• 한국자기공명학회논문지
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• 제16권1호
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• pp.22-33
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• 2012

Tid1, belonging to the Hsp40/DnaJ family of proteins, functions as a cochaperone of cytosolic and mitochondrial Hsp70 proteins. In particular, the N-terminal J-domain of Tid1 (Tid1-JD) constitutes the major binding sites for proteinprotein interactions with client proteins, including p53, as well as its partner chaperone, Hsp70. In the present study, soluble, recombinant protein of Tid1-JD could be obtained by using the pCold vector system, and backbone NMR assignments were completed using the isotope $[^{13}C/^{15}N]$-enriched protein. Far-UV CD result implied that Tid1-JD is an ${\alpha}$-helical protein and the secondary structure determined using chemical shift data sets indentified four ${\alpha}$-helices with a loop region containing the HPD (conserved tripeptide of His, Pro and Asp) motif. Additionally, NMR spectra under different conditions implied that the HPD motif, which is a critical region for protein-protein interactions of Tid1-JD, would possess dynamic properties.

• Investigative Magnetic Resonance Imaging
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• 제19권2호
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• pp.117-121
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• 2015

Chordoid glioma is a rare, low-grade brain neoplasm typically located in the third ventricle. Herein, we report an unusual case of histologically confirmed chordoid glioma located in the pituitary fossa and suprasellar region, not attached to the third ventricle. A 57-year-old woman presented with a 2-month history of headache and visual disturbance. Magnetic resonance imaging revealed an ovoid mass in the pituitary fossa and suprasellar region, compressing the optic chiasm without involvement of the third ventricle. The tumor showed low signal intensity on T1-weighted images and iso- to high signal intensity on T2-weighted images, with strong and homogenous contrast enhancement. Subtotal resection was performed via the transcranial approach, and the patient subsequently received adjuvant gamma knife radiosurgery. However, the residual mass showed disease progression 5 months after the initial surgery.

• Steel and Composite Structures
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• 제51권4호
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• pp.457-471
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• 2024

In this research, for the first time the instability boundaries for a spinning shaft reinforced with graphene nanoplatelets undergone the principle parametric resonance are determined and examined taking into account the gyroscopic effect. In this respect, the extracted equations of motion in our previous research (Ref. Asadi et al. (2023)) are implemented and efficiently upgraded. In the upgraded discretized equations the effect of the Rayleigh's damping and the varying spinning speed is included that leads to a different dynamical discretized governing equations. The previous research was about the free vibration analysis of spinning graphene-based shafts examined by an eigen-value problem analysis; while, in the current research an advanced mechanical analysis is addressed in details for the first time that is the dynamics instability of the aforementioned shaft subjected to the principal parametric resonance. The spinning speed of the shaft is considered to be varied harmonically as a function of time. Rayleigh's damping effect is applied to the governing equations in order to regard the energy loss of the system. Resorting to Bolotin's route, Floquet theory and β-Newmark method, the instability region and its accompanied boundaries are defined. Accordingly, the effects of the graphene nanoplatelet on the instability region are elucidated.

• 대한전기학회논문지
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• 제33권5호
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• pp.173-180
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• 1984

The spectra of scattering light fromlaser-produced plasma near its fundamental and second harmonic wavelength were observed respectively by means of spectroscopic technique. The experimental results and the generation mechanism of nonlinear effects such as the second garmonics and the brillouin scattering were analysed theoretically. The spectra of reflected laser light became wider than that of incident laser light. And the peak of spectrum of reflected light shifted to red-side from that of incident light. The second harmonic light is generated from the nonlinear interaction of the incident laser light and the electron plasma wave excited in resonance region by the oblique incidence of laser light to the plasma. The Brillouin backscattering from laser-produced plasmas of hydrogen and deuterium has shown an isotope effect in the red-side region of the generated second harmonic light. This isotope shift is explained by the parametric instability at the cutoff (resonance) region using frequency-and phase-matching conditions of the waves.

• 한국자기공명학회논문지
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• 제20권1호
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• pp.22-26
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• 2016

FANCJ is a DNA helicase which contributes genome stability by resolving G-quadruplex DNA from 5' to 3' direction. In addition to main ATPase helicase core, FANCJ has the protein binding region at its C-terminal part. BRCA1 and BLM are the binding partner of FANCJ and these protein-protein interactions contribute genomic stability and the proper response to replication stress. As the first attempt for studying FANCJ-BLM interaction, we prepared BLM binding region of FANCJ and characterized with CD and NMR spectroscopy. FANCJ (881-941) with N-ter 6xHis was purified as the oligomer. Secondary structure prediction based on CD data revealed that FANCJ (881-941) composed with ${\beta}$ sheet, turn and coils.$^1H-^{15}N$ HSQC spectra showed nonhomogeneous peak intensities with less number of peaks comparing than the number of amino acids in the construct. It indicated that optimization should be necessary for detailed further structural studies.

• 한국임상수의학회지
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• 제21권1호
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• pp.58-61
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• 2004

A 5-year old female shih-tzu referred to the veterinary Teaching Hospital, College of Veterinary Medicine, Konkuk University. The patient was presented with a mass of ventral to pubic region and intraperineal region. CBC, chemistry, x-ray, fine needle aspiration, biopsy and MRI was performed. The dog was definitively diagnosed as lipoma based on cytologic and histopathologic examination. In order to remove the mass, an approach with two direction was made. First, intraperineal region was removed about 40%, and then ventral to pubic was removed the remainder. And inserted penrose drain for obliterate dead space to prevent the accumulation of serous discharge. The dog is clinically normal and being monitored for development of any abnormal signs for the time being. In this case, diagnostic MRI was very useful procedure. it revealed accurate location of a lipoma and useful manner for decision of surgical approach to remove.

