• 대한이식학회지
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• 제28권3호
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• pp.113-120
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• 2014

Two-signal models are useful in explaining various types of immune responses. In particular, secondary, so-called costimulatory, signals are critically required for the process of T-cell activation, survival, differentiation, and memory formation. Early studies in rodent models showed that targeting T-cell costimulatory pathways elicits immunological tolerance, providing a basis for development of costimulatory therapeutics in allograft rejection. However, as the classic definition of T-cell costimulation continues to evolve, simple blockade of costimulatory pathways has limitations in prevention of allograft rejection. Furthermore, functions of costimulatory molecules are much more diverse than initially anticipated and beyond T cells. In this mini-review, we will discuss CD137-CD137L bidirectional signals as examples showing that two-signals can be applicable to multiple phases of immune responses.

• Journal of Korean Vacuum Science & Technology
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• 제6권2호
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• pp.76-78
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• 2002

We have carried out the first-principle electronic structure calculations to investigate the spacer layer formation of Fe/Si multilayered films (MLF) and compared with the results obtained by optical spectroscopy. The computer-simulated spectra based on various structural models of MLF showed that neither FeSi$_2$ nor B2O-phase FeSi, which are semiconducting, could be considered as the spacer layers in the Fe/Si MLF for the strong antiferromagnetic coupling. The optical properties of the spacer extracted from the effective optical response of the MLF strongly support its metallic nature. The optical conductivity spectra of various phases of Fe-Si compounds were calculated and compared with the extracted optical properties of the spacer. From the above theoretical investigations it is concluded that a E2-phase metallic FeSi compound is spontaneously formed at the interfaces during deposition.

• Computers and Concrete
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• 제31권2호
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• pp.139-149
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• 2023

This article investigates the statically analysis regarding the thermal buckling behavior of a nonuniform small-scale nanobeam made of functionally graded material based on classic beam theories along with the nonlocal Eringen elasticity. The material distribution of functionally graded structures is composed of temperature-dependent ceramic and metal phases in axial and thickness directions, called two-dimensional functionally graded (2D-FG). The partial differential (PD) formulations and end conditions are extracted by using to the conservation energy method. The porosity voids are assumed in the nonuniform functionally graded (FG) structure. The thermal loads are in the axial direction of the beam. The extracted nonlocal PD equations are also solved by employing generalized differential quadrature method (GDQM). Last but not least, the information acquired is used to produce miniature sensors, providing a unique perspective on the growth of nanoelectromechanical systems (NEMS).

• JSTS:Journal of Semiconductor Technology and Science
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• 제11권3호
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• pp.135-145
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• 2011

Accurate process characterization and optimization are the first step for a successful advanced process control (APC), and they should be followed by continuous monitoring and control in order to run manufacturing processes most efficiently. In this paper, process characterization and recipe optimization methods with multiple outputs are presented in high density plasma-chemical vapor deposition (HDP-CVD) silicon dioxide deposition process. Five controllable process variables of Top $SiH_4$, Bottom $SiH_4$, $O_2$, Top RF Power, and Bottom RF Power, and two responses of interest, such as deposition rate and uniformity, are simultaneously considered employing both statistical response surface methodology (RSM) and neural networks (NNs) based genetic algorithm (GA). Statistically, two phases of experimental design was performed, and the established statistical models were optimized using performance index (PI). Artificial intelligently, NN process model with two outputs were established, and recipe synthesis was performed employing GA. Statistical RSM offers minimum numbers of experiment to build regression models and response surface models, but the analysis of the data need to satisfy underlying assumption and statistical data analysis capability. NN based-GA does not require any underlying assumption for data modeling; however, the selection of the input data for the model establishment is important for accurate model construction. Both statistical and artificial intelligent methods suggest competitive characterization and optimization results in HDP-CVD $SiO_2$ deposition process, and the NN based-GA method showed 26% uniformity improvement with 36% less $SiH_4$ gas usage yielding 20.8 ${\AA}/sec$ deposition rate.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.469-473
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• 2013

