• Biomolecules & Therapeutics
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• v.17 no.2
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• pp.144-150
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• 2009

Reactive oxygen species play a role in signal transduction and in many human diseases. B-cell activating factor (BAFF) plays a role for mature B cell generation and maintenance and for the incidence of autoimmune diseases. We previously reported that BAFF expression was induced by ROS. In this study, we investigated whether ROS-induced BAFF expression was affected by toll-like receptor (TLR) 4 or myeloid differentiation primary response gene (MyD) 88. BAFF expression was increased by serum deprivation that is an experimental modification to produce ROS. In contrast, TLR4 and MyD88 were decreased by serum deprivation. Although ROS production was decreased in TLR4-nonfunctional or MyD88-deficient splenocytes as compared to that in control mice, serum deprivation increased ROS production and augmented BAFF expression in both cells. $50{\mu}M\;H_2O_2$ also increased BAFF expression in TLR4-deficient or MyD88-deficient splenocytes. Collectively, results show that BAFF expression may be mediated by TLR4 or MyD88-independent manner and TLR4 or MyD88 may not be required in BAFF expression.

• Earthquakes and Structures
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• v.23 no.1
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• pp.23-34
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• 2022

This paper presents experimental studies on reinforced concrete moment resisting frames that have engineered cementitious composite (ECC) in plastic hinge length (PHL) of beam/column members and beam-column joints. A two-story frame structure reduced by a 1:3 scale was further tested through a shake-table (seismic simulator) using multiple levels of simulated earthquake motions. One model conformed to all the ACI-318 requirements for IMRF, whereas the second model used lower-strength concrete in the beam/column members outside PHL. The acceleration time history of the 1994 Northridge earthquake was selected and scaled to multiple levels for shake-table testing. This study reports the observed damage mechanism, lateral strength-displacement capacity curve, and the computed response parameters for each model. The tests verified that nonlinearity remained confined to beam/column ends, i.e., member joint interface. Calculated response modification factors were 11.6 and 9.6 for the code-conforming and concrete strength deficient models. Results show that the RC-ECC frame's performance in design-based and maximum considered earthquakes; without exceeding maximum permissible drift under design-base earthquake motions and not triggering any unstable mode of damage/failure under maximum considered earthquakes. This research also indicates that the introduction of ECC in PHL of the beam/column members' detailing may be relaxed for the IMRF structures.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.4
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• pp.11-20
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• 2004

This paper suggests the site-dependent ductility factor which is a key component of response modification factor(R). To compute the ductility factor, a group of 1,860 ground motions recorded from 47 earthquake was considered. Based on the local site conditions at the recording station, ground motions were classified into four groups according to average shear wave velocity. This site classification was consistent with site categories of the UBC(1997), NEHRP(1997) and IBC 2000(1997). Based on the results of regression analysis, a simplified equations were proposed to compute site-dependent ductility factors. The proposed equations were relatively simple and provide a good estimation of mean ductility factors. Based on the proposed equation, ductility factors considering the site conditions can be evaluated in accordance with the present building codes.

• Journal of the Earthquake Engineering Society of Korea
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• v.13 no.6
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• pp.39-46
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• 2009

The selection of an evaluation response spectrum can have a significant effect on the seismic fragility evaluation of a structure. A method for modifying the seismic fragility parameters that are calculated based on the design spectrum is described in this study. The modification factor is used to modify the original fragility parameters. The HCLPF (High Confidence of Low Probability of Failure) acceleration levels of the electric system using previous design spectrum and uniform hazard spectrum (UHS) were compared. Finally, seismic risk analyses were performed according to a uniform hazard spectrum. From the results, it was concluded that based on the design spectrum, seismic risk for the electric system might be underestimated.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.1
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• pp.13-21
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• 1992

In the previous study, car interior noise was analyzed using structural acoustic mode coupling coefficients and noise response in vehicle compartment model was simulated by the developed special purpose program. As a continued study, this paper presents a practical scheme for the interior noise reduction of a passenger car. Noisy panels on the vehicle compartment wall could be easily identified by the analysis using mode coupling coefficients. Numerical simulation for noise reduction was carried out on a simplified vehicle compartment model by using panel contribution factor and the noise reduction effect was verified by the structural modification test using Steel Skin (damping sheet).

• Earthquakes and Structures
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• v.19 no.3
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• pp.197-214
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• 2020

Diagrid structures have been introduced as a fairly modern lateral load-resisting system in the design of high-rise buildings. In this paper, a novel diagrid system called tube-in-tube diagrid building is introduced and assessed through pushover and incremental dynamic analyses. The main objectives of this paper are to find the optimum angle of interior and exterior diagrid tube and evaluate the efficiency of diagrid core on the probability of collapse comparing to the conventional diagrid system. Finally, the seismic performance factors of the proposed system are validated according to the FEMA P695 methodology. To achieve these, 36-story diagrid buildings with various external and internal diagonal angles are designed and then 3-D nonlinear models of these structures developed in PERFORM-3D. The results show that weight of steel material highly depends on diagonal angle of exterior tube. Adding diagrid core generally increases the over-strength factor and collapse margin ratio of tall diagrid buildings confirming high seismic safety margin for tube-in-tube diagrid buildings under severe excitations. Collapse probabilities of both structural systems under MCE records are less than 10%. Finally, response modification factor of 3.0 and over-strength factor of 2.0 and 2.5 are proposed for design of typical diagrid and tube-in-tube diagrid buildings, respectively.

