• 사상체질의학회지
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• 제18권3호
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• pp.1-11
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• 2006

1. Objectives The purpose of this study is to find the kinds & meaninings of Qi in Lee Je-Ma's writings. 2. Methods We analyzed Lee Je-Ma's writings which contain the related contents of Qi's kinds & meanings 3. Results and Conclusions 1) There are distinctive Qi features of $sorrow{\cdot}anger{\cdot}joy{\cdot}pleasure$(哀怒僖樂) which are different from one of seven mode emotions(七情) in ${\ulcorner}$Gyukchigo(格致藁)${\lrcorner}$. 2) When $Water{\cdot}grain's$ Qi(臟氣) is the base of the human's Qi, $Nature{\cdot}emotion's$ Qi(性${\cdot}$情氣) is managing. And $Lung{\cdot}Spleen{\cdot}Liver{\cdot}Kidneys's$ Qi(肺脾肝腎氣) is the representative concept resulted by the complex operation of $Water{\cdot}grain's$ Qi(水穀之氣) and $Nature{\cdot}emotion's$ Qi. Each Qi stands for its protensity as follows ; Lung's Qi for extrorse propensity of Yang(Z), Spleen's Qi for upward propensity of Yang(陽), Liver's Qi for introrse propensity of Eum(陰), Kidneys's Qi for downward propensity of Eum(陰). 3) Jang's Qi is more important than medicine's Qi and medicine's Qi has a limitation about recovering jang's Qi. So that it is very important to take care of one's mind. 4) Controling mind Qi is controling Nature & emotion's Qi. Thus controling mind Qi si the best plan for jang's Qi and controling with medicine's Qi is the next policy. 5) Qi influences all aspect of personality, disease, application of medicines and ordinary symptoms. So that Qi is the kernel of the Sasang Constitutional Medicine.

• 대한의용생체공학회:의공학회지
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• 제41권1호
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• pp.48-54
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• 2020

In this paper, we deal with a liver fibrosis classification problem using ultrasound B-mode images. Commonly representative methods for classifying the stages of liver fibrosis include liver biopsy and diagnosis based on ultrasound images. The overall liver shape and the smoothness and roughness of speckle pattern represented in ultrasound images are used for determining the fibrosis stages. Although the ultrasound image based classification is used frequently as an alternative or complementary method of the invasive biopsy, it also has the limitations that liver fibrosis stage decision depends on the image quality and the doctor's experience. With the rapid development of deep learning algorithms, several studies using deep learning methods have been carried out for automated liver fibrosis classification and showed superior performance of high accuracy. The performance of those deep learning methods depends closely on the amount of datasets. We propose an enhanced U-net architecture to maximize the classification accuracy with limited small amount of image datasets. U-net is well known as a neural network for fast and precise segmentation of medical images. We design it newly for the purpose of classifying liver fibrosis stages. In order to assess the performance of the proposed architecture, numerical experiments are conducted on a total of 118 ultrasound B-mode images acquired from 78 patients with liver fibrosis symptoms of F0~F4 stages. The experimental results support that the performance of the proposed architecture is much better compared to the transfer learning using the pre-trained model of VGGNet.

• Journal of Veterinary Science
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• 제22권5호
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• pp.73.1-73.11
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• 2021

Background: Feline calicivirus (FCV) is a common pathogen of felids, and FCV vaccination is regularly practiced. The genetic variability and antigenic diversity of FCV hinder the effective control and prevention of infection by vaccination. Improved knowledge of the epidemiological characteristics of FCV should assist in the development of more effective vaccines. Objectives: This study aims to determine the prevalence of FCV in a population of cats with FCV-suspected clinical signs in Hangzhou and to demonstrate the antigenic and genetic relationships between vaccine status and representative isolated FCV strains. Methods: Cats (n = 516) from Hangzhou were investigated between 2018 and 2020. The association between risk factors and FCV infection was assessed. Phylogenetic analyses based on a capsid coding sequence were performed to identify the genetic relationships between strains. In vitro virus neutralization tests were used to assess antibody levels against isolated FCV strains in client-owned cats. Results: The FCV-positive rate of the examined cats was 43.0%. Risk factors significantly associated with FCV infection were vaccination status and oral symptoms. Phylogenetic analysis revealed a radial phylogeny with no evidence of temporal or countrywide clusters. There was a significant difference in the distribution of serum antibody titers between vaccinated and unvaccinated cats. Conclusions: This study revealed a high prevalence and genetic diversity of FCV in Hangzhou. The results indicate that the efficacy of FCV vaccination is unsatisfactory. More comprehensive and refined vaccination protocols are an urgent and unmet need.

