• IMMUNE NETWORK
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• v.4 no.2
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• pp.81-87
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• 2004

Background: In the thymus, developing thymocytes continually interact with thymic epithelial cell components. Self MHC restriction of mature T cells are imposed in the thymus through interaction of immature double positive thymocytes and thymic cortical epithelial cells. The site of negative selection, however, is a matter of debate. Through systemic injection of anti-TCR antibody or antigenic peptides, investigators suggested that most of the negative selection occurs in the thymic cortex. But the requirements for negative selection, i.e cellular counterparts and costimulatory molecules are more available in the medulla or cortico-medullary junction rather than in the thymic cortex. Methods: The direct and indirect pathways of thymocyte death after systemic anti-TCR antibody injection were separated through several experimental systems. B6 mice were either adrenalectomized or sham-adrenalectomized to evaluate the role of endogenous glucocorticoids from adrenal gland. Role of TNF were evaluated through using TNF receptor double knockout mice. Results: We found that without indirectly acting mediators such as $TNF-\alpha$ or corticosteroid, double positive thymocyte death were minimal by systemic injection of anti-TCR antibody in TNF receptor double knockout neonatal mice. Also by analyzing neonatal wild-type mice with adoptively transferred mature T cells, only peripheral activation of mature T cells could induce extensive double positive thymocyte death. Conclusion: Thus, systemically injected anti-TCR antibody mediated thymocyte death are mostly induced through indirect pathway.

• Journal of Communications and Networks
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• v.15 no.5
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• pp.476-485
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• 2013

In this paper, the effective capacity of a multiple-input multiple-output (MIMO) system in two different cases with receive antenna selection (RAS) and transmit antenna selection (TAS) schemes is investigated. A closed-form solution for the maximum constant arrival rate of this network with statistical delay quality of service (QoS) constraint is extracted in the quasi-static fading channel. This study is conducted in two different cases.When channel state information (CSI) is not available at the MIMO transmitter, implementation of TAS is difficult. Therefore, RAS scheme is employed and one antenna with the maximum instantaneous signal to noise ratio is chosen at the receiver. On the other hand, when CSI is available at the transmitter, TAS scheme is executed. In this case, one antenna is selected at the transmitter. Moreover, an optimal power-control policy is applied to the selected antenna and the effective capacity of the MIMO system is derived. Finally, this optimal power adaptation and the effective capacity are investigated in two asymptotic cases with the loose and strict QoS requirements. In particular, we show that in the TAS scheme with the loose QoS restriction, the effective capacity converges to the ergodic capacity. Then, an exact closed-form solution is obtained for the ergodic capacity of the channel here.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.3
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• pp.950-975
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• 2016

Device-to-Device (D2D) communication underlaying cellular networks is a promising add-on component for future radio communication systems. It provides more access opportunities for local device pairs and enhances system throughput (ST), especially when mobile relays (MR) are further enabled to facilitate D2D links when the channel condition of their desired links is unfavorable. However, mutual interference is inevitable due to spectral reuse, and moreover, selecting a suitable transmission mode to benefit the correlated resource allocation (RA) is another difficult problem. We aim to optimize ST of the hybrid system via joint consideration of mode selection (MS) and RA, which includes admission control (AC), power control (PC), channel assignment (CA) and relay selection (RS). However, the original problem is generally NP-hard; therefore, we decompose it into two parts where a hierarchical structure exists: (i) PC is mode-dependent, but its optimality can be perfectly addressed for any given mode with additional AC design to achieve individual quality-of-service requirements. (ii) Based on that optimality, the joint design of MS, CA and RS can be viewed from the graph perspective and transferred into the maximum weighted independent set problem, which is then approximated by our greedy algorithm in polynomial-time. Thanks to the numerical results, we elucidate the efficacy of our mechanism and observe a resulting gain in MR-aided D2D communication.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.11
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• pp.1091-1097
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• 2017

Sales of commercial-type cooling fans intended for application in military electronics are often discontinued during equipment production. This results in requirements for alternative fan selection as well as equipment performance and reliability tests, such as high-temperature operation testing. This study deals with alternative fan selection and verification methods that can be used during the production process. First, an alternative fan was selected by calculating the flow and pressure required to effectively cool the equipment, then the feasibility of the selected fan was verified using a reliable CFD heat dissipation analysis model. Following this, a high-temperature operation test was performed using the alternative fan in the equipment. Results demonstrated that the equipment satisfied its required function in a high-temperature environment, and the main parts as well as internal air temperature were found to be thermally stable.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38A no.10
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• pp.858-864
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• 2013

In the 4G wireless environment, one of the important issues is to discover and select an access network suited for users. In this thesis, we propose a new network selection mechanism using group decision making and evaluate the effect of network selection schemes for vertical handover in heterogeneous wireless networks. We consider the group of users with similar QoS requirements search for the available access network simultaneously and a service area consist of multiple access networks with various characteristics. We divide the access networks with similar characteristics split into a group. Between each group, the one group is selected and within that group, the best access networks will be assigned according to priority order by network selection algorithm. We evaluate and compare the performance of three representative MADM schemes: GRA, SAW and TOPSIS. The MATLAB simulation results indicate the proposed algorithm can make a more effective choice according to the networks' characteristics and user's preference.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.6
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• pp.1279-1286
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• 2021

