• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3213-3218
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• 2012

When patients with advanced breast cancer (ABC) are treated with neoadjuvant chemotherapy (NACT), efficacy is monitored by the extent of tumor shrinkage. Since their publication in 1981, World Health Organization (WHO) guidelines have been widely practiced in clinical trials and oncologic practice, for standardized tumor response evaluation. With advances in cancer treatment and tumor imaging, a simpler criterion based on one-dimensional rather than bi-dimensional (WHO) tumor measurement, named Response Evaluation Criteria in Solid Tumors (RECIST) was introduced in 2000. Both approaches have four response categories: complete response, partial response, stable disease and progressive disease (PD). Bi-dimensional measurement data of 151 patients with ABC were analysed with WHO and RECIST criteria to compare their response categories and inter criteria reproducibility by Kappa statistics. There was 94% concordance and 9/151 patients were recategorized with RECIST including 6/12 PD cases. RECIST therefore under-estimates and delays diagnosis of PD. This is undesirable because it may delay or negate switch over to alternate therapy. Analysis was repeated with a new criteria named RECIST-Breast (RECIST-B), with a lower threshold for PD (${\geq}10%$ rather than ${\geq}20%$ increase of RECIST). This showed higher concordance of 97% with WHO criteria and re-categorization of only 4/151 patients (1/12 PD cases). RECIST-B criteria therefore have advantages of both ease of measurement and calculations combined with excellent concordance with WHO criteria, providing a practical clinical tool for response evaluation and offering good comparison with past and current clinical trials of NACT using WHO guidelines.

• Tuberculosis and Respiratory Diseases
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• v.80 no.2
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• pp.136-142
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• 2017

Assessing response to therapy allows for prospective end point evaluation in clinical trials and serves as a guide to clinicians for making decisions. Recent prospective and randomized trials suggest the development of imaging techniques and introduction of new anti-cancer drugs. However, the revision of methods, or proposal of new methods to evaluate chemotherapeutic response, is not enough. This paper discusses the characteristics of the Response Evaluation Criteria In Solid Tumor (RECIST) version 1.1 suggested in 2009 and used widely by experts. It also contains information about possible dilemmas arising from the application of response assessment by the latest version of the response evaluation method, or recently introduced chemotherapeutic agents. Further data reveals the problems and limitations caused by applying the existing RECIST criteria to anti-cancer immune therapy, and the application of a new technique, immune related response criteria, for the response assessment of immune therapy. Lastly, the paper includes a newly developing response evaluation method and suggests its developmental direction.

• Journal of Fashion Business
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• v.15 no.3
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• pp.1-21
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• 2011

This study is designed to identify how Demographic Factors affect Fashion Orientation(value), Fashion Response, and Buying Criteria. A total of 355 usable data was collected from housewives in three metropolitan cities(Seoul, Daejeon, Sungnam) in Korea. Young housewives who have one child are a market segment whose buying power is recognized by both the retailers and the market. The housewives' fashion orientation consists of four categories : social orientation, practical orientation, political orientation, and aesthetic orientation. The housewives' fashion response is classified into three areas : self conscious, self esteem, and self monitoring. The criteria of buying children's wear consists of nine components. As a result, the key reason for buying children' wear was 'attractive design'. Research result showed that POLITICAL ORIENTATION(SE beta=.229, p<.001) was more effective than AESTHETICS ORIENTATION(SE beta=.203, p<.001), for enhancing SELF-CONSCIOUS RESPONSE and SELF-ESTEEM RESPONSE. Therefore, this study suggests that the key factor for understanding trend can be a human self concept, consciousness, values, and orientation. The housewives' fashion orientation is responsible for 18.7% of BRAND ROYALTY(F = 20.172, p<.001) from among nine buying criteria. More poignantly, POLITICAL ORIENTATION covered 66.9% of selection of BRAND ROYALTY, and it explained 34.6% of selection of DESIGN among nine buying criteria. Thus, it showed that POLITICAL ORIENTATION(SE beta=.331, p<.001) is more effective than SOCIAL ORIENTATION(SE beta=.146), for upgrading BRAND ROYALTY. In addition, it showed that POLITICAL ORIENTATION(SE beta=.238, p<.001) is more effective than AESTHETICS ORIENTATION(SE beta=.040) for upgrading DESIGN evaluation. Housewives' fashion orientation, and fashion response are differentiated by demographic factors, such as occupation, women's career, husband' job, income, and location related to social status.

