• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 추계학술대회
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• pp.631-636
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• 2004

The sway motion control problem of a container hanging on the trolly is considered in the paper. In the container crane control problem, suppressing the residual swing motion of the container at the end of acceleration, deceleration or the case of that the unexpected disturbance input exists is main issue. For this problem, in general, many trolley motion control strategies are introduced and applied. In this paper, we introduce and synthesize a swing motion control system in which a small auxiliary mass is installed on the spreader made by ourselves. In this control system, the actuator reacting against the auxiliary mass applies inertial control forces to the container to reduce the swing motion in the desired manner. Especially, we apply the $H_{\infty}$ based gain-scheduling control technique the anti-sway control system design problem of the controlled plant. In this control system, the controller dynamics are adjusted in real-time according to time-varying plant parameters. And the experiment result shows that the proposed control strategy is shown to be useful to the case of time-varying system and, robust to disturbances like winds and initial sway motion.

• Journal of Chest Surgery
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• 제23권1호
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• pp.192-200
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• 1990

The results of conventional operative resection of diffuse subaortic stenosis[tunnel subaortic stenosis] have been less than satisfactory. We have performed modified Konno operation to enlarge the outflow tract of both ventricle with a patch in three patients with diffuse tunnel subaortic stenosis in the department of Thoracic and Cardiovascular Surgery, Seoul National University Children`s Hospital. Preoperative left ventricular aortic pressure gradients were 135 mmHg, 50 mmHg, 80 mmHg respectively in these patients. After right ventriculotomy, the septotomy was done and extended beyond the limit of the stenosis and fibrous and/or muscular tissue was removed from each edge of septal incision. After adequate widening of the tunnel subaortic stenosis with various patches, right ventricle was closed primarily or with prosthetic patches successfully. One patient who was diagnosed as complete atrioventricular septal defect had complete AV block preoperatively and was implanted permanent pacemaker, and others who were sinus rhythm preoperatively have no serious postoperative rhythm disturbance. One patient developed mild postoperative aortic insufficiency and one who had preoperative aortic insufficiency has still same grade of aortic insufficiency after operation. All had good postoperative hemodynamics without any postoperative residual pressure gradient.

• Clinical and Experimental Pediatrics
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• 제52권3호
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• pp.380-384
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• 2009

급성 횡단성 척수염은 갑자기 발생하는 하지의 진행성 쇠약과 감각 장애가 특징이며, 대부분의 환자가 선행하는 바이러스 감염 증상의 병력을 가진다. 원인이 되는 선행 바이러스는 Epstein-Barr 바이러스, 헤르페스, 인플루엔자, 풍진, 볼거리, 수두 바이러스 등이 있다. 대개 발병 1주 내에 회복을 보이기 시작하지만 수 주 또는 수 개월 동안 지속되는 경우도 있으며, 방광 기능 장애와 하지 쇠약감 등의 후유증이 남을 수 있는 소아에서 비교적 발병이 드문 질환이다. 저자들은 수두를 앓고 난 뒤 전신 마비를 주소로 내원하여 척수 자기공명영상에서 횡단성 척수염을 진단받고, 치료 후 경미한 방광 기능 장애만 남고 거의 완전한 회복을 보인 1예를 경험하였기에 보고하는 바이다.

• Structural Engineering and Mechanics
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• 제29권5호
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• pp.489-504
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• 2008

In piezoelectric flexible structures, the contribution of vibration modes to the dynamic response of system may change with the location of piezoelectric actuator patches, which means that the ability of actuators to control vibration modes should be taken into account in the development of modal reduction model. The spatial $H_2$ norm of modes, which serves as a measure of the intensity of modes to system dynamical response, is used to pick up the modes included in the reduction model. Based on the reduction model, the paper develops the state-space representation for uncertain flexible tructures with piezoelectric material as non-collocated actuators/sensors in the modal space, taking into account uncertainties due to modal parameters variation and unmodeled residual modes. In order to suppress the vibration of the structure, a dynamic output feedback control law is designed by imultaneously considering the conflicting performance specifications, such as robust stability, transient response requirement, disturbance rejection, actuator saturation constraints. Based on linear matrix inequality, the vibration control design is converted into a linear convex optimization problem. The simulation results show how the influence of vibration modes on the dynamical response of structure varies with the location of piezoelectric actuators, why the uncertainties should be considered in the reductiom model to avoid exciting high-frequency modes in the non-collcated vibration control, and the possiblity that the conflicting performance specifications are dealt with simultaneously.

