• Korean Journal of Clinical Pharmacy
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• v.33 no.4
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• pp.221-241
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• 2023

Background: The purpose of this systematic review was to investigate the effects of digital therapeutics for insomnia on sleep disorders and mental health improvement compared to the control group. Methods: Following the guidelines on systematic review(PRISMA, NECA), a literature search was conducted through PubMed, Cochrane Library, EMBASE, RISS, KISS, and KoreaMed using keywords. The Cochrane Risk of Bias Tool and Review Manager version 5.3 were used for risk of bias and effect size assessment. Results: Thirty eight RCT met criteria for inclusion. When compared against three control conditions, the digital therapeutics for insomnia was an effective intervention for improvement sleep disorders and mental health in comparison to waiting list and Patient-directed care with some intervention by medical staff. However, digital therapeutics for insomnia were no more effective than face-to-face CBT-I control group. Conclusion: The efficacy of digital therapeutics for insomnia was evaluated differently depending on the control group. Therefore, in phase 3 clinical trials for efficacy evaluation, it is necessary to review whether the control group has been properly established.

• Journal of Preventive Medicine and Public Health
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• v.57 no.1
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• pp.1-7
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• 2024

Objectives: Adjusting for potential confounders is crucial for producing valuable evidence in outcome studies. Although numerous studies have been published using the Korea National Health Insurance Claim Database, no study has critically reviewed the methods used to adjust for confounders. This study aimed to review these studies and suggest methods and applications to adjust for confounders. Methods: We conducted a literature search of electronic databases, including PubMed and Embase, from January 1, 2021 to December 31, 2022. In total, 278 studies were retrieved. Eligibility criteria were published in English and outcome studies. A literature search and article screening were independently performed by 2 authors and finally, 173 of 278 studies were included. Results: Thirty-nine studies used matching at the study design stage, and 171 adjusted for confounders using regression analysis or propensity scores at the analysis stage. Of these, 125 conducted regression analyses based on the study questions. Propensity score matching was the most common method involving propensity scores. A total of 171 studies included age and/or sex as confounders. Comorbidities and healthcare utilization, including medications and procedures, were used as confounders in 146 and 82 studies, respectively. Conclusions: This is the first review to address the methods and applications used to adjust for confounders in recently published studies. Our results indicate that all studies adjusted for confounders with appropriate study designs and statistical methodologies; however, a thorough understanding and careful application of confounding variables are required to avoid erroneous results.

• The Journal of KAIRB
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• v.4 no.1
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• pp.1-4
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• 2022

Although disaster research participants are in a more vulnerable state than general research participants, various ethical issues to be considered in the study may be overlooked due to the special situation of disaster. Therefore, research ethics should be considered to reduce damage to study participants and maximize benefits. In addition, from the perspective of researchers, ethical considerations should be applied in the disaster research process, so research ethics awareness should be established. In addition, at the health care institution and national level, it is necessary to prepare research ethics that reflect the Korean situation while meeting international standards in consideration of the characteristics of local communities. In Korea, after the Ferry Sewol accident in 2014, social interest in disaster mental health increased and the National Trauma Center was established in 2018, raising the need for disaster mental health ethics guidelines. Therefore, this review aims to discuss the significance of six items: specificity of the study, prior consent and autonomy, community participation, confidentiality and feedback provision, risk minimization, and research support. So far, the experience of disaster mental health research is not sufficient in South Korea. Therefore, the current guidelines are required to be continuously revised through practical experience in the future.