• Journal of the Earthquake Engineering Society of Korea
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• v.21 no.4
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• pp.181-188
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• 2017

Current seismic design provisions such as ASCE 7-10 provide criteria for selecting ground motions for conducting response history analysis. This study is the sequel of a companion paper (I - Ground Motion Selection) for assessment of the ASCE 7-10 criteria. To assess of the ASCE 7-10 criteria, nonlinear response history analyses of twelve single degree of freedom (SDF) systems and one multi-degree of freedom (MDF) system are conducted in this study. The results show that the target seismic demands for SDF can be predicted using the mean seismic demands over seven and ten ground motions selected according to the proposed method within an error of 30% and 20%, respectively

• Nuclear Medicine and Molecular Imaging
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• v.43 no.5
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• pp.369-385
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• 2009

In this paper, the authors intended to summarize briefly the features of lymphoma with regard to $^{18}F$-FDG PET for assessment of tumor response to therapy, to describe why assessment of treatment response should be performed, to review what method so far has been used in monitoring treatment response, to discuss what limitations of morphologic imaging criteria for assessing tumor response are, in compared with $^{18}F$-FDG PET, and to introduce recently proposed criteria for assessing tumor response in malignant lymphoma. And also the authors emphasize the need to understand the characteristics of diagnostic performance of $^{18}F$-FDG PET in several clinical settings in order to interpret $^{18}F$-FDG PET results appropriately, and to encourage the use of interval likelihood ratio to enhance clinical implications of test results which, in turns, allows referring physicians to understand the meaning of interpretation with easy. Until recently, treatment response has been assessed according to the morphologic criteria. Metabolic imaging with $^{18}F$-FDG PET was adopted to have important role for treatment assessment in IWC+PET criteria proposed recently by IHP. To accomplish this role, we should perform and interpret $^{18}F$-FDG PET according to IWC+PET criteria. It is important for referring physicians to understand the various limitations of $^{18}F$-FDG PET and pitfalls in PET interpretation, and to understand that clinical information are needed by nuclear medicine physicians to optimize the interpretation of $^{18}F$-FDG PET.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.6
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• pp.946-954
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• 2016

Energy industry is undergoing a paradigm shift in customer participation in the smartgrid. Customers traditionally consume electrical power. But nowadays not only do they generate electricity from private distributed generations, they can participate in demand response programs with their negawatt power which means a theoretical unit of power representing an amount of energy saved. Therefore development of decision-making criteria for electric load aggregation becomes a greater consideration as an amount of energy saved from demand response resources increases. This paper proposes load aggregators' decision-making criteria in the industrial sector where it made up the largest portion in demand response portfolio in order to assure reliability performance for demand response resources.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.21 no.11
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• pp.1036-1042
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• 2011

APR1400 RVI CVAP using the non-prototype category II is being conducted to verify integrity of the RVI design and to secure the CVAP technology. The measurement programs are to confirm vibration analysis results for reactor internals during pre-operational and initial startup testing and to determine the safety margin. One of the important basis for the measurement programs is test acceptance criteria. Therefore, this paper is on establishment of response instrumentation test acceptance criteria for APR1400 RVI CVAP. The established acceptance criteria show that the stress criteria of APR1400 RVI are more conservative values than those of the valid prototype plant(Palo Verde unit 1) and, the displacement criteria of the inner barrel assembly and the upper guide structure were established to 0.03 in and 0.01 in, respectively.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2011.10a
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• pp.212-218
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• 2011

APR1400 RVI CVAP using the non-prototype category is being conducted to verify integrity of the RVI design and to secure the CVAP technology. The measurement programs are to confirm vibration analysis results for reactor internals during preoperational and initial startup testing and to detemine the safety margin. One of the important basis for the measurement programs is test acceptance criteria. Therefore, this paper is on establishment of response instrumentation test acceptance criteria for APR1400 RVI CVAP. The established acceptance criteria show that the stress criteria of APR1400 RVI are more conservative values than those of the valid prototype plant(Palo Verde unit 1) and, the displacement criteria of the IBA and the UGS were established to 0.03 in and 0.01 in, respectively.

• Journal of the Earthquake Engineering Society of Korea
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• v.18 no.5
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• pp.231-240
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• 2014

This study reviews the status and validity of seismic design criteria (SDC) for major facilities in Korea, which are composed of performance criteria and technical standard. Various facilities with different seismic design response spectra are analyzed to identify their seismic performance and necessity of eventual retrofit. The results are used to derive improvement directions of SDC. It is also concluded that the technical standard should be improved after the revision of the performance criteria.

• International Journal of Automotive Technology
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• v.7 no.7
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• pp.769-776
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• 2006

A mathematical model is developed in this paper to define the interaction between the occupant and vehicle passenger compartment and to predict the occupant dynamic response during a sudden impulse load. Two different types of occupants are considered in this study, child and adult occupants. The occupants are considered as lumped masses connected to the child seat and vehicle's body masses by means of restraint systems. In addition, the occupant restraint characteristics of seat belt and airbag are represented by stiffness and damping elements. To obtain the dynamic response of the occupant, the equations of motion of the occupants during vehicle collisions are developed and analytically solved. The occupant's acceleration and relative displacement are used as injury criteria to interpret the results. It is demonstrated from the numerical simulations that the dynamic response and injury criteria are easily captured and analyzed. It is also shown that the mathematical models are flexible, useful in optimization studies and it can be used at initial design stage.