• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1817-1820
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• 2015

Background: Hemoglobin A1c(HgA1c) is a marker of poor gylcemic control and elevation HgA1c is associated with increased risk of many cancers. We aimed to determine the HgA1c levels in endometrial cancer cases and any relationship with stage and grade of disease. Materials and Methods: A retrospective data review was performed between June 2011 and October 2012 at a tertiary referral center in Turkey. The study included 35 surgically staged endometrial cancer patients and 40 healthy controls. Preoperative HgA1c levels drawn within 3 months before surgery were compared. Also the relationships between HgA1c levels and stage, grade and hystologic type of cancer cases were evaluated. Results: The mean HgA1c levels were statistically significantly higher at $6.19{\pm}1.44$ in endometrial cancer cases than the $5.61{\pm}0.58$ in controls (p=0.027). With endometrial cancer cases, the mean HgA1c level was found to be $6.62{\pm}1.40$ for stage I and $6.88{\pm}1.15$ for stages II-IV (p=0.07). The figures were $6.74{\pm}1.65$ for endometrioid and $6.63{\pm}1.41$ for non-endometrioid type tumors (p=0.56). Mean HgA1c levels of $6.72{\pm}1.14$ for grade 1 and $6.62{\pm}1.42$ for grade 2-3 were observed (p=0.57). Conclusions: HgA1c levels in endometrial cancer patients were statistically higher than healthy controls. However, HgA1c did not show any significant correlation with stage, grade and histologic type in endometrial cancer cases.

• Archives of Reconstructive Microsurgery
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• 제11권1호
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• pp.67-72
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• 2002

Purpose : Treatment of giant cell tumor of distal radius can be treated in several ways according to the agressiveness of the tumor. We treated 3 cases of widely involved giant cell tumor of distal radius with wide resection and proximal fibular graft and report the results with review of literatures. Material and Method : We have treated 3 cases of giant cell tumor of the distal radius since last 1990. Among 3 cases, two cases were grade III radiologically and treated by wide resection of distal radius and vascularized proximal fibular graft, and one case, grade II radiologically, treated by distal radial resection and non-vascularized proximal fibular graft. We followed up clinical results of above three cases 9 years, 12 years and 2 years. Result : In all three cases, tranplanted fibula graft showed solid union but grade III tumors recurred at 4 year and 6 year postoperatively. One of the case which recurred 4 year later was treated with secondary wide resection and wrist fusion with autogenous iliac bone graft, and didn't show any recurrent finding for these 5 years after re-operation. And another grade III, which recurred at 6th post-operative year, is under follow-up for 6 years after recur without 2nd operation. Grade II case didn't show any recurrent findings on 2 year follow-up. Conclusion : Grade III cases recurred at 4 year and 6 year follow-up. The cause of recurrence was thought to be invasion of remaining tumor cell in the soft tissue. To prevent recurrence, complete resection of primary tumor was necessary.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.423-426
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• 2014

Aim: To evaluate the agreement between colposcopic diagnosis and cervical pathology a retrospective chart review was performed. Materials and Methods: This study included 437 patients who underwent colposcopy and cervical biopsy or conization at Siriraj Hospital from October 2010 - December 2012. The patient clinical characteristics, cervical cytology results, colposcopic diagnoses, cervical pathology results were recorded and correlations between variables were analyzed. Results: Agreement of colposcopic diagnosis and cervical pathology was matched in 253 patients (57.9%). The strength of agreement with weighted Kappa statistic was 0.494 (p<0.001). Colposcopic diagnoses more often overestimated (31.1%) than underestimated (11%) the cervical pathology. Agreement of colposcopic diagnosis and cervical pathology within 1 grade was found in 411 patients (94.1%). Positive predictive value (PPV) of high grade colposcopy or more was 75.5%, whereas the negative predictive value (NPV) of insignificant and low grade colposcopy was 83.8%. False positives of high grade colposcopy or more were 21%. False negatives of insignificant or low grade colposcopy were 19.1%. Conclusions: Strength of agreement between colposcopic diagnosis and cervical pathology was found to be only moderate. A biopsy at colposcopy should be performed at a gold standard level to detect high grade lesions.

