• 대한예방의학회:학술대회논문집
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• 1994.02a
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• pp.417-425
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• 1994

Although animal studies have been used most often for quantitative risk assessment, it is generally recognized that well-conducted epidemiologic studies would provide the best basis for estimating human risk. However, there are several features related to the design and analysis of epidemiologic studies that frequently limit their usefulness for quantitating risks. The lack of accurate information on exposure in epidemiologic studies is perhaps the most frequently cited limitation of these studies for risk assessment. However. other features of epidemiologic study design, such as statistical power, length of follow-up, confounding, and effect modification, may also limit the inferences that can be drawn from these studies. Furthermore, even when the aforementioned limitations are overcome, substantial uncertainty exists concerning the choice of an appropriate statistical (or biologic) model for extrapolation beyond the range of exposures observed in a particular study. This paper focuses on presenting a review and discussion of the methodologic issues involved in using epidemiologic studies for risk assessment. This review concentrates on the use of retrospective, cohort, mortality studies of occupational groups for assessing cancer risk because this is the most common application of epidemiologic data for quantitative risk assessment (QRA). Epidemiologic data should not be viewed as a panacea for the problems inherent in using animal bioassay data for QRA. Rather, information that can be derived from epidemiologic and toxicologic studies complement one another, and both data sources need to be used to provide the best characterization of human risk.

• Journal of the Korean Magnetic Resonance Society
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• v.24 no.3
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• pp.91-95
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• 2020

Transthyretin (TTR) is an abundant protein in blood plasma and cerebrospinal fluid (CSF), working as a homo-tetrameric complex to transport thyroxine (T₄) and a holo-retinol binding protein. TTR is well-known for its amyloidogenic property; several types of systemic amyloidosis diseases are caused by aggregation of either wild-type TTR or its variants, for which more than 100 mutations were reported to increase the amyloidogenicity of TTR. The rate-limiting step of TTR aggregation is the dissociation of a monomeric subunit from a tetrameric complex. A wide range of biochemical and biophysical techniques have been employed to elucidate the TTR aggregation processes, among which nuclear magnetic resonance (NMR) spectroscopy contributed much to characterize the structural and functional features of TTR during its aggregation processes. The present review focuses on discussing the recent advances of our understanding to the amyloidosis mechanism of TTR and to the structural features of its monomeric aggregation-prone state in solution. We expect that the present review provides novel insights to appreciate the molecular basis of TTR amyloidosis and to develop novel therapeutic strategies to treat diverse TTR-related diseases.

• Ceramist
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• v.22 no.3
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• pp.316-327
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• 2019

Carbon nitride has drawn broad interdisciplinary attention in diverse fields such as catalyst, energy storage, gas adsorption, biomedical sensing and even imaging. Intensive studies on carbon dioxide (CO₂) capture using carbon nitride materials with various nanostructures have been reported since it is needed to actively remove CO₂ from the atmosphere against climate change. This is mainly due to its tunable structural features, excellent physicochemical properties, and basic surface functionalities based on the presence of a large number of -NH or -NH₂ groups so that the nanostructured carbon nitrides are considered as suitable materials for CO₂ capture for future utilization as well. In this review, we summarize and highlight the recent progress in synthesis strategies of carbon nitride nanomaterials. Their superior CO₂ adsorption capabilities are also discussed with the structural and textural features. An outlook on possible further advances in carbon nitride is also included.

• Journal of Korean Elementary Science Education
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• v.29 no.3
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• pp.292-306
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• 2010

The purpose of this study was to review the current state and characteristics of instruments used to assess individual understanding of the nature of science (NOS). This study conducted a series of content analyses of the articles published in a total of seven Korean and international journals from 1990 to 2009. A total of 99 research papers and assessment tools were categorized according to their features such as item type, the method of development, philosophical perspectives and others. So, evaluation domains of the instruments were also compared with the features of the NOS endorsed in some standards science education documents internationally well known, such as Benchmarks for Science Literacy (AAAS, 1993), National Science Education Standards (NRC, 1996). It was found that VNOS was the most frequently used instrument used for the last 20 years. There was a difference between characteristics of instruments used in Korean journals and these in international journal, such as philosophical perspectives, item type. Moreover, the results showed that there were only a few of instruments to ask about ethics of scientists, significance of science process skill and the context. NOS instruments focused only on limited aspects of NOS emphasized by the standard documents.

• The Korean Journal of Cytopathology
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• v.18 no.1
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• pp.74-80
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• 2007

Parathyroid tumors may be difficult to distinguish from thyroid follicular lesions, especially when a tumor is nonfunctioning. We report here two cases of asymptomatic parathyroid carcinoma preoperatively misdiagnosed as thyroid follicular lesions, and one case of parathyroid adenoma showing hyperparathyroidism, and review the cytologic features favoring the diagnosis of parathyroid neoplasm. The cytologic findings that are characterized by clean background, monomorphic small cells, cohesive three-dimensional papillary clusters, small tight clusters with scattered naked nuclei, and well-defined clear cytoplasm favor a diagnosis for the parathyroid lesions. Cytologic findings such as macrofollicular structure, presence of colloid and macrophages, and presence of perivacuolar cytoplasmic granules on May-Grunwald-Giemsa stain support a diagnosis of a thyroid follicular lesion. The cytomorphology of parathyroid tumors is so variable that the distinction from a thyroid lesion cannot be based on the presence or absence of a single feature only but on the cytologic features as a whole.

