• 제목/요약/키워드: Reproductive/developmental

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STUDY ON THE DEVELOPMENTAL TOXICITY OF THIMEROSAL

  • Kwack, Seung-Jun;Rhee, Gyu-Seek;Kim, Soon-Sun;Kim, So-Hee;Sohn, Kyung-Hee;Chae, Soo-Young;Park, Yo-Woo;Park, Kui-Lea
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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    • pp.71-72
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    • 2002

  • Thimerosal is a mercury-containing compound used in trace amounts to prevent bacteria and other organisms from contaminating vaccines, especially in opened multi-dose vials. The toxicity of mercury is well known and those most at risk are occurred in unborn and newborn babies.(omitted)

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STUDY ON THE DEVELOPMENTAL TOXICITY OF THIMEROSAL

  • Kwack, Seung-Jun;Rhee, Gyu-Seek;Kim, Soon-Sun;Kim, So-Hee;Sohn, Kyung-Hee;Chae, Soo-Young;Choi, Yo-Woo;Park, Kui-Lea
    • 한국환경성돌연변이발암원학회:학술대회논문집
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    • 한국환경성돌연변이발암원학회 2002년도 Current Trends in Toxicological Sciences
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    • pp.71-72
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    • 2002

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Uterotrophic Assays of Pyrethroid Insecticides in Immature Rats

  • Kim, Soon-Sun;Rhee, Gyu-Seek;Lee, Rhee-Da;Kwack, Seung-Jun;Lim, Kwon-Jo;Yhun, Hyo-Jung;Choi, Kwang-Sik;Park, Kui-Lea
    • 한국환경성돌연변이발암원학회:학술대회논문집
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    • 한국환경성돌연변이발암원학회 2003년도 추계학술대회
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    • pp.149-149
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    • 2003

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생식 · 발생독성시험의 방법적 고찰과 최신 연구 동향 (The Recommended Approaches and Recent Trends in Reproductive and Developmental Toxicology)

  • 곽승준;조대현
    • Toxicological Research
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    • 제21권4호
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    • pp.271-278
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    • 2005

  • Reproductive and developmental toxicology is concerned with various physical or chemical agents interfering with fertility in both gender or normal growth of offsprings. Reproductive and developmental toxicology is rather a complex science, with many fields, i.e., various endpoints are involved and many different mechanisms of action. For that reason, diverse aspects must be considered when attempting to assess possible adverse health effects in the area of reproductive and developmental toxicology. The thalidomide tragedy made it clear to regulatory authorities around the world that systematic, comprehensive evaluation of the reproductive cycle was needed to adequately evaluate the potential of medicinal drugs to impair the process of reproduction or the development of embryos, fetuses, and children. International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) and U.S. Food and Drug Administration (FDA) developed a guideline to assess the reproductive and developmental toxicity. Also these guidelines have since been applied to the detection and regulation of environmental toxicants, food additives, and so on. Although it was hoped that testing procedures of guideline would be updated constantly to reflect the current state of the science in reproductive and developmental toxicology, it was not until this decade that regulatory guidelines and testing methods have been altered in a significant way. In this paper, we would like to present the recommended approaches and recent trends for improvement of testing guidelines or experimental methods in reproductive and developmental toxicology.

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