• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1995-1998
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• 2013

Objective: To study the expression of the mismatch repair proteins hMSH2 and nm23 in sporadic colorectal cancer, determine any inter-relationship, and further investigate any clinical significance. Methods: Expression of hMSH2 and nm23 proteins was assessed in 87 colorectal cancer tissues by SP immunohistochemistry, with analysis of survival using follow-up data. Results: In the sporadic colorectal cancer tissues, nm23 protein expression appeared independent of the histological type (P>0.05), but correlated with the invasion depth and lymphatic metastasis (P<0.05). In contrast, hMSH2 protein expression was not significantly correlated with these clinicopathologic features (P>0.05), although it positively correlated with that of nm23 protein in the sporadic colorectal cancers (rs=0.635, P<0.05). Combined expression of the two was found to be related with invasion depth, lymphatic metastasis and prognosis of sporadic colorectal cancer (P<0.05). Conclusion: nm23 protein level was related with the degree of malignancy, and could be used as an index to predict the invasion and metastasis potential. The expression of hMSH2 protein is positively correlated that of nm23 protein, and the combined expression of the two has certain guiding significance for the prognosis of sporadic colorectal cancer.

• Computational Structural Engineering : An International Journal
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• v.1 no.1
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• pp.59-69
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• 2001

This study is intended to propose a systematic approach for reliability-based assessment of life cycle cost (LCC) effectiveness and economic efficiency for cost-effective seismic upgrading of existing bridges. The LCC function is expressed as the sum of the upgrading cost and all the discounted life cycle damage costs, which is formulated as a function of the Park-Ang damage index and structural damage probability. The damage costs are expressed in terms of direct damage costs such as repair/replacement costs, human losses and property damage costs, and indirect damage costs such as road user costs and indirect regional economic losses. For dealing with a variety of uncertainties associated with earthquake loads and capacities, a simulation-based reliability approach is used. The SMART-DRAIN-2DX, which is a modified version of the well-known DRAIN-2DX, is extended by incor-porating LCC analysis based on the LCC function developed in the study. Economic efficiencies for optimal seismic upgradings of the continuous PC segmental bridges are assessed using the proposed LCC functions and benefit-cost ratio.

• Ocean and Polar Research
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• v.29 no.4
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• pp.319-326
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• 2007

Coastal marine ecosystems continue to suffer unrelenting pressures from human population growth, increased development, and climate change. Moreover, these systems' capacity for self-repair is declining with such increases in anthropogenic production of various pollutants. What is the present health status or condition of the coastal ecosystem? If our coastal areas are unhealthy, which conditions are considered serious? To answer such questions, the United States, Canada, and Australia are currently assessing coastal ecosystem health using systematic monitoring programs as well as identifying and implementing management plans to improve the health of degraded coastal ecosystems. To evaluate marine environments, Korea is currently using a limited number of factors to estimate water quality. In fact, we are ill-prepared for assessing coastal ecosystem health because no biologically specific criteria are in place to measure the responses to various pollutants. We should select ecosystem-specific indicators from physicochemical stressors and evaluate the subsequent biological responses within each ecosystem. Furthermore, a set of practical indicators should be generated by considering the characteristics and uses of a local coastal area and the key issues at hand. The values of indicators should be presented as indices that allow understanding by the general public as well as by practitioners, policy makers, environmental managers and other stakeholders.

• Earthquakes and Structures
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• v.7 no.5
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• pp.609-626
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• 2014

The capabilities of a high-resolution Digital Image Correlation (DIC) system are presented within the context of deformation measurements of full-scale concrete columns tested under reversed cyclic loading. The system was developed to have very high-resolution such that material strains on the order of the cracking stain of concrete could be measured on the surface of full-scale structural members. The high-resolution DIC system allows the measurement of a wide range of deformations and strains that could only be inferred or assumed previously. The DIC system is able to resolve the full profiles of member curvatures, rotations, plasticity spread, shear deformations, and bar-slip induced rotations. The system allows for automatic and objective measurement of crack widths and other damage indices that are indicative of cumulated damage and required repair time and cost. DIC damage measures contrast prevailing proxy damage indices based on member force-deformation data and subjective damage measures obtained using visual inspection. Data derived from high-resolution DIC systems is shown to be of great use in advancing the state of behavioral knowledge, calibrating behavioral and analytical models, and improving simulation accuracy.

• Korean Journal of Bronchoesophagology
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• v.6 no.1
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• pp.90-95
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• 2000

Isolated(H-type) tracheoesophageal fistula without esophageal atresia occurs in approximately 4% of esophageal anomalies, and represents the least form of abnormal laryngotracheo-esophageal communication. Its symptoms such as coughing and choking The during the feeding, abdominal distension and recurrent pneumonitis usually start from birth. Diagnosis is made between 4 days to 4 years using the contrast esophagography and/or tracheoscopy. In case of diagnostic delay the postoperative mortality is not negligible and the most common cause of mortality is respitatory problems(infection, respiratory distress). So early diagnosis is essential in the newborn period with high index of suspicion. We report a case of H-type TEF in which operative repair was successful with references to recent literature.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.1
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• pp.126-135
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• 2017

Objectives : The purpose of this study was to evaluate the therapeutic efficacy of Sae-ssack(sprout) therapy on atrophic acne scars. Methods : Twenty patients had atrophic acne scars on the face were treated with Sae-ssack therapy. Sae-ssack therapy consists of a total of three treatments, a first-stage Sae-ssack acupuncture, a second-stage texture treatment, and a third-stage anti-pigmentation therapy. The evaluation of the treatment effect was made by the Korean medical doctor who did not participate in the procedure, and the PGA(Physician's Global Assessment), QGASC(Qualitative Global Acne Scarring Grade System) and patient satisfaction were used as the evaluation index. Results and Conclusions : According to the above indicates, the Sae-ssack therapy was evaluated to be effective in the repair of atrophic acne scars. There were no visible or consistent side effects and patient satisfaction was also very high.

