• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.2
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• pp.89-101
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• 2019

In recent times, the number of men with late-onset hypogonadism has increased, and interest on this topic has also increased. This study was conducted to investigate effects of the mixture extract of Fructus amomi Amari, Eucommiae cortex, Bombyx batryticatus on improve late-onset hypogonadism. The experimental subjects consisted of three groups: a control group consisting of 8-week-old male ICR mice that had undergone no treatment, an aging-elicited group (AE group) consisting of 50-week-old ICR male mice that had undergone no treatment, and a Mixed herbal extract treatment group (MT group) consisting of 50-week-old ICR male mice that had undergone the mixture extract of Fructus amomi Amari, Eucommiae cortex, Bombyx batryticatus treatment (0.1 g/kg/day) for 6 months. After the experiment, the mice from all the experimental groups were dissected, and they were analyzed through histochemical and immunohistochemical methods. The mixture extract of Fructus amomi Amari, Eucommiae cortex, Bombyx batryticatus reduces aging-induced cell damage and oxidative stress and increases the secretion of serotonin and B-endorphin in aged mice, and promotes spermatogenesis in seminiferous tubules and reduces apoptosis and oxidative stress, and increases androgen receptor, $17{\beta}-HSD$ and GnRH, increases the ratio of smooth muscle to collagen fibers in the corpus cavernosum, increases eNOS, decreases PDE-5 and oxidative stress in aged mice, so it improves depression, reproductive, sexual problems caused by Late-onset hypogonadism. the mixture extract of Fructus amomi Amari, Eucommiae cortex, Bombyx batryticatus inhibits the induction of osteoporosis by increasing decreased bone matrix distribution due to aging, increasing the activities of OPC and OPN, which are produced in osteoblasts, and decreasing RANKL, MMP-3 activity, increasing OPG activity. It also reduces muscle damage, oxidative stress, inflammation and apoptosis of muscle tissue, and increases Myo-D in the sartorius muscle of aged mice for improving muscle atrophy caused by by Late-onset hypogonadism.

• The Southeast Asian review
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• v.28 no.1
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• pp.53-82
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• 2018

The $14^{th}$ general election which should be held by August 2018 has been a dominant factor for Malaysian politics, economy, social changes and foreign policy in 2017. UMNO, the dominant party within the ruling governmental coalition, has focused on securing Malay support, voters which made them to sought political cooperation with PAS, Malaysia's Islamist opposition party. A consequent event followed by the strategic ties between the two parties is the rise of political Islam in Malaysia though PAS' 'Islamization' or 'desecularization' has never been adopted by UMNO. The rise of political Islam and Malay support have become the most important factor for the next election, which increasingly enhanced the role of 3R of Malaysia politics; Race, Religion, and Royalty. The Pakatan Harapan (PH), the newly formed opposition coalition without PAS, has elected Mahathir Mohamad, the former Prime Minister, as its candidate for prime minister. Malaysian economy and foreign policy seem to be subordinated to politics. Stabilizing ringgit and restoring economic growth enabled the Najib's government to reveal 'election budget' for 2018. Najib has spoken out Islam-related international issues including the Rohingya crisis and Jerusalem issue. It is to some extent the extension of domestic politics. The rise of political Islam will be a highly influential not only in the coming election but in the political and social development in the aftermath of the election.

• Animal Bioscience
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• v.34 no.4
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• pp.567-574
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• 2021

Objective: In this study we investigated the effect of seasonal thermal stress on milk production and milk compositions between Holstein and Jersey dairy cows under the temperate-climate in Korea. Methods: A total of 9 Holstein lactating dairy cows (2.0±0.11 parity) which had a daily milk yield of 29.77±0.45 kg, and days in milk of 111.2±10.29 were selected similarly at the beginning of the experiments in each season. Also, a total of 9 Jersey lactating dairy cows (1.7±0.12 parity) which had a daily milk yield of 20.01±0.43 kg, and days in milk of 114.0±9.74 were selected similarly at the beginning of the experiments. Results: Results showed that the average ambient temperature (℃) and temperature-humidity index (THI) were higher in summer, and were lower in winter (p<0.05). The average relative humidity (RH, %) was higher in autumn than that of other seasons (p<0.05). Milk production was significantly decreased (Holstein 29.02 kg/d and Jersey 19.75 kg/d) in autumn than in other seasons (Holstein 30.14 kg/d and Jersey 20.96 kg/d). However, the milk production was negatively correlated in Holstein cows, and positively correlated in Jersey cows with THI values increased from 16 to 80. In addition, milk yield was increased by 15% in Holstein cows and decreased by 11% in Jersey cows with the THI values increased from 16 to 20. The fat and protein content percentage was significantly higher in Jersey milk than in Holstein milk, furthermore the fat and protein content yield was higher in Jersey cow milk than that of Holstein cow's milk with all THIs. Conclusion: From the study results, we concluded that Jersey cows might be less adaptable to low temperature of the winter, and this would have a negative impact on dairy farmer income since Korea's milk price estimation system places a higher value on milk yield than on milk compositions or sanitary grades.