• Journal of Korean Neurosurgical Society
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• 제54권2호
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• pp.86-92
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• 2013

Objective : Surgical results for anterior choroidal artery (AChA) aneurysms have previously been reported as unsatisfactory due to inadvertent occlusion of the AChA, while the low incidence of AChA aneurysms hampers the accumulation of surgical experience. The authors reviewed their related surgical experience to document the ischemic complications and surgical outcomes. Methods : Identification of the AChA at its origin by rigorous visual scrutiny, careful microdissection, and meticulous clip placement to avoid the AChA origin are all crucial surgical maneuvers. A retrospective review of a surgical series of 62 consecutive cases of an AChA aneurysm between 2004 and 2012 was performed. Results : All patients, except for five (8.1%) with a small residual neck, showed complete aneurysm obliteration in postoperative angiographic evaluations. There was no incidence of procedure-related permanent AChA syndrome or oculomotor nerve palsy, while three (4.8%) patients suffered from transient AChA syndrome. The clinical outcomes [the 3-month modified Rankin Scale (mRS)] of the patients were related to their preoperative World Federation of Neurologic Surgeons (WFNS) grade. As regards the 3-month mRS, significant differences were found between patients with an unruptured aneurysm (WFNS grade 0; n=20), good-grade subarachnoid hemorrhage (WFNS grade 1-3; n=30), and poor-grade subarachnoid hemorrhage (WFNS grade 4-5; n=4). Conclusion : In surgical treatment of AChA aneurysms, a risk of AChA insufficiency can be minimized by taking every precaution to preserve the AChA patency and intraoperative monitoring. In addition, the surgical outcome is primarily determined by the preoperative clinical state.

• Journal of Gastric Cancer
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• 제10권4호
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• pp.175-181
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• 2010

Purpose: There is controversy over the treatment for low grade dysplasia, while resection is recommended for high grade dysplasia. But the concordance of the grade of dysplasia between pre- and post-resection is low because of sampling errors with endoscopic biopsy. We attempted to establish a clearer direction for the treatment of dysplasia by clarifying the discrepancy between the pre- and postresection diagnoses. Materials and Methods: We performed a retrospective review of 126 patients who had undergone resection with the diagnosis of dysplasia on biopsy at Bundang CHA Hospital from 1999 to 2009. Results: Seventy patients were diagnosed with low grade dysplasia and 56 patients were diagnosed with high grade dysplasia. Among the 33 patients who received gastrectomy with lymph node dissec-tion, 30 patients were revealed to have invasive cancers and 4 patients showed lymph node metastasis. Discordance between the diagnoses from biopsy and resection occurred in 55 patients (44%). There was no correlation on the comparative analysis between the size, location or gross type of lesion and the grade of dysplasia. Conclusions: The rate of discordance between the diagnoses of endoscopic biopsy and the post resection pathologic report was as high as 44%. Endoscopic mucosal resection was not sufficient for some patients who were diagnosed with dysplasia on biopsy due to the presence of lymph node metastasis. It is necessary to be prudent when determining the follow-up and treatment based solely on the result of the biopsy.

• Nuclear Engineering and Technology
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• 제41권4호
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• pp.447-454
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• 2009

This paper is a technical review of the research and development results of the Korea Nuclear Instrumentation and Control System (KNICS) project and Nu-Tech 2012 program. In these projects man-machine interface system architecture, two digital platforms, and several control and protection systems were developed. One platform is a Programmable Logic Controller (PLC) for a digital safety system and another platform is a Distributed Control System (DCS) for a non-safety control system. With the safety-grade platform PLC, a reactor protection system, an engineered safety feature-component control system, and reactor core protection system were developed. A power control system was developed based on the DCS. A logic alarm cause tracking system was developed as a man-machine interface for APR1400. Also, Integrated Performance Validation Facility (IPVF) was developed for the evaluation of the function and performance of developed I&C systems. The safety-grade platform PLC and the digital safety system obtained approval for the topical report from the Korean regulatory body in February of 2009. A utility and vendor company will determine the suitability of the KNICS and Nu- Tech 2012 products to apply them to the planned nuclear power plants.

