Cortisol is present in high concentration in the ovary and its receptor is expressed in the ovarian cells. Moreover, cortisol is known to have a role in steroid synthesis and cell metabolism in human granulosa and lutein cells. However, little is known of the role of cortisol presenting in high concentration in the follicles after LH surge on the granulosa-lutein cells. Therefore, the this study we evaluated the apoptosis and the production of progesterone $(P_4)$ and estradiol $(E_2)$ in the granulosa-lutein cells that are obtained during oocyte-retrieval after treatment with 5, 50, and $500{\mu}g/m\ell$ cortisol and 1 IU/$m\ell$ FSH. Results of DNA fragment analysis and TUNEL assay demonstrated that DNA fragmentation and the rate of apoptotic cells were increased in a dose-dependent manner showing a significant increase in 50 and $500{\mu}g/m\ell$ cortisol treated cells. We found, however, that FSH did not suppress the apoptosis of the cells induced by cortisol. In the results of chemiluminescence assay for $P_4$ and $E_2$, $P_4$ production was decreased by cortisol treatment, whereas $E_2$ was not changed. We also demonstrated that FSH did not inhibit the suppressive effect of GnRH on $P_4$ production as the result of apoptosis. The present study suggests that cortisol of high concentration could cause the apoptosis of human granulosa-lutein cells by suppressing the production of $P_4$. However, we need more studies to elucidate the mechanism by which cortisol induces apoptosis in human granulosa-lutein cells in view of the fact that our results are inconsistent with previous reported data.
Kim, Kwang-Hyung;Jeong, Yeo Min;Cho, Youn-Sup;Chung, Uran
Korean Journal of Agricultural and Forest Meteorology
/
v.18
no.1
/
pp.42-54
/
2016
It is highly anticipated that warming temperature resulting from global climate change will affect the phenological pattern of kiwifruit, which has been commercially grown in Korea since the early 1980s. Here, we present the potential impacts of climate change on the variations of flowering day of a gold kiwifruit cultivar, Haegeum, in the Jeonnam Province, Korea. By running six global climate models (GCM), the results from this study emphasize the uncertainty in climate change scenarios. To predict the flowering day of kiwifruit, we obtained three parameters of the 'Chill-day' model for the simulation of Haegeum: $6.3^{\circ}C$ for the base temperature (Tb), 102.5 for chill requirement (Rc), and 575 for heat requirement (Rh). Two separate validations of the resulting 'Chill-day' model were conducted. First, direct comparisons were made between the observed flowering days collected from 25 kiwifruit orchards for two years (2014-15) and the simulated flowering days from the 'Chill-day' model using weather data from four weather stations near the 25 orchards. The estimation error between the observed and simulated flowering days was 5.2 days. Second, the model was simulated using temperature data extracted, for the 25 orchards, from a high-resolution digital temperature map, resulting in the error of 3.4 days. Using the RCP 4.5 and 8.5 climate change scenarios from six GCMs for the period of 2021-40, the future flowering days were simulated with the 'Chill-day' model. The predicted flowering days of Haegeum in Jeonnam were advanced more than 10 days compared to the present ones from multi-model ensemble, while some individual models resulted in quite different magnitudes of impacts, indicating the multi-model ensemble accounts for uncertainty better than individual climate models. In addition, the current flowering period of Haegeum in Jeonnam Province was predicted to expand northward, reaching over Jeonbuk and Chungnam Provinces. This preliminary result will provide a basis for the local impact assessment of climate change as more phenology models are developed for other fruit trees.
The development of Schizaphis graminum (Rondani) was studied at various constant temperatures ranging from 15 to $32.5^{\circ}C$, with $65{\pm}5%$ RH, and a photoperiod of 16L:8D. Mortality of the $1_{st}-2_{nd}\;and\;the\;3_{rd}-4_{th}$ stage nymphs were similar at most temperature ranges while at high temperature of $32.5^{\circ}C$, more $3_{rd}-4_{th}$ stage individuals died. The total developmental time ranged from 13.8 days at $15^{\circ}C$ to 4.9 days at $30.0^{\circ}C$ suggesting that the higher the temperature, the faster the development. However, at higher end temperature of $32.5^{\circ}C$ the development took 6.4 days. The lower developmental threshold temperature and effective accumulative temperatures for the total immature stage were $6.8^{\circ}C$ and 105.9 day-degrees, respectively and the nonlinear shape of temperature related development was well described by the modified Sharpe and DeMichele model. The normalized cumulative frequency distributions of developmental period for each life stage were fitted to the three-parameter Weibull function. The attendance of shortened developmental times was apparent with $1_{st}-2_{nd}\;nymph,\;3_{rd}-4_{th}$ nymph, and total nymph stages in descending order. The coefficient of determination $r^2$ ranged between 0.80 and 0.87.
