• Herbal Formula Science
• /
• v.18 no.1
• /
• pp.155-167
• /
• 2010

Objectives : In order to investigate the antidepressant effects of Forsythiae Fructus(FF), we performed the Forced Swimming Test(FST). Also the expressions of corticotropin-releasing factor (CRF), c-Fos and tyrosine hydroxylase(TH) were measured by immunohistochemical method at paraventricular nucleus(PVN), ventral tegmental area(VTA) and locus coeruleus(LC). Methods : Spraque-Dawley rats were administered FF extract(100 mg/kg, 400 mg/kg) intragastrically three times prior to the FST. Results : The duration of immobility in the FST was significantly decreased in the FF 100 mg/kg, 400 mg/kg groups(p<0.05). The expression of CRF was significantly reduced in the FF 100 mg/kg and 400 mg/kg groups(p<0.001). c-Fos expression was significantly decreased at PVN in the FF 100 mg/kg group(p=0.069). TH expression at VTA was significantly increased in the FF 100 mg/kg and 400 mg/kg groups(p<0.05). TH expression at LC was not significantly changed(p=0.346). Conclusion : According to the results, it can be suggested that Forsythiae Fructus has antidepressant effect via the decreased immobility through the reduction of CRF and c-Fos expression at PVN.

• Journal of Energy Engineering
• /
• v.17 no.4
• /
• pp.212-217
• /
• 2008

This study carried out the safety evaluation of non-refillable butane can for portable gas range equipped with relief valve for prevention of explosion. The can is heated by electric heater at the real using condition and the extreme condition after installing at a portable gas range for checking the operating pressure and the evaluating suitability of releasing flux. And the possibility of fire or explosion was tested when the gas was released from the relief valve at the real condition. As a result of this safety evaluation test, a non-refillable butane can with relief valve prevents the can from exploding by control of internal pressure.

• The Journal of Korean Physical Therapy
• /
• v.31 no.3
• /
• pp.157-160
• /
• 2019

Purpose: We compared the activation pattern of the mirror neurons (MN) between two types of hand movement according to action observation using functional MRI. Methods: Twelve right-handed healthy subjects (5 male and 7 female, mean age $21.92{\pm}2.02years$) participated in the experiment. During fMRI scanning, subjects underwent two different stimuli on the screen: 1) video clips showing repeated grasping and releasing of the ball via simple hand movement (SHM), and (2) video clips showing an actor performing a Purdue Pegboard test via complex hand movement (CHM). paired t-test in statistical parametric mapping (SPM) was used to compare the activation differences between the two types of hand movement. Results: CHM as compared with the SHM produced a higher blood oxygen level dependent (BOLD) signal response in the right superior frontal gyrus, left inferior and superior parietal lobules, and lingual gyrus. However, no greater BOLD signal response was found by SHM compared with CHM (FWE corrected, p<0.05). Conclusion: Our findings provided that the activation patterns for observation of SHM and CHM are different. CHM also elicited boarder or stronger activations in the brain, including inferior parietal lobule called the MN region.

• Journal of Drive and Control
• /
• v.18 no.2
• /
• pp.46-55
• /
• 2021

A forklift is a powered industrial vehicle used to lift and move materials over short distances. Nowadays, almost all forklifts are equipped with an automatic transmission due to its improved operator comfort and increased productivity. Thanks to marked improvement of transmission control unit equipped with highly-advanced microcontrollers, recently developed automatic transmission for forklift have various auxiliary functions such as creep, auto retardation, and automatic shift with excellent shift quality. This paper deals with the creep function which enables one to maneuver a forklift at the designated low speed by slip control of clutches. The design of creep function was based on four modes of creep operation depending on the status of the operator's shift lever and accelerator pedal. Control algorithms and control parameters for each mode were designed to achieve the desired static and dynamic performance. Vehicle test for the designed creep function was carried out with an independently developed embedded controller. Test results confirmed good creep speed control without speed error at a steady state with a mild shift shock during mode changes by stepping or releasing the accelerator.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.37 no.4
• /
• pp.422-428
• /
• 2010

Giomer is fluoride-releasing, resin-based dental materials that comprise PRG(pre-reacted glass ionomer) filler. The purpose of this study was to evaluate the shear bond strength of Giomer using self-etching primer systems to bovine dentin. Bovine incisors were mounted in self-curing orthodontic resin and the facial surfaces were wet ground on SIC paper to expose the dentin. Total 100 samples were made and divided randomly into 4 groups, Giomer group(I), Composite resin group(II) and Compomer group(III), Giomer and single bottle adhesive group(IV). The shear bond strengths of 25 samples per each group were measured using universal testing machine. And data were analyzed statistically with One-way ANOVA and Scheffe test. Giomer group(I) showed the significantly higher bond strength than Compomer group(III)(p<0.05). There was no significant difference between Giomer group(I) and Composite resin group(II)(p>0.05). And there is no significant difference between gourp(I) and group(IV). Based on the results of present study, the use of Giomer as an esthetic restorative material for primary teeth might be justified. It is considered that more study about the fluoride releasing ability is needed to evaluate the anticariogenic effect of giomer.

• Journal of Digital Convergence
• /
• v.18 no.4
• /
• pp.55-65
• /
• 2020

The factors for service quality improvement of frozen and refrigerated warehouses are derived and the differences in perception about service quality improvement between shippers and operators of frozen and refrigerated cargos are analyzed. The objective of this study is to propose quality improvement measures for frozen and refrigerated cargo services using the importance-performance analysis (IPA). As a result, 15 analysis factors were derived. It was found through independent sample t-test that there is no difference in perception about quality improvement between shippers and operators. Furthermore, four top priority investment areas were derived from the IPA: maintaining temperature and humidity, securing variable storage space, on-time stocking and releasing, and providing information service. Meanwhile, inventory management service ability, on-time stocking and releasing, and reliable cargo storage ability needed urgent improvement. This study has industrial implications in that it proposes practical improvement measures for service quality improvement.