• Fashion & Textile Research Journal
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• v.24 no.5
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• pp.655-665
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• 2022

This study evaluated the validity of a newly developed mobility protocol examining the comfort functions and requirements of personal protective equipment (PPE) for COVID-19 healthcare workers. Eight males (age: 24.7 ± 3.0 y, height: 173.4 ± 2.3 cm, and body weight 69.9 ± 3.7 kg) participated in the following three PPE conditions: (1) Plastic gown ensemble, (2) Level D ensemble, and (3) Powered air purifying respirator (PAPR) ensemble. The mobility protocol consisted of 10 different tasks in addition to donning and doffing. The 10 tasks were repeated twice at an air temperature of 25oC with 74% RH. The results showed significant differences among the three PPE conditions in mean skin temperature, local skin temperatures (the forehead, thigh, calf, and foot), clothing microclimate (the chest and back), thermal sensation, thermal comfort, and humidity sensation, while there were no significant differences in heart rate or total sweat rate. At rest, the subjects felt less warm and more comfortable in the PAPR than in the Level D condition (P<0.05). However, subjective perceptions in the PAPR and Level D conditions became similar as the tasks progressed and mean skin and leg temperature became greater for the PAPR than the Level D condition (P<0.05). An interview was conducted just after completing the mobility test protocol, and suggestions for improving each PPE item were obtained. To sum up, the mobility test protocol was valid for evaluating the comfort functions of PPE for healthcare workers and obtaining requirements for improving the mobility of each PPE item.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.27-27
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• 2023

최근 기후위기 등으로 인해 생물다양성 감소 우려가 높아지고 있으며, 식물유전자원 보존의 강화를 위해 수많은 국제협약이 체결되고 있다. 자국의 생물다양성을 보호하고, 전 세계의 기후위기 취약식물의 보존을 위해 대한민국 산림청은 세계 최초로 지하터널형 야생식물종자 영구저장시설인 '시드볼트(Seed Vault)'를 경상북도 봉화에 설립하였다. 시드볼트는 안전한 종자의 저장을 위해 온도 -20℃, 습도 RH 40% 이하를 유지하며, 환경 변화를 최소화하기 위해 매일 시설 점검을 진행하고 있다. 시드볼트의 미션은 '기후위기 대응 생물다양성 확보'이며, 전 세계 종자저장의 선도기관으로 2022년 12월 기준으로 5,424종 192,625점을 확보하였으며, 2030년까지 1만 종 30만 점을 목표로 하고 있다. 전 세계 식물 종의 보호를 위해 국제기구와 협력하고 있으나, 해외 종자의 저장이 더욱 강화되어야 하며, 향후 시드볼트 종자저장 네트워크 구축에 참고하기 위한 해외 사례를 조사하였다. 아시아에서는 중국이 다량의 식물종을 수집하고 있으나, 해당 자료에 대한 공개는 이루어지지 않고 있으며, 일본은 농업식량 식물자원 중심으로 종자를 보존하고 있으며, 태국, 대만, 싱가포르 및 몽골 및 중앙아시아 국가의 종자수집과 보존은 근래 확대되는 추세이다. FAO의 Plant Genetic Resources for Food And Agriculture 관련 수집 자료에 따르면, 아시아지역 25개 국가에서 984,019점의 식물유전자원을 보고하였다. 본 연구를 바탕으로 아시아지역의 종자보존 네트워크를 구축하여 해외 종자의 안전한 저장을 통해 아시아 야생식물자원 다양성 보전 가치를 통합하는 시설로 성장하고자 한다.

