Large scale secular registry or surveillance systems have been accumulating vast data that allow mathematical modeling of cancer incidence and mortality rates. Most contemporary models in this regard use time series and APC (age-period-cohort) methods and focus primarily on predicting or analyzing cancer epidemiology with little attention being paid to implications for designing cancer registry, surveillance or evaluation initiatives. This research models age-specific cancer incidence rates using logistic growth equations and explores their performance under different scenarios of data completeness in the hope of deriving clues for reshaping relevant data collection. The study used China Cancer Registry Report 2012 as the data source. It employed 3-parameter logistic growth equations and modeled the age-specific incidence rates of all and the top 10 cancers presented in the registry report. The study performed 3 types of modeling, namely full age-span by fitting, multiple 5-year-segment fitting and single-segment fitting. Measurement of model performance adopted adjusted goodness of fit that combines sum of squred residuals and relative errors. Both model simulation and performance evalation utilized self-developed algorithms programed using C# languade and MS Visual Studio 2008. For models built upon full age-span data, predicted age-specific cancer incidence rates fitted very well with observed values for most (except cervical and breast) cancers with estimated goodness of fit (Rs) being over 0.96. When a given cancer is concerned, the R valuae of the logistic growth model derived using observed data from urban residents was greater than or at least equal to that of the same model built on data from rural people. For models based on multiple-5-year-segment data, the Rs remained fairly high (over 0.89) until 3-fourths of the data segments were excluded. For models using a fixed length single-segment of observed data, the older the age covered by the corresponding data segment, the higher the resulting Rs. Logistic growth models describe age-specific incidence rates perfectly for most cancers and may be used to inform data collection for purposes of monitoring and analyzing cancer epidemic. Helped by appropriate logistic growth equations, the work vomume of contemporary data collection, e.g., cancer registry and surveilance systems, may be reduced substantially.
The purpose of this study is to consider the interaction between surface water and groundwater in basin scale by developing TANK_GS model. The soil moisture structure of tank model with 3 tanks is improved to simulate the appropriate stream-aquifer interactions. Maximum likelihood method is applied to calibrate parameters with variance functions to deal with heteroscedasticity of residuals. The parameters of improved TANK_GS model and variance function are simultaneously estimated by Simulated Annealing method, a global optimization technique. The results of TANK-GE are compared to those of the SWMM-GE model which had been developed to consider the stream-aquifer interactions. The new TANK_GS model and SWMM-GE model are applied to Gapcheon basin, which belongs to Geum River basin. TANK_GS model showed better model performance compared to the original TANK model and characterized the relationship of stream-aquifer interactions as satisfactorily as the SWMM-GE model. The sustainable groundwater yield can be estimated for the regional water resources planning using the TANK_GS model
Objectives Advanced researches on the relationship between obesity and heart rate variability (HRV), heretofore, focused on characteristics of HRV depending on the state of obesity. However, the previous researches have not quantified predictive power of HRV toward the obesity-related variables, which is rather more meaningful for clinicians who regularly treat obese patients. Hence, we designed a research to investigate whether HRV could predict serum levels of obesity-related metabolites. Methods Ninety obese premenopausal women meeting the inclusion criteria were recruited. The HRV test, blood sampling, and measurement of physical traits were conducted. Multiple regression analysis of the measurement data was carried out, putting obesity-related metabolites (insulin, glucose, triglyceride, hs-CRP, HDL, LDL, total cholesterol) as outcome variables and the others as predictors. To select appropriate predictive variables, the Akaike's Information Criterion (AIC) was applied. Normality and homoskedasticity of residuals for each model were tested to identify if there were any violations of the regression analysis's basic assumption. Logarithm transformation was used for the values of the concentration of metabolites and the HRV. Results The regression model including Total Power (TP) value and BMI had significant predictive power for serum insulin concentration (F(2, 88)=835.7, p<0.001, $R^2=0.95$). The regression coefficient of ln (TP) was -0.1002. However, it was not sure if the HRV could predict concentrations of other metabolites. Conclusions The results suggest that the Total Power (TP) value of the HRV can predict the level of serum insulin. If the BMI could be assumed as being constant, when the TP value is multiplied by n, the predicted change of insulin could be drawn by multiplying $n^{-0.1002}$. The uncertainty of this model can be assumed as approximately 5%.