Background: The purpose of this study is to examine the risk of uncontrolled chemotherapy-induced nausea and vomiting (CINV) among patients receiving low emetogenic chemotherapy (LEC) with and without granisetron injection as the primary prophylaxis in addition to dexamethasone and metochlopramide. Materials and Methods: This was a single-centre, prospective cohort study. A total of 96 patients receiving LEC (52 with and 42 without granisetron) were randomly selected from the full patient list generated using the e-Hospital Information System (e-His). The rates of complete control (no CINV from days 1 to 5) and complete response (no nausea or vomiting in both acute and delayed phases) were identified through patient diaries which were adapted from the MASCC Antiemesis Tool (MAT). Selected covariates including gender, age, active alcohol consumption, morning sickness and previous chemotherapy history were controlled using the multiple logistic regression analyses. Results: Both groups showed significant difference with LEC regimens (p<0.001). No differences were found in age, gender, ethnic group and other baseline characteristics. The granisetron group indicated a higher complete response rate in acute emesis (adjusted OR: 0.1; 95%CI 0.02-0.85; p=0.034) than did the non-granisetron group. Both groups showed similar complete control and complete response rates for acute nausea, delayed nausea and delayed emesis. Conclusions: Granisetron injection used as the primary prophylaxis in LEC demonstrated limited roles in CINV control. Optimization of the guideline-recommended antiemetic regimens may serve as a less costly alternative to protect patients from uncontrolled acute emesis.

• 한국정보통신학회논문지
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• 제16권10호
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• pp.2095-2100
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• 2012

본 논문에서는 위치인식기반 WPAN 시스템에서 송수신 안테나간의 상관관계가 존재하는 MIMO-OFDM 환경인 경우 채널의 페이딩에 의한 영향을 완화시키고 통신링크 성능향상과 신뢰성을 증대시킬 수 있는 CS(channel sounding) 기법을 제안하며, 또한 본 논문에서는 sounding신호를 통해 채널 전파특성을 측정하여 CS기법으로 추정오차가 최적화된 송신단과 수신단간의 채널 전파특성을 측정한다. 이 제안된 기법을 통해 수신단에서 간단한 연산을 통하여 채널 용량을 증가 시켜 주며, 송신단에서 채널의 정보를 이용하여 최적의 전력 할당 할 수 있고, 채널 용량의 증가를 얻을 수 있게 된다.

• The Korean Journal of Pain
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• 제19권2호
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• pp.137-141
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• 2006

Background: It has been known that melatonin is involved in the modulation of nociceptive transmission. However, the effect of melatonin administered spinally has not been examined. Therefore, we examined the effect of melatonin on the formalin-induced or thermal-induced nociception at the spinal level. Methods: Intrathecal catheter was inserted into the subarachnoid space of male Sprague-Dawley rats. Pain was assessed by formalin test (induced by injection of $50{\mu}l$ of a 5% formalin solution to the hindpaw) or Hot-Box test (induced by radiant heat application to the hindpaw). The effect of intrathecal melatonin was examined on flinching behavior in the formalin test or withdrawal response in Hot-Box test. Results: Intrathecal melatonin produced a limited, but dose-dependent reduction of the flinching response during phase 1 and 2 in the formalin test. In addition, melatonin delivered at evening also decreased the flinching response in both phases of the formalin test. Melatonin restrictively increased the withdrawal latency in Hot-Box test. Conclusions: These results suggest that melatonin is active against the formalin- and thermal-induced nocicpetion at the spinal level, but the effect is limited.

