• Clinical and Experimental Pediatrics
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• v.64 no.10
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• pp.511-518
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• 2021

The prevalence of childhood obesity is increasing worldwide at an alarming rate. While obesity is known to increase a variety of cardiovascular and metabolic diseases, it also acts as a risk factor for the development and progression of chronic kidney disease (CKD). During childhood and adolescence, severe obesity is associated with an increased prevalence and incidence of the early stages of kidney disease. Importantly, children born to obese mothers are also at increased risk of developing obesity and CKD later in life. The potential mechanisms underlying the association between obesity and CKD include hemodynamic factors, metabolic effects, and lipid nephrotoxicity. Weight reduction via increased physical activity, caloric restriction, treatment with angiotensin-converting enzyme inhibitors, and judicious bariatric surgery can be used to control obesity and obesity-related kidney disease. Preventive strategies to halt the obesity epidemic in the healthcare community are needed to reduce the widespread deleterious consequences of obesity including CKD development and progression.

• Molecules and Cells
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• v.44 no.12
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• pp.883-892
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• 2021

Genome-wide chromosome conformation capture (3C)-based high-throughput sequencing (Hi-C) has enabled identification of genome-wide chromatin loops. Because the Hi-C map with restriction fragment resolution is intrinsically associated with sparsity and stochastic noise, Hi-C data are usually binned at particular intervals; however, the binning method has limited reliability, especially at high resolution. Here, we describe a new method called HiCORE, which provides simple pipelines and algorithms to overcome the limitations of single-layered binning and predict core chromatin regions with three-dimensional physical interactions. In this approach, multiple layers of binning with slightly shifted genome coverage are generated, and interacting bins at each layer are integrated to infer narrower regions of chromatin interactions. HiCORE predicts chromatin looping regions with higher resolution, both in human and Arabidopsis genomes, and contributes to the identification of the precise positions of potential genomic elements in an unbiased manner.

• American Studies
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• v.42 no.2
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• pp.1-29
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• 2019

The recent census project that non-Hispanic White will be minority in thirty years has been accepted by the conservative media and politicians as the factor that threatens the authentic American national identity. The concerns about the majority-minority population chance influenced the election of Donald Trump who explicitly claimed the restriction of immigration, promising strong controls over the entry of undocumented immigrants. In the process, 'white-nationalism' based on the connection of racial whites and authentic American identity has been central issues in American society. In this sense, this paper examines who has been included/excluded from 'racial Whites' throughout the American history relating to the American identity politics and how these processes have shown the covert strategies of the whites for maintaining their privileges.

• Molecules and Cells
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• v.46 no.11
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• pp.664-671
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• 2023

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we review findings regarding the role of mRNA quality control in the aging and longevity of Caenorhabditis elegans, an outstanding model for aging research. We discuss the recently discovered functions of the proper regulation of nonsense-mediated mRNA decay, ribosome-associated quality control, and mRNA splicing in the aging of C. elegans. We describe how mRNA quality control contributes to longevity conferred by various regimens, including inhibition of insulin/insulin-like growth factor 1 (IGF-1) signaling, dietary restriction, and reduced mechanistic target of rapamycin signaling. This review provides valuable information regarding the relationship between the mRNA quality control and aging in C. elegans, which may lead to insights into healthy longevity in complex organisms, including humans.

• Journal of the Korean Applied Science and Technology
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• v.35 no.4
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• pp.1145-1155
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• 2018

The purpose of this study was to investigate the effect of dietary restriction(DG), aerobic exercise(EG), dietary restriction with aerobic exercise(DEG) on weight, improvement of obesity, blood lipid profiles and metabolic risk factors of obese female college students. Experiments was conducted 5 times a week for 8 weeks. DG spent 300kcal/day, and EG used 300kcal/day to run, DEG each consumed 150kcal/day limits. As s result, in case of body composition, weight(p<.011) and BMI(p<.008) were decreased in DG group, and weight(p<.044, p<.017), body fat(p<.047, p<.018), BMI(p<.03, p<.008), body fat%(p<.036, p<.015) and WHR(p<.049, p<.027) were decreased in EG and DEG groups. In case of blood lipid profiles's change, there are some differences on TC(p<.006), TG(p<.047) according to the time. In DG:HDL-C(p<.028), in EG:TG(p<.038), in DEG:TC(p<.014), LDL-C(p<.007) have decreased. In case of metabolic risk factor's change, there are some differences on FBG(p<.001), insulin(p<.004), HOMA-IR(p<.001), leptin(p<.000), adiponectin(p<.038), resistin(p<.010) according to time. In DG:HOMA-IR(p<.035) and leptin(p<.007), EG:FBG(p<.043) and leptin(p<.003), DEG:FBG(p<.014), insulin(p<.005), HOMA-IR(p<.005), leptin(p<.016), and resistin(p<.040) have decreased. In conclusion, combined treatment of eating restriction with aerobic exercise was the most effective way to improvement of weight, blood lipid profiles and metabolic risk factors in obese female college students rather than respectively alone treatment.

• Journal of Animal Science and Technology
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• v.48 no.1
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• pp.1-8
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• 2006

KIT encodes a mast/stem cell growth factor receptor and is known as a possible candidate gene responsible for dominant white coat color in mammals. To investigate the genetic variation of KIT gene in Korean wild boars(Sus scrofa coreanus), we carried out PCR-RFLP and DNA sequencing for three exons(exons 17, 19, and 20) and intron 19 of the KIT gene in Korean wild boars. PCR-RFLP results using NlaⅢ restriction enzyme in the breakpoint region between exon 17 and intron 17 and AciⅠ restriction enzyme in exon 19 indicate that Korean wild boars did not have previously identified white coat color related splicing mutation and missense mutation, respectively. These results also indicate matings between Korean wild boars could not give white coat color offsprings. We also found new SNPs in exons 19(C2661T) and 20(A2760G). Of these, the SNP in exon 20 is a missense mutation which might induce the change of amino acid iso-leucine to valine. However, no relationship was identified with this missense mutation and coat color. In this study, breed specific new SNPs were identified in exons 19, 20 and intron 19 and these results will give important information for genetic variation of porcine KIT gene.

