• Journal of the Korea institute for structural maintenance and inspection
• /
• v.4 no.3
• /
• pp.161-168
• /
• 2000

A series of in-situ inspection and measurements have been conducted to estimate rebar corrosion incidence of concrete bridges in Seoul metropolitan area. The objectives of this study were to obtain the fundamental data to analysis the causes of rebar corrosion and to establish the repair strategies of deteriorated concrete bridges due to corrosion. The results of this study had been analysed to identify the extent of chloride content and incidence of rebar corrosion by construction ages and by members. After measuring chloride content in concrete, it was concluded that about 76% of all tests on samples from concrete exceed the maximum acceptable limit to risk of chloride-induced corrosion. On the whole, slabs had the most highly chloride content. About 16% of the concrete bridges had a value lower than -350mV (vs. CSE), so it could concluded that the excessive chloride content and carbonation were a major causes of rebar corrosion. Concrete member which carbonation depth penetrates toward rebar was 39% among all tests on samples. The major causes of rebar corrosion were highly chloride content 50%, concrete carbonation 38%, poorly visual condition 6% and etc, 6%.

• Journal of Microbiology and Biotechnology
• /
• v.27 no.2
• /
• pp.207-218
• /
• 2017

Clustered regulatory interspaced short palindromic repeats (CRISPR) in association with CRISPR-associated protein (Cas) is an adaptive immune system, playing a pivotal role in the defense of bacteria and archaea. Ease of handling and cost effectiveness make the CRISPR-Cas system an ideal programmable nuclease tool. Recent advances in understanding the CRISPR-Cas system have tremendously improved its efficiency. For instance, it is possible to recapitulate the chronicle CRISPR-Cas from its infancy and inaugurate a developed version by generating novel variants of Cas proteins, subduing off-target effects, and optimizing of innovative strategies. In summary, the CRISPR-Cas system could be employed in a number of applications, including providing model systems, rectification of detrimental mutations, and antiviral therapies.

• Journal of Microbiology and Biotechnology
• /
• v.16 no.10
• /
• pp.1577-1582
• /
• 2006

Cartilage tissue engineering has emerged as an alternative approach for reconstruction or repair of injured cartilage tissues. In this study, rabbit chondrocytes were cultured in a three-dimensional environment to fabricate a new cartilaginous tissue with the application of tissue engineering strategies based on biodegradable PLGA microspheres. Chondrocytes were seeded on PLGA microspheres and cultured on a rocking platform for 5 weeks. The PLGA microspheres provided more surface area to adhere chondrocytes compared with PLGA sponge scaffolds. The novel system facilitated uniform distribution of the cells on the whole of the PLGA microspheres, thus forming a new cartilaginous construct at 4 weeks of culture. The histological and immunohistochemical analyses verified that the number of chondrocytes and the amount of extracellular matrix components such as proteoglycans and type II collagen were significantly greater on the PLGA microspheres constructs as compared with those on the PLGA sponge scaffolds. Therefore, PLGA microspheres enhanced the function of chondrocytes compared with PLGA sponge scaffolds, and thus might be useful for formation of cartilage tissue in vitro.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2018.05a
• /
• pp.446-446
• /
• 2018

The urban rivers have unique hydraulic characteristics between natural rivers and artificial canals. These hydraulic characteristics determine the characteristics of urban rivers with small environmental capacity and fragile ecosystems. With the development and utilization of natural resources, the pollutants that have been produced enter the river through different channels, which seriously damages the urban river ecosystem. Therefore, how to restore contaminated water to a normal state and reproduce a natural, self-regulating ecosystem is one of the most concerned issues in recently. Eco-hydraulics is a cross-disciplinary subject of hydraulics biology and ecology. It is closely related to the protection of rivers, wetlands, and ecological self-repair. In this study, The basic principle of eco-hydraulics is concisely described and its approaches to protection and rehabilitation of river are introduced. The conception of establishing gardenesque eco-pond for urban use is suggested. The strategies including changing the hydrodynamic features of rivers, adjusting the breeds and species and constructing the gardenesque eco-pond for improving the exist ing urban rivers are proposed. It provides scientific information and guidance for the restoration of rivers and wetlands by studying the close relationship between river hydraulic characteristics, currents, and rivers and ecosystems.

• Journal of Korean Foot and Ankle Society
• /
• v.25 no.2
• /
• pp.95-99
• /
• 2021

The surgical treatment of Achilles tendinopathy can be considered after the failure of conservative treatment, and the surgical methods may be divided into two groups; treatments for insertional and non-insertional tendinopathy. In the case of insertional tendinopathy, debridement including tendon and calcification of the diseased lesion, reattachment of the tendon, and calcaneal ostectomy of the Haglund lesion are the primary treatments. If reattachment is not possible, reconstruction should be performed by other methods such as tendon transfer. As a result of surgery for insertional tendinopathy, there is an improvement in the pain and function after surgery, but there are some patients whose pain does not completely disappear. Some residual pain may persist; therefore, the overall success rate of the surgery can be expected to be 80% to 90%. For the patients of non-insertional tendinopathy, conservative treatment through eccentric exercise is the primary treatment, and most of them have reported good results. In case of failure after various conservative treatments, debridement of the diseased lesion and repair of the remaining tendon would be the primary surgical treatments. If the remaining tendon is not sufficient, reconstruction such as tendon transfer should be considered.