• Imaging Science in Dentistry
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• v.36 no.2
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• pp.81-88
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• 2006

Purpose : To review developmental salivary gland defect based on 12 reported cases and literature, and to guide radiographic diagnosis of this entity. Materials and Methods : The 12 cases of developmental salivary gland defect of Chosun University Dental Hospital in the last 4 years were analyzed and compared with previous reported cases. Result : 11 of the 12 cases were found in men, indicating a very strong male predilection. The peak age was in the 6th decade. These defects were situated just above or at the inferior border of mandible between the first molar and the mandibular angle, and always Inferior to the mandibular canal. Only one case was superimposed with the mandibular canal, 6 cases were superimposed with the inferior border of the mandible. Conclusion : Characteristically, these defects had a special radiographic features such as ovoid shaped well-defined radiolucency located just above or at the inferior border of the mandible between the first molar and the mandibular angle, and always inferior to the mandibular canal. The recognition of these radiographic features were diagnostically valuable.

• International Journal of Fluid Machinery and Systems
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• v.8 no.4
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• pp.254-263
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• 2015

The failure of hydraulic turbine runners is a rare event. So in order to assess the reliability of these components one cannot rely solely on the number of observed failures in a given population. However, as there is a limited number of degradation mechanisms involved, it is possible to use physically-based reliability models. Such models are often more complicated but are able to account for physical parameters in the degradation process. They can therefore help provide solutions to improve reliability. With such models, the effect of materials properties on runner reliability can be highlighted. This paper presents a brief review of the Kitagawa-Takahashi diagram which links the damage tolerance approach, based on fracture mechanics, to the stress or strain-life approaches. Using simplified response spectra based on runner stress measurements, we will show how fatigue reliability is sensitive to materials fatigue properties, namely fatigue crack propagation behaviour and fatigue limit obtained on S-N curves. Furthermore, we will review the influence of the main microstructural features observed in 13%Cr-4%Ni stainless steels commonly used for runner manufacturing. The goal is ultimately to identify the most influential microstructural features and to quantify their effect on fatigue reliability of runners.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.45 no.4
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• pp.180-185
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• 2019

Masson's tumor or intravascular papillary endothelial hyperplasia is an inflammatory soft tissue lesion that rarely occurs in the maxillofacial region and skeletal system. Precise clinical and para-clinical investigation is necessary for the accurate diagnosis and correct treatment of this lesion. This paper presents a massive intravascular papillary endothelial hyperplasia lesion in the bony tissue of the mandible. Histopathology features, clinical appearance, and suitable management are discussed, with a complete review of the literature. The patient underwent composite resection of the lesion as well as reconstruction. No recurrence was observed during 6 years of follow-up. To the best of our knowledge, this is the fourth case of Masson's tumor in mandibular skeletal tissue, which has unique and distinctive features due to its size and location. A rare occurrence in skeletal tissue, complex clinical presentations, and complicated histopathologic findings present diagnostic challenges for treatment of this lesion.

• Imaging Science in Dentistry
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• v.51 no.4
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• pp.447-454
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• 2021

A 16-year-old male presented with pain in the right posterior mandible on chewing that had lasted for several months. The radiographic features of the lesion included a radiolucent-radiopaque mixed-density mass with a radiolucent rim attached to the root of the mandibular right first molar. The preliminary radiographic diagnosis was benign cementoblastoma, which was confirmed by histopathological examination following surgical excision. The lesion recurred 3 years after treatment; radiographically, it consisted of 3 round foci with mixed radiopacity, each with a radiolucent rim near the root of the mandibular right second premolar and the edentulous postoperative region. The lesion was diagnosed as recurrent benign cementoblastoma and a second surgery was scheduled. This report presented an unusual case of recurrent benign cementoblastoma following surgical excision and extraction of the involved tooth, along with a literature review on reported cases of recurrent benign cementoblastoma with a focus on its clinical features and the best treatment options.

• Agricultural and Biosystems Engineering
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• v.7 no.1
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• pp.27-41
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• 2006

Assessment of nitrogen and chlorophyll content from crop leaves can help growers adjust N fertilizer rates to meet the demands of the crop. Numerous researchers have presented their studies about spectral signature of plant leaves to characterize the plant features. However, interrelational review and summary were limited and a communication gap exists between the plant science and optical engineering. Understanding the mechanism of leaf interaction to electromagnetic radiation and factors affecting spectrophotometric measurements can enhance the foundation of optical remote sensing technologies. This paper provides extensive review of previous works in optical sensing and explains the basics of plant optics, spectral measurements for plant stress, factors that affect sensitivity to spectral analysis, and applications that deploy optical remote sensing technologies.