• Investigative Magnetic Resonance Imaging
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• 제19권2호
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• pp.117-121
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• 2015

Chordoid glioma is a rare, low-grade brain neoplasm typically located in the third ventricle. Herein, we report an unusual case of histologically confirmed chordoid glioma located in the pituitary fossa and suprasellar region, not attached to the third ventricle. A 57-year-old woman presented with a 2-month history of headache and visual disturbance. Magnetic resonance imaging revealed an ovoid mass in the pituitary fossa and suprasellar region, compressing the optic chiasm without involvement of the third ventricle. The tumor showed low signal intensity on T1-weighted images and iso- to high signal intensity on T2-weighted images, with strong and homogenous contrast enhancement. Subtotal resection was performed via the transcranial approach, and the patient subsequently received adjuvant gamma knife radiosurgery. However, the residual mass showed disease progression 5 months after the initial surgery.

• Molecules and Cells
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• 제42권7호
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• pp.530-545
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• 2019

Tumor cells can vary epigenetically during ionizing irradiation (IR) treatment. These epigenetic variegations can influence IR response and shape tumor aggressiveness. However, epigenetic disturbance of histones after IR, implicating in IR responsiveness, has been elusive. Here, we investigate whether altered histone modification after IR can influence radiation responsiveness. The oncogenic CXCL12 mRNA and protein were more highly expressed in residual cancer cells from a hepatoma heterotopic murine tumor microenvironment and coculture of human hepatoma Huh7 and normal IMR90 cells after radiation. H3K4 methylation was also enriched and H3K9 methylation was decreased at its promoter region. Accordingly, invasiveness and the subpopulation of aggressive $CD133^+/CD24^-$ cells increased after IR. Histone demethylase inhibitor IOX1 attenuated CXCL12 expression and the malignant subpopulation, suggesting that responses to IR can be partially mediated via histone modifications. Taken together, radiation-induced histone alterations at the CXCL12 promoter in hepatoma cells are linked to CXCL12 upregulation and increased aggressiveness in the tumor microenvironment.

• Geomechanics and Engineering
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• 제33권5호
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• pp.453-462
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• 2023

Intermediate Geomaterials (IGMs) are natural formation materials that exhibit the engineering behavior (strength and compressibility) between soils and rocks. The engineering behavior of such material is highly unpredictable as the IGMs are stiffer than soils and weaker/softer than rocks. Further, the characterization of such material needs exposure to both soil and rock mechanics. In most conventional designs of geotechnical structures, the engineering properties of the IGMs are either aligned with soils or rocks, and this assumption may end up either in an over-conservative design or under-conservative design. Hence, many researchers have attempted to evaluate its actual engineering properties through laboratory tests. However, the test results are partially reliable due to the poor core recovery of IGMs and the possible sample disturbance. Subsequently, in-situ tests have been used in recent years to evaluate the engineering properties of IGMs. However, the respective in-situ test finds its limitations while exploring IGMs with different geological formations at deeper depths with the constraints of sampling. Standard Penetration Test (SPT) is the strength-based index test that is often used to explore IGMs. Moreover, it was also observed that the coefficient of variation of the design parameters (which represents the uncertainties in the design parameters) of IGMs is relatively high, and also the studies on the probabilistic characterization of IGMs are limited compared with soils and rocks. With this perspective, the present article reviews the laboratory and in-situ tests used to characterize the IGMs and explores the shear strength variation based on their geological origin.

• Journal of Korean Neurosurgical Society
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• 제30권4호
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• pp.472-478
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• 2001

