• Korean Journal of Applied Biomechanics
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• v.22 no.2
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• pp.131-140
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• 2012

This study was to investigate the relationship between the distance and projection factors, angle factors of javelin in women's javelin throwing. The data were collected in the 2011 National Sports Festivals for 11 players. Three-Dimensional motion analysis using a system of 4 video cameras at a sampling frequency of 60 fields/s was performed for this study. The factors of release conditions calculated using Matlab 2009a program. The statical analysis on the records(n=42) included mean and standard deviation of the mean(SD), Pearson's product moment correlation coefficient(SPSS Version 16.0 for Windows). There was a statistically significant positive relationship between the records and release velocity(r=.866, p<.01), height(r=.433, p<.01) and height rate(r=.340, p<.05). The attitude angle, release angle, and attack angle showed not a statistically significant relationship between the records. The medial-lateral tilt angle of javelin showed not a statistically significant relationship between the records, but the yaw angle of javelin(r=.549, p<.01) showed a statistically significant positive relationship between the records.

• Carbon letters
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• v.11 no.2
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• pp.122-126
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• 2010

The alginate-based hydrogel was prepared as a pH-sensitive drug delivery system. To enhance the drug loading capacity, activated carbon was introduced as a drug absorbent. The iron oxide was incorporated into the alginate matrix for the magnetic transferring to the target organ. The activated carbon and iron-oxide were dispersed uniformly in the alginate hydrogel. The drug release from the alginate/activated carbon composite hydrogel was carried out in various pH conditions with vitamin B12 and Lactobacillus lamnosers as model drugs. The fast and sustainable release of drug was observed in the basic condition due to the pH-sensitive solubility of alginate. The novel drug delivery system having pH-sensitive release property and magnetic movement to target place was developed by using the alginate/activated carbon composite magnetic hydrogels.

• Korean Journal of Soil Science and Fertilizer
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• v.44 no.4
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• pp.545-550
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• 2011

Urea intercalated into montmorillonite (MT) exhibits remarkably enhanced N use efficiency, maintaining its fast effectiveness. This study dealt with the release property of urea from metal-urea-clay hybrid with MT (MUCH) under continuous-flow conditions and the cumulative impacts of its successive application on physicochemical properties of soils. Releases of urea were completed within 4 hrs under continuous-flow condition regardless of the types and the leaching solutions. However, urea release property was significantly affected by both the form of fertilizer and the presence of electrolytes in solution. The fast release property of urea from MUCH in continuous-flow condition was not significantly affected by soil properties such as soil pH and soil texture. In addition, its successive application did not lead to any noticeable change in soil physicochemical properties, water stable aggregate rate, water holding capacity and cation exchange capacity in both sandy loam and clay loam soils. Therefore, this study strongly supported that urea intercalated into MT could be applied as fast-effective N fertilizer, in particular for additional N supply.

• Archives of Pharmacal Research
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• v.29 no.7
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• pp.598-604
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• 2006

In many conventional drug delivery systems in vogue, failure to deliver efficient drug delivery at the target site/organs; is evident as a result, less efficacious pharmacological response is elicited. Microspheres can be derived a remedial measure which can improve site-specific drug delivery to a considerable extent. As an application, Lung-targeting Ofloxacin-loaded gelatin microspheres (GLOME) were prepared by water in oil emulsion method. The Central Composite Design (CCD) was used to optimize the process of preparation, the appearance and size distribution were examined by scanning electron microscopy, the aspects such as in vitro release characteristics, stability, drug loading, loading efficiency, pharmacokinetics and tissue distribution in albino mice were studied. The experimental results showed that the microspheres in the range of $0.32-22\;{\mu}m$. The drug loading and loading efficiency were 61.05 and 91.55% respectively. The in vitro release profile of the microspheres matched the korsmeyer’s peppas release pattern, and release at 1h was 42%, while for the original drug, ofloxacin under the same conditions 90.02% released in the first half an hour. After i.v. administration (15 min), the drug concentration of microspheres group in lung in albino mice was $1048\;{\mu}g/g$, while that of controlled group was $6.77\;{\mu}g/g$. GLOME found to release the drug to a maximum extent in the target tissue, lungs.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.20 no.2
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• pp.231-241
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• 2022

Several countries, including Korea, are considering the direct disposal of spent nuclear fuels. The radiological safety assessment results published after a geological repository closure indicate that the instant release is the main radiation source rather than the congruent release. Three Safety Case reports recently published were reviewed and the IRF values of seven long-lived radionuclides, including relevant experimental results, were compared. According to the literature review, the IRF values of both the CANDU and low burnup PWR spent fuel have been experimentally measured and used reasonably. In particular, the IRF values of volatile long-lived nuclides, such as ¹²⁹I and ¹³⁵Cs, were estimated from the FGR value. Because experimental leaching data regarding high burnup spent nuclear fuels are extremely scarce, a mathematical modelling approach proposed by Johnson and McGinnes was successfully applied to the domestic high burnup PWR spent nuclear fuel to derive the IRF values of iodine and cesium. The best estimate of the IRF was 5.5% at a discharge burnup of 55 GWd tHM^-1.