• Journal of Acupuncture Research
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• v.29 no.6
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• pp.1-10
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• 2012

Objectives : The aim of this review was to summarize and assess researches reporting thermal properties of moxibustion. Methods and Materials : We searched one electronic database(PubMed) and two journals(The Journal of Korean Medicine and The Journal of Korean Acupuncture & Moxibustion Society) and for the articles published until Nov. 2012. The articles reporting thermal characteristic of moxibustion were selected and reviewed. 31 articles were included and assessed in this review. The type of moxibustion, the material beneath moxbustion, main outcome and the amount of information were reviewed. The amount of information was defined as 1 for one main outcome reported in each article. Results : Direct moxibustion were used in 15 articles and indirect moxibustion were used in 19 articles. 11 researches used anti-heating plate for the material beneath moxibustion, one article used steel ring, agar with anti-heating plate, six articles used skin and another six articles used heater. Two articles used animals and another two articles used metals. The mean value of the amount of information was $4.41{\pm}2.94$(SD). Conclusions : Research articles assessing properties of moxibustion have been consistently published since 1993, and employed various methodologies. The amount of information has been associated with four section analysis and is currently decreasing. Research assessing properties of moxibustion with clinical effectiveness is needed.

• Journal of Korean Biological Nursing Science
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• v.12 no.1
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• pp.63-72
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• 2010

Purpose: The purpose of this study is to assess the effects of raloxifene in prevention of cardiovascular disease in postmenopausal women. Methods: A systematic literature review was conducted. Data sources: The existing literature from 1986 to 2009 was searched electronically using the data base of Medline with the key words of hypertension, obesity, diabetes, cholesterol, lipid, myocardial infarction, coronary events with combination of raloxifene. Study selection: The criteria for inclusion in the review were 1) an randomized clinical trial (RCT), 2) postmenopausal women, 3) English or Korean language. Finally, 15 articles were included in the review. Data extraction: Findings from the studies were organized according to the results of lipid profile changes by two authors. Results: Among 15 articles, 12 studies reported the beneficial effects of raloxifene on LDL cholesterol and 9 studies on total cholesterol in the postmenopausal women. Conclusion: The consistent results on reduction of LDL cholesterol and total cholesterol in raloxifene using postmenopausal women were confirmed. However, the effect of raloxifene on other components of lipid profile and endothelial function were still remaining controversial.

• Journal of Pharmacopuncture
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• v.22 no.4
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• pp.204-209
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• 2019

Premenstrual syndrome (PMS) encompasses a vast array of physical and psychological symptoms. Of the herbal supplements mentioned for remedy PMS symptoms, chamomile used as an effective herbal medicine. The overall purpose of this review was to determine the efficacy of chamomile on the treatment PMS. An extensive research review using Web of Science, the Cochrane Controlled Trials Register database, PubMed, Chinese Biomedical Database (CBM), CINAHL, China National Knowledge Infrastructure (CNKI), Psych INFO, Social Science Research Network, SID, Google Scholar, Iran Doc, Magiran and Iran Medex. Eligible studies were identified from English and Persian databases, published between 1990 and 2019. Studies were screened independently by two researchers who performed the data extraction. Of Twenty-seven studies identified, Eight RCTs met our inclusion criteria. Chamomile has been used to treat PMS relief because of therapeutic properties such as anti-inflammatory effects (Chamazulene and α-Bisabolol); anti-spasmodic effects (Apigenin, Quercetin, and Luteolin, Metoxicomarin, Matrisin, and Phytoestrogens); anti-anxiety effects (Glycine, Flavonoid). The results of this review show that Chamomile is effective for the treatment of PMS. Based on these results, we believe that Chamomile can be used as good herbal medicine to treat in women with PMS.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6477-6483
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• 2014