• Journal of Dental Anesthesia and Pain Medicine
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• 제19권4호
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• pp.181-189
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• 2019

Local anesthetic systemic toxicity (LAST) refers to the complication affecting the central nervous system (CNS) and cardiovascular system (CVS) due to the overdose of local anesthesia. Its reported prevalence is 0.27/1000, and the representative symptoms range from dizziness to unconsciousness in the CNS and from arrhythmias to cardiac arrest in the CVS. Predisposing factors of LAST include extremes of age, pregnancy, renal disease, cardiac disease, hepatic dysfunction, and drug-associated factors. To prevent the LAST, it is necessary to recognize the risk factors for each patient, choose a safe drug and dose of local anesthesia, use vasoconstrictor, confirm aspiration and use incremental injection techniques. According to the treatment guidelines for LAST, immediate application of lipid emulsion plays an important role. Although lipid emulsion is commonly used for parenteral nutrition, it has recently been widely used as a non-specific antidote for various types of drug toxicity, such as LAST treatment. According to the recently published guidelines, 20% lipid emulsion is to be intravenously injected at 1.5 mL/kg. After bolus injection, 15 mL/kg/h of lipid emulsion is to be continuously injected for LAST. However, caution must be observed for >1000 mL of injection, which is the maximum dose. We reviewed the incidence, mechanism, prevention, and treatment guidelines, and a serious complication of LAST occurring due to dental anesthesia. Furthermore, we introduced lipid emulsion that has recently been in the spotlight as the therapeutic strategy for LAST.

• 식물병연구
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• 제25권1호
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• pp.29-32
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• 2019

가시박(Sicyos angulatus)은 대표적인 외래 생태계교란식물로 전국적으로 확산되어 발생하고 있다. 국내에서 기주선택성이 있으면서 균핵을 형성하는 Sclerotinia trifoliorum BWC98-105 균주의 균사 배양체와 구형 펠렛으로 가시박에 대한 병원성을 실내, 온실 및 현장실험에서 확인하였다. 온실실험에서 균사 배양체는 접종 후 익일부터 균사생장이 관찰되었고, 5일부터 시들기 시작하였고, 7일부터 특징적인 표징(sign)인 균핵의 형성이 관찰되었고, 14일 시점에서는 식물체가 고사되고 대부분의 균핵이 성숙한 갈색으로 변했다. 이러한 현상은 현장실험에서도 확인되었다. 따라서 S. trifoliorum BWC98-105의 가시박에 대한 줄기마름병(stem blight) 증상을 보고하고자 한다. 또한 균핵형성균 S. trifoliorum BWC98-105의 균핵으로 제조된 구형 펠렛은 향후 가시박 관리를 위한 바이오제초제로써 가능성이 높다고 사료되었다.

• 한국가족관계학회지
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• 제21권2호
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• pp.77-96
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• 2016

Objectives: The aims of this study are to examine the associations between marital satisfaction and life satisfaction among Korean retirees in later life and to test whether the degrees of associations increased over time. Method: Nationally representative Korean Longitudinal Study of Ageing data from wave 1 (in 2006) to wave 4 (in 2012) was utilized and retirees in later life (65-89 years old, N=402) were analyzed. Latent growth modeling (LGM) and model constraint were applied using Mplus 7.3. Age, sex, household income, subjective health, depressive symptoms and elapsed time after retirement were included as control variables. Results: Linear unconditional LGM fitted the data well and showed gradual decrease in life satisfaction. Conditional LGM revealed significant associations between marital satisfaction and life satisfaction from time 1 to time 4. According to model constraint test, the size of associations between marital satisfaction and life satisfaction did not change with time. Conclusions: To sum up these results, the associations between marital satisfaction and life satisfaction were significant and relatively stable over time among retirees in later life. This study suggests one's spouse is a fundamental component of social convoy among Korean retirees in later life. Therefore, intervention programs targeted toward enhancing marital relationships among retirees' couples will help them to live a better life.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권4호
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• pp.144-153
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• 2021