• International Journal of Advanced Culture Technology
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• 제10권1호
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• pp.81-96
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• 2022

Based on a survey conducted on 125 students in the Department of Computer Engineering at K University, the following results were obtained by analyzing ways to improve academic ability. Male students should pay more attention to grade points management than female students before completing their military service. Students with high self-assessed academic ability score higher than students with low self-assessed academic ability. As long as students don't spend too much time, a student's part-time job is not an obstacle to their study. Compared to Seoul, Gyeonggi, and Incheon regions, students from Gangwon and other regions should pay special attention to some pre-classes to understand regular university lectures. In undergraduate education, a student's major aptitude is not a big problem. In order to change major, students need counseling about their major's aptitude only at the beginning semester. In order to get good grades, the achievement of the will to study is more important than the will to study itself. Professors should encourage students to review what they have learned in class after class and always assure students sincerity in their studies through the counseling process.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5755-5762
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• 2015

Background: Short-course preoperative radiation (SCRT) with delayed surgery was found to increase pathologic complete response (pCR) rates in several trials. However, there was no clear answer on whether SCRT or long-course chemo-radiotherapy (LCRT) is more effective. Therefore we conducted this meta-analysis to evaluate the safety and efficacy of SCRT versus LCRT, both with delayed surgery, for treatment of rectal cancer. Materials and Methods: The literature was searched from PubMed, EMBASE, Web of Science, Cochrane Library and clinicaltrials.gov up to November, 2014. Quality of the randomized controlled trials (RCTs) was evaluated according to the Cochrane's risk of bias tool of RCT. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was used to rate the level of evidence. Review Manager 5.3 was employed for statistical analysis. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated. Results: Three RCTs, with a total of 357 rectal cancer patients, were included in this systematic review. Metaanalysis results demonstrated there were no significantly differences in sphincter preservation rate, local recurrence rate, grade 3~4 acute toxicity, R0 resection rate and downstaging rate. Compared with SCRT, LCRT was associated with significant increase in the pCR rate [RR=0.49, 95%CI (0.31, 0.78), P=0.003]. Conclusions: In terms of sphincter preservation rate, local recurrence rate, grade 3~4 acute toxicity, R0 resection rate and downstaging rate, SCRT with delayed surgery is as effective as LCRT with delayed surgery for management of rectal cancer. LCRT significantly increased pCR rate compared with SCRT. Due to risk of bias and imprecision, further multi-center large sample RCTs were needed to confirm this conclusion.

• 대한교통학회지
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• 제25권5호
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• pp.79-90
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• 2007

도로의 최대종단경사는 차량의 등판능력에 좌우된다. 과거에 비해 차량의 성능이 좋아질수록 도로의 최대종단경사는 조정될 수 있다. 하지만, 미국(AASHTO, 1990, 2004)에서는 설계기준트럭이 300lb/hp에서 200lb/hp로 성능이 상승했음에도 불구하고, 적용되는 최대 종단경사는 거의 변화가 없다. 따라서, 현재 차량의 성능을 고려한 최대종단경사의 검토 및 조정의 검토가 필요한 실정이다. 특히 국내의 지형은 산악지가 많고, 험준한 지역이 많으므로 실정에 맞도록 최대종단경사의 검토가 필요하다. 본 연구에서는 차량의 성능의 개선과 도로 설계자가 당면한 결정의 문제를 인식하고 세계 각국의 지형과 최대종단경사 적용기준을 비교하여 우리나라의 최대종단경사의 적정성을 확인한다. 또한, 교통시뮬레이션 프로그램을 이용하여 차량의 성능향상에 따른 새로운 트럭 성능곡선을 토대로 최대종단경사를 판단한 결과 $1{\sim}2%$ 정도 종단경사 완화가 가능한 것으로 판단한다.

• Journal of the Korean Wood Science and Technology
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• 제43권1호
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• pp.25-35
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• 2015

본 연구에서는 국산 침엽수재의 육안 등급구분과 허용응력설정에 관한 국내의 학술논문을 정리하였다. 국립산림과학원 고시(KFRI 1995-27, KFRI 2000-39, KFRI 2007-3, KFRI 2009-1)를 활용하여 국산 낙엽송재의 육안 등급 구분한 연구를 비교한 결과 등급구분 비율이 연구자마다 상이했다. 보다 신뢰할 수 있는 등급구분 분류를 위해서 공증된 목재이용 기관에서 숙련된 연구자에 의한 등급구분을 시행하여야 할 것으로 사료된다. 허용응력설정에 관한 연구를 고찰한 결과, 연구자 마다 허용응력산출 방법이 ASTM D 245, KS F 2152, JAS 1990으로 모두 상이했다. 이는 침엽수 구조용재(KS F 3020)에서 기준허용응력을 제시하고 있지만 허용응력을 산출하는 명확한 방법이 제시되어 있지 않기 때문인 것으로 나타났다. 따라서 공식적인 허용응력 결정방법이 제정되어야 할 것으로 사료된다.