-produced a more active artifact, sanjoinine-Ahl, which provides a scientific basis for heat-processing (roasting) of this Oriental medicine.