• Molecules and Cells
• /
• v.42 no.1
• /
• pp.1-7
• /
• 2019

Macrophage is an important innate immune cell that not only initiates inflammatory responses, but also functions in tissue repair and anti-inflammatory responses. Regulating macrophage activity is thus critical to maintain immune homeostasis. Tyro3, Axl, and Mer are integral membrane proteins that constitute TAM family of receptor tyrosine kinases (RTKs). Growing evidence indicates that TAM family receptors play an important role in anti-inflammatory responses through modulating the function of macrophages. First, macrophages can recognize apoptotic bodies through interaction between TAM family receptors expressed on macrophages and their ligands attached to apoptotic bodies. Without TAM signaling, macrophages cannot clear up apoptotic cells, leading to broad inflammation due to over-activation of immune cells. Second, TAM signaling can prevent chronic activation of macrophages by attenuating inflammatory pathways through particular pattern recognition receptors and cytokine receptors. Third, TAM signaling can induce autophagy which is an important mechanism to inhibit NLRP3 inflammasome activation in macrophages. Fourth, TAM signaling can inhibit polarization of M1 macrophages. In this review, we will focus on mechanisms involved in how TAM family of RTKs can modulate function of macrophage associated with anti-inflammatory responses described above. We will also discuss several human diseases related to TAM signaling and potential therapeutic strategies of targeting TAM signaling.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.46 no.3
• /
• pp.148-160
• /
• 2023

The air transport industry is experiencing unprecedented fluctuations in aviation demand through the Covid-19 pandemic, and is more focused than ever on maintaining and generating business profitability. During the pandemic, demand for air cargo has soared, and the conversion business from passenger aircrafts to freighters(P2F) is drawing attention as a new business in the aviation maintenance industry. This study derives important factors to be considered in order to successfully carry out the P2F project through a wide range of cases and related literature, and analyzes the relative importance of each factor using the analytic hierarchy process. Through a survey of 33 aviation maintenance experts with more than 20 years of field experience, the importance of main factors and their sub factors was determined and implications were drawn. As a primary result, in order to succeed in the P2F project, the main factors were identified in the order of skill, finance, and location. The most important sub factors for each main factors were identified in order of securing airframe modification skill, securing infrastructure construction cost, and creating P2F business complex and district. The quantified success factors suggested the critical direction for the successful development of Korea's P2F business, and presented viable and specific business strategies and implementation plans for each factors.

• Geomechanics and Engineering
• /
• v.37 no.1
• /
• pp.21-29
• /
• 2024

The effective management of damage in tunnels is crucial for ensuring their safety, longevity, and operational efficiency. In this paper, we propose an educational management model tailored specifically for addressing damage in tunnels, utilizing numerical solution techniques. By leveraging advanced computational methods, we aim to develop a comprehensive understanding of the factors contributing to tunnel damage and to establish proactive measures for mitigation and repair. The proposed model integrates principles of tunnel engineering, structural mechanics, and numerical analysis to facilitate a systematic approach to damage assessment, diagnosis, and management. Through the application of numerical solution techniques, such as finite element analysis, we demonstrate the efficacy of the proposed model in simulating various damage scenarios and predicting their impact on tunnel performance. Additionally, the educational component of the model provides valuable insights and training opportunities for tunnel management personnel, empowering them to make informed decisions and implement effective strategies for ensuring the structural integrity and safety of tunnel infrastructure. Overall, the proposed educational management model represents a significant advancement in tunnel management practices, offering a proactive and knowledge-driven approach to addressing damage and enhancing the resilience of tunnel systems.

