• Journal of Microbiology and Biotechnology
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• v.34 no.2
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• pp.415-424
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• 2024

This study reveals that low-molecular-weight collagen peptide (LMWCP) can stimulate the differentiation and the mineralization of MC3T3-E1 cells in vitro and attenuate the bone remodeling process in ovariectomized (OVX) Sprague-Dawley rats in vivo. Moreover, the assessed LMWCP increased the activity of alkaline phosphatase (ALP), synthesis of collagen, and mineralization in MC3T3-E1 cells. Additionally, mRNA levels of bone metabolism-related factors such as the collagen type I alpha 1 chain, osteocalcin (OCN), osterix, bone sialoprotein, and the Runt family-associated transcription factor 2 were increased in cells treated with 1,000 ㎍/ml of LMWCP. Furthermore, we demonstrated that critical bone morphometric parameters exhibited significant differences between the LMWCP (400 mg/kg)-receiving and vehicle-treated rat groups. Moreover, the expression of type I collagen and the activity of ALP were found to be higher in both the femur and lumbar vertebrae of OVX rats treated with LMWCP. Finally, the administration of LMWCP managed to alleviate osteogenic parameters such as the ALP activity and the levels of the bone alkaline phosphatase, the OCN, and the procollagen type 1 N-terminal propeptide in OVX rats. Thus, our findings suggest that LMWCP is a promising candidate for the development of food-based prevention strategies against osteoporosis.

• Archives of design research
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• v.19 no.1 s.63
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• pp.329-334
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• 2006

Present age are embossing importance and role of tourism industry according to increase of tourists number by internationalization gradually. Susan is necessity to ready our unique cultural special quality that is correct to this because is intending international sightseeing city in APEC, PIFF etc. Specially, the hotel does the mediation deposit role which provides the place it will be able to experience our specific culture in the tourists. The Comodo-Hotel situated in Jung-gu, Susan has elements the Korean traditional culture, but there is problem that these elements is not applied to room interior. Therefore, hotel room remodeling applied to Aesthetic Attributes of the Korea Traditional does so that tourists do it so that may experience our culture familiarly and advances continuously and preserves and inherits our culture together and become universal culture. Target hotel room chooses by Standard-double, Deluxe-twin, Semi-Suite-ondol three type and applies modernity and Traditional characteristics of Korean culture variously and proposes interior remodeling.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.11a
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• pp.169-172
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• 2006

Wall construction apartment built before 1988 years need internal examination reinforcement according to existing laws ans regulations at remodeling because do not earthquake resistant design. Established newly wall to interest paid back at the same time a the principal direction for wall construction apartment internal examination reinforcement, and satisfied internal examination standard because uses width displacement between floor. This study analyzes displacement value such as latitude and presented position of efficient reinforcement wall and wall quantity at earthquake resistant design of wall construction apartment.

• Proceedings of the Korean Institute of Interior Design Conference
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• 2005.10a
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• pp.201-204
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• 2005

In this building, we never use the existing construction methods such as disassembly, destruction and newly construction to ensure the eco-friendly building and to decrease of waste disposal. We make customers feel newly by using minimum materials, pursuing the 'Best Design Using Lower Material' slogan and remodeling the building partially. The line is the most informal type one which is lack of intention. This line formation is harmonized with self-efficiency and completeness that are not required for unnecessary things, and simple unification which has not alternatives or obstacles.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2014.05a
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• pp.188-189
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• 2014

Recently, structural system of apartment building is changing from wall type to column type to accommodate various life styles of residents in Korea. Reinforced-concrete bearing wall structures have been mainly used in apartment construction since 1980's. It is impossible to remove the bearing wall in case of remodeling a house, so that the lightweight wall is needed to apply to the column type structure of the Long Life Housing. Therefore, the purpose of this study is to evaluate the construction performance of the wall. Constructibility reviews are performed throughout interview survey from builders who charge with managing the construction of the lightweight wall in field. This paper present that constructor prefer the bearing wall rather than the lightweight wall because of the schedule delay, difficulty of management, and lack of skilled labor. The results indicate what we should improve on the lightweight wall from now on.

