• STI Policy Review
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• v.3 no.2
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• pp.79-91
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• 2012

With the globalisation of the world's economies and the increasing role of multinational corporations in the generation of knowledge, global research and development (R&D) activities in emerging countries are following a new trend. This paper describes case studies of two large companies and discussion of the motives (demand vs. supply) and tasks (demand-driven vs. supply-driven) of R&D activities outside their home country. This work is based on an analysis of four overseas R&D units of two Korean ICT companies - here, ICT refers to goods and services in the information technology and communication technology fields - in India and China. The research findings are as follows: (1) The overseas R&D activities of Korean ICT enterprises in emerging countries may be driven by a combination of demand and supply factors of host countries; and (2) Korean overseas R&D centres in emerging countries may need to carry out both demand- and supply-driven tasks in view of the overlap between demand and supply factors of the host countries. Based on the results of this research, the following policy implications can be drawn for encouraging more effective overseas R&D activities of Korean enterprises in emerging countries. First, the government needs to expand the support systems so that enterprises can manage local R&D centres more effectively and actively use the variety of local support systems and useful information. Second, the government needs to expand the support systems so that the overseas R&D centres of Korean enterprises revitalise collaborations with locally excellent universities and research institutions.

• The Journal of the Acoustical Society of Korea
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• v.39 no.4
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• pp.342-350
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• 2020

Acoustic and vibration research activities for the structural development of Korean space launch vehicles are introduced in this paper. Various dynamic loads exerted on a launch vehicle during its operation are summarized. The acoustical design method of payload fairings which protect satellites from harsh launch environment was reviewed. Several acoustic research activities were performed to enhance the analytical prediction ability during the development period of the Naro and the Nuri launcher. Specifically, the following research activities are reviewed: a test and vibro-acoustic analysis of composite cylinders whose layup properties are varied, a research on low-frequency acoustic load reduction by an acoustic resonator array and an acoustic test on the cylinder part of the Naro payload fairing. A vibro-acoustic analysis result for the Nuri launcher was introduced and predicted acoustic and vibration levels and measured ones are shown to be in a good agreement.

• Journal of Microbiology and Biotechnology
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• v.7 no.1
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• pp.49-51
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• 1997

In order to obtain a hybrid synthetic peptide with a more potent antifungal activity than magainin-2 but without hemolytic activity, four hybrid peptides were designed from the sequences of magainin 2 and cecropin A and their antifungal activities against Trichosporon beigelii were investigated. The result showed that analogue 2 and 4 exhibited better antifungal activity against T. beigelii than magainin-2 but no hemolytic activities. The peptides, therefore, could be used as models for the development of potent antifungal peptides.

• Archives of Pharmacal Research
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• v.27 no.5
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• pp.518-523
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• 2004

An allergic reaction ensues after antigen binds to mast cell or basophil high affinity IgE receptor, Fc$\varepsilon$RI, resulting in degranulation of various inflammatory mediators that produce various allergic symptoms. In this study, i) we isolated the active component for the inhibition of mast cell degranulation from the extract of leaves of Castanea crenata and identified it as quercetin; ii) we established the total synthesis procedure of quercetin; iii) using quercetin as positive control, we excavated some lead compounds that possess inhibitory activities for mast cell degranulation by screening the chemical libraries of 1,3-oxazolidine derivatives prepared by solid phase combinatorial chemistry. Some of 1,3-oxazolidine compounds possessing acetyl and 3',4'-dichlorophenyl group displayed strong inhibitory activities on Fc$\varepsilon$RI-mediated mast cell degranulation, suggesting that they can be used as lead compounds for the development of anti-allergic agents.

• Korean Journal of Pharmacognosy
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• v.10 no.1
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• pp.1-8
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• 1979

The naturally occurring coumarins are likely to be a large and important group of plant products which are not only metabolic products of the living cells but possess varied physiological and pharmacological actions. Investigations concerning various biological activities of natural coumarins have been undertaken by many investigators in continuing effort. The authors describe on experimental results of biological activities of coumarin derivatives with particular emphasis on 10 different activities that are considered to be of importance in view of the development of new drugs from natural resources.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.3
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• pp.129-138
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• 2016

