• Molecules and Cells
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• v.41 no.10
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• pp.900-908
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• 2018

Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) ${\gamma}$. Although TZDs are synthetic ligands for $PPAR{\gamma}$, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.14 no.11
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• pp.972-980
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• 2002

This work is aimed at estimating the effects of various factors on the energy consumption of Korean-style apartment houses using TRNSYS. The factors considered here include the nominal size of floor area, type of remodeling, azimuth, sidewall insulation, and window type. Based on some assumptions, an actual apartment house is simplified into a model that is used for thermal load calculations. The simplified model is validated by showing a good agreement with the actual one in the predicted result. Remodeling balconies into unconditioned buffer spaces yields a favorable thermal performance in comparison with the original type regardless of the nominal size. Incorporating balconies into a conditioned indoor space leads to sharp increases in thermal loads, which must be avoided in view of energy conservation as well as structural problem. A quantitative assessment on the azimuthal effect indicates that the heating energy can be saved up to 16％ by taking the south or southeast direction. Reduction in the heating load with enhancing the sidewall insulation is gradual, so that a cost-effectiveness analysis may be needed when amending the regulations concerned. Glazing appears to significantly affect the heat transfer through window. A typical case illustrates that the heating load is decreased about 25％ by simply adopting triple glazing instead of double glazing.

• Korean Journal of Construction Engineering and Management
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• v.18 no.6
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• pp.89-97
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• 2017

The number of Aged Apartment units is expected to increase as time went on. Living standards are getting better and they want a new apartment space as the economy progresses. Therefore, it is necessary to prepare for the increasing remodeling market through the feasibility evaluation method that can be applied to the remodeling project of the apartment house. The purpose of this study is to analyze the social pricing factors affecting the Officially assessed individual House Price for the analysis model of commercial house remodeling. The collected samples were analyzed using multiple regression analysis of 350 prices included in 127 lots. Middle school level, high school level, total number of households, and floor area ratio were extracted. As a result of comparing the Officially assessed individual House Price by applying to the remodeling case, the difference between the existing Officially assessed individual House Price and the improvement Officially assessed individual House Price is different. The accessibility with the subway station is included in the land price, and there is no change in the number of stories and directions because it is customized remodeling. There was a difference in the disclosure price depending on the type of factor extraction by the evaluator in a batch application of the disclosure price factors. The research can be used as a model for future remodeling business feasibility analysis.

• Archives of design research
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• v.15 no.1
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• pp.191-202
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• 2002

As family types have been diverse, patterns of living and living space became diverse as much as users are. Therefore, it is needed to provide various remodeled design of living space corresponding to changes of users'living patterns, and to provide these remodeling process to users directly on the web. In this paper, use scenario for the Internet-based Virtual Apartment Remodeling Simulator is researched as an export system to remodel space in accordance with users diverse lifestyle paradigm and the website is developed. The study consists of four parts. First, the general concept of remodeling, including the range and types of remodeling, are defined, and the misleading terms in this field are reviewed and organized by secondary research Second, fixed factors and variable factors are differentiated in the complex building for residence and business that was decided as a basic building type in this study. Third, there needed a database for consulting, final material, pre-estimation real estimation for simulation of remodeling. This database was introduced along with floor plan and elevation. Finally, the remodeling simulator is presented by the case study developed on the web. The system structure and use scenario are also presented. In order to present and inspect design alternatives, prototype was produced. The Final simulator was enhanced by defeating problems regarding interface efficiency and missing information of existing online site.

• The korean journal of orthodontics
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• v.31 no.1 s.84
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• pp.97-105
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• 2001

In many cases of orthodontic treatment the upper anterior teeth are retracted. Periodontal problems may arise during incisor retraction, if the amount of tooth movement and the amount of remodeling in the anterior cortical bone are not the same. Therefore in this study, to find out the relationship between the amount of tooth movement and the amount of bone remodeling during retraction of the upper anterior teeth, lateral cephalograms of 56 female patients over 18-year-old were taken before and after treatment. Among the 56 patients, two groups were divided according to the type of root movement during retraction. 26 patients mainly moved by tipping and 30 by bodily movement. The cephalograms taken before and after treatment were superimposed upon the true horizontal plane. In the Tip-Group, the horizontal bone remodeling/tooth movement ratio was 1:1.63, and in the Torque-Group it was 1:1.66. Because the amount of tooth movement and the amount of bone remodeling were not the same in both groups, in the Tip-Group the root apex moved away from the palatal cortical plate and closer to the labial cortical plate, whereas in the Torque-Group the root moved away from the labial cortical plate and closet to the palatal cortical plate. Therefore, there are limitations in the amount of incisor retraction in patients with a very thin anterior cortical plate in the maxilla, and in patients with severe skeletal discrepancies orthognathic surgery should be considered and when orthodontic camouflage treatment is the only possible method, the orthodontist must be aware of the limitations of treatment.