• Journal of Pharmaceutical Investigation
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• v.40 no.3
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• pp.187-192
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• 2010

We aimed to evaluate the effect of temperature, pH, and light conditions on the stability of porcine placental extract (PPE)-loaded liposomes with different surface charges. The size distribution profiles and in vitro release patterns were investigated by dynamic light scattering method and spectrophotometry. The stability of PPE-loaded liposomes was affected by the surface charges of the liposomes. As compared to neutral and anionic liposomes, cationic liposome formulations showed significantly lower physical stability. At the test storage conditions of different temperatures and pHs, the mean sizes of cationic PPE-loaded liposomes substantially increased. In contrast, neutral and anionic liposomes did not reveal significant changes in mean sizes upon various storage conditions. The neutral and anionic liposomes showed no significant differences in the release profiles of PPE after storage at various temperatures and pHs. Our results indicate that anionic and neutral liposome compositions might be more suitable for the formulations of PPE providing the higher stability.

• Journal of Radiation Protection and Research
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• v.28 no.4
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• pp.291-298
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• 2003

The KN-12 transport cask has been designed to transport 12 PWR spent nuclear fuel assemblies and to comply with the regulatory requirements for a Type B(U) package. The containment boundary of the cask is defined by a cask body, a cask lid, lid bolts with nuts, O-ring seals and a bolted closure lid. The containment vessel for the cask consists of a forged thick-walled carbon steel cylindrical body with an integrally-welded carbon steel bottom and is closed by a lid made of stainless steel, which is fastened to the cask body by lid bolts with nuts and sealed by double elastomer O-rings. In the cask lid an opening is closed by a plug with an O-ring seal and covered by the bolted closure lid sealed with an O-ring. The cask must maintain a radioactivity release rate of not more than the regulatory limit for normal transport conditions and for hypothetical accident conditions, as required by the related regulations. The containment requirements of the cask are satisfied by maintaining a maximum air reference leak rate of $2.7{\times}10^{-4}ref.cm^3s^{-1}$ or a helium leak rate of $3.3{\times}10^{-4}cm^3s^{-1}$ for normal transport conditions and for hypothetical accident conditions.

• Journal of the korean Society of Automotive Engineers
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• v.7 no.3
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• pp.74-82
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• 1985

Using single-zone heat release model and quasi-steady model, computer program for calculating the compression ignition engine cycle was composed. The properties in the cylinder were calculated in terms of crank angle and the effects of various operating conditions on rate of heat release and on engine performance were studied. The predicted values for the engine under consideration have shown good agreement with published data.

• Korean Journal of Computational Design and Engineering
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• v.14 no.2
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• pp.122-128
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• 2009

The failure responses of adhesively bonded, hat stiffened structures are studied through numerical analysis using the finite element method. The responses are evaluated numerically for the bonded hat section/substrate structures containing different combinations of materials. It is studied what kind of material combinations causes the easier crack initiation in the structure. This study is conducted under plane strain conditions and J-integral via a commercial code ABAQUS as a total critical energy release criterion was used for observation on crack initiation. Also, the influence of adhesive on the structure is studied.

• Animal cells and systems
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• v.3 no.2
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• pp.103-113
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• 1999

Many in-depth reviews related to regulations of prolactin secretion are available. We will, therefore, focus on controversial aspects using personal opinion in this review. The neuroendocrine control of prolactin secretion from the anterior pituitary gland involves multiple factors including prolactin-release inhibiting factor (PIF) and prolactin releasing factor (PRF). The PIF exerts a tonic inhibitory control in the physiological conditions. The PIF should be able to effectively inhibit prolactin release or a lifetime, but the inhibitory action of dopamine cannot be sustained for a long period of time. Perifusion of a high concentration of dopamine (l ,000 nM) could not sustain inhibitory action on prolactin release but when a small amount of ascorbic acid (0.1 mM) is added in a low concentration of dopamine (3 nM) solution, prolactin release was inhibited for a long period. Ascorbate is essential for dopamine action to inhibit prolactin release. We have, therefore, concluded that the PIF is dopamine plus ascorbate. The major transduction system for dopamine to inhibit prolactin release is the adenylyl cyclase system. Dopamine decreases cyclic AMP concentration by inhibiting adenylyl cyclase, and cyclic AMP stimulates prolactin release. However, the inhibitory mechanism of dopamine on prolactin release is much more complex than simple inhibition of CAMP production. The dopamine not only inhibits cyclic AMP synthesis but also inhibits prolactin release by acting on a link(s) after the CAMP event in a chain reaction for inhibiting prolactin release. Low concentrations of dopamine stimulate prolactin release. Lactotropes are made of several different subtypes of cells and several different dopamine receptors are found in pituitary. The inhibitory and stimulatory actions induced by dopamine can be generated by different subtype of receptors. The GH$_4$ZR$_7$ cells express only the short isoform (D$_{2s}$) of the dopamine receptor, as a result of transfecting the D$_{2s}$ receptors into GH$_4$C$_1$ cells which do not express any dopamine receptors. When dopamine stimulates or inhibits prolactin release in GH$_4$ZR$_7$ cells, it is clear that the dopamine should act on dopamine D$_{2s}$ receptors since there is no other dopamine receptor in the GH$_4$ZR$_7$. Dopamine is able to stimulate prolactin release in a relatively low concentration while it inhibits in a high concentration in GH$_4$ZR$_7$. These observations indicate that the dopamine D$_2$ receptor can activate stimulatory and/or inhibitory transduction system depending upon dopamine concentrations.