• 생물정신의학
• /
• 제7권2호
• /
• pp.131-139
• /
• 2000

Even the pharmacotherapy is more effective than placebo for the treatment of depression, the outcome of pharmacoltherapy remains unsatisfactory for many patients. Apart from side effects, there are two major limitations of antidepressant therapy. One is the delayed onset of improvement and another is partial response. In order to address these clinical dilemmas, many psychiatrists more commonly employ add-on therapy. In past, the practice of using multiple drugs to enhance treatment response was called polypharamcy, and was disparaged as poor clinical practice. However, with improved understanding of how drugs affects the central nervous system and increased communication in journals and on computer networks about the relative merits of specific combinations, the scientific basis for the combining drugs is being defined. Indeed, the use of multiple medications as a stratege to enhance response has become both acceptable and widespread now a days. It is now referred to more positively as add-on therapy, co-medication, combination therapy, or drug augmentation. Thus, as the methods of practical strategies for treatment of depression, switching classes antidepressant drugs, combination therapy, augmentation strategies and brief treatment algorithm will be presented with items of considerations. However, when combination of drugs being tried, knowledges about the action of mechanism, pharamcokinetics, and pharmacodynamics are essential to cope with the possible adversive reactions and to get the appropriate responses for the treatment of depressive symptoms.

• Radiation Oncology Journal
• /
• 제36권3호
• /
• pp.172-181
• /
• 2018

Successful anticancer strategies require a differential response between tumor and normal tissue (i.e., a therapeutic ratio). In fact, improving the effectiveness of a cancer therapeutic is of no clinical value in the absence of a significant increase in the differential response between tumor and normal tissue. Although radiation dose escalation with the use of intensity modulated radiation therapy has permitted the maximum tolerable dose for most locally advanced cancers, improvements in tumor control without damaging normal adjacent tissues are needed. As a means of increasing the therapeutic ratio, several new approaches are under development. Drugs targeting signal transduction pathways in cancer progression and more recently, immunotherapeutics targeting specific immune cell subsets have entered the clinic with promising early results. Radiobiological research is underway to address pressing questions as to the dose per fraction, irradiated tumor volume and time sequence of the drug administration. To exploit these exciting novel strategies, a better understanding is needed of the cellular and molecular pathways responsible for both cancer and normal tissue and organ response, including the role of radiation-induced accelerated senescence. This review will highlight the current understanding of promising biologically targeted therapies to enhance the radiation therapeutic ratio.

• 한국시뮬레이션학회:학술대회논문집
• /
• 한국시뮬레이션학회 1994년도 추계학술발표회 및 정기총회
• /
• pp.1-2
• /
• 1994

With the prevalence of computers in modern organizations, simulation is receiving more atention as an effectvie decision -making tool. Simualtion is a computer-based numerical technique which uses mathmatical and logical models to approximate the behaviror of a real-world system. However, iptimization of synamic stochastic systems often defy analytical and algorithmic soluions. Although a simulation approach is often free fo the liminting assumption s of mathematical modeling, cost and time consiceration s make simulation the henayst's last resort. Therefore, whenever possible, analytical and algorithmica solutions are favored over simulation. This paper discussed the issues and procedrues for using simulation as a tool for optimization of stochastic complex systems that are dmodeled by computer simulation . Its emphasis is mostly on issues that are speicific to simulation optimization instead of consentrating on the general optimizationand mathematical programming techniques . A simulation optimization problem is an optimization problem where the objective function. constraints, or both are response that can only be evauated by computer simulation. As such, these functions are only implicit functions of decision parameters of the system, and often stochastic in nature as well. Most of optimization techniqes can be classified as single or multiple-resoneses techniques . The optimization of single response functins has been researched extensively and consists of many techniques. In the single response category, these strategies are gradient based search techniques, stochastic approximate techniques, response surface techniques, and heuristic search techniques. In the multiple response categroy, there are basically five distinct strategies for treating the responses and finding the optimum solution. These strategies are graphica techniqes, direct search techniques, constrained optimization techniques, unconstrained optimization techniques, and goal programming techniques. The choice of theprocedreu to employ in simulation optimization depends on the analyst and the problem to be solved. For many practival and industrial optimization problems where some or all of the system components are stochastic, the objective functions cannot be represented analytically. Therefore, modeling by computersimulation is one of the most effective means of studying such complex systems. In this paper, after discussion of simulation optmization techniques, the applications of above techniques will be presented in the modeling process of many flexible manufacturing systems.