• Journal of Chest Surgery
• /
• v.32 no.5
• /
• pp.471-479
• /
• 1999

Background: Patients with tetralogy of Fallot(TOF), pulmonary atresia(PA) and major aortopulmonary collateral arteries(MAPCAs) have been managed by heterogenous surgical strategies. We have taken 5 different surgical approaches to this lesion. In this study, relative advantages and disadvantages of each strategy were discussed by analyzing our surgical results. Material and Method: Between January 1986 and June 1998, 50 patients aged 1 to 177(39${\pm}$31) months at a various morphologic spectrum of this lesion were treated at our institution. The groups, which were classified according to the initial approaches, consisted of one-stage unifocalization(A-1, n=9), staged unifocalization(A-2, n=11), right ventricle to pulmonary artery connection(RV-PA)(B-1, n=11), one-stage RV-PA plus unifocalization (B-2, n=11), and one-stage definitive repair(C, n=8). Morphologic charateristics, operative mortalities, and probabilities of definitive repair were compared between the groups and the causes of death, complications and the follow-up results were described. Result: Mean ages at the first operation were 57${\pm}$18(A-1), 42${\pm}$48(A-2), 18${\pm}$14(B-1), 52${\pm}$55(B-2), and 32${\pm}$34(C) months (p<0.05). Mean numbers of MAPCAs were least in group C (A-1=4.3${\pm}$1.0, A-2=4.5${\pm}$1.3, B-1=4.1${\pm}$1.9, B-2=4.1${\pm}$1.6, C=3.4${\pm}$1.8 : p<0.05). The ratios of the direct and the indirect MAPCAs in each group were not different between the grousps (A-1=91%/9%, A-2=78%/22%, B-1=80%/20%, B-2=80%/20%, C=81%/19% : p>0.05). Nineteen patients had more than 1 dependent MAPCAs. True pulmonary arteries were not present 13 patients and they were confluent in 29. A total of 101 operations were performed. Operative mortalities of initial procedures were 33%(3/9, A-1), 18%(2/11, A-2), 0%(0/11, B-1), 36%(5/11, B-2) and 13%(1/8, C) (p<0.05). Percentages of the definitive repair among the patients of each group were 22%(2/9, A-1), 18%(2/11, A-2). 45%(5/11, B-1), 27%(4/11, B-2), and 100%(8/8, C)(p<0.05). Hypoxic respiratory and cardiac failure(6), hypoxic encephalopathy(2) and sepsis(4) were the major causes of death. Phrenic nerve palsy occured in 5 patients. Thirty-one patients among the survivals have been followed up for a mean duration of 74${\pm}$42(3-145) months. One and five year actuarial survival rates were 73% and 73 %. Conclusion: In conclusion, Right ventricle to pulmonary artery connection used in patients with TOF/PA/MAPCA as an inital procedure appeared to be highly successful in enhancing the chance of satisfactory definitive repair without the significant surgical risks. One-stage total repair at an ealier age group could be performed safely with the resonable outcomes. Unifocalization approach, whether it was performed in a single stage or in the multiple stages, resulted in the high operative mortality and the lowest chance of definitive repair, however more tailored selection of the patients and the long follow-up is mandatory to prove the usefulness of this approach.

• Journal of Chest Surgery
• /
• v.32 no.7
• /
• pp.621-627
• /
• 1999

Background: Sixty five cases with congenitally corrected transposition of the great arteries (CCTGA) indicated for biventricular repair were operated on between 1984 and september 1998. Comparison between the results of the conventional(classic) connection(LV-PA) and the anatomic repair was done. Material and Method: Retrospective review was carried out based on the medical records of the patients. Operative procedures, complications and the long-term results accoding to the combining anomalies were analysed. Result: Mean age was 5.5$\pm$4.8 years(range, 2 months to 18years). Thirty nine were male and 26 were female. Situs solitus {S,L,L} was in 53 and situs inversus{I,D,D} in 12. There was no left ventricular outflow tract obstruction(LVOTO) in 13(20%) cases. The LVOTO was resulted from pulmonary stenosis(PS) in 26(40%)patients and from pulmonary atresia(PA) in 26(40%) patients. Twenty-five(38.5%) patients had tricuspid valve regurgitation(TR) greater than the mild degree that was present preoperatively. Twenty two patients previously underwent 24 systemic- pulmonary shunts previously. In the 13 patients without LVOTO, 7 simple closure of VSD or ASD, 3 tricuspid valve replacements(TVR), and 3 anatomic corrections(3 double switch operations: 1 Senning+ Rastelli, 1 Senning+REV-type, and 1 Senning+Arterial switch opera tion) were performed. As to the 26 patients with CCTGA+VSD or ASD+LVOTO(PS), 24 classic repairs and 2 double switch operations(1 Senning+Rastelli, 1 Mustard+REV-type) were done. In the 26 cases with CCTGA+VSD+LVOTO(PA), 19 classic repairs(18 Rastelli, 1 REV-type), and 7 double switch operations(7 Senning+Rastelli) were done. The degree of tricuspid regurgitation increased during the follow-up periods from 1.3$\pm$1.4 to 2.2$\pm$1.0 in the classic repair group(p<0.05), but not in the double switch group. Two patients had complete AV block preoperatively, and additional 7(10.8%) had newly developed complete AV block after the operation. Other complications were recurrent LVOTO(10), thromboembolism(4), persistent chest tube drainage over 2 weeks(4), chylothorax(3), bleeding(3), acute renal failure(2), and mediastinitis(2). Mean follow-up was 54$\pm$49 months(0-177 months). Thirteen patients died after the operation(operative mortality rate: 20.0%(13/65)), and there were 3 additional deaths during the follow up period(overall mortality: 24.6%(16/65)). The operative mortality in patients underwent anatomic repair was 33.3%(4/12). The actuarial survival rates at 1, 5, and 10 years were 75.0$\pm$5.6%, 75.0$\pm$5.6%, and 69.2$\pm$7.6%. Common causes of death were low cardiac output syndrome(8) and heart failure from TR(5). Conclusion: Although our study could not demonstrate the superiority of each classic or anatomic repair, we found that the anatomic repair has a merit of preventing the deterioration of tricuspid valve regurgitations. Meticulous selection of the patients and longer follow-up terms are mandatory to establish the selective advantages of both strategies.