• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.517-520
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• 2012

Single original gemcitabine is commonly used as salvage treatment in platinum-resistant ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma (PPA) with a satisfactory outcome. However, efficacy data fro this regimen are limited. We therefore conducted a retrospective study to evaluate the outcome of patients who received single-agent generic gemcitabine (GEMITA) after development of clinical platinum resistance. The study period was between May 2008 and December 2010. Gemcitabine was administered intravenously in two different schedules: 1,000 $mg/m^2$ on day 1,8, and 15 every 28 days; and on days 1 and 8 every 21 days with the same dosage. Administration was until disease progression was noted. The response rate was evaluated using the Gynecologic Cancer Intergroup (GCIG) criteria while toxicity was evaluated according to WHO criteria. Sixty-six patients met the inclusion criteria in the study period. Two-thirds of them received gemcitabine as the second and third line regimen. The overall response rate was 12.1%. The median progression free survival and overall survival was 2 and 10 months, respectively. With the total 550 courses of chemotherapy,the patients developed grades 3 and 4 hematologic toxicity as follows: anemia, 1.5%; leukopenia, 13.7%; neutropenia, 27.3%; and thrombocytopenia, 3.0%. In conclusion, single agent generic gemcitabine revealed a modest efficacy in patients with platinum-resistant ovarian cancer, fallopian tube cancer and PPA without serious toxicity.

• 국제초고층학회논문집
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• 제1권1호
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• pp.15-19
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• 2012

Occupant footfalls are often the most critical source of floor vibration on upper floors of buildings. Floor motions can degrade the performance of imaging equipment, disrupt sensitive research equipment, and cause discomfort for the occupants. It is essential that low-vibration environments be provided for functionality of sensitive spaces on floors above grade. This requires a sufficiently stiff and massive floor structure that effectively resists the forces exerted from user traffic. Over the past 25 years, generic vibration limits have been developed, which provide frequency dependent sensitivities for wide classes of equipment, and are used extensively in lab design for healthcare and research facilities. The same basis for these curves can be used to quantify acceptable limits of vibration for human comfort, depending on the intended occupancy of the space. When available, manufacturer's vibration criteria for sensitive equipment are expressed in units of acceleration, velocity or displacement and can be specified as zero-to-peak, peak-to-peak, or root-mean-square (rms) with varying frequency ranges and resolutions. Several approaches to prediction of floor vibrations are currently applied in practice. Each method is traceable to fundamental structural dynamics, differing only in the level of complexity assumed for the system response, and the required information for use as model inputs. Three commonly used models are described, as well as key features they possess that make them attractive to use for various applications. A case study is presented of a tall building which has fitness areas on two of the upper floors. The analysis predicted that the motions experienced would be within the given criteria, but showed that if the floor had been more flexible, the potential exists for a locked-in resonance response which could have been felt over large portions of the building.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.1370-1378
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• 2007

고속철도 교량은 고속주행 열차의 차축 주기하중 효과와 교량 고유의 동적특성에 의한 동적 증폭 효과로 인하여 구조물의 안전성에 영향을 받는다. 그리고 교량의 과도한 변형으로 인하여 차륜과 레일의 접촉력 감소, 궤도틀림 등의 윤중 변동이 일어나 열차의 주행안전성 및 승차감을 저해할 수 있다. 이러한 궤도 안전성을 확보하기 위하여 동적거동에 대한 교량상판수준의 수직가속도 제한, 차륜-레일간의 접촉과 열차주행 안전성 확보를 위한 상판 면틀림 제한, 단부 회전각 변위 제한, 차량하중에 의한 교량의 수직 처짐 제한을 반드시 만족시켜야 하며, 필수적으로 공진에 대한 검토도 이루어져야 한다. 신설되는 호남고속철도에서는 기존의 경부고속철도와 다른 콘크리트 도상을 적용하고, 궤도간격, 설계열차하중 등이 변경되어 적용되므로 새로운 동적안정성 요구조건을 적용하게 된다. 본 연구에서는 콘크리트교량에 비해 진동특성이 취약한 것으로 알려진 강합성 거더 고속철도 교량의 동적거동 분석을 수행하였다.

• 한국재난정보학회 논문집
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• 제10권3호
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• pp.466-480
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• 2014

대한민국은 사회적 고령화 문제와 더불어 재난현장 대응활동의 주역인 소방공무원 조직의 연령 구성비의 고연령화 문제 또한 심각한 상황에 이를 것으로 전망된다. 대표적인 재난대응조직인 서울소방의 경우 향후 10년~15년 사이에 50대 이상의 비율이 31%에서 40%에 이를 것으로 예상되는데, 이는 재난 현장에서 강인한 체력과 건강한 신체를 필수 요소로 하는 소방공무원에 있어서는 일반직 공무원과는 달리 심각한 문제가 되지 않을 수 없다. 본 연구는 서울 소방공무원의 연령현황과 추이를 분석하고 국내 최초로 현장활동 소방공무원의 현장활동 한계의 기준 연령을 정의하고 3가지 분석기준을 통해 개괄적이나마 현장활동 한계기준을 도출하고, 이 기준을 통해 추이분석을 하였다.

