• 한국자동차공학회논문집
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• 제12권2호
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• pp.17-23
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• 2004

A cylindrical constant volume combustion bomb is used to investigate the combustion characteristics and to analyze the heat quantity of homogeneous charge methane-air mixture under various initial pressures, excess air ratios and ignition times. As the overall pressure increase, the values of maximum combustion pressure, maximum heat release rate and cumulative heat release have been increased. But it is not very meaningful to compare with some values such as maximum combustion pressure, maximum heat release rate and cumulative heat release for different overall pressure due to the different heat energy of supplied fuel. So the each value is needed to be compared with normalized value, which is divided by the entered fuel energy. To analyze the heat quantity, some definitions including the CHR ratio, the UHC ratio and the HL ratio are needed and are calculated. As the overall pressure increase, the CHR ratios and the UHC ratios have been decreased, while the HL ratios have been increased. The CHR ratio of 300 ms has the higher value than that of 10000ms, and the HL ratios of 300 ms have a lower value.

• Geomechanics and Engineering
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• 제14권5호
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• pp.439-451
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• 2018

The stress path characteristics of surrounding rock in the formation of gob were analysed and the unloading was solved. Taking Chengchao Iron Mine as the engineering background, the model for analysing the instability of deep gob was established based on the mechanism of stress relief in deep mining. The energy evolution law was investigated by introducing the local energy release rate index (LERR), and the energy criterion of instability of surrounding rock was established based on the cusp catastrophe theory. The results showed that the evolution equation of the local energy release energy of the surrounding rock was quartic function with one unknown and the release rate increased gradually during the mining. The calculation results showed that the gob was stable. The LERR per unit volume of the bottom structure was relatively smaller, which mean the stability was better. The LERR distribution showed that there was main energy release in the horizontal direction and energy concentration in the vertical direction which meet the characteristics of deep mining. In summary, this model could effectively calculate the stability of surrounding rock in the formation of gob. The LERR could reflect the dynamic process of energy release, transfer and dissipation which provided an important reference for the study of the stability of deep mined out area.

• 상하수도학회지
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• 제13권2호
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• pp.89-94
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• 1999

In this study small glass columns with 2.5cm inner diameter and 24.5cm length were used as many as the sample numbers to study the effects of initial pH, temperature, dissolved oxygen concentration, and sediment depth on the release of phosphorus from lake sediment. No phosphorus release occurred at $10^{\circ}C$ with all pHs, and release rate at $25^{\circ}C$ was higher than that at $35^{\circ}C$ with pH 4 and reverse trends were observed at pH 7 and 10. Under all conditions, DO concentrations were decreased and equilibrium was obtained after 4-8 days when phosphorus release started and the Do concentrations were less than 1 mg/l. Sediment depth had little effect on phosphorus release rate. It was found that relation between released SRP(Soluble Reactive Phosphorus) concentration and time was zero order reaction and reaction rate coefficients were obtained. The amount of phosphorus release from lake sediment can be predicted by considering these k values.

• Journal of the Korean Wood Science and Technology
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• 제36권2호
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• pp.1-8
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• 2008

This study was performed to evaluate the burning characteristics of wood-based materials and the effect of surface treatment of fire retardant using cone calorimeter. Four types of wood-based materials, such as Plywood, Oriented Strand Board (OSB), Particle Board (PB) and Medium Density Fiberboard (MDF), were tested at a constant heat flux of $50kW/m^2$ to investigate the time to ignition, mass loss rate, heat release rate, effective heat of combustion, etc. In addition, each type of wood-based material was tested at the same heat flux after fire retardant treatment on the surface to evaluate the effect of this treatment on the burning characteristics. The surface treatment of fire retardant, by the amount of $110g/m^2$, delayed the time to ignition almost twice. However, it was indicated that heat release rate, mass loss rate, and effective heat of combustion were not significantly affected by fire retardants treatment for all types of wood-based materials.

• Journal of Pharmaceutical Investigation
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• 제34권6호
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• pp.471-475
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• 2004

Tamsulosin has been frequently used for the treatment of benign prostatic hyperplasia. To avoid dose-dependent side effects of tamsulosin upon oral administration, the development of sustained-release delivery system is required, that can maintain therapeutic drug levels for a longer period of time. The aim of this study was therefore to formulate sustained-release tamsulosin matrix tablets and assess their formulation variables. We designed enteric coated sustained-release tamsulosin matrices to fulfill above statement. Aqueous microchannels in the enteric film need to be formed in order to obtain tamsulosin release even in an acidic environment such as gastric region. In the sustained-release tamsulosin matrix, low viscosity hydroxypropylmethylcellulose was used as a rate controller. Povidone K30 was also added to the matrices to facilitate water uptake so that a decrease in the release rate of tamsulosin as time elapses was prevented, possibly leading to pseudo zero-order release of the drug. The matrices were enteric-coated with hydroxypropylmethylcellulose phthalate (HPMCP), along with povidone K30 as an aqueous microchannel former. With the aqueous microchannels formed within the enteric film, tamsulosin could be released in an acidic condition. The release of tamsulosin decreased with increasing thickness of HPMCP membrane while the release rates of tamsulosin from those having different HPMCP thickness in pH 7.2 aqueous media were not considerably different, indicating that the enteric film was promptly dissolved at pH 7.2. These results clearly suggest that the sustained-release oral delivery system for tamsulosin could be designed with satisfying drug release profile approved by the KFDA.

