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The pharmacological effect of the methanol extracts from Acanthopanax senticosus after immobilized and chronic swimming stresses in rats

  • Park, Hee-Dong;Kim, Yu-Ji;Yang, You-Jong;Lee, Jae-Joon;Lee, Jung-Joon;Lee, Myung-Koo
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.264.2-265
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    • 2002
  • Acanthopanax senticosus has been used clinically as tonic. anti-rheumatic and prophylactic purpose for chronic bronchitis. hypertension. ischemic heart disease. and gastric ulcer. We investigated the effects of methanol extracts from Acanthopanax senticosus (KS. KR. MS, MR, HS. HR, SS and SR) on catecholamine and cortisol content of serum after immobilization and on the exercise time to exhaustion in chronic swimming stressed rats. (omitted)

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Synthesis of Substituted Imidazolidin-2-ones as Aminoacyl-tRNA Synthase Inhibitors

  • Eum, Hee-Sung;Lee, Yu-No;Kim, Song-Mi;Baek, A-Young;Son, Min-Ky;Lee, Keun-Woo;Ko, Seung-Whan;Kim, Sung-Hoon;Yun, Sae-Young;Lee, Won-Koo;Ha, Hyun-Joon
    • Bulletin of the Korean Chemical Society
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    • v.31 no.3
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    • pp.611-614
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    • 2010
  • Substituted imidazolidin-2-ones deduced as potential inhibitors of IleRS by docking simulations were synthesized from an aziridine-2-carboxaldehyde. Reductive amination of an aziridine-2-carboxaldehyde with dipeptides for the substituents at N1 and followed by aziridine-ring expansion with triphosgene afforded 4-chloromethylimidazolidin-2-ones whose chloride were further manipulated towards phenylurea, pyrimidin-2-yl-urea or benzenesulfonamide at C4.

A Preliminary Study to Determine Comprehensive Research and Development Plans for Promoting Mental Health Services

  • Kim, Chul Eung;Ko, Young-Mi;Lee, Sang-Uk;Choi, SungKu;Han, Kiwan;Park, Se Jin;Jo, MinKyung;Park, Yu Kyong;Lee, Hye Young;Park, Subin
    • Osong Public Health and Research Perspectives
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    • v.9 no.6
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    • pp.314-324
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    • 2018
  • Objectives: The aim of this study was to analyze research and development projects in mental health services in Korea, using priority evaluation of mental health promotion policies to determine direction of the service. Methods: An online survey was conducted that targeted experts in the mental health service regarding promotion of mental health in Korea in 2016. The survey was based on 32 policy projects that resulted from 12 strategies according to 4 policy objectives. Results: Analysis of 32 mental health projects were assessed regarding the possibility of technology development success, magnitude of the ripple effect, and necessity of a national response. It was observed that 3 policy projects relevant to suicide, had a high relative priority. This was followed by policies for improvement of health insurance and the medical benefit cost system, and policies for reinforcement of crisis psychological support such as those for disaster victims. Conclusion: The prioritization of mental health services should place an emphasis on promotion of a healthy mental lifestyle, rehabilitation support for patients with serious mental illness, and reinforcement of social safety networks for suicide prevention.