• Science of Emotion and Sensibility
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• v.23 no.2
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• pp.13-22
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• 2020

This study aimed to investigate the association between asthma and emotions, such as depression, stress, and health awareness. We observed the effects of blood indices on asthma in Korean adults. Data from 5852 adults were taken from the 2017 Seventh Korea National Health and Nutrition Examination Survey and analyzed using a multivariate logistic regression model. The probability of asthma occurrence in over 65 years old was higher than in 19-44 years old (OR = 1.48), and asthma occurrence was high in subjects with low educational (OR = 1.89) and income (OR = 2.07) levels. With regard to marital status, singleness and divorce and dye were found to have increased the probability of asthma occurrence by 1.62- and 2.30-folds, respectively. The restriction of activities was another factor that increased with asthma occurrence (OR = 2.39). In terms of emotions, general health awareness was significantly 3.45 times increased the probability of asthma occurrence at their health bad awareness. Furthermore, depression (OR = 1.782) was shown to have increased asthma occurrence. The blood index of C-CRP 1.12 times increased the probability of asthma occurrence. The factors that influenced asthma occurrence were age, education, income, marital status, the restriction of activities, general health awareness, depression, and C-CRP. Emotional factors and blood indices are potential risk factors for the development of asthma in Korean adults. By understanding the increased risks of asthma occurrence with general characteristics and emotional factors and blood indices, the management and prevention of asthma should include the management of emotional factors.

• Toxicological Research
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• v.28 no.2
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• pp.129-137
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• 2012

Probabilistic ecological risk assessment (PERA) for deriving ecological protective concentration (EPC) was previously suggested in USA, Australia, New Zealand, Canada, and Netherland. This study suggested the EPC of cadmium (Cd) based on the PERA to be suitable to Korean aquatic ecosystem. First, we collected reliable ecotoxicity data from reliable data without restriction and reliable data with restrictions. Next, we sorted the ecotoxicity data based on the site-specific locations, exposure duration, and water hardness. To correct toxicity by the water hardness, EU's hardness corrected algorithm was used with slope factor 0.89 and a benchmark of water hardness 100. EPC was calculated according to statistical extrapolation method (SEM), statistical extrapolation $method_{Acute\;to\;chronic\;ratio}$ ($SEM_{ACR}$), and assessment factor method (AFM). As a result, aquatic toxicity data of Cd were collected from 43 acute toxicity data (4 Actinopterygill, 29 Branchiopoda, 1 Polychaeta, 2 Bryozoa, 6 Chlorophyceae, 1 Chanophyceae) and 40 chronic toxicity data (2 Actinopterygill, 23 Branchiopoda, 9 Chlorophyceae, 6 Macrophytes). Because toxicity data of Cd belongs to 4 classes in taxonomical classification, acute and chronic EPC (11.07 ${\mu}g/l$ and 0.034 ${\mu}g/l$, respectively) was calculated according to SEM technique. These values were included in the range of international EPCs. This study would be useful to establish the ecological standard for the protection of aquatic ecosystem in Korea.

• The Journal of Korean Society for Radiation Therapy
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• v.8 no.1
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• pp.29-35
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• 1996

We are often faced with the clinical situations that is inevitably extended SSD for electron beam therapy due to anatomical restriction or applicator structure. But there are some difficulties in accurately predicting output and properties. In electron beam treatment , unlike photon beam the decrease in output for extended SSD does not follow inverse-square law accurately because of a loss of side scatter equilibrium, which is particularly significant for small cone size and low energies. The purpose of our study is to analyze the output in changing with the energy, cone size, air gap beyond the standard SSD and to compare inverse-square law factor derived from calculated effective SSD, mominal SSD with measured output factor. In addition, we have analyzed the change of PDD for several cones with different SSDs which range from 100cm to 120cm with 5cm step and with different energies(6MeV, 9MeV, 12MeV, 16MeV, 20MeV). In accordance with our study, an extended SSD produces a significant change in beam output, negligible change in depth dose which range from 100cm to 120cm SSDs. In order to deliver the more accurate dose to the neoplastic tissue, first of all we recommend inverse-square law using the table of effective SSDs with cone sizes and energies respectively or simply to create a table of extended SSD air gap correction factor. The second we need to have an insight into some change of dose distribution including PPD, penumbra caused by extended SSD for electron beam therapy.

• The Journal of the Korea Contents Association
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• v.12 no.4
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• pp.495-509
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• 2012

Journals are the main indicator to evaluate the level of the studies of a country. The main purpose of this study is to suggest the improvements of the current journal evaluation system to enhance the level of journal quality. To accomplish the above purpose, the 631 researchers are surveyed by internet for their recognition. The major findings are as follows. Firstly, the current registration process need to be maintained, however, need to reinforce the conditions to level up the journal level and to extend the term for keeping the rate. Secondly, the professionalism and credibility of the appraisers need to be reinforced to increase the equity and rationality of the current evaluation system. Thirdly, the evaluation process for the newly entering journal need to be more strict than the current system. Fourthly, the Korean citation index or Kor-Factor need to be applied to evaluate the domestic journals. Lastly, the restriction policy is need to constrain the number of journals.