KSCE Journal of Civil and Environmental Engineering Research
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v.13
no.2
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pp.173-182
/
1993
This paper presents an algorithm to derive the representative unit hydrograph for the real environment of a watershed. For a given watershed, the conventional methods give several different unit hydrographs by storm events. In this study the LP model is somewhat modified based on the previous study by Mays et also as follows: the objective function is designed to minimize the sum of weighted residuals. An additional constraint of moving average is added to prevent the unit hydrograph from the occurence of oscillation which was not active in Mays's paper. Configuration of rainfall matrix was improved to reduce its dimension in accordance with Diskin's review point. In spite of the superiority of LP approach in terms of representativeness, all the methods were very sensitive to the validity of baseflow separation and rainfall-loss. Several methods of the separations for rainfall excesses and direct runoffs were applied and no preferred methods were identified. This is the matter of judgement considering catchment and rainfall characteristics. This algorithm was applied to a real watershed of the Wi stream in the Nak-dong river. Compared with the IHP results by conventional methods, this optimized representative unit hydrograph demonstrated relatively smaller and shorter values in terms of the peak discharge and the basin lag respectively, and the oscillation of its falling limb successfully eliminated owing to the additional constraints of moving averages.
The standard GARCH model imposing symmetry on the conditional variance, tends to fail in capturing some important features of the data. This paper, hence, introduces the models capturing asymmetric effect. They are the EGARCH model and the GJR model. We provide the systematic comparison of volatility models focusing on the asymmetric effect of news on volatility. Specifically, three diagnostic tests are provided: the sign bias test, the negative size bias test, and the positive size bias test. This paper shows that there is significant evidence of GARCH-type process in the data, as shown by the test for the Ljung-Box Q statistic on the squared residual data. The estimated unconditional density function for squared residual is clearly skewed to the left and markedly leptokurtic when compared with the standard normal distribution. The observation of volatility clustering is also clearly reinforced by the plot of the squared value of residuals of export volume and values. The unconditional variance of both export volumes and export value indicates that large shocks of either sign tend to be followed by large shocks, and small shocks of either sign tend to follow small shocks. The estimated export volume news impact curve for the GARCH also suggests that $h_t$ is overestimated for large negative and positive shocks. The conditional variance equation of the GARCH model for export volumes contains two parameters ${\alpha}$ and ${\beta}$ that are insignificant, indicating that the GARCH model is a poor characterization of the conditional variance of export volumes. The conditional variance equation of the EGARCH model for export value, however, shows a positive sign of parameter ${\delta}$, which is contrary to our expectation, while the GJR model exhibits that parameters ${\alpha}$ and ${\beta}$ are insignificant, and ${\delta}$ is marginally significant. That indicates that the asymmetric volatility models are poor characterization of the conditional variance of export value. It is concluded that the asymmetric EGARCH and GJR model are appropriate in explaining the volatility of export volume, while the symmetric standard GARCH model is good for capturing the volatility.
Son, Moon;Lee, Son-Kap;Kim, Jong-Sun;Kim, In-Soo;Lee, Kun
Economic and Environmental Geology
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v.40
no.1
s.182
/
pp.87-101
/
2007
A variety of informations obtained from satellite image, digital elevation relief map (DEM), borehole logging, televiewer, geophysical prospecting, etc were synthetically analyzed to investigate subsurface geological and structural characteristics and to evaluate geohazard pertinent to fault-damage in the Busan metropolitan city. It is revealed that the geology is composed of the Cretaceous andesitic$\sim$dacitic volcanics, gabbro, and granitoid and that at least three major faults including the Dongrae fault are developed in the study area. Based on characteristics of topography, fault-fractured zone, and isobath maps of the Quaternary sediments and weathered residuals of the basement, the Dongrae fault is decreased in its width and fracturing intensity of damaged zone from south toward north, and the fault is segmented around the area between the Seomyeon and Yangieong junctions. Meanwhile, we drew a geohazard sectional map using the five major parameters that significantly suggest damage intensity of basement by fault, i.e. distance from fault core, TCR, RQD, uniaxial rock strength, and seismic velocity of S wave. The map is evaluated as a suitable method to express the geological and structural characteristics and fault-damaged intensity of basement in the study area. It is, thus, concluded that the proposed method can contribute to complement and amplify the capability of the present evaluation system of rock mass.