• Journal of Korean Society of Water and Wastewater
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• v.20 no.6
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• pp.911-918
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• 2006

This study was conducted to evaluate the effect of the launder type on settling performance and hydrodynamic behavior within the two certain full-scale sedimentation basins (each flow rate/one basin; $10,000m^3/d$); one is the transverse typed launder(existing basin) and the other is building the finger type launder in combination with the longitudinal baffle. Comparative experimental investigations have been carried out through residual turbidity and particle concentration measurements in each effluent from two basins with the transverse and the finger type launders, respectively. From the experimental results, we could observe that turbidity removal rate in the finger type launder basin (modified basin) is about 30% higher than that in the transverse type launder basin (existing basin). Also, from the measurement of total particle concentration in each effluent, the removal efficiency was improved about 27% within modified basin compared to the existing basin. In order to explain the comparative experimental results and investigate the hydridynamic behavior within each basin in more detail, we conducted computational fluid dynamics (CFD) simulation and verified simulation results with acoustic Doppler velocimetry (ADV) technique. From the CFD simulation, it was investigated that extreme upward flow occurs underneath of the transverse launder. On the other hand, in the case of modified basin, the upward flow, which occurred in the beneath of launder, was much less than that in the existing basins.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.19 no.4
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• pp.1-17
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• 2016

In this study, remodeling projects are perceived as a sustainable urban management policy to boost the value of old apartments and stimulate urban regeneration and development. To evaluate the physical environmental performance of external spaces of remodeled apartments, an evaluation model was developed. After applying it to the target places, the following results were obtained. First, analysis of the external space change index of the target apartments revealed that institutional standards are necessary in line with the building arrangement type, parking lot expansion method, and changes in the building-to-land ratio. Second, the score ratio as to the external space change index performance is as follows: safety (48.30); pleasantness (25.90); convenience (18.90); eco-friendliness (14.90). In other words, "safety" had the biggest score ratio. Third, to boost the external space performance of remodeled apartments, the needs of residents and neighboring environmental plans should be considered from a communality standpoint.

• Journal of the Korean housing association
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• v.21 no.3
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• pp.33-40
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• 2010

Apartments have been the most prevalent type of housing in Korea for the past few decades. During those times, apartments have emerged as one of the most attractive real estate properties in Korea, with the still growing population living in them. Now that over twenty years have passed since the 1970s and 1980s when apartment construction started booming, building stocks are increasing that need refurbishment. In this concern, apartment extension has raised public interest for the past few years, as the remodeling of them has mainly been considered in terms of increasing asset value in Korea. It comes through in our study that these extension types are examined by such items as building core types, number of rooms and front and rear bays in unit, and other design features related to extension techniques. The objective of this study is to suggest a way to produce the best quality possible of unit plan through extension.

• Journal of Chest Surgery
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• v.45 no.4
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• pp.205-212
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• 2012

Aortic valve sparing operations were developed to preserve the native aortic valve during surgery for aortic root aneurysm as well as surgery for ascending aortic aneurysms with associated aortic insufficiency. There are basically two types of aortic valve sparing oprations: remodeling of the aortic root and reimplantation of the aortic valve. These operations have been performed for over two decades and the clinical outcomes have been excellent in experienced hands. Although remodeling of the aortic root is physiologically superior to reimplantation of the aortic valve, long-term follow-up suggests that the latter is associated with lower risk of developing aortic insufficiency. Failure of remodeling of the aortic root is often due to dilatation of the aortic annulus. Thus, this type of aortic valve sparing should be reserved for older patients with ascending aortic aneurysm and normal aortic annulus whereas reimplantation of the aortic valve is more appropriate for young patients with inherited disorders that cause aortic root aneurysms. This article summarizes the published experience with these two operations. They are no longer experimental procedures and should be part of the surgical armamentarium to treat patients with aortic root aneurysm and ascending aortic aneurysms with associated aortic insufficiency.

• Proceedings of the SAREK Conference
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• 2008.06a
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• pp.569-574
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• 2008

Recently, the domestic remodeling market is increased in scale. This study is to develop the sanitary piping system which improves quality of life and facility performance when the aged public housing is remodeled. Above all, we found out three standard floor plans in bathrooms of the public housing. And then, the plan and section types of the sanitary piping system were developed for the on-floor piping, a construction cost of each section types was estimated to review the economical fact. Also, the field mock-up test was performed in the type of the pipe shaft with on-floor pit. In result, the developed sanitary piping system was available for the remodeling public housing without a great facility cost. Additionally, the sanitary pipe was replaced easily through the shaft and on-floor fit. And a noise was reduced to a lower unit when the water flowed down.