Objectives : The authors present a retrospective analysis of 100 consecutive adult patients harboring craniopharyngiomas who underwent microsurgical resection between 1981 and 1999 to assess the long-term outcome of surgical treatment and to determine the most optimal management strategy. Methods : The extent of surgical removal was divided into four categories ; GTR(gross total removal), RSTR(radical subtotal removal), STR(subtotal removal),and PR(partial removal). The median follow-up period was 50 months(4-198). CT scan and/or MR imaging and hormonal status were evaluated to the last follow-up. Results : Visual disturbance was the most common presentation, which was improved in 42 cases and aggravated in 19 cases following the operation. Hypopituitarism was detected in 56 patients preoperatively, 82 during the immediate postoperative period, and 76 at the last follow-up. Improvement of pituitary function was not observed in any of these patients. Twenty of 100 patients showed recurrence at the mean of 27 months(3 to 196). The median progression-free survival(PFS) time of all patients was 145 months and 5-year PFS rate was 74%. Five-year PFS rate of GTR or RSTR group(71%) was significantly higher than that of STR or PR group(30%)(p=0.01). Postoperative radiation therapy significantly prolonged the PFS from 94 months in non-radiation group to 182 months(p=0.002). However, there was no statistical difference in number of patients who required hormonal replacement therapy between radiation and non-radiation group. Conclusion : Visual disturbance can be improved by early diagnosis and surgical decompression. GTR or RSTR in selected patients is considered a proper surgical strategy. Post-operative radiation therapy for residual tumors must be considered, although the ideal timing of radiation therapy is to be determined.

• Current Optics and Photonics
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• 제1권2호
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• pp.107-112
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• 2017

An adaptive optics system can be simulated or analyzed to predict its closed-loop performance. However, this type of prediction based on various assumptions can occasionally produce outcomes which are far from actual experience. Thus, every adaptive optics system is desired to be tested in a closed loop on an optical test bench before its application to a telescope. In the close-loop test bench, we need an atmospheric simulator that simulates atmospheric disturbances, mostly in phase, in terms of spatial and temporal behavior. We report the development of an atmospheric turbulence simulator consisting of two point sources, a commercially available deformable mirror with a $12{\times}12$ actuator array, and two random phase plates. The simulator generates an atmospherically distorted single or binary star with varying stellar magnitudes and angular separations. We conduct a simulation of a binary star by optically combining two point sources mounted on independent precision stages. The light intensity of each source (an LED with a pin hole) is adjustable to the corresponding stellar magnitude, while its angular separation is precisely adjusted by moving the corresponding stage. First, the atmospheric phase disturbance at a single instance, i.e., a phase screen, is generated via a computer simulation based on the thin-layer Kolmogorov atmospheric model and its temporal evolution is predicted based on the frozen flow hypothesis. The deformable mirror is then continuously best-fitted to the time-sequenced phase screens based on the least square method. Similarly, we also implement another simulation by rotating two random phase plates which were manufactured to have atmospheric-disturbance-like residual aberrations. This later method is limited in its ability to simulate atmospheric disturbances, but it is easy and inexpensive to implement. With these two methods, individually or in unison, we can simulate typical atmospheric disturbances observed at the Bohyun Observatory in South Korea, which corresponds to an area from 7 to 15 cm with regard to the Fried parameter at a telescope pupil plane of 500 nm.

• 한국지반공학회논문집
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• 제19권5호
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• pp.223-232
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• 2003

본 연구에서는 DSC를 이용한 구성방정식을 이용하여 토목섬유 사이의 접촉전단 응력과 변위와의 관계를 모델링하였다. DSC 모델은 두 개의 기준 상태, 즉 상대적으로 손상되지 않은 RI 상태와 완전히 파괴된 FA 상태와 한가지의 교란 함수로 구성된다. 본 모델은 통합된 모델로서, RI 상태를 탄성-완전 소성 모델, 계층적 단일 항복곡면 (HiSS) 모델 등 다양한 모델을 이용하여 모사할 수 있다. 한편 본 모델은 탄성과 소성 변위를 동시에 고려할 수 있다는 장점을 가지고 있다. 4가지의 대형 직접전단 시험으로부터 측정된 자료와 측정자료로부터 도출된 모델 변수를 이용하여 재해석한 결과를 서로 비교하여, 둘 사이의 비교 결과가 상당히 일치함을 발견하였으며, 특히 표면이 매끄러운 지오멤브레인의 접촉면에서는 매우 상관관계를 보였다. 비록 표면이 거친 지오멤브레인이 포함된 접촉면에서는 예측 최대 전단강도가 실험결과와 약간의 차이를 보이기는 하였지만, 전체적으로 본 모델이 최대 전단응력이 나타나는 변위점과 대변형에서의 전단강도를 상당히 정확히 예측하였으며, 이를 통해 본 모델이 변형율 연화 현상을 보이는 접촉면 전단거동의 모델링에 유용함을 확인하였다.