Objectives: Anxiety disorders are the most common psychiatric disorders in adolescents and seem to occur the earliest among all forms of psychopathology. The aim of this study was to investigate the association of anxiety severity with health risk behaviors and mental health in adolescents. Methods: Data from the 2020 Korean Youth Risk Behavior Web-Based Survey were analyzed. A total of 54948 adolescents responded to the 7-item Generalized Anxiety Disorder Scale (GAD-7) for the assessment of their anxiety severity as well as to the mental health and health risk behavior survey. Logistic regression analysis, t tests, and variance analysis of a complex sample general linear model were used to examine the association of anxiety severity with health behaviors and mental health. Results: After statistical adjustment for sociodemographic characteristics, the subjects in the severe anxiety group were significantly more likely to be current smokers (odds ratio [OR]: 2.08, 95% confidence interval [CI]: 1.72-2.50), current drinkers (OR: 1.91, 95% CI: 1.67-2.19), experience habitual substance use (OR: 10.89, 95% CI: 8.22-14.42), have sexual intercourse (OR: 2.10, 95% CI: 1.76-2.51), and have unprotected intercourse (OR: 2.21, 95% CI: 1.67-2.92) than those in the normal group. Anxiety severity negatively correlated with sleep satisfaction and happiness, but positively correlated with stress perception, loneliness, depressive symptoms, and suicidality. Conclusion: Adolescent anxiety is associated with health risk behaviors and poor mental health. Thus, early screening and intervention for anxiety in adolescents could contribute to the management and coping of youth health risk behaviors in the community.

• 정보보호학회논문지
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• 제31권6호
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• pp.1105-1114
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• 2021

최근 급상승한 암호 화폐의 인기로 인해 암호 화폐 채굴 악성코드인 크립토재킹 위협이 증가하고 있다. 특히 웹 기반 크립토재킹은 피해자가 웹 사이트에 접속만 하여도 피해자의 PC 자원을 사용해 암호 화폐를 채굴할 수 있으며 간단하게 채굴 스크립트만 추가하면 되기 때문에 공격이 쉽고 성능 열화와 고장의 원인이 된다. 크립토재킹은 피해자가 피해 상황을 인지하기 어렵기 때문에 크립토재킹을 효율적으로 탐지하고 차단할 수 있는 연구가 필요하다. 본 연구에서는 크립토재킹의 대표적인 감염 증상과 스크립트를 지표로 활용하여 효과적으로 크립토재킹을 탐지하는 프레임워크를 제안하고 평가한다. 제안한 크립토재킹 탐지 프레임워크에서 행위 기반 동적 분석 기법으로 컴퓨터 성능 지표를 학습한 K-Nearest Neighbors(KNN) 모델을 활용했고, 스크립트 유사도 기반 정적 분석 기법은 악성 스크립트 단어 빈도수를 학습한 K-means 모델을 크립토재킹 탐지에 활용했다. 실험 결과에 따르면 KNN 모델은 99.6%의 정확도를 보였고, K-means 모델은 정상 군집의 실루엣 계수가 0.61인 것을 확인하였다.

• Journal of Forest and Environmental Science
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• 제38권3호
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• pp.159-173
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• 2022

Genus of Rhododendron has been used in traditional medicine since ancient times and is known to be effective in immune function, inflammation, and cold symptoms. And the reason for this activity is the flavanonol type among flavonoids in the genus of Rhododendron. Among the flavanonol types, Taxifolin-3-O-arabinopyranoside was isolated from the root of native R. mucronulatum in Korea, and the structure was finally identified through HPLC, LC-MS/MS, ¹H-NMR, and ¹³C-NMR. Taxifolin-3-O-arabinopyranoside is a compound mainly found in R. mucronulatum, a representative species of the genus of Rhododendron, and exhibits antioxidant, anti-inflammatory, and anti-atopic activities. In this study, Taxifolin-3-O-arabinopyranoside was chemotaxonomic significant in 5 species of the genus Rhododendron native to Korea (R. mucronulatum, R. mucronulatum var. ciliatum, R. schlippenbachii, R. yedoense var. Poukhanense, R. japonicum for. Flavum). Compared with the existing literature, Taxifolin-3-O-arabinopyranoside was identified for the first time in 4 species of Rhododendron except for the R. mucronulatum.

• 대한화장품학회지
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• 제49권3호
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• pp.225-230
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• 2023

본 연구에서는 모발 내부의 다공성 구조를 광학 현미경을 이용하여 모발의 손상 없이 관찰하였으며, 해당 결과를 이용하여 모발 내부 다공성을 정량적으로 표현하고자 하였다. 모발 내부 밀도 저하가 모발의 굽힘 및 인장 특성에 미치는 영향에 대한 실험을 진행하였으며, 모발 내부의 밀도 저하를 발생시키는 원인에 대하여 알아보고자 내인적 요인과 외인적 요인에 대한 실험을 실시하였다. 내인적 요인으로는 노화의 대표 증상의 하나인 흰머리의 다공성을 평가 정상 모발과 비교하였다. 외인적 요인으로는 일상생활에서 대표적으로 모발의 손상을 유발할 수 있는 요인인 계면활성제와 열에 의하여 모발 내부 밀도가 감소 하는 것을 관찰하였다. 또한, 아미노산과 모발 지질 소질을 방지할 수 있는 소재를 이용하여 모발 내부 밀도를 증가시키고 윤기를 증가시킬 수 있음을 확인하였다.