• 국제물리치료학회지
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• 제5권2호
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• pp.723-729
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• 2014

The purpose of this study is to understand the relationship between female college students' stress level and premenstrual syndrome so that it can provide baseline data on how to cope with the syndrome. The study subjects are 250 female college students in Gyungbook area. This study chose 199 appropriate subjects and collected data. As per general menstrual phases, this study investigated the age when one had her first period, regularity and duration of period, and amount of bleeding. It used a measurement tool to measure stress level and premenstrual syndrome. Most of the subjects experienced their first period before the age of 13. The menstrual period was irregular with the duration of less than 7 days. 123 subjects had normal amount of bleeding. 121 subjects were experiencing high level of stress over 2.4. The correlation between the level of stress and premenstrual syndrome factors showed significant static correlation for each factor. Especially, the correlation between digestive system and response of autonomic nervous system was .996 and negative emotion and behavioral change was .635, and negative emotion and pain was .614 which were relatively high. The regression analysis of factors of premenstrual syndrome depending on the subjects' stress level indicated that response of autonomic nervous system had the biggest effect in the low stress group while behavioral change, negative emotion, pain, decreased concentration, water congestion, response of autonomic nervous system, and skin change had the biggest effect in the high stress group with statistical significance. Based on the result, it can be said that higher premenstrual stress is closely related to the premenstrual syndrome one experiences for some female college students.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2007년도 정기총회 및 학술발표대회
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• pp.137-139
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• 2007

한반도의 지각에 대한 지진파의 파형들을 피킹하기 위하여 한반도의 남동부지역에서 시행된 폭파로부터 각 관측소에서 관측된 지진자료를 2 차원 수치 순산모델링으로 계산된 이론적인 신호와 비교하였다. 실제 지진자료와 같은 완전한 파형을 얻기 위해서는 실체파뿐만 아니라 표면파를 포함한 모든 파형을 이론적으로 생성하여야 한다. 또한, 각 파형의 Q 값을 고려하여 그 감쇄 정도를 파악하여야 실제 파형과 똑 같은 이론적인 파형을 만들 수 있다. 본 연구에서는 FEM(Finite Element Method)과 FDM(Finite Difference Method) 같은 전형적인 수치 모델링 기법 대신에 수도스펙트럼기법(pseudo-spectral method)을 사용하여 이론적인 파형을 계산하였다. Q 값을 고려하지 않았기 때문에 완전한 파형을 얻기에는 어려움이 있었다. 그러나 각 관측소에 도달하는 실체파의 초기 파형들의 주시를 실제 파형과 맞추었다는 데에 그 성과가 있다고 할 수 있다. 본 연구의 궁극적인 목표는 수치 모델링을 통하여 지진원의 위치와 종류를 밝혀 내는데 그 정확성을 높이는 것이다.

• 터널과지하공간
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• 제10권1호
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• pp.25-32
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• 2000

본 논문에서는 기존의 불연속 변형 해석(DDA)방법에 대한 두 가지 방향의 새로운 개선 방법들이 제시되었다. 이 개선 방법들은 암반에 연속적인 하중 재하 또는 제하, 그리고 록볼트, 숏크리트와 콘크리트 가이닝에 의한 보강으로 구성되었다. 이 방법들에 의하여 추가로 개선된 새로운 DDA프로그램에 대한 몇 가지 적용 예들이 제시되었다. 또한, 경부고속철도 공사의 일부인 운주 터널의 지하굴착에 대한 시뮬레이션을 통하여 굴착순서, 그리고 록볼트와 숏코리트에 의한 보강이 터널안정에 미치는 영향을 연구하였다. 그 결과 부적절한굴착순서는 터널의 안정성에 악영향을 미치나, 록볼트와 숏크리트에 의한 보강은 터널을 안정화 시킨다는 사실을 밝혀내었다. 그 결과 두 가지 개선방법이 추가된 DDA프로그램은 지하구조물 설계에 있어서 유용한 해석방법으로 사용될 수 있다는 사실을 보여주었다. 특히 시공단계(굴착, 보강)를 보다 사실적으로 시뮬레이션 할 수 있다.