• 한국정밀공학회지
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• 제24권3호
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• pp.117-123
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• 2007

This paper describes a three-probe system that can be used to measure the parallelism and straightness of a pair of rails simultaneously. The parallelism is measured using a modified reversal method, while the straightness is measured using a sequential two-point method. The measurement algorithms were analyzed numerically using a pair of functionally defined rails to validate the three-probe system. Tests were also performed on a pair of straightedge rails with a length of 250 mm and a maximum straightness deviation of $0.05{\mu}m$, as certified by the supplier. The experimental results demonstrated that the parallelism-measurement algorithm had a cancellation effect on the probe stage motion error. They also confirmed that the proposed system could measure the slope of a pair of rails about $0.06{\mu}rad$. Therefore, by combining this technique with a sequential differential method to measure the straightness of the rails simultaneously, the surface profiles could be determined accurately and eliminate the stage error. The measured straightness deviation of each straight edge was less than $0.05{\mu}m$, consistent with the certified value.

• 한국소음진동공학회논문집
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• 제23권2호
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• pp.152-159
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• 2013

A structural health monitoring(SHM) technique for locating impact position in a composite plate is presented in this paper. The technique employs a single sensor and spatial focusing properties of time reversal(TR) and inverse filtering(IF). We first examine the focusing effect of back-propagated signal at the impact position and its surroundings through simulation. Impact experiments are then carried out and the localization images are found using the TR and IF signal processing, respectively. Both techniques provide accurate impact location results. Compared to existing techniques for locating impact or acoustic emission source, the proposed methods have the benefits of using a single sensor and not requiring knowledge of material properties and geometry of structures. Furthermore, it does not depend on a particular mode of dispersive Lamb waves that is frequently used in the SHM of plate-like structures.

• 한국발생생물학회지:발생과생식
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• 제14권1호
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• pp.1-5
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• 2010

We investigated the androgenic effects of 11-ketotestosterone (11-KT) on gonadal sex reversal and spermatogenesis in honeycomb grouper Epinephelus merra by method of gonadal biopsy. 11-KT was injected intramuscularly at a concentration of 1 and $10{\mu}g$ body weight. The proportion of cross sectional area of the gonad occupied by each germ cell type was measured and compared pre- and post-injection group. During the sex change phase, the distribution ratio of oocytes was decreased in all fish of 11-KT treatment group while the distribution ratio of spermatocytes was increased than pre-injection group. In male phase, all fish of 11-KT treatment group shown the increased distribution ratio of spermatocytes, but the distribution ratio of spermatozoa was decreased than pre-injection group. The present results suggest that 11-KT can stimulate degeneration of oocytes, proliferation of spermatocytes and spermiation in honeycomb grouper.

• Bulletin of the Korean Chemical Society
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• 제32권10호
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• pp.3666-3674
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• 2011

Overexpression of P-glycoprotein (Pgp) is associated with multidrug resistance (MDR) of tumor cells to a number of chemotherapeutic drugs. Pgp inhibitors have been shown to effectively reverse Pgp-mediated MDR. We prepared a series of phenoxy-N-phenylacetamide derivatives and tested for their ability to inhibit Pgp as potential MDR reversing agents, using a Pgp over-expressing MCF-7/ADR cell line. Some of the synthesized compounds exhibited moderate to potent reversal activity. Of note, compound 4o showed a 3.0-fold increased inhibition compared with verapamil, a well-known Pgp inhibitor. In addition, co-treatment of the representative compound 4o and a substrate anticancer agent doxorubicin resulted in a remarkable increase in doxorubicin's antitumor effect and inhibition of DNA synthesis in the MCF-7/ADR cell line. Taken together, these findings suggest that compound 4o could be a useful lead for development of a novel Pgp inhibitor for treatment of MDR.

• 한국식품위생안전성학회지
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• 제14권2호
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• pp.172-178
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• 1999

Previous studies have shown that methanol extract and its butanol fraction of Carthamus tinctorius L. Semen have the hepatoprotective effect on the CCl4-induced hepatotoxicity. The hepatoprotective effect of subfractions has been evaluated by analyzing blood and hepatocyte biochemical analyses and biotransformation enzyme analyses. Treatment of BS-5, subfraction has significantly decreased the activities of alanine aminotransferase and aspartate aminotransferase. In addition, the levels of cholesterol and triglyceride in liver have been decreased as compared with that of CCl4 treated rats. The hepatoprotective effect of BS-5, subfraction on the CCl4-induced hepatotoxicity would be mediated of the attenuation of the level of cytochrome P450 and the enhancement of the activity of glutathion S-transferase.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2005년도 춘계학술대회 논문집
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• pp.313-316
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• 2005

