• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.517-520
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• 2012

Single original gemcitabine is commonly used as salvage treatment in platinum-resistant ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma (PPA) with a satisfactory outcome. However, efficacy data fro this regimen are limited. We therefore conducted a retrospective study to evaluate the outcome of patients who received single-agent generic gemcitabine (GEMITA) after development of clinical platinum resistance. The study period was between May 2008 and December 2010. Gemcitabine was administered intravenously in two different schedules: 1,000 $mg/m^2$ on day 1,8, and 15 every 28 days; and on days 1 and 8 every 21 days with the same dosage. Administration was until disease progression was noted. The response rate was evaluated using the Gynecologic Cancer Intergroup (GCIG) criteria while toxicity was evaluated according to WHO criteria. Sixty-six patients met the inclusion criteria in the study period. Two-thirds of them received gemcitabine as the second and third line regimen. The overall response rate was 12.1%. The median progression free survival and overall survival was 2 and 10 months, respectively. With the total 550 courses of chemotherapy,the patients developed grades 3 and 4 hematologic toxicity as follows: anemia, 1.5%; leukopenia, 13.7%; neutropenia, 27.3%; and thrombocytopenia, 3.0%. In conclusion, single agent generic gemcitabine revealed a modest efficacy in patients with platinum-resistant ovarian cancer, fallopian tube cancer and PPA without serious toxicity.

• International Journal of High-Rise Buildings
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• v.1 no.1
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• pp.15-19
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• 2012

Occupant footfalls are often the most critical source of floor vibration on upper floors of buildings. Floor motions can degrade the performance of imaging equipment, disrupt sensitive research equipment, and cause discomfort for the occupants. It is essential that low-vibration environments be provided for functionality of sensitive spaces on floors above grade. This requires a sufficiently stiff and massive floor structure that effectively resists the forces exerted from user traffic. Over the past 25 years, generic vibration limits have been developed, which provide frequency dependent sensitivities for wide classes of equipment, and are used extensively in lab design for healthcare and research facilities. The same basis for these curves can be used to quantify acceptable limits of vibration for human comfort, depending on the intended occupancy of the space. When available, manufacturer's vibration criteria for sensitive equipment are expressed in units of acceleration, velocity or displacement and can be specified as zero-to-peak, peak-to-peak, or root-mean-square (rms) with varying frequency ranges and resolutions. Several approaches to prediction of floor vibrations are currently applied in practice. Each method is traceable to fundamental structural dynamics, differing only in the level of complexity assumed for the system response, and the required information for use as model inputs. Three commonly used models are described, as well as key features they possess that make them attractive to use for various applications. A case study is presented of a tall building which has fitness areas on two of the upper floors. The analysis predicted that the motions experienced would be within the given criteria, but showed that if the floor had been more flexible, the potential exists for a locked-in resonance response which could have been felt over large portions of the building.

• Proceedings of the KSR Conference
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• 2007.11a
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• pp.1370-1378
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• 2007

High speed railway bridge is affected on safety of bridge by dynamic amplification effect, when dynamic response of bridge is equal to effect cycle load for rolling stock axle according to high speed operation train. And excessive deformation of structure has negative effect on operation safety of train and comfort of passenger due to fluctuation of wheel load by torsion of track etc. and decrease of contact force on vehicle wheel-rail. To ensure the safety of track and train operation safety, it is have to perform the study on resonance and deformation of structure. That criteria and requirement of railway bridge is limitation of vertical acceleration on deck for dynamic behavior of structure, contact of vehicle wheel and rail, limitation of face distortion and rotation angle of end deck, and limitation of vertical displacement by train. Unlike KYEONGBU High Speed Railway, New constructed HONAM High Speed Railway have to applied the new requirement for dynamic behavior safety according to change of condition which is type of ballast (slab ballast), interval of track, and actual rolling stock load. Therefore, in this paper, it was conformed the dynamic characteristic due to parameter, which related with above mentioned criteria, for steel composite bridges.

• Journal of the Society of Disaster Information
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• v.10 no.3
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• pp.466-480
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• 2014

In addition to aging social problem, the problem of older age structure ratio in the fire service organization playing the leading role of the disaster response activities is also expected to be this serious situation. In the case of Seoul fire fighting organization, it is expected that the ratio of over the age 50 reaches 31% or 40% between from 10 to 15 years later from now on, but this will be a serious problem in the fire fighting personnel needing a healthy body and physical strength in the disaster situation unlike the civil servants of general staff. Therefore, the purpose of this study is to take measures that can adapt to a new disaster environment of Increasing proportion of the elderly population by presenting the criteria of age limit of fire fighting field activities to analyze the relevance of the ability to perform on-site activities and age of Seoul fire civil servants, by using three analysis criteria.