• Journal of Korean Society of Steel Construction
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• v.22 no.2
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• pp.129-137
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• 2010

In this study, a five-story steel frame was designed in accordance with KBC2005 to evaluate the effect of the beam-column connection on the structural behavior. The connections were designed as a fully rigid connection and as a semirigid connection. A fiber model was utilized to describe the moment-curvature relationship of the steel beam and column, and a three-parameter power model was adopted for the moment-rotation angle of the semirigid connection. To evaluate the effects of higher modes on structural behavior, the structure was subjected to a KBC2005-equivalent lateral load and lateral loads considering higher modes. The structure was idealized as a separate 2D frame and as a connected 2D frame. The pushover analysis of 2D frames for the lateral load yielded the top displacement-base shear force, design coefficients such as overstrength factor, ductility ratio, and response modification coefficient, demanded ductility ratio for the semirigid connection,and distribution of plastic hinges. The sample structure showed a greater response modification coefficient than KBC2005, the higher modes were found to have few effects on the coefficient, and the lateral load of KBC2005 was found to be conservative. The TSD connection was estimated to secure economy and safety in the sample structure.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.3
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• pp.33-42
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• 2004

While transforming the inelastic system into the equivalent elastic one gives an advantage of simpler analysis, the actual inelastic behavior of the system is hardly modeled in the capacity spectrum method (CSM). Therefore, the accuracy of CSM depends on the precise estimation of equivalent period and damping ratio as well as the modification of the elastic response spectrum and the corresponding demand spectrum. In this paper, the effect of demand spectrums on the accuracy of CSM is evaluated. First, the response reduction factors provided in ATC-40 and Euro Code are evaluated. Numerical analysis results indicated that the acceleration responses obtained using the factor of Euro Code are closer to the actual response than those obtained using the factors of ATC-40. Next, the accuracy of CSM is evaluated constructing the demand spectrum using the absolute acceleration responses and pseudo acceleration responses. The results obtained using the absolute acceleration responses were found to be generally larger than those obtained using the pseudo ones. Since CSM often underestimates the response, the use of absolute acceleration response gives the response relatively closer to the exact ones. However, the difference becomes negligible as the hardening ratio and the yield strength ratio become larger.

• Journal of the Earthquake Engineering Society of Korea
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• v.23 no.6
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• pp.311-319
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• 2019

The number of aged bridges is increasing so that bridges over 30 years old account for about 11% of all bridges. Consequently, the development of a seismic performance evaluation method that considers the effects of ageing is essential for a seismic retrofitting process for improvement of the seismic safety of existing old bridges. Assessment of the damage situation of bridges after the recent earthquakes in Korea has been limited to the bearings, anchor, and concrete mortar on piers. The purpose of this study is to evaluate the seismic responses of PSC box girder bridges by considering the ageing effect of rubber bearings (RBs) and lead-rubber bearings (LRBs). The modification factor proposed by AASHTO is used to take into account the ageing effect in the bearings. PSC box girder bridges with RBs and LRBs were 3D modeled and analyzed with the OpenSEES program. In order to evaluate the ageing effect of RBs and LRBs, 40 near fault and 40 far field records were used as the input earthquakes. When considering the effect of ageing, the displacement responses and shear forces of bridge bearings (RBs and LRBs) were found to increase mostly under the analytical conditions. It was shown that the effect of ageing is greater in the case of RBs than in the case of LRBs.

• Steel and Composite Structures
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• v.35 no.4
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• pp.599-609
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• 2020

The tension-only braced frames (TOBFs) are widely used as a lateral force resisting system (LFRS) in low-rise steel buildings due to their simplicity and economic advantage. However, the system has poor seismic energy dissipation capacity and pinched hysteresis behavior caused by early buckling of slender bracing members. The main concern in utilizing the TOBF system is the determination of appropriate performance factors for seismic design. A formalized approach to quantify the seismic performance factor (SPF) based on determining an acceptable margin of safety against collapse is introduced by FEMA P695. The methodology is applied in this paper to assess the SPFs of the TOBF systems. For this purpose, a trial value of the R factor was first employed to design and model a set of TOBF archetype structures. Afterwards, the level of safety against collapse provided by the assumed R factor was investigated by using the non-linear analysis procedure of FEMA P695 comprising incremental dynamic analysis (IDA) under a set of prescribed ground motions. It was found that the R factor of 3.0 is appropriate for safe design of TOBFs. Also, the system overstrength factor (Ω₀) was estimated as 2.0 by performing non-linear static analyses.