• Journal of Korean Society on Water Environment
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• v.26 no.1
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• pp.156-159
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• 2010

Peroxide is used frequently to provide electron acceptors to aerobes for the purpose of in situ bioremediation of contaminated soil/sediment. In this study, oxygen release rate of peroxides and factors affecting on dissolution and diffusion of oxygen into pore water were evaluated. Peroxides studied in this study were magnesium peroxide ($MgO_2$), calcium peroxide ($CaO_2$), and sodium percarbonate ($Na_2CO_3{\cdot}1.5H_2O_2$). $Na_2CO_3{\cdot}1.5H_2O_2$ showed the highest oxygen release rate per unit mass and the shortest release duration time among three peroxides. A simple first-order decay model for predicting the release rate of oxygen from peroxide into pore water was presented and used to fit the experimental data. The first order oxygen release rate constants k for $MgO_2$, $CaO_2$ and $Na_2CO_3{\cdot}1.5H_2O_2$ were 0.45 /hr, 3.22 /hr and 134 /hr, respectively. If $MgO_2$ was mixed with clay, oxygen release rate was lowered significantly mainly due to limitation of contact area and diffusion, implying that oxygen can be provided to the indigenous aerobes for the extended period of time.

• Journal of International Academy of Physical Therapy Research
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• v.10 no.1
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• pp.1739-1745
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• 2019

Background: There have been many studies on self-myofascial release (SMR) stretching, but there are few comparative studies on the effects of massages using a release ball, which is a type of the SMR method. Objective: To investigate the immediate effects of release ball massage and self-stretching on proprioceptive sensory, hamstring's temperature, range of motion (ROM) muscle strength,. Design: Crossover study. Methods: Thirty women in 20's at S University in Busan voluntarily participated in the study. Participants were random to release ball group (n=15) or self-stretching group (n=15). Both groups performed 3 sets of exercises, stretching for 30 seconds and resting for 15 seconds in each position. The proprioceptive sensory, temperature of the hamstring muscle, ROM, and strength were measured before exercise, 5 minutes after exercise, and 30 minutes after exercise. Results: Release ball group showed significant differences in muscle length and temperature over time (p<.05). The comparison between two group over time showed significant differences in muscle length, temperature, and muscle strength (p<.05). Conclusions: These results demonstrate that release ball massage and self-stretching are beneficial for improving hamstring's temperature, ROM and muscle strength.

• Journal of Pharmaceutical Investigation
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• v.23 no.3
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• pp.9-18
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• 1993

Sugar spheres loaded with melatonin (MT) were coated with $Aquacoat^{\circledR}$ to control the release rate of MT over 8 hours. A zero-order release pattern over 8 hours was obtained with 20% coating on 8-10 mesh beads in USP basket dissolution studies. MT in 20% coated beads was quite stable at room temperature with less than 5% MT degraded during 6 months' storage. Dissolution profiles were also unchanged after 6 months. An oral preparation containing MT-loaded uncoated beads for immediate release and 20% coated beads with $Aquacoat^{\circledR}$ for controlled release over 8 hours was evaluated in six human subjects. When total 0.5 mg MT as low dose (immediate release portion of MT, 0.1 mg) was administered to four subjects, average peak plasma MT concentration was reached at about 600 pg/ml and maintained at about 10 pg/ml over 8 hours. Plasma MT concentration-time profiles were similar in shape to computer-simulated profiles. However, maximal plasma MT concentrations were three times greater compared to computer simulated curve. These results suggest that MT dose, ratio of immediate and controlled release MT, and pharmacokinetic parameters selected are adjusted to mimic endogenous MT concentration-time curve. In another study, 0.2 mg MT having 10% of immediate release portion and 80% controlled release portion produced plasma MT concentration-time curve which is more similar to endogenous profiles. A low bioavailability (<20%) may result from extensive first pass metabolism and remaining amounts of MT from controlled beads. A good correlation between plasma MT concentration and urinary excretion rate of 6-sulphatoxymelatonin (6-STMT), a major metabolite of MT was observed. As plasma MT concentration increased, urinary excretion rate of 6-STMT increased concomitantly. The linear relation between plasma MT and urinary excretion rate of 6-STMT was statistically significant. This result suggests that urinary 6-STMT may be used as an index of circadian rhythms of MT in humans.