Most of the red ginseng (RG) products contain active substances derived from hot water or alcohol extraction. Since active substances of RG are divided into two types - water-soluble and liposoluble - water or alcohol is needed as an extraction solvent and this leads the different extraction yields and components of the active substances. To overcome the limit, whole red ginseng powder can be used and consumed by consumers. In this study, the physicochemical properties and extractable active substance contents of variable-sized RG powder ($158.00{\mu}m$, $8.45{\mu}m$, and $6.33{\mu}m$) were analyzed, and dispersion stability was measured to investigate the suitable size of RG powder for industrial processing. In the results, no significant difference was found from the changes in color intensity and thiobarbutric acid tests at $4^{\circ}C$, $25^{\circ}C$, and $40^{\circ}C$ for 4 weeks. There was no significant difference on the production of antioxidants and ginsenoside among the samples (p>0.05). In dispersion stability, $RG-158.00{\mu}m$ was precipitated immediately, and the dispersion stabilities between $RG-8.45{\mu}m$ and $RG-6.33{\mu}m$ showed no significant difference. It implies that fine RG is suitable for the production process. With further study, it seemed that the physicochemical effects of RG particle sizes can be clearly revealed.
In temperate zone planting rice at different date subjects the Crop to different climatic condition. The present study aimed at comparison of the change in source-sink relationship of the Japonica(J) and that of IndicaxJaponica(I$\times$J) type rice cultivars caused by shift of heading date. Two J- and two I$\times$J-type cultivars were made to head on August 16, August 26, and September 5. Sink capacity was changed by shift of heading date in different mode between the types of cultivars. In both types major determinant of sink capacity was number of effective tillers, and the number of spikelets per panicle was the minor. In J-type earlier planting/heading was beneficial to increased panicle numbers and this was due mainly to a larger diurnal difference in temperature. I$\times$J-type cultivars favored a higher daily mean temperature to increase the sink capacity. The ability of source at heading, in terms of leaf area per panicle, chlorophyll content per spiklet, photosynthetic ability of leaves per unit area at 25$\^{\circ}C$, carbohydrate and N contents of leaves, was not so different among different heading dates in both types. However, the source activity was governed principally by temperature during grain filling. The J-type cultivars headed on Sept. 5 and I$\times$J-type cultivars headed later than August 16 could not have had sufficient source activity in grain filling due to lower temperature.
Kang, S. M;Kang, N. J;Cho, J. L;Kim, Z. H;Kwon, Y. W
KOREAN JOURNAL OF CROP SCIENCE
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v.38
no.4
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pp.350-359
/
1993
The effect of gibberellic acid ($GA_3) and abscisic acid (ABA) on KCl-enhanced proteolysis of senescing leaves of rice(Oryza sativa L. cv. Chilsung) was studied. Emphasis was given to their effects on KCI-enhanced efflux of amino acids and proteinase activity. When treated singly, $GA_3 affected leaf proteolysis little, while ABA increased proteolysis, the rate of amino acid efflux, and ribulose -1,5 -bisphosphate carboxylase / oxygenase (Rubisco)-degrading endoproteinase activity. An additive increase in all three parameters mentioned above was observed when leaves were treated with ABA and KCl. No such an additive effect was found when $GA_3 was treated with KCl. Both $GA_3 and ABA helped to alleviate the KCI-suppressed activity of Rubisco-degrading exoproteinases. The additive increase in proteolysis of rice leaves in the presence of both ABA and KCl could thus be ascribed to a further increase in the efflux of protein hydrolyzates and Rubisco-degrading endoproteinase activity. An increase in proteolysis was accompanied by a decrease in water absorption, and the combined treatment of ABA with KCl resulted in a further reduction of water absorption.
Objectives: The aim of this study was to evaluate the usefulness of Anti-mullerian hormone (AMH) as a predictive marker for ovarian response and cycle outcome in IVF cycles. Methods: From Jan., to Aug., 2007, 111 patients undergoing IVF/ICSI stimulated by short or antagonist protocol were selected. On cycle day 3, basal serum AMH level and FSH level were measured. The correlation between basal serum AMH or FSH, and COH outcome was analyzed and IVF outcome was compared according to the AMH levels. To determine the threshold value of AMH for poor- and hyper-response, ROC curve was analyzed. Results: Serum AMH showed higher correlation coefficient (r=0.792, p<0.001) with the number of retrieved mature oocyte than serum FSH (r=-0.477, p<0.001). According to ovarian response, FSH and AMH leves showed significant differences among poor, normal, and hyperresponder. For predicting poor (${\leq}2$ oocytes) and hyperresponse (${\geq}17$ oocyets), AMH cut-off values were 0.5 ng/ml (the sensitivity 88.9% and the specificity 89.5%) and 2.5 ng/ml (sensitivity 85.7%, specificity 87.0%), respectively. According to the AMH level, patients were divided into 3 groups: low (${\leq}0.60\;ng/ml$), normal ($0.60{\sim}2.60\;ng/ml$), and high AMH (${\geq}2.60\;ng/ml$). The number of retrieved mature oocytes was significantly higher ($2.7{\pm}2.2$, $8.1{\pm}4.8$, $16.5{\pm}5.7$) and total gonadotropin dose was lower ($3530.5{\pm}1251.0$, $2957.1{\pm}1057.6$, and $2219.2{\pm}751.9\;IU$) in high AMH group (p<0.001). There was no significant difference in fertilization rates and pregnancy rates (23.8%, 34.0%, 37.5%) among the groups. Conclusions: Basal serum AMH level correlated better with the number of retrieved mature oocytes than FSH level, suggesting its usefulness for predicting ovarian response. However, IVF outcome was not significantly different according to the AMH levels. Serum AMH level presented good cut-off value for poor- or hyper-responders, therefore it could be useful in prediction of cycle cancellation, gonadotropin dose, and OHSS risk in IVF cycles.