The objectives of this study were to investigate color patterns of shell and mantle edge pigmentation of a Pacific oyster, C. gigas, and to estimate variance components of the two colors. A sample of 240 F0 oysters was collected from six aquaculture farms in Tongyeong, Korea to measure shell color and mantle edge pigmentation. Among the F0s, male and female individuals with black (white) shell and black (white) mantle edge were selected and mated to generate three F1 full-sib black (white) cross families (N = 265). Two and four F2 cross families (N = 286) were also produced from black and white F1 selected individuals, respectively. Variance component estimates due to residuals and families within color were obtained using SAS PROC VARCOMP procedures to estimate heritability of shell and mantle edge pigmentation. In the F0 generation, about 29% (11%) had black (white) color for both shell and mantle edge. However, in the F1 and F2 black (white) cross families, 75% (67%) and 100% (100%) of oysters had black (white) shell colors, and 59% (23%) and 79% (55%) had black (white) mantle edge, respectively. Spearman correlation coefficients between shell and mantle edge color were 0.25, 0.74, and 0.92 in F0, F1, and F2 generations, respectively, indicating that, with generations of selection process, an individual with black (white) shell color is more likely to have black (white) mantle edge pigmentation. This suggests that shell color could be a good indicator trait for mantle edge pigmentation if selection of both the colors is implemented for a couple of generations. Estimates of heritability were 0.41 and 0.77 for shell color and 0.27 and 0.08 for mantle edge pigmentation in the F1 and F2 generations, respectively, indicating that, in general, significant proportions of phenotypic variations for the shell and mantle edge colors are explained by genetic variations between individuals. These results suggest that the two color traits are inheritable and correlated, enabling effective selection on shell and mantle edge color.
KSCE Journal of Civil and Environmental Engineering Research
/
v.31
no.5B
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pp.449-457
/
2011
Recently, increasing heavy rainfalls due to climate change and/or variability result in hydro-climatic disasters being accelerated. To cope with the extreme rainfall events in the future, hydrologic frequency analysis is usually used to estimate design rainfalls in a design target year. The rainfall data series applied to the hydrologic frequency analysis is assumed to be stationary. However, recent observations indicate that the data series might not preserve the statistical properties of rainfall in the future. This study incorporated the residual analysis and the hydrologic frequency analysis to estimate design rainfalls in a design target year considering the non-stationarity of rainfall. The residual time series were generated using a linear regression line constructed from the observations. After finding the proper probability density function for the residuals, considering the increasing or decreasing trend, rainfalls quantiles were estimated corresponding to specific design return periods in a design target year. The results from applying the method to 14 gauging stations indicate that the proposed method provides appropriate design rainfalls and reduces the prediction errors compared with the conventional rainfall frequency analysis which assumes that the rainfall data are stationary.
Journal of the Korea Academia-Industrial cooperation Society
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v.21
no.10
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pp.197-205
/
2020
Compared to aerial photogrammetry, UAV photogrammetry has advantages in acquiring and utilizing high-resolution images more quickly. The production of 3D models using UAV photogrammetry has become an important issue at a time when the applications of 3D spatial information are proliferating. Therefore, this study assessed the feasibility of utilizing 3D models produced by UAV photogrammetry through quantitative and qualitative analyses. The qualitative analysis was performed in accordance with the LODs (Level of Details) specified in the 3D Land Spatial Information Construction Regulation. The results showed that the features on planes have a high LoD while features with elevation differences have a low LoD due to the occlusion area and parallax. Quantitative analysis was performed using the 3D coordinates obtained from the CPs (Checkpoints) and edges of nearby structures. The mean errors for residuals at CPs were 0.042 m to 0.059 m in the horizontal and 0.050 m to 0.161 m in the vertical coordinates while the mean errors in the structure's edges were 0.068 m and 0.071 m in horizontal and vertical coordinates, respectively. Therefore, this study confirmed the potential of 3D models from UAV photogrammetry for analyzing the digital twin and slope as well as BIM (Building Information Modeling).
Endosulfan-${\alpha}$ endosulfan-${\beta}$ and endosulfan-sulfate, which are classified as pesticides, were degraded by use of UV energy and ultrasonic irradiation. The degradation residuals were analysed by gas chromatography with an electron capture detector and TOC (total oragnic carbon) analysis. The reactions were conducted in a quartz annular reactor equipped with a low pressure mercury multilamp (8Wx2) and a sonic generator. All the aqueous solutions were concentrated as 10 mg/L initially. Endosulfans were degraded each to result in 48.2% (${\alpha}$), 50.0% (${\beta}$) and 76.5% (sulfate) of removal efficiency by UV energy, and 66.9% (${\alpha}$), 55.8% (${\beta}$) and 72.7% (sulfate) by ultrasonic irradiation, respectively. In contrast to the results of the single-component solutions, degradation of the endosulfan-sulfate was greatly suppressed to result in the lowest degradation rate and removal efficiency in the three-component solutions. This finding suggests that there should be a reversible reaction with a substantially low equilibrium constant between endosulfan-${\alpha}$ or -${\beta}$ and -sulfate in the coexistence of the three endosulfans. TOC data showed the endosulfans were decomposed by 20%~40% toward complete mineralization, producing a quantity of intermediates induced by the radical reactions. We found that all the decay reactions considered in this study nicely fell into pseudo first-order rate.
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