Background: Shammah is a traditional form of chewing tobacco [smokeless tobacco, (ST)] that is commonly used in the Middle East especially in Saudi Arabia (KSA), Yemen and Sudan. The Substance Abuse Research Centre (SARC) at Jazan University noted that no adequate research and information on the prevalence of shammah use in the province of Jazan, and KSA as well, has been provided in the scientific literature. Materials and Methods: An intensive systematic review of online databases was performed, including AMED (The Allied and Complementary Medicine Database), Biological Abstracts, Cochrane Collection Plus, Dentistry and Oral Sciences Source, E-Journals Database, EBSCO Discovery Service, MEDLINE, PEMSoft, PEP Archive, PsycARTICLES, scopus, Sciencedirect and Google Scholar. Results: Shammah is a mixture of powdered tobacco, lime, ash, black pepper, oils and flavorings. ST in KSA is placed in the buccal or lower labial vestibule of the mouth. The user (or dipper) spits out insoluble debris. The importation of ST products is prohibited in KSA. Accessible information on legislative action to control the use of ST in KSA appeared in 1990. The actual percentage use may be higher, than reported since shammah is illegal in KSA and there may be some reluctance to admit to its use. Conclusions: This review paper is an initial step in a funded research project by SARC to understand the pattern of use of shammah and provide adequate epidemiological data. One goal of this review is to generate further data for public health education.

• Safety and Health at Work
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• v.4 no.4
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• pp.177-186
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• 2013

The use of nanoparticles (NPs) in industry is increasing, bringing with it a number of adverse health effects on workers. Like other chemical carcinogens, NPs can cause cancer via oxidative DNA damage. Of all the molecules vulnerable to oxidative modification by NPs, DNA has received the greatest attention, and biomarkers of exposure and effect are nearing validation. This review concentrates on studies published between 2000 and 2012 that attempted to detect oxidative DNA damage in humans, laboratory animals, and cell lines. It is important to review these studies to improve the current understanding of the oxidative DNA damage caused by NP exposure in the workplace. In addition to examining studies on oxidative damage, this review briefly describes NPs, giving some examples of their adverse effects, and reviews occupational exposure assessments and approaches to minimizing exposure (e.g., personal protective equipment and engineering controls such as fume hoods). Current recommendations to minimize exposure are largely based on common sense, analogy to ultrafine material toxicity, and general health and safety recommendations.

• Child Health Nursing Research
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• v.28 no.1
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• pp.9-22
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• 2022

Purpose: The purpose of this study was to identify the gaps in research related to developmentally supportive care in the neonatal intensive care unit (NICU). The ultimate goal was to explore directions of further research on developmentally supportive care for premature patients. Methods: The Arksey and O'Malley scoping review method was used. Articles on developmentally supportive care for preterm infants in the NICU, written in English or Korean, were identified through electronic search engines. A total of 279 papers were identified in the initial search, of which 22 full-text papers were included in this review. Results: Several nursing studies have been published in the past 5 years. The important elements of developmentally supportive care were family-centered care and management of the NICU environment. The primary developmentally supportive care interventions were training programs to promote the care competency of NICU nurses. Conclusion: It is necessary to actively develop comprehensive developmental support interventions that consider the various elements of developmentally supportive care for preterm infants. Additional studies should be done to develop programs that provide direct intervention for premature infant and their families.

• Asia-Pacific Journal of Business
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• v.12 no.3
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• pp.361-378
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• 2021

Purpose - The purpose of this study is to classify KOSPI listed companies according to their organizational character type based on MBTI. Design/methodology/approach - This study collected 109,989 reviews from an online firm review website, Jobplanet. Using these reviews and the descriptions about organizational character, we conducted document similarity analysis. Doc2Vec technique was hired for the analysis. Findings - First, there are more companies belonging to Extraversion(E), Intuition(N), Feeling(F), and Judging(J) than Introversion(I), Sensing(S), Thinking(T), and Perceiving(P) as organizational character types of MBTI. Second, more companies have EJ and EP as the behavior type and NT and NF as the decision-making type. Third, the top-3 organizational character type of which firms have among 16 types are ENTJ, ENFP, and ENFJ. Finally, companies belonging to the same industry group were found to have similar organizational character. Research implications or Originality - This study provides a noble way to measure organizational character type using firm review big data and document similarity analysis technique. The research results can be practically used for firms in their organizational diagnosis and organizational management, and are meaningful as a basic study for various future studies to empirically analyze the impact of organizational character.