• Clinical and Experimental Reproductive Medicine
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• v.37 no.4
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• pp.349-359
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• 2010

Objective: This study was performed to compare the clinical outcome of elective single embryo transfer (eSET) performed at the cleavage stage to that of elective double embryo transfer (eDET). Methods: Of the women less than 36 years old who visited Daegu Maria from January 2008 to April 2009, the only women (n=330) with more than 8 mm of endometrial thickness and at least one good quality embryo, who were treated with GnRH agonist long protocol, were included in this study. After information about complications that can arise by multiple embryo transfer, either eSET or eDET was conducted by their request (167 and 163, respectively).Results: The implantation rate of eSET group was significantly higher than that of eDET group (53.9% vs. 40.2%, p<0.01). The twin pregnancy rate of eSET group was significantly lower than that of eDET group (1.1% vs. 32.3%, p<0.001). However, there were no significant differences between two groups in the clinical pregnancy (53.3% vs. 60.7%, p=0.172), ongoing pregnancy (47.3% vs. 54.6%, p=0.185) and live birth rates (44.9% vs. 50.9%, p=0.275). The number of the surplus embryos which developed to the blastocyst stage and cryopreserved at that stage was significantly higher in eSET group than that of eDET group ($3.2{\pm}2.6$ vs. $2.1{\pm}2.4$, p<0.001). Conclusion: These results suggest that eSET should reduce significantly the multiple baby pregnancy without decreasing the whole pregnancy rate in women with less than 36 years old.

• Journal of Bio-Environment Control
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• v.21 no.4
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• pp.343-347
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• 2012

The purpose of this study was to examine the dwarfing effect in variable temperature treatments on 1-year-old and 3-year-old Chloranthus glaber. The plants grown in four difference growth chamber under a mean light intensity $500{\pm}20$ lux, RH of $40{\pm}5%$, and temperature of $5^{\circ}C$, $10^{\circ}C$, $15^{\circ}C$, and $20^{\circ}C$ for 120 days from January 3, 2011. And then they were moved into a glass house (50% shading). In 1-year-old seedlings, the rate of plant height elongation was lowest at $5^{\circ}C$, but plant growth was not good. The number of leaves and leaf width were highly increased by $10^{\circ}C$ treatment although the plant height was slightly increased. Also the plant height of $15^{\circ}C$ and $20^{\circ}C$ was decreased and defoliation was started from the bottom leaves. Thus, $10^{\circ}C$ treatment was thought to be the most appropriate for dwarfing effect of 1-year-old seedlings. In 3-year-old seedlings, the plant height tended to increase with temperature, and growth pattern showed a similar trend between $5^{\circ}C$ and $10^{\circ}C$, $15^{\circ}C$ and $20^{\circ}C$. The number of leaves increased the most at $5^{\circ}C$. Lateral branches per node were mainly occurred at $5^{\circ}C$ and $10^{\circ}C$, whereas they almost didn't happen at $15^{\circ}C$ and $20^{\circ}C$. Flowering rate at $5^{\circ}C$ and $10^{\circ}C$ reached more than 90% and 60%, respectively, but it was too low at $15^{\circ}C$ and $20^{\circ}C$ until the end of August. From these results, it could improve plant quality of 1-year-old and 3-year-old Chloranthus glaber making compact potted plants when temperatures were maintained at $10^{\circ}C$ and $5^{\circ}C$, respectively.

• Korean journal of applied entomology
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• v.46 no.1 s.145
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• pp.51-56
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• 2007

The two species of rice bugs causing pecky rice, Cletus punctiger and Cletus schmidti are often observed coexisting in the rice fields of nearby fallow land. Direct feeding damage to rice by C. punctiger and C. schmidti can lead to a reduction in grain quality and quantity. These studies were carried out to investigate the development of C. punctiger and C. schmidti at various constant temperatures ranging from 20 to $30^{\circ}C$, 65% RH, and a photoperiod of 16L:8D. Egg hatchability of C. punctiger/C. schmidti at the temperatures of 20, 25 and $30^{\circ}C$ were 80.6/88.0, 91.7/96.3, 96.4/96.2%, respectively. The development periods of eggs of C. punctiger/C. schmidti at the temperatures of 20, 25, and $30^{\circ}C$ were 16.4/18.4, 9.4/10.2 and 6.4/7.3 days, respectively. Mean developmental periods of 1 st, 2nd, 3rd, 4th and 5th nymphs of C. punctiger/c. schmidti at $30^{\circ}C$ were 2.1/2.0, 3.5/4.0, 3.3/5.6, 3.2/4.8 and 5.8/6.9 days, respectively. Oviposition began 8.1 days after emergence at $25^{\circ}C$, and the longevity of female and male were 120.0 and 117.3 days, respectively. Total number of eggs through the life of female were 245.5 laying 2.2 eggs a day in average at $25^{\circ}C$. The development periods of egg and nymphs of C. punctiger were relatively shorter than those of C. schmidti. Availability of male had affected the egg hatchability greatly that laid at 30th day after 60 days period of oviposition in the presence of adult male of C. punctiger. The fertile eggs laid by the female together with male was 92.1% but those without male was only 9.6%.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.5
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• pp.478-486
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• 2009