• 품질경영학회지
• /
• 제51권4호
• /
• pp.607-618
• /
• 2023

Purpose: In this study, we proposed a plan to establish and implement a safety and health management system by utilizing corporate resources so that manufacturing companies can effectively respond to the Serious Accident Punishment Act. Methods: We identified critical factors and response strategies necessary for manufacturing companies to respond to the Severe Accident Punishment Act effectively and surveyed employees working at the company regarding their importance and performance. Results: In this study, we presented a method of strategically constructing the response strategies (20) shown in previous studies by matching them with the company's resources (leadership, organization, budget, education, and awareness). In particular, leadership refers to the ability of managers who can prevent serious accidents by carrying out safety and health security obligations to avoid safety and health hazards or risks to employees in the business or workplace that is controlled, operated, and managed. Conclusion: Based on the manager's firm leadership, the system's purpose and direction must be accurately set and sufficiently communicated to members. In addition, for companies to identify and improve risk factors on their own, a Process approach must be established to improve execution by referring to legal standards together with field managers and supervisors.

• 한국경영과학회지
• /
• 제23권2호
• /
• pp.67-81
• /
• 1998

An Automated Guided Vehicle System (AGVS) with a unidirectional loop guide path is modeled as a discrete-time stationary Markov chain. It is discussed how to estimate the mean response time, the utilization, and the cycle time of AGV for a delivery order. Three common operation strategies for idle vehicles - central zone positioning rule, circulatory loop positioning rule and point of release positioning rule - are analyzed. These different operation strategies are compared with each other based on the performance measures.

• 생물정신의학
• /
• 제5권2호
• /
• pp.162-165
• /
• 1998

The serotonin reuptake inhibitors(SRIs) and the serotonin selective reuptake inhibitors(SSRIs) are considered the first choice agents for pharmacologic treatment of obsessive-compulsive disordr(OCD). However, many patients with OCD experience little or no improvement in their symptoms when treated with SRIs or SSRIs. Patients who have experienced a partial or no response to an SRI/SSRI at 10 to 12 weeks are often considered for augmentation strategies. Nearly every class of psychotropic medications has been tried in an open fashion, though augmentation strategies have been somewhat disappointing.

• 품질경영학회지
• /
• 제25권2호
• /
• pp.28-46
• /
• 1997

This paper considers robust design strategies for off-line quality control, with the use of experimental design and response surface methodology, in situations where all products have multiple quality characteristics. These strategies can be developed using the desirability concept of desirability functions to determine the settings of the design factors, not only to get the average performances on target but also to minimize variability around the target values.

• 산업경영시스템학회지
• /
• 제23권56호
• /
• pp.55-64
• /
• 2000

There is more than a single quality characteristic and they are often of varying or mixed target types. The purpose of this paper is to develop general strategies for solving the multiple response robust design problem. The desirability function provides an important tool to solve problems that have different types of target since the desirability values all the range between zero and one. Several combinations of arithmetic averages, geometric averages, and standard deviations are used in the various strategies to find the best design point.

• 아동학회지
• /
• 제36권5호
• /
• pp.155-171
• /
• 2015

The purposes of this study were firstly, to examine the emergence of complex strategies for emotional regulation in 3 and 4 years old children, and secondly, to analyze the corresponding relationship of the preschoolers' strategies for emotional regulation and their mothers' responses. The subjects comprised 66 preschoolers(33 boys, 33 girls) and their mothers in J city. The results were as follows. First, the preschoolers' strategies for emotional regulation in frustrating episodes occurred in the following order; instrumental behaviors, cognitive reappraisal, distraction behaviors, and comforting behaviors. Second, the mother's responses to frustrating episodes occurred in the following order; cognitive reappraisal, instrumental behaviors, comforting behaviors, and distraction behaviors. Third, the corresponding relationship of the preschooler's strategies for emotional regulation and the mothers' responses to frustrating episodes were found to be of a similar patterns (e.g. preschoolers' cognitive reappraisal strategy and mothers' cognitive reappraisal response).

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 2004년도 요약집 춘계학술발표대회
• /
• pp.511.1-511.1
• /
• 2004