• Journal of Sensor Science and Technology
• /
• v.9 no.3
• /
• pp.233-241
• /
• 2000

This paper presents comparative results of various commonly used anti-stiction methods for polysilicon surface micromachining using identical test structures. Four different types of cantilevers - single cantilevers, cantilevers with dimples, cantilevers with anti-stiction tip, cantilevers with plate - with different widths and lengths were employed as test structures. The detachment length of cantilevers was examined depending on the anti-stiction methods and test structure types. After sacrificial layer was removed, evaporation and sublimation drying methods were used in the drying step when takes place the stiction between structure and substrate. Various final rinsing liquids such as methanol, IPA, and DI water were employed to compare anti-stiction results depending on surface tension and rinsing temperature. For sublimation drying method, methanol was used as an intermediate rinsing liquid. Also, the influence of a stress gradient of the polysilicon was investigated by performing the identical anti-stiction experiments on identical test structures with a stress gradient. In conclusion, sublimation drying method showed superior results to various evaporation drying methods and hence it is considered the best method for releasing polysilicon microstructure in polysilicon surface micromachining.

• Biomolecules & Therapeutics
• /
• v.21 no.4
• /
• pp.313-322
• /
• 2013

Previous studies have demonstrated that repeated administration of the exogenous stress hormone corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis and results in depression and anxiety. The current study sought to verify the impact of catechin (CTN) administration on chronic CORT-induced behavioral alterations using the forced swimming test (FST) and the elevated plus maze (EPM) test. Additionally, the effects of CTN on central noradrenergic systems were examined by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity in rat brains. Male rats received 10, 20, or 40 mg/kg CTN (i.p.) 1 h prior to a daily injection of CORT for 21 consecutive days. The activation of the HPA axis in response to the repeated CORT injections was confirmed by measuring serum levels of CORT and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Daily CTN administration significantly decreased immobility in the FST, increased open-arm exploration in the EPM test, and significantly blocked increases of TH expression in the locus coeruleus (LC). It also significantly enhanced the total number of line crossing in the open-field test (OFT), while individual differences in locomotor activities between experimental groups were not observed in the OFT. Taken together, these findings indicate that the administration of CTN prior to high-dose exogenous CORT significantly improves helpless behaviors, possibly by modulating the central noradrenergic system in rats. Therefore, CTN may be a useful agent for the treatment or alleviation of the complex symptoms associated with depression and anxiety disorders.

• Journal of Microbiology and Biotechnology
• /
• v.22 no.5
• /
• pp.708-720
• /
• 2012

In this study, we assessed the effects of ginsenoside Re (GRe) administration on repeated immobilization stress-induced behavioral alterations using the forced swimming test (FST), the elevated plus maze (EPM), and the active avoidance conditioning test (AAT). Additionally, we examined the effect of GRe on the central adrenergic system by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brain. Male rats received 10, 20, or 50 mg/kg GRe (i.p.) 30 min before daily exposures to repeated immobilization stress (2 h/day) for 10 days. Activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to repeated immobilization was confirmed by measuring serum levels of corticosterone (CORT) and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Repeated immobilization stress increased immobility in the FST and reduced open-arm exploration in the EPM test. It also increased the probability of escape failures in the AAT test, indicating a reduced avoidance response. Daily administration of GRe during the repeated immobilization stress period significantly inhibited the stress-induced behavioral deficits in these behavioral tests. Administration of GRe also significantly blocked the increase in TH expression in the locus coeruleus (LC) and the decrease in BDNF mRNA expression in the hippocampus. Taken together, these findings indicate that administration of GRe prior to immobilization stress significantly improved helpless behaviors and cognitive impairment, possibly through modulating the central noradrenergic system in rats. These findings suggest that GRe may be a useful agent for treating complex symptoms of depression, anxiety, and cognitive impairment.

• The Korean Journal of Physiology and Pharmacology
• /
• v.18 no.3
• /
• pp.191-200
• /
• 2014

We investigated the anxiolytic-like activity of ${\alpha}$-asarone (AAS) from Acorus gramineus in an experimental rat model of anxiety induced by repeated administration of the exogenous stress hormone corticosterone (CORT). The putative anxiolytic effect of AAS was studied in behavioral tests of anxiety, such as the elevated plus maze (EPM) test and the hole-board test (HBT) in rats. For 21 consecutive days, male rats received 50, 100, or 200 mg/kg AAS (i.p.) 30 min prior to a daily injection of CORT. Dysregulation of the HPA axis in response to the repeated CORT injections was confirmed by measuring serum levels of CORT and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Daily AAS (200 mg/kg) administration increased open-arm exploration significantly in the EPM test, and it increased the duration of head dipping activity in the HBT. It also blocked the increase in tyrosine hydroxylase (TH) expression in the locus coeruleus (LC) and decreased mRNA expression of brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, in the hippocampus. These results indicated that the administration of AAS prior to high-dose exogenous CORT significantly improved anxiety-like behaviors, which are associated with modification of the central noradrenergic system and with BDNF function in rats. The current finding may improve understanding of the neurobiological mechanisms responsible for changes in emotions induced by repeated administration of high doses of CORT or by elevated levels of hormones associated with chronic stress. Thus, AAS did exhibit an anxiolytic-like effects in animal models of anxiety.