Purpose: 5-iododeoxyuridine analogues have been exclusively developed for the potential antiviral and antitumor therapeutic agents. In this study, we synthesized carbocyclic radioiododeoxyuridineanalogue (ddIVDU) and carbocyclic intermediate as efficient carbocyclic radiopharmaceuticals. Materials and Methods: The synthesis is LAH reduction, hetero Diels-Alder reaction as key reactions including Pd(0)-catalyzed coupling reaction together with organotin. MCA-RH7777 (MCA) and MCA-tk (HSV1-tk positive) cells were treated with various concentration of carbocyclic ddIVDU, and GCV. Cytotoxicity was measured by the MTS methods. For in vitro uptake study, MCA and MCA-tk cells were incubated with 1uCi of [$^{125}I$]carbocyclic ddIVDU. Accumulated radioactivity was measured after various incubation times. Results: The synthesis of ddIVDU and precursor for radioiodination were achieved from cyclopentadiene in good overall yield, respectively. The radioiododemetallation for radiolabeling gave more than 80% yield with > 95% radiochemical purity. GCV was more toxic than carbocyclic ddIVDU in MCA-tk cells. Accumulation of [$^{125}I$]carbocyclic ddIVDU was higher in MCA-tk cells than MCA cells. Conclusion: Biological data reveal that ddIVDU is stable in vitro, less toxic than ganciclovir (GCV), and selective in HSV1-tk expressed cells. Thus, this new carbocyclic nucleoside, referred to in this paper as carbocyclic 2',3'-didehydro-2',3'-dideoxy-5- iodovinyluridine (carbocyclic ddIVDU), is a potential imaging probe for HSV1-tk.

• Journal of Bio-Environment Control
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• v.28 no.2
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• pp.178-184
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• 2019

Strawberry ($Fragaria{\times}ananassa$) is one of the most important and popular fruit crops in the world, and 'Sulhyang' is one of the principal cultivars cultivated in the Republic of Korea for the domestic market. The growth and flower induction in strawberry is the process which influences directly on fruit bearing and yield of this crop. In this study, effect of benzyladenine (BA), gibberellic acid ($GA_3$), and salicylic acid (SA) on growth and flower bud induction in strawberry 'Sulhyang' was investigated. The 3-week-old runner plants, grown in 21-cell propagation trays, were potted and cultivated in growth chambers with $25^{\circ}C/15^{\circ}C$ (day/night) temperatures, 70% relative humidity (RH), and light intensity of $300{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$ photosynthetic photon flux density (PPFD) provided by white light emitting diodes (LEDs). The runner plants were treated with one of three concentrations, 0 (control), 100, and $200mg{\cdot}L^{-1}$ of BA, $GA_3$, or SA solution. The chemicals were sprayed two times on leaves of runner plants at an interval of two weeks. After 9 weeks the results showed that the application of all chemicals caused reduction of root length and chlorophyll (SPAD) content as compared to the control. The lowest chlorophyll (SPAD) content was recorded in plants treated with $GA_3$. However, the treatment of $200mg{\cdot}L^{-1}$ $GA_3$ promoted leaf area, leaf fresh weight, and plant fresh weight. The greatest flower induction (85%) and number of inflorescences (4.3 inflorescences per plant) were observed in the treatment of $200mg{\cdot}L^{-1}\;SA$, followed by $100mg{\cdot}L^{-1}\;SA$. Overall, results suggest that foliar application of $GA_3$ solution could accelerate plant growth, while foliar application of SA solution could induce hastened flowering. Further studies may be needed to find out the relationship between $GA_3$ and SA solutions treated in a combination, and the molecular mechanism involved in those responses observed.