• International Journal of High-Rise Buildings
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• v.11 no.4
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• pp.347-362
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• 2022

Current vibration serviceability assessment criteria for wind-induced vibrations in tall buildings are based largely on human 'perception' thresholds which are shown not to be directly translatable to human 'acceptability' of vibrations. There is also a considerable debate about both the metrics and criteria for vibration acceptability, such as frequency of occurrence or peak vs mean vibration, and how these might vary with the nature of the vibration. Furthermore, the design criteria are necessarily simplified for ease of application so cannot account for a range of environmental, situational and human factors that may enhance or diminish the impact of vibrations on serviceability. The dual-site VSimulators facility was created specifically to provide an experimental platform to address gaps in understanding of human response to building vibration. This paper considers how VSimulators can be used to inform general design guidance and support design of specific buildings for habitability, in terms of vibration, which allow engineers and clients to make informed decisions with regard to sustainable design, in terms of energy and financial cost. This paper first provides a brief overview of current vibration serviceability assessment guidelines, and the current understanding and limitations of occupants' acceptability of wind-induced motion in tall buildings. It then describes how the dual-site VSimulators facility at the Universities of Bath and Exeter can be used to assess the effects of motion and environment on human comfort, wellbeing and productivity with examples of how the facility capabilities have been used to provide new, human experience based experimental research approaches.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2000.04a
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• pp.194-201
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• 2000

In this study the modified seismic coefficient method for seismic analysis of buried box structures is developed for practical purpose. The loading coefficient in the modified seismic coefficient method is determined from the results of the response displacement analysis. In the developed method adequate velocity response spectrum in accordance with soil condition is also needed to seismic design of buried box structures, In order to investigate applicability of the modified seismic coefficient method various analyses are performed with different parameters such as depth of base rock height and width of box buried depth and value of standard penetration test. Results from the modified seismic coefficient method are compared with those of the response displacement method in terms of the maximum bending moment and the location of it. From the comparison it is shown that the feasibility of the modified seismic coefficient method for seismic analysis of buried box structures.

• Proceedings of the Korea Concrete Institute Conference
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• 2001.05a
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• pp.921-926
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• 2001

In this paper the biaxial failure criteria and stress-strain response for plain concrete are studied under uniaxial and biaxial stress(compression-compression, compression-tension, and tension-tension combined stress). The concrete specimens of a square plate type are used for uniaxial and biaxial loading. The experimental data indicate that the strength of concrete under biaxial compression, f2/fl=-l/-1, is 17 percent larger than under uniaxial compression and the poisson's ratio of concrete is 0.1745. On the base of the results, a biaxial failure envelope for plain concrete that the uniaxial strength is 398kgf/$cm^{2}$ are developed. The biaxial failure behaviors for three biaxial loading areas are also plotted respectively. In addition, the characteristics of stress-strain response under biaxial compression are compared and verified with the experimental and analytical results.

• Journal of the Korean Society of Safety
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• v.27 no.1
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• pp.44-48
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• 2012

The seismic safety of long-period cable-stayed bridges is assessed by probabilistic finite element analysis and reliability analysis under NFE. The structural response of critical members of cable-stayed bridges is evaluated using the developed probabilistic analysis algorithm. In this study, the real earthquake recording(Chi-Chi Earthquake; 1997) was selected as the input NFE earthquake for investigating response characteristics. The probabilistic response and reliability index shows the different aspect comparing the result from FFE earthquake. Therefore, the probabilistic seismic safety assessment on NFE earthquakes should be performed for the exact evaluation of long-period cable-stayed bridges and the earthquake resistant design criteria should be complemented.

• Journal of the Korean Operations Research and Management Science Society
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• v.26 no.4
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• pp.71-82
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• 2001

Using the computer simulation method, we invest19ate the probability distribution of maximum eigenvalue of pair-wise comparison matrix, which has been used as a parameter for measuring the consistency of responses in analytic hierarchy process (AHP). We show that the shape of the distribution of the maximum eigenvalue is different according to the dimension of the matrix. In addition, we cannot find any evidence that the distribution of the Consistency Index is a Normal distribution, which has been claimed in the Previous literature. Accordingly, we suggest using so called K-index calcu1ated based on the concept of cumulative distribution function lather than based on that of arithmetic mean because the probabilistic distribution cannot be assumed to be a Normal distribution. We interpret the simulation results by comparing them with the suggestion of Saaty[11]. Our results show that using Saaty＇s value could be too generous when the dimension of the matrix is 3 and strict over 4. Finally, we propose new criteria for measuring the response consistency in AHP.

• Coupled systems mechanics
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• v.7 no.3
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• pp.269-280
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• 2018

Post-earthquake damages investigation in past and recent earthquakes has illustrated that the ground motion spatial variation plays an important role in the structural response of long span bridges. For the structural control of seismic-induced vibrations of cable-stayed bridges, it is extremely important to include the effects of the ground motion spatial variation in the analysis for design of an effective control system. The feasibility and efficiency of different vibration control strategies for the cable-stayed bridge under multiple support excitations have been examined to enhance a structure's ability to withstand earthquake excitations. Comparison of the response due to non-uniform input ground motion with that due to uniform input demonstrates the importance of accounting for spatial variability of excitations. The performance of the optimized designed control systems for uniform input excitations gets worse dramatically over almost all of the evaluation criteria under multiple-support excitations.