The empirical/statistical models to estimate the ground Particulate Matter ($PM_{2.5}$) concentration from Geostationary Ocean Color Imager (GOCI) Aerosol Optical Depth (AOD) product were developed and analyzed for the period of 2015 in Seoul, South Korea. In the model construction of AOD-$PM_{2.5}$, two vertical correction methods using the planetary boundary layer height and the vertical ratio of aerosol, and humidity correction method using the hygroscopic growth factor were applied to respective models. The vertical correction for AOD and humidity correction for $PM_{2.5}$ concentration played an important role in improving accuracy of overall estimation. The multiple linear regression (MLR) models with additional meteorological factors (wind speed, visibility, and air temperature) affecting AOD and $PM_{2.5}$ relationships were constructed for the whole year and each season. As a result, determination coefficients of MLR models were significantly increased, compared to those of empirical models. In this study, we analyzed the seasonal, monthly and diurnal characteristics of AOD-$PM_{2.5}$model. when the MLR model is seasonally constructed, underestimation tendency in high $PM_{2.5}$ cases for the whole year were improved. The monthly and diurnal patterns of observed $PM_{2.5}$ and estimated $PM_{2.5}$ were similar. The results of this study, which estimates surface $PM_{2.5}$ concentration using geostationary satellite AOD, are expected to be applicable to the future GK-2A and GK-2B.
Journal of Korean Society of Environmental Engineers
/
v.31
no.11
/
pp.1041-1050
/
2009
The ambient temperature and concentration of carbon dioxide in Gwangju and the reducing method of temperature, air pollutants were investigated using the atmospheric data in Gwangju. Average ambient temperature ($T_{a-ave}$ was $13.5^{\circ}C$ during 1961 to 2008. The temperature was predicted as increasing of about $2.7^{\circ}C$ in 2108 after 100 years using the trend line of regression equation. Carbon dioxide was 370.7 and 391.4 ppm at Anmyundo, in 1999 and 2008, respectively, showing proportionally increased as ambient temperature. The temperature at Gwangju, $14.2^{\circ}C$ during 1997 to 2008, was a little higher than at neighboring counties as Naju, Damyang, Hwasoon, and Jangsung. In Gwangju, Spring will start in mid-January of 2108, Summer in mid-May, Autumn in mid-October, and Winter in last-December. The average relative humidity in the air ($RH_{a-ave}$) was gradually decreased as the temperature inversely increased. The average $CO_2$ was 457 ppm, which is 65.6 ppm higher than that in Anmyundo, korean background area of $CO_2$ in 2008. Carbon dioxide showed positive correlation, both of them, with carbon monoxide (0.87) and relative humidity (0.48).
Fashion is subjected to newness and change by itself. Fashion trend and tendency which could predict next season akeady indicated that digital and cybel11ation environment lliould be factors in fashion. Changes in future life styles and values caused by digital environment must be variables as fashion objects by themselves. Therefore digital environment of a fashion itself and that all encountered in fashion will not only be an existing situation but also an objective and a factor which must be pursued with fashionable sense in future fashion. Advanced technology and social change in relation to digital environment requires that educational method as well as its content will be changed on the scene of education for future. Thus we should seek an educational direction in fashion design for future society in which digital environment requires new paradigm. Subject to these backgrounds this study has an intension to study the change in fashion extensively influenced by expanded digital environment on a limited situational level of fashion design education and to suggest an educational direction for professional in future fashion design who will serve as a core of fashion area in the future. It is essential that education of professional in fashion for future should be achieved by digital-minded level that eagerly understands and accepts future society in which digital environment will be a main axis. It is necessary for this to make them expetience computers, digital media including CAD program. We have to note that education of digital media is more effective and applicable when accomplished in CAI level which can be related and expetienced with fashion education rather than mere functional training in media themselves. Intellectual creativity will be a vety source of producing values and national competence in 21st centtury. Education of design professional in fashion area must positively accept these environmental charactetistics in future society, as well as deeply reflect the education for the future.
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