This study suggests the user's needs for a smart parking service that enables parking lot search and advance reservation service, and is a study on the user's preference selection model related to fees (reservation fee, penalty fee), etc. Two types of user preference models in the form of logit models were constructed by composing a response questionnaire for smart parking service. The first is a model for selecting a smart parking lot, which suggests a situation in which the probability of selection is higher than that of a general parking lot in the relationship between usage fee and cost. The second is a parking ticket reservation discount selection model, and the smart parking service selection probability was analyzed through the relationship model between the reservation amount and the penalty. It can be used as a design requirement that enables sophisticated and various types of smart parking service considering users' preferences.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.3
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• pp.22-30
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• 2010

This paper proposes a combination system of Adaptive Modulation and Coding (AMC) and Multiple Input Multiple Output (MIMO), which improves the throughput and has a better reliability. In addition, the system includes Precoding, Antenna Subset Selection and MIMO Mode Selection scheme. Finally, we make a performance analysis of the proposed system. The principal environmental parameters for the simulation experiment consist of a frequency non-selective rayleigh fading channel and a Spreading Factor (SF) of 16. Other parameters may be included in order to fulfill the requirements of the HSDP A Standard. The proposed system has a higher throughput and more reliability than the conventional system, which does not include MIMO Mode Selection scheme, Precoding or Antenna Subset Selection. According to the simulation results, the proposed system reaches the maximum throughput at 8dB, presentlng an improvement of 6dB and twice higher throughput, respect to the conventional system. Specifically, at the point of -6dB, the conventional system reaches 2.5Mbps, while the proposed system reaches 6.4Mbps at the same SNR. Also, at the point of 2dB, each system reaches 7.5Mbps (conventional system) and 15.3Mbps (proposed system), with near twice the difference. According to the results exposed above, we can conclude that the system proposed in this paper has, as the greatest contribution, the improvement of the throughput, especially, the average throughput.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.04a
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• pp.135-138
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• 2000

This paper is intended to propose what manufacturing configuration (manufacturing planning and shop floor control) is suitable for the tire industry. Basically tire-manufacturing process is mixed-products, parallel-disconnected-flow-shop. Both throughput time and cycle tine are very short, the variety of tires is very high, the setup time is long, shop floor data reporting requirements is high, and there are many equipments and people working. And with no exception, tire industry also now confronts increasing requirements of delivery conformance with the above peculiar characteristics of tire manufacturing and changing market environments, this paper suggests, weekly master scheduling with no MRP is desirable and traditional kanban is right selection for shop floor control/scheduling. This paper describes why this configuration should be, using the manufacturing engineering principles and some new insights like four primitives of parallel flow shop. Generally known that shop with high parallel-product-mix and long setup time isn't good candidate for kanban. The four primitives of parallel flow shop explain why kanban is also useful scheduling technique in that environment.

• Structural Engineering and Mechanics
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• v.43 no.4
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• pp.545-560
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• 2012

Design codes provide the minimum requirements for the design of code-compliant structures to ensure the safety of the life and property. As for code-exceeding buildings, the requirements for design are not sufficient and the approval of such structures is vague. In mainland China in recent years, a large number of code-exceeding tall buildings, whether their heights exceed the limit for the respective structure type or the extent of irregularity is violated, have been constructed. Performance-based seismic design (PBSD) approach has been highly recommended and become necessary to demonstrate the performance of code-exceeding tall buildings at least equivalent to code intent of safety. This paper proposes the general methodologies of performance-based seismic analysis and design of code-exceeding tall buildings in Mainland China. The PBSD approach proposed here includes selection of performance objectives, determination of design philosophy, establishment of design criteria for structural components and systems consistent with the desirable and transparent performance objectives, and seismic performance analysis and evaluation through extensive numerical analysis or further experimental study if necessary. The seismic analysis and design of 101-story Shanghai World Financial Center Tower is introduced as a typical engineering example where the PBSD approach is followed. The example demonstrates that the PBSD approach is an appropriate way to control efficiently the seismic damage on the structure and ensure the predictable and safe performance.

• Journal of Institute of Control, Robotics and Systems
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• v.22 no.8
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• pp.603-609
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• 2016

This paper presents an optimally designed master device mechanism for teleoperated interventional robotic system. The interventional procedures using the teleoperated robotic system and the physicians' requirements are summarized. The master device should implement 5-DOF motion including 2-DOF translational motion for the entry position control, 2-DOF rotational motion for the orientation control, and 1- DOF translational motion for needle insertion. The handle assembly includes a 1-DOF translational mechanism for needle insertion and buttons for operation mode selection. The mechanisms for the 2-DOF translational motion and the 2-DOF rotational motion are designed using motors and brakes based on the various mechanisms to satisfy all the above requirements, respectively. Absolute position sensors are adopted to implement automatic initial positioning and orientation matching at the first step of needle insertion.