• 국제초고층학회논문집
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• 제11권4호
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• pp.347-362
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• 2022

Current vibration serviceability assessment criteria for wind-induced vibrations in tall buildings are based largely on human 'perception' thresholds which are shown not to be directly translatable to human 'acceptability' of vibrations. There is also a considerable debate about both the metrics and criteria for vibration acceptability, such as frequency of occurrence or peak vs mean vibration, and how these might vary with the nature of the vibration. Furthermore, the design criteria are necessarily simplified for ease of application so cannot account for a range of environmental, situational and human factors that may enhance or diminish the impact of vibrations on serviceability. The dual-site VSimulators facility was created specifically to provide an experimental platform to address gaps in understanding of human response to building vibration. This paper considers how VSimulators can be used to inform general design guidance and support design of specific buildings for habitability, in terms of vibration, which allow engineers and clients to make informed decisions with regard to sustainable design, in terms of energy and financial cost. This paper first provides a brief overview of current vibration serviceability assessment guidelines, and the current understanding and limitations of occupants' acceptability of wind-induced motion in tall buildings. It then describes how the dual-site VSimulators facility at the Universities of Bath and Exeter can be used to assess the effects of motion and environment on human comfort, wellbeing and productivity with examples of how the facility capabilities have been used to provide new, human experience based experimental research approaches.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2000년도 춘계 학술발표회 논문집 Proceedings of EESK Conference-Spring
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• pp.194-201
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• 2000

In this study the modified seismic coefficient method for seismic analysis of buried box structures is developed for practical purpose. The loading coefficient in the modified seismic coefficient method is determined from the results of the response displacement analysis. In the developed method adequate velocity response spectrum in accordance with soil condition is also needed to seismic design of buried box structures, In order to investigate applicability of the modified seismic coefficient method various analyses are performed with different parameters such as depth of base rock height and width of box buried depth and value of standard penetration test. Results from the modified seismic coefficient method are compared with those of the response displacement method in terms of the maximum bending moment and the location of it. From the comparison it is shown that the feasibility of the modified seismic coefficient method for seismic analysis of buried box structures.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2001년도 봄 학술발표회 논문집
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• pp.921-926
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• 2001

In this paper the biaxial failure criteria and stress-strain response for plain concrete are studied under uniaxial and biaxial stress(compression-compression, compression-tension, and tension-tension combined stress). The concrete specimens of a square plate type are used for uniaxial and biaxial loading. The experimental data indicate that the strength of concrete under biaxial compression, f2/fl=-l/-1, is 17 percent larger than under uniaxial compression and the poisson's ratio of concrete is 0.1745. On the base of the results, a biaxial failure envelope for plain concrete that the uniaxial strength is 398kgf/$cm^{2}$ are developed. The biaxial failure behaviors for three biaxial loading areas are also plotted respectively. In addition, the characteristics of stress-strain response under biaxial compression are compared and verified with the experimental and analytical results.

• 한국안전학회지
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• 제27권1호
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• pp.44-48
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• 2012

The seismic safety of long-period cable-stayed bridges is assessed by probabilistic finite element analysis and reliability analysis under NFE. The structural response of critical members of cable-stayed bridges is evaluated using the developed probabilistic analysis algorithm. In this study, the real earthquake recording(Chi-Chi Earthquake; 1997) was selected as the input NFE earthquake for investigating response characteristics. The probabilistic response and reliability index shows the different aspect comparing the result from FFE earthquake. Therefore, the probabilistic seismic safety assessment on NFE earthquakes should be performed for the exact evaluation of long-period cable-stayed bridges and the earthquake resistant design criteria should be complemented.

• 한국경영과학회지
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• 제26권4호
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• pp.71-82
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• 2001

Using the computer simulation method, we invest19ate the probability distribution of maximum eigenvalue of pair-wise comparison matrix, which has been used as a parameter for measuring the consistency of responses in analytic hierarchy process (AHP). We show that the shape of the distribution of the maximum eigenvalue is different according to the dimension of the matrix. In addition, we cannot find any evidence that the distribution of the Consistency Index is a Normal distribution, which has been claimed in the Previous literature. Accordingly, we suggest using so called K-index calcu1ated based on the concept of cumulative distribution function lather than based on that of arithmetic mean because the probabilistic distribution cannot be assumed to be a Normal distribution. We interpret the simulation results by comparing them with the suggestion of Saaty[11]. Our results show that using Saaty＇s value could be too generous when the dimension of the matrix is 3 and strict over 4. Finally, we propose new criteria for measuring the response consistency in AHP.

• Coupled systems mechanics
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• 제7권3호
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• pp.269-280
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• 2018

Post-earthquake damages investigation in past and recent earthquakes has illustrated that the ground motion spatial variation plays an important role in the structural response of long span bridges. For the structural control of seismic-induced vibrations of cable-stayed bridges, it is extremely important to include the effects of the ground motion spatial variation in the analysis for design of an effective control system. The feasibility and efficiency of different vibration control strategies for the cable-stayed bridge under multiple support excitations have been examined to enhance a structure's ability to withstand earthquake excitations. Comparison of the response due to non-uniform input ground motion with that due to uniform input demonstrates the importance of accounting for spatial variability of excitations. The performance of the optimized designed control systems for uniform input excitations gets worse dramatically over almost all of the evaluation criteria under multiple-support excitations.