• Journal of Chest Surgery
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• v.27 no.8
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• pp.695-699
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• 1994

Pectus excavatum. the most common congenital chest wall deformity, is manifested by deformity of the costal cartilages resulting in a depressed and often rotated sternum. Surgical correction of this disease is frequently indicated for aesthetic improvement. The most popular current repair involves resection of abnormal costal cartilages, sternal osteotomy and mobilization, followed by fixation of the sternum in the corrected position.12 patients have been operated upon for pectus excavatum by the Adkins` method for 8 years in our hospital and the results were as follows: 1. All the patients were male. Age distribution was 2-26 years[average 10.8 years] and 69.2% were below 7 years. 2. The deformity was found at neonate or infant in the most of the patients [92.3 %] 3. The subjective symptoms were frequent URI[35.7%], dyspena on exertion[21.4%], chest dis comfort[7.1%], asthma [7.1%] and most of the patients didn`t like their appearance. 4. Combined diseases were urticaria in 2 cases, bilateral cryptomhism and pulmonary tuberculosis in 1 case each other. 5. Welch index ranged from 1.7 to 5.0 with the average of 3.47. 6. Postoperative complications were pneumothorax [45.5%], wound infection [36.4%] and skin necrosis [18.2%]. Although the period of follow-up was short in some cases there was no relapse.

• Journal of the Korea institute for structural maintenance and inspection
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• v.6 no.4
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• pp.189-199
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• 2002

This study is intended to propose a systematic procedure for the development of the conditional assessment based on the safety of structures and the cost effective performance criteria for designing and upgrading of bridge structures. As a result, a set of cost function models for a life cycle cost analysis of bridge structures is proposed and thus the expected total life cycle costs (ETLCC) including initial (design, testing and construction) costs and direct/indirect damage costs considering repair and replacement costs, human losses and property damage costs, road user costs, and indirect regional economic losses costs. Also, the optimum safety indices are presented based on the expected total cost minimization function using only three parameters of the failure cost to the initial cost (${\tau}$), the extent of increased initial cost by improvement of safety (${\nu}$) and the order of an initial cost function (n). Through the enough numerical invetigations, we can positively conclude that the proposed optimum design procedure for bridge structures based on the ETLCC will lead to more rational, economical and safer design.

• Journal of Intelligence and Information Systems
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• v.6 no.2
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• pp.99-110
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• 2000

오늘날의 기업은 상품을 판매하는 것 뿐만 아니라 기업의 신용과 이미지를 위해 그 상품에 대한 사후처리(After Service) 업무에 많은 투자를 하고 있다. 이러한 양질의 사후서비스를 고객에게 공급하기 위해서는 많은 인력을 합리적으로 관리해야 하며 요청되는 고장수리 서비스 업무의 신속한 해결을 위해 업무를 인력에게 합리적으로 배정을 해야 한다. 그러므로, 회사의 비용을 최소화하면서 정해진 시간에 요청된 작업을 처리하기 위해서는 인력들에게 작업을 배정하고 스케줄링하는 문제가 발생된다. 본 논문에서는 이러한 문제를 해결하기 위해서 화학계기의 A/S작업을 인력에게 합리적으로 배정 하는 스케줄링 시스템에 관한 연구이다. 먼저 스케줄링 모델을 HP사의 화학분석 및 시스템을 판매, 유지보수 해주는 Y사의 작업 스케줄을 분석하여 필요한 도메인과 고객서비스전략과 인력관리전략에서 제약조건을 추출하였고 여기에 스케줄링 문제를 해결하기 위한 방법으로 제약만족문제(CSP) 해결기법인 도메인 여과기법을 적용하였다. 도메인 여과기법은 제약조건에 의해 변수가 갖는 도메인의 불필요한 부분을 여과하는 것으로 제약조건과 관련되어 있는 변수의 도매인 크기가 축소되는 것이다. 또한, 스케줄링을 하는데에 있어서 비용적인 측면에서의 스케줄링방법과 고객만족도에서의 스케줄링 방법을 비교하여 가장 이상적인 해를 찾는데 트래이드오프(Trade-off)를 이용하여 최적의 해를 구했으며 실험을 통해 인력에게 더욱 효율적으로 작업들을 배정 할 수 있었고 또한, 정해진 시간에 많은 작업을 처리 할 수 있었으며 작업을 처리하는데 있어 소요되는 비용을 감소하는 결과를 얻을 수 있었다.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.10
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• pp.102-111
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• 2021

Maintainability is a major design parameter that includes availability as well as reliability in a RAM (reliability, availability, maintainability) analysis, and is an index that must be considered when developing a system. There is a lack of awareness of the importance of predicting and analyzing maintainability; therefore, it is dependent on past-experience data. To improve the utilization rate, maintainability must be managed as a key indicator to meet the user's requirements for failure maintenance time and to reduce life-cycle costs. To improve the maintainability-prediction accuracy in the detailed design stage, we present a maintainability-prediction method that applies Method B of the Military Standardization Handbook (MIL-HDBK-472) Procedure V, as well as a Korean maintainability-prediction software package that reflects the system complexity.