The train-centric control systems development has some distinct points in that a big size of government budget is in general expended in there and the development duration seems to be long. In addition, the changes are ever made continuously in the capability and operational requirements for Trains. Thus, the impact of the potential changes in the required operational capability on the development activities can induce some type of project risks [7]. As such, proper management of project risk has been one of crucial subjects in the train systems development. All these notes combined together make it the significance of the safety management process be raised further up in the train-centric control systems development. As such, the underlying safety management process should be capable of appropriately handling the potential risks that can be created due to the unexpected changes and the long-term development period. The process should also be complemented for the safety consideration of train-centric control systems, for instance, stop. To study these aspect is the objective of the paper. To do so, a step-by-step approach to analyzing the safety management process is first presented. Then, to enhance the process some necessary and useful activities are added in terms of risk and safety management. Then, to pursue some enhancement on the process, a set of necessary and useful activities are added in terms of risk and safety management. The resultant process is further analyzed and tailored using a design structure matrix method. The resultant process is applied in a train-centric control development as a case study.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.5
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• pp.261-272
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• 2022

Agriculture and the rural sector play a crucial part in Vietnam's socio-economic growth. The study's goal is to see how technology transfer from young intellectual research activities affects the economic evolution of Vietnam's agriculture and rural sector in the 4.0 technology era. The research has used a quantitative method through analysis of linear structural model SEM, with a survey scale including 480 samples that are managers in departments and branches in agriculture and rural sector in the provinces in Vietnam. Research results show that technology transfer from research activities of the young intellectual has a direct and positive impact on economic development in agriculture and rural sector. This level of impact will increase with the participation of the intermediary factors such as awareness of managers, trust, and mechanisms in the mobilization and use of resources. These results contribute to both theoretical and practical aspects when proving the impact of technology transfer from the research activity of the young intellectual to the economic development in the field of agriculture and rural sector in the 4.0 era and the mediating role of awareness of managers, trust and mechanisms in the mobilization and use of resources.

• Preventive Nutrition and Food Science
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• v.7 no.3
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• pp.261-264
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• 2002

The physiologically relevant functional properties of various solvent extracts from Salicornia herbacea leaves were investigated by measuring lipid peroxidation, DPPH radical scavenging, nitrite scavenging, and xanthine oxidase inhibition. Ethyl ether, chloroform, ethyl acetate and n-butanol fractions obtained from the 80% aqueous ethanol extracts of Salicornia herbacea leaves showed strong antioxidative activities in linoleic acid methyl esters. Peroxide values (POV) were not significantly different among the samples treated with the different fractions; the incubation time required to reach a peroxide value of 80 meq/kg was about 40 hrs. However, control linoleic acid methyl esters had POV of more than 480 meq/kg after 40 hrs. The DPPH radical scavenging activity of the ethyl acetate fraction was much more effective than diethyl ether, n-butanol, chloroform and water fractions, with an $IC_{50}$/ of 279 $\mu\textrm{g}$/mL, but less effective than ascorbic acid ($IC_{50}$/ : 67 $\mu\textrm{g}$/mL). The nitrite scavenging activities of all fractions increased as pH decreased. Among the fractions, nitrite scavenging activities of diethyl ether and ethyl acetate fractions at pH 1.2 were highest at 59.0 and 56.2%, respectively. The diethyl ether fraction obtained from the 80% aqueous ethanol extract of Salicornia herbacea loaves was the most effective inhibitor of xanthine oxidase of all the solvent extracts at 84% inhibition for a 1 mg/mL concentration. These results suggest that Salicornia herbacea leaf extracts may be effective antioxidants, not only in food stability, but also in human health.

• Journal of fish pathology
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• v.18 no.3
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• pp.239-245
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• 2005

Galla Rhois was extracted with various solvents such as ethyl alcohol, ethyl acetate, n-hexane, and n-butyl alcohol, and antibacterial activity of the extracts were also tested. The ethyl acetate extracted Galla Rhois showed high antibacterial activities and was the most effective extract, was further fractionated into 8 subfractions with silica gel column chromatography. The subfractions 4 and 5 exhibited an excellent antibacterial activity against Streptococcus iniac KCTC3657.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.1079-1084
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• 2002

Systems engineering technology development program for Korea next-generation high-speed railway(KNHR) system in progress is a national large-scale system development program that is not only a large-size and complex but also multi-disciplinary in nature. Using the RDD-IOO, a systems engineering tool, the KNHR program can establish requirements traceability and development process management in the course of development. This paper presents the results from a computer-aided systems engineering application to KNHR system technology development project over the three years of activities. The traceability among the system design database in the vertical direction of SE process, as the results of the first year and the second year research was accomplished. The database in both the requirement management domain and the project management domain was developed and set up the traceability between them in the horizontal direction of the SE process in the V model as the results of the third year research. Therefore, KNHR design database was built to support the life-cycle management of the system as well as to reuse the knowledge in future programs. In the following development phase, this database will be utilized to accomplish the test and integration activities providing a baseline database. The outcome of the study contributes to the establishment of the model-based systems engineering approach as a best practice in the accumulation and advancement of systems engineering technology for railway system development.