• 보건행정학회지
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• 제11권3호
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• pp.121-150
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• 2001

This study was conducted to investigate provider's behavior change after releasing the information on the Cesarean section rate. Claims data filed at the National Health Insurance Corporation was used for this analysis and the focus of this study was the change of cesarean rate after the public disclosure of information. Average rates of the year 1999 and 2000 were compared, on the institutional basis, and range and coefficient of variation were estimated. For the last decade, Cesarean section rate has been increased dramatically. Clinical or demographic factors could not adequately explain the increase. Instead, nonclinical factors, such as financial incentive, physician's convenience, practice characteristics, etc., were more significant in explaining the increasing rate. Providers' behavior was significantly affected by the public release of information: after the release, average rate was decreased by 10.2%, and variations were also decreased. In particular, the extent of decrease was explained mainly by nonclinical factor rather than clinical ones. The results suggest that disseminating practice information to providers and consumers could contribute to reducing unnecessary medical service.

• Archives of Pharmacal Research
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• 제8권1호
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• pp.7-14
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• 1985

Membrane-coated tablet of isonicotinic acid hydrazide (INAH) which releases INAH at the zero-order kinetics was deveoped. It consisted of a soluble tablet core surrounded by a porous membrane which controls the diffusion rate. Tablet cores were prepared by compressing granules of INAH and polyvinyl chloride (PVC) dissolved in methyl ethyl ketone in which micronized sucrose were suspended. Diffusion rate of INAH from the tablet through the membrane was constant until the loaded INAH in the core was almost released. The rate was independent of pH of the dissolution medium. Water-soluble sucrose particles behaved as a poreproducing material in the water-insoluble PVC film coat. The pH independency of the rate was probably due to the high solubility of INAH in the water of wide pH range. The diffusion rate of INAH could be controlled by chnaging the composition of the membrane or the coat weight. This membrane-coated INAH tablet seemed to be a powerful candidate for the controlled release drug delivery system (DDS) of INAH or other highly watersoluble drugs.

• KSBB Journal
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• 제22권4호
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• pp.213-217
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• 2007

첨가제가 단백질 약물 방출 속도 및 약물 제제 제조 및 구조에 미치는 영향을 고찰하였다. 친수성 첨가제인 D-sorbitol의 경우 친유성 첨가제보다 단백질 약물 방출 속도를 감소시킬 수 있었으며 최적의 농도는 3% (w/v)로 나타났다. 또한 제제 제조시 점도를 낮게 유지할 뿐 아니라 상분리 없는 균일한 pluronic 용액상태를 유지하여 약물이 첨가될 경우에 균일한 약물제제를 만들 수 있었다. 한편 D-sorbitol은 pluronic 수용액의 CMC를 낮추고 마이셀 표면에 작용하여 구조를 강화하는 역할을 수행하는 것으로 보인다. 따라서 pluronic 제제에 D-sorbitol을 첨가하여 단백질 약물의 안정성을 향상시키고 효과적인 약물전달 시스템을 설계할 수 있었다.

• Journal of Pharmaceutical Investigation
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• 제32권4호
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• pp.327-330
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• 2002

Alginate based polymeric matrices were designed for controlled release and stabilization of cefaclor in gastrointestinal fluid. Cefaclor is known to be acid stable and subjected to be degraded at neutral and alkaline pHs. In order to achieve an effective release profile of cefaclor in gastrointestinal tract, a particular strategy in dosage form design should be required from the view point of maintaining its activity. The amphiphilic nature of cefaclor allowed its controlled release using ionic polymers based on ionic interaction between the drug and polymers. The thrust of this study was to develop a technique that delivers cefaclor keeping effective release rate in the intestinal tract. Considering the fast degradation of cefaclor in the intestinal fluid, the matrices were designed to release surplus amount of cefaclor. The alginate based matrices demonstrated increase in release rate in the simulated intestinal fluid, which was favorable to compensate the degraded portion of cefaclor. In addition, stabilization of cefaclor in the intestinal fluid was obtained by employing citric acid that provides an local acidic environment. The matrices might be valuably used for the development of an oral cefaclor dosage form.

• Journal of Pharmaceutical Investigation
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• 제20권1호
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• pp.13-18
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• 1990

Hydrocortisone (HC) sustained-release suppositories were prepared by using a solid matrix of methacrylic acid-methacrylic acid methyl ester copolymer $(Eudragit\;L_{100}^{R}:\;EL)$ as a poorly water soluble carrier and polyethylene glycole 1540 (PEG) as an water soluble carrier. HC release rate was controlled by complexation with ${\beta}-cyclodextrin$ $({\beta}-CyD)$ which was confirmed by X-ray diffractometry, IR-spectroscopy and differential scanning calorimetry. Release rate of HC from the EL-PEG matrix suppositories decreased with increase of EL contents. The release rale from $HC-{\beta}-CyD$ complex decreased in the following order: $HC-{\beta}-CyD/PEG$ > HC/PEG > $HC-{\beta}-CyD/EL_{10%}-PEG$ > $HC/EL_{10%}-PEG$ > $HC-{\beta}-CyD/EL_{15%}-PEG$ > $HC/EL_{15%}-PEG$ > $HC-{\beta}-CyD/EL_{20%}-PEG$ > $HC/EL_{20%}-PEG$. The crystallinity of HC in polymer matrix was identified using X-ray diffractometer and the surface of matrix suppositories after release test was examined by scanning electron microscopy. The sustained release of HC from these matrix suppositories was attributed to the network structure of EL.