• Journal of the Korea Society for Simulation
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• v.8 no.4
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• pp.73-87
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• 1999

Order Review/Release (ORR) System is the linkage between planning system and actual production. Reduction of the waiting time on the machines, work in process and lead time variation may be achieved by adopting ORR strategies. But researchers on the ORR do not agree on the effectiveness of ORR. Some say that the overall system flow time may be increased if ORR is adopted, but others say that ORR can reduce work in process, flow time and variation of flow time. The objective of this research is to clarify under what environments order release strategy is effective. Simulation study was conducted in a hypothetical job shop. The experimental results show that dispatching rule is much more important than ORR is in controlling the shop floor. But the results indicate that ORR can reduce mean shop flow time, average work in process and variation of shop flow time under such environments where utilization level is high and planned order is weekly released to the order pool. And the results also show that the effect of plan smoothing on the ORR is insignificant, which is inconsistent with the results of the previous researches.

• Journal of Korean Institute of Industrial Engineers
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• v.25 no.2
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• pp.192-203
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• 1999

This paper deals with the order release problem for minimizing weighted earliness and tardiness as well as Work In Process (WIP) in dynamic job shop environments. A newly designed hierarchical order release mechanism is developed for efficient real-time control of the earliness/tardiness and WIP. The hierarchical order release mechanism consists of the order release plan and the order release control which is composed of two procedures. The experimental results show that the proposed order release mechanism is superior to other four order release mechanisms under overall simulation conditions of utilization rate, due-date allowances, and earliness/tardiness cost structures. In addition, the difference of total cost among the four dispatching rules is much more reduced in the proposed order release mechanism than in other release mechanisms.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.4
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• pp.1239-1247
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• 2010

In this paper, we were researched decision problem called an optimal release policies after testing a software system in development phase and transferring it to the user. The applied model of release time exploited infinite failure non-homogeneous Poisson process This infinite failure non-homogeneous Poisson process is a model which reflects the possibility of introducing new faults when correcting or modifying the software. The intensity function used Gompertz, Preto and Log-logstic pattern which has the efficient various property. Thus, optimal software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement becomes an optimal release policies. In a numerical example, after trend test applied and estimated the parameters using maximum likelihood estimation of inter-failure time data, estimated software optimal release time.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.1
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• pp.23-26
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• 2009

During operations, neurosurgeons usually perform multiple temporary occlusions of parental artery, possibly resulting in the neuronal damage. It is generally thought that neuronal damage by cerebral ischemia is associated with extracellular concentrations of the excitatory amino acids. In this study, we measured the dynamics of extracellular glutamate release in 11 vessel occlusion(VO) model to compare between single occlusion and repeated transient occlusions within short interval. Changes in cerebral blood flow were monitored by laser-Doppler flowmetry simultaneously with cortical glutamate level measured by amperometric biosensor. From real time monitoring of glutamate release in 11 VO model, the change of extracellular glutamate level in repeated transient occlusion group was smaller than that of single occlusion group, and the onset time of glutamate release in the second ischemic episode of repeated occlusion group was delayed compared to the first ischemic episode which was similar to that of single 10 min ischemic episode. These results suggested that repeated transient occlusion induces less glutamate release from neuronal cell than single occlusion, and the delayed onset time of glutamate release is attributed to endogeneous protective mechanism of ischemic tolerance.

• Journal of the Korea Society of Computer and Information
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• v.15 no.5
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• pp.125-132
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• 2010

Decision problem called an optimal release policies, after testing a software system in development phase and transfer it to the user, is studied. The applied model of release time exploited infinite non-homogeneous Poisson process. This infinite non-homogeneous Poisson process is a model which reflects the possibility of introducing new faults when correcting or modifying the software. The failure life-cycle distribution used exponential and non-exponential family which has various intensity. Thus, software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement becomes an optimal release policies. In a numerical example, after trend test applied and estimated the parameters using maximum likelihood estimation of inter-failure time data, estimated software optimal release time.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.8
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• pp.1903-1910
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• 2009

In this paper, we were researched decision problem called an optimal release policies after testing a software system in development phase and transferring it to the user. The applied model of release time exploited infinite failure non-homogeneous Poisson process This infinite failure non-homogeneous Poisson process is a model which reflects the possibility of introducing new faults when correcting or modifying the software. The failure life-cycle distribution used the Weibull distribution which has the efficient various property which has the place efficient quality. Thus, optimal software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement becomes an optimal release policies. In a numerical example, after trend test applied and estimated the parameters using maximum likelihood estimation of inter-failure time data, estimated software optimal release time.

• KSBB Journal
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• v.5 no.4
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• pp.377-382
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• 1990

The characteristics controlled drug release have been studied for biodegradable polymer matrix. Polymer matrix was prepared from glycerine, prednisolone and dextran. Mathematical analysis of the data showed that the release behavior actually conformed to the Higuchi's diffusion controlled model. The release time was increased as drug loading doses increased, whereas decreased as glycerine concentration increased. The release rate did not change by varying molecular weight of dextran.