• 대한불안의학회지
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• 제10권1호
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• pp.44-51
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• 2014

Objective : The amygdala has been considered to be a critical region in the pathophysiology of social anxiety disorder, but subregional connectivity pattern has not been examined yet despite lots of previous functional neuroimaging studies. Methods : Resting-state functional magnetic resonance imaging data was obtained in 19 patients with social anxiety disorder and 20 normal controls, and default mode functional connectivity with each of basolateral, centromedial and superficial areas of the amygdala was measured and compared between the two groups. Results : Differential amygdala-based networks between the two groups were distributed to all over the brain. In particular, however, a bias on the amygdala-cingulate pathway was observed in the superficial amygdala only. Connectivity strengths between the superficial amygdala and perigenual anterior cingulate cortex were correlated with scores of social interaction and avoidance. Conclusion : Our findings provide new insights into understanding of the intrinsic cognitive bias model of social anxiety disorder. An abnormality in superficial amygdala-anterior cingulate connectivity may influence on cognitive processing of socially-relevant information in social anxiety disorder.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 춘계학술대회논문집
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• pp.909-917
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• 2007

Recently the trend of automobile industry is that IQS evaluation index against a sensitivity quality is increasing. To reduce rattle noise due to speaker sound at low frequencies, it is required the advanced investigation of a package tray panel and a door module panel. This paper optimized the design parameters of package tray panel according to the theoretical background about robust design and suggested the design guideline for resonance avoidance and the reduction of vibrational sensitivity considering the excitation frequency of woofer speaker. In addition, it is suggested the design guideline of a door module panel through the sensitivity analysis in case of the speaker excitation. Finally, the design factor analysis of the quality deviation of a mother-car will make it possible to guarantee the stable characteristics of vehicle vibration in the early stage of vehicle development. These improvements can lead to shortening the time needed to develop better vehicles.

• 한국소음진동공학회논문집
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• 제17권8호
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• pp.673-682
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• 2007

Recently the trend of automobile industry is that IQS evaluation index against a sensitivity quality is increasing. To reduce rattle noise due to speaker sound at low frequencies, it is required the advanced technology analysis process of body structure. This paper optimized the design parameters of package tray panel according to the theoretical background about robust design and suggested the design guideline for resonance avoidance and the reduction of vibrational sensitivity considering the excitation frequency of woofer speaker. And this paper described the design process of a door module panel through the sensitivity analysis in case of the door speaker excitation. Finally, the analysis of the quality deviation using mother car is suggested to guarantee the stable characteristics of vehicle vibration in the early stage of vehicle development. These improvements can lead to shortening the time needed to develop better vehicles.

• Journal of Korean Neurosurgical Society
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• 제66권5호
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• pp.511-524
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• 2023

Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte colony stimulating factor (G-CSF) treatment. In addition, the effects of G-CSF on brain functions were examined by magnetic resonance (MR) imaging and histopathologically. Methods : This study used 24 female Wistar albino rats. Drug administration (saline or G-CSF) was started at the beginning of the study and continued for 15 days after whole-brain radiotherapy (WBRT). WBRT was given on day 7 of the start of the study. At the end of 15 days, the behavioral tests, including the three-chamber sociability test, open field test, and passive avoidance learning test, were done. After the behavioral test, the animals performed the MR spectroscopy procedure. At the end of the study, cervical dislocation was applied to all animals. Results : G-CSF treatment positively affected the results of the three-chamber sociability test, open-space test and passive avoidance learning test, cornu Ammonis (CA) 1, CA3, and Purkinje neuron counts, and the brain levels of brain-derived neurotrophic factor and postsynaptic density protein-95. However, G-CSF treatment reduced the glial fibrillary acidic protein immunostaining index and brain levels of malondialdehyde, tumor necrosis factor-alpha, nuclear factor kappa-B, and lactate. In addition, on MR spectroscopy, G-CSF had a reversible effect on brain lactate levels. Conclusion : In this first designed brain irradiation animal model, which evaluated G-CSF effects, we observed that G-CSF had reparative, neuroprotective and anti-neurodegenerative effects and had increased neurotrophic factor expression, neuronal counts, and morphology changes. In addition, G-CSF had a proven lactate-lowering effect in MR spectroscopy and brain materials.

• 한국산학기술학회논문지
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• 제17권4호
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• pp.734-742
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• 2016

최근 21세기에 접어들어 무분별한 발전의 결과로 석탄, 석유 등의 화석연료가 고갈되고 있으며, 지구 온난화가 진행중이다. 이미 유럽과 미국 등의 선진국에서는 신재생 에너지 분야에 관심을 갖고 있으며, 그 중에서도 풍력에너지가 많은 관심을 받고 있다. 풍력발전타워는 운용 중 주기적인 하중의 발생으로 만들어지는 주파수를 회피하여 설계를 해야 한다. 일반적으로 구조해석 과정 시 지반을 고정단 경계조건으로 해석한다. 하지만, 고정단 경계조건의 경우 지반 조건 상호작용을 고려하지 못하여 목표 진동수를 벗어나게 된다. 본 연구에서는 용량 별 지반경계 조건 및 기초의 근입깊이를 고려한 고유진동수 효과를 연구하였으며, 변수에 따른 차이를 확인하였다. 결과적으로 고정단 경계조건 모델은 지반조건과 근입깊이의 영향을 받지 않으며, Coupled Spring 경계조건 모델은 지반조건에는 영향을 받지만, 근입깊이에는 영향을 받지 않는다. Winkler Spring 경계조건의 경우에는 지반조건과 근입깊이에 모두 영향을 받는다. 하지만, 얕은 깊이의 지반에서는 지반조건의 영향을 받지 않으므로 Coupled Spring 경계조건 모델을 활용한 지반조건 별 해석을 수행하는 것이 효과적이다.