• Journal of the Korea Furniture Society
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• v.25 no.3
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• pp.182-187
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• 2014

Underground shopping center has become a important commercial facility due to their good accessibility to the public transport. However, underground shopping center has high risk of air contaminants emission like formaldehyde and lowered indoor air quality. In this study, formaldehyde concentration of the underground shopping center was estimated according to the renovation and characteristics of space. It was found that newly renovated underground shopping center has low formaldehyde concentration. In case of closed entrance type, the formaldehyde concentration was 320 % higher than open type. Formaldehyde concentration was varied by product type and especially, high formaldehyde concentration was measured near the stores selling nail polish and cosmetics. It is important to apply appropriate ventilation system according to characteristics of space.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.54 no.2
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• pp.53-59
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• 2005

In this paper, optimum shape design of permanent magnet in slotted type Permanent Magnet Linear Synchronous Motor(PMLSM) is progressed for minimization of detent force owing to structure of slot-teeth and thrust ripple by harmonic magnetic flux of permanent magnet. In order to reduce remodeling time as changing design parameter for Permanent Magnet shape optimization, the moving model node technique was applied. The characteristics of thrust and detent force computed by finite element analysis are acquired equal effect both skewed basic model and optimum model which is optimization of permanent magnet shape. In addition to, thrust per unit volume is improved 4.l2[%] in optimum model.

• Journal of the Korean Institute of Rural Architecture
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• v.17 no.1
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• pp.121-128
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• 2015

The elderly rate in South Korea in 2013 is over 12%. Especially, the elderly rate in rural area is 36%, i.e., in rural area, one of three is people aged 65 and over. Senior community project in rural that is being promoted by the government. This project is to improve the quality of life health and welfare services for the elderly in rural Area. This paper investigates cases used as living space by interview and remodeling senior centers (village community center) for the elders living alone in rural areas. In Gimje two the nation's first senior centers were remodeled in 2006 (for both the village community center) and were begun to use these as group homes. Evaluation was a success. Since then, these were increased by approximately 20 centers per year by year and are currently 108 centers at the end of 2011. In Chungcheongnam-do, a pilot project has been begun for communal living by remodeling the senior center (for both the village community center) and elderly housing. Municipalities are similar in their business (is mostly). Senior community center projects can proceed smoothly in the direction of some of the following tips and suggestions to promote. Senior community center should be expanded for 'private room type'. Government must support the operating costs. It will increase employment in rural areas. Senior community center should be 'Home Atmosphere'.

• Archives of Plastic Surgery
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• v.38 no.3
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• pp.222-227
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• 2011

Purpose: Autogenous particulate bone grafting is a type of autogenous bone graft that consists of small particles of cortical and cancellous bone. Autogenous particulate bone grafting has been used for calvarial bone defect after calvarial defect of craniosynostosis and prevention of temporal depression after fronto-orbital advancement. The results were followed up and studied for effectiveness of autogenous calvarial particulate bone grafting. Methods: Cranial vault remodeling and fronto-orbital advancement was performed for six craniosynostosis patient from August 2005 to October 2007. Autogenous particulate bone grafting was harvested from endocortex of separated cranial vault and if insufficient, from extocortex of occipital region using Hudson brace & D'Errico craniotomy bit and was grafted on the calvarial bone defect of cranial vault and temporal hollow. Fibrin glues were added to the harvested particulated bone for adherence and shaping of paticles. Results: Autogenous particulate bone grafting was followed-up at least longer than I year. The calvarial bony defects following primary cranial remodeling were successfully covered and postoperative temporal depressions after fronto-orbital advancement were also well prevented by grafted particulated bone. Conclusion: Autogenous calvarial particulate bone graft can be harvested in infants and young children with minimal donor site morbidity. It effectively heals cranial defects in children and during fronto-orbital advancement reduces the prevalence of osseous defects independent of patient age. It's easy and effective method of reconstruction of calvarial defect.

• Journal of Microbiology and Biotechnology
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• v.28 no.10
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• pp.1614-1625
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• 2018

Periodontitis, which is a severe inflammatory disease caused by endotoxins secreted from oral pathogens, destructs gingival tissue and alveolar bone. Curcuma xanthorrhiza, commonly called Java turmeric, has been shown to possess anti-bacterial and anti-inflammatory activities. The present study evaluated the inhibitory effect of C. xanthorrhiza supercritical extract (CXS) standardized with xanthorrhizol on lipopolysaccharide (LPS)-induced periodontitis in an animal model. LPS was topically injected into the periodontium of Sprague-Dawley rats to induce periodontitis and CXS (30 and $100mg{\cdot}kg^{-1}{\cdot}day^{-1}$) was orally administered after day 12. Histologically, CXS inhibited the collapse of gingival tissue by preventing cell infiltration. CXS significantly downregulated the expression of matrix metalloproteases (MMPs) and inflammation-related biomarkers, such as nuclear factor-kappa B ($NF-{\kappa}B$) and interleukin-1 beta ($IL-1{\beta}$) in gingival tissue. CXS also improved bone remodeling by downregulating osteoclastic transcription factors, such as nuclear factor of activated T-cells c1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K. In addition, CXS upregulated osteoblast differentiation-related markers, alkaline phosphate (ALP) and collagen type I alpha (COLA1). Thus, CXS can ameliorate periodontitis by inhibiting inflammation and improving bone remodeling.