In the present study, Bauschinger effect was investigated for the micro-alloying forging steel which has been developed for about 30 years ago to save energy consumption by eliminating the heat treatment processes in the forging industry. The micro-alloying steels used fur cold forging industry mainly aim to replace the usual carbon steel. With the conventional carbon steels, all the deformation history can be eliminated after the final heat treatment(quenching and tempering). In the case of micro-alloying forging steels, however, the prior deformation history should be taken into consideration to meet the mechanical property requirement since the microstructure of micro-alloying steels might exhibit the Bauschinger effect, which was not needed to consider in the case of conventional carbon steel having quenching and tempering treatment. In the present study, the reverse loading tests were carried out to determine the Bauschinger effect of micro-alloying steel which composed of ferrite and cementite phases.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제24권1호
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• pp.51-58
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• 2018

Purpose: In this study, through the comparison of the pressure fluctuation and air exchange volume in negative isolation room according to the type of the door and door opening/closing speeds, which is one of the main factors causing the cross contamination of the negative pressure isolation room, establishes standard operating procedures to prevent cross contamination in high risk infectious diseases and isolation room design. Methods: In this study, the air flow each of the room is analyzed using ANASYS CFX CODE for flow analysis. In addition, the grid configuration of the door is constructed by applying Immersed Solid Methods. Results: The pressure fluctuation due to the opening and closing of the hinged door was very large when the moment of the hinged door opened and closed. Especially, at the moment when the door is closed, a pressure reversal phenomenon occurs in which the pressure in the isolation room is larger than the pressure in the anteroom. On the other hand, the pressure fluctuation due to the opening and closing of the sliding door appeared only when the door was closed, but the pressure reversal phenomenon not occurred at the moment when the sliding door was closed, unlike the hinged door. As the opening and closing speed of the hinged door increases, the air exchange volume is increased. However, as the opening and closing speed of the sliding door is decreased, the air exchange volume is increased. Implications: According to the results of this study, it can be concluded that the pressure fluctuation due to the opening and closing of the hinged door is greater than the pressure fluctuation due to the opening and closing of the sliding door. In addition, it can be confirmed that the pressure reversal phenomenon, which may cause to reduce the containment effect in negative pressure isolation room, is caused by the closing of the hinged door. Therefore, it is recommended to install a sliding door to maintain a stable differential pressure in the negative isolation room. Also, as the opening and closing speed of the hinged door is slower and the opening and closing speed of the sliding door is faster, the possibility of cross contamination of the room can be reduced. It is therefore necessary to establish standard operating procedures for negative isolation room for door opening and closing speeds.

• 한국산학기술학회논문지
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• 제20권8호
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• pp.122-132
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• 2019

본 연구는 상품 특성 및 상황에 따른 선호역전 현상이 선택에 어떠한 영향을 미치는 지를 규명하여 소비자 의사결정 논리체계를 살펴보고, 선택변화에 영향을 미치는 변인들을 규명하여 효과적인 의사결정 및 마케팅 전략을 수립하는데 목적이 있다. 본 연구의 목적인 소비자 선호역전과 선택변화 간의 영향관계를 확인하기 위해 3가지의 연구문제를 설정하였으며, 범주형 종속변수를 고려하여 다항로지스틱 회귀분석을 실시하였다. 연구 결과, 의료서비스 상품과 일반 제조품의 선호도 감소가 선택변화 및 선택연기에 유의한 영향을 미치는 것을 확인함으로써 연구문제 1을 해결하였다. 그리고 의료서비스 상품에서 속성의 중요도에 따른 선택변화가 일반 제조품에 비해 더욱 민감하게 작용한 반면, 선호역전에 따른 선택변화가 일반 제조품에서 더욱 높게 나타남을 확인하였다. 본 연구는 기존의 선호 및 선호역전 연구와는 다른 관점에서 소비자의 중심가치로서의 선호 개념을 조명하여 선택 간의 인과관계를 확인하였으며, 선호역전에 따른 선택변화 뿐만 아니라 선택연기와 같은 다른 대안까지 포함할 수 있음을 연구결과로 제시함에 따라 그에 따른 이론 실무적 시사점을 제공하는 데 의의가 있다.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2007년도 The 1st International Symposium on Advanced Magnetic Materials
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• pp.212.1-212.1
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• 2007

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1998년도 가을 학술발표논문집(II)
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• pp.525-528
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• 1998

This paper reports on tests of reinforced concrete shear walls for wall-type apartment structure under axial loads and the cyclic reversal of lateral loads with different confinement of the boundary elements. Confinement of the extreme element by U-stirrups and tie hooks seems to be as effective as closed stirrups. The shear strength capacity seems not to be increased by the confinement but deformation capacity improved.