• Journal of Korean Neurosurgical Society
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• 제53권4호
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• pp.235-240
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• 2013

Fusiform aneurysms on the basilar artery (BA) trunk are rare. The microsurgical management of these aneurysms is difficult because of their deep location, dense collection of vital cranial nerves, and perforating arteries to the brain stem. Endovascular treatment is relatively easier and safer compared with microsurgical treatment. Selective occlusion of the aneurysmal sac with preservation of the parent artery is the endovascular treatment of choice. But, some cases, particularly giant or fusiform aneurysms, are unsuitable for selective sac occlusion. Therefore, endovascular coiling of the aneurysm with parent vessel occlusion is an alternative treatment option. In this situation, it is important to determine whether a patient can tolerate parent vessel occlusion without developing neurological deficits. We report a rare case of fusiform aneurysms in the BA trunk. An 18-year-old female suffered a headache for 2 weeks. Computed tomography and magnetic resonance image revealed a fusiform aneurysm of the lower basilar artery trunk. Digital subtraction angiography revealed a $7.1{\times}11.0$ mm-sized fusiform aneurysm located between vertebrovasilar junction and the anterior inferior cerebellar arteries. We had good clinical result using endovascular coiling of unruptured fusiform aneurysm on the lower BA trunk with parent vessel occlusion after confirming the tolerance of the patient by balloon test occlusion with induced hypotension and accompanied by neurophysiologic monitoring, transcranial Doppler and single photon emission computed tomography. In this study, we discuss the importance of preoperative meticulous studies for avoidance of delayed neurological deficit in the patient with fusiform aneurysm on lower basilar trunk.

• 한국전산구조공학회논문집
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• 제26권5호
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• pp.351-358
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• 2013

본 논문에서는 Pothead를 지지하는데 사용하는 지그의 고유진동수를 일정 범위로 제한하여 Pothead와 공진을 일으키지 않도록 하는 지그의 최적 설계안을 제시한다. 쿤 터커(Kuhn-Thucker) 조건을 적용한 최적기준법(Optimality criteria method)을 사용하여 위상 최적화를 수행하였고, 이 과정에서 유한요소 크기기 최적 형상에 미치는 영향을 검토하였다. 또한 위상 최적화 결과를 바탕으로 실험 계획법(Design of experiments)과 반응 표면법(Response surface method)을 사용하여 형상 및 치수 최적화를 수행하여 비교용 지그에 비해 전체 질량이 30% 감소되는 결과를 얻었다. 마지막으로 최적화된 지그의 내진 해석을 수행한 Pothead의 응답은 Metal Handbook에서 제시된 내진 응답을 만족하고 있다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2013년도 춘계학술대회 논문집
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• pp.835-841
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• 2013

Modern solid-state gyroscopes (HRG) with hemispherical resonators from high-purity quartz glass and special surface superfinishing and ultrathin gold coating become the best instruments for precise-grade inertial reference units (IRU) targeting long-term space missions. Designing of these sensors could be a notable contribution into development of Korea as a space nation. In participial, 40mm diameter thin-shell resonator from high-purity fused quartz, fabricated as a single-piece with its supporting stem has been designed, machined, etched, tuned, tested, and delivered by STM Co. (ATS of Ukraine) several years ago; an extremely-high Q-factor (upto 10~20 millions) has been shown. Understanding of the best way how to match such a unique sensor with inner glass assembly of the gyro means how to use the high potential in a maximal extent; and this has become the urgent task. Inner quartz glass assembly has a very thin indium (In) layer soldered the resonator and its silica base (case), but effects of internal resonances between operational modal pair of the shell-cup and its side (parasitic) modes can notable degrade the potential of the sensor as a whole, instead of so low level of resonator's intrinsic losses. Unfortunately, there are special combinations of dimensions of the parts (so-called, "resonant sizes"), when intensive losses of energy occurs. The authors proposed to use the length of stem's fixture as an additional design parameter to avoid such cases. So-called, a cyclic scheme of finite element method (FEM) and ANSYS software were employed to estimate different combinations of gyro assembly parameters. This variant has no mismatches of numerical origin due to FEM's discrete mesh. The optimum length and dangerous "resonant lengths" have been found. The special attention has been paid to analyses of 3D effects in a cup-stem transient zone, including determination of a difference between the positions of geometrical Pole of the resonant hemisphere and of its "dynamical Pole", i.e., its real zone of oscillation node. Boundary effects between the shell (cup) and 3D short "beams" (inner and outer stems) have been ranged. The results of the numerical experiments have been compared with the classic model of a quasi-hemispherical shell band with inextensional midsurface, and the solution using Rayleigh's functions of the $1^{st}$ and $2^{nd}$ kinds. To guarantee the truth of the recommended sizes to a designer of the real device, the analytical and FEM results have been compared with experimental data for a party of real resonators. The consistency of the results obtained by different means has been shown with errors less than 5%. The results notably differ from the data published earlier by different researchers.