• The Journal of Korean Physical Therapy
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• 제24권2호
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• pp.66-72
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• 2012

Purpose: The purpose of this study is to explore the importance of the image distortion correction in the cross sectional area measurement for the iliopsas muscle, tensor fasciae latae muscle, gluteus maximus muscle and the knee extensor muscles, by using (magnetic resonance imaging) MRI. Methods: This study was performed using an open 0.32T MRI system. To estimate the image distortion, T1 images for an AAPM homogeneity/linearity phantom were acquired, and the region in which the maximum geometric distortion was less than or equal to the pixel size (1.6 mm) of the images, it was defined as the distortion correction-free region. The T2 images for a human subject's pelvis and thigh in normal positions were obtained. Then, after the regions of interest in the pelvis and thigh were moved into the distortion correction-free region, T2 images for the pelvis and thigh were scanned with the same imaging parameters used in the previous T2 imaging. The cross-sectional areas were measured in the two T2 images that were obtained in the normal position, and the distortion correction-free region, as well as the area error caused by geometric image distortion was calculated. Results: The geometrical distortion is gradually increased, from the magnet center to the outer region, in axial and coronal plane. The cross-sectional area error of gluteus maximus muscle and the knee extensors was as high as 9.27% and 3.16% in before and after distortion correction, respectively. Conclusion: The cross-sectional area of the muscles that suffered from the geometrical distortion is necessary to correct for the estimation of the intervention.

• 한국자기공명학회논문지
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• 제21권3호
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• pp.90-95
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• 2017

The Z-DNA domain of human ADAR1 ($Z{\alpha}_{ADAR1}$) produces B-Z junction DNA through preferential binding to the CG-repeat segment and destabilizing the neighboring AT-rich region. However, this study could not answer the question of how many base-pairs in AT-rich region are destabilized by binding of $Z{\alpha}_{ADAR1}$. Thus, we have performed NMR experiments of $Z{\alpha}_{ADAR1}$ to the longer DNA duplex containing an 8-base-paired (8-bp) CG-repeat segment and a 12-bp AT-rich region. This study revealed that $Z{\alpha}_{ADAR1}$ preferentially binds to the CG-repeat segment rather than AT-rich region in a long DNA and then destabilizes at least 6 base-pairs in the neighboring AT-rich region for efficient B-Z transition of the CG-repeat segment.

• International Journal of Computer Science & Network Security
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• 제21권5호
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• pp.1-8
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• 2021

Prostate cancer is one of the most diagnosed malignancies found across the world today. American cancer society in recent research predicted that over 174,600 new prostate cancer cases found and nearly 31,620 death cases recorded. Researchers are developing modest and accurate methodologies to detect and diagnose prostate cancer. Recent work has been done in radiology to detect prostate tumors using ultrasound imaging and resonance imaging techniques. Transrectal ultrasound and Magnetic resonance images of the prostate gland help in the detection of cancer in the prostate gland. The proposed paper is based on comparison and analysis between two novel image segmentation approaches. Seed region growing and cluster based image segmentation is used to extract the region from trans-rectal ultrasound prostate and MR prostate images. The region of extraction represents the abnormality area that presents in men's prostate gland. Detection of such abnormalities in the prostate gland helps in the identification and treatment of prostate cancer

• 한국방사선학회논문지
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• 제7권3호
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• pp.245-249
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• 2013

천연 탄탈의 중성자포획에 의한 공명에너지를 측정하기 위하여 교토대학의 원자로연구소의 46-MeV 전자선형가속기의 광핵반응에서 발생하는 중성자를 이용하였다. 중성자포획에서 발생되는 즉발감마선을 BGO($Bi_4Ge_3O_{12}$)섬광검출장치로 측정하였다. 검출장치는 탄탈 시료에서 발생되는 즉발감마선을 기하학적으로 모두 측정하도록 만들어져 있으며 측정되어진 전기적 신호를 탄탈의 중성자 공명에너지 동정하는 스펙트럼구성에 사용하였다. 연구에서 사용되어진 중성자의 에너지는 1 ~ 200 eV 영역에 대하여 각각의 공명에너지를 분석하였다. 중성자에너지 측정은 중성자 비행시간법(TOF: Time-of-Flight)을 통하여 측정하였다. 광핵반응을 통한 중성자발생에서는 고에너지영역에서 강한 제동복사선이 발생하므로 수 keV영역 이하 영역의 중성자에너지에 대해서만 중성자공명을 측정하였다. 얻어진 Ta에 대한 중성자 포획 공명에너지 측정결과는 이전의 실험에 의한 측정 결과들 및 ENDF/B-VI와 Mughabghab의 평가된 값들과 비교 및 검토를 하였다. 측정되어진 공명들은 4.28 eV에서 거대 공명들을 측정하였고 그 이상의 에너지 영역의 다른 공명들도 이론에 의해서 계산되어진 값들과 비교하였다. 144.3 eV를 제외한 공명들은 평가값들과 거의 일치하는 경향을 보였다.