• Journal of Korean Neurosurgical Society
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• 제58권4호
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• pp.379-384
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• 2015

Objective : To investigate the risks and pattern of evolution of peritumoral brain edema (PTE) after stereotactic radiosurgery (SRS) for asymptomatic intracranial meningiomas. Methods : A retrospective study was conducted on 320 patients (median age 56 years, range 24-87 years) who underwent primary Gamma Knife radiosurgery for asymptomatic meningiomas between 1998 and 2012. The median tumor volume was 2.7 cc (range 0.2-10.5 cc) and the median follow-up was 48 months (range 24-168 months). Volumetric data sets for tumors and PTE on serial MRIs were analyzed. The edema index (EI) was defined as the ratio of the volume of PTE including tumor to the tumor volume, and the relative edema indices (rEIs) were calculated from serial EIs normalized against the baseline EI. Risk factors for PTE were analyzed using logistic regression. Results : Newly developed or increased PTE was noted in 49 patients (15.3%), among whom it was symptomatic in 28 patients (8.8%). Tumor volume larger than 4.2 cc (p<0.001), hemispheric tumor location (p=0.005), and pre-treatment PTE (p<0.001) were associated with an increased risk of PTE. rEI reached its maximum value at 11 months after SRS and decreased thereafter, and symptoms resolved within 24 months in most patients (85.7%). Conclusion : Caution should be exercised in decision-making on SRS for asymptomatic meningiomas of large volume (>4.2 cc), of hemispheric location, or with pre-treatment PTE. PTE usually develops within months, reaches its maximum degree until a year, and resolves within 2 years after SRS.

• 한국안전학회지
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• 제32권6호
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• pp.150-156
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• 2017

A frozen road surface increases traffic accidents during the winter season. Hence, information on easily-frozen road sections and their specificities are required to prevent traffic accidents. Frozen road surfaces are determined by equipment measuring road surface temperatures. However, there are limitations in investigating the entire road network. Therefore, it is imperative to develop new methods that effectively determine road surface freezing risks. Meteorologically, road surfaces are frozen when the actual temperature cools down to the dew point temperature. Under this condition, there is likely to be frost if relative humidity reaches 100% and frozen road surfaces as the temperature gets lower. Meteorological characteristics give us an alternative to a direct measurement road surface temperature to estimate risks of road surface freezing. Based on the clues, the relationship between severity of traffic accidents and temperature changes is empirically investigated using Paju weather data. The results reveal that as the temperature gets lower and changes in current temperature are relatively small, the severity of traffic accidents become higher. In addition, the same is true when the difference between current temperature and the dew point temperature is relatively small, as it increases possibilities of road surface freezing. Future studies must investigate how current temperature and the dew point temperature affect road surface freezing and thereby establish a time-space scope to estimate possible road surface freezing sections using only weather and road material type data. This would provide invaluable information for predicting and preventing frozen road accidents based on weather patterns.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6681-6686
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• 2013

Background: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. Methods: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. Results: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). Conclusions: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.

• Safety and Health at Work
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• 제8권2호
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• pp.169-174
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• 2017

Background: We assessed the cancer risks of four different Finnish asbestos-exposed cohorts. We also explored if the cohorts with varying profiles of asbestos exposure exhibited varying relative risks of cancer. Methods: The incident cancer cases for the asbestos-exposed worker cohorts were updated to the end of 2012 using the files of the Finnish Cancer Registry. The previously formed cohorts consisted of asbestos mine workers, asbestosis patients, asbestos sprayers, and workers who had taken part in a screening study based on asbestos exposure at work. Results: The standardized incidence ratio (SIR) for mesothelioma varied from about threefold to > 100-fold in the different cohorts. In the screening cohort the SIR for mesothelioma was highest in 2003-2007, In other cohorts it was more constant in 5-year period inspection. The SIR for lung cancer was about twofold to tenfold in all except the screening cohort. Asbestos sprayers were at the highest risk of mesothelioma and lung cancer. Conclusion: The SIR for mesothelioma is high in all of the cohorts that represent different kinds of asbestos exposure. The smaller SIR for mesothelioma in the screening cohort with lowest level of asbestos exposure might suggest dose-responsiveness between asbestos exposure and mesothelioma. It does seem that the highest risk of lung cancer in these cohorts except in the youngest of the cohorts, the screening cohort, is over. The highest SIR for lung cancer of the asbestosis patient and sprayers cohort is explained by their heavy asbestos exposure.

• Nuclear Engineering and Technology
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• 제49권2호
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• pp.411-425
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• 2017

Using a probabilistic safety assessment, a risk evaluation framework for an aircraft crash into an interim spent fuel storage facility is presented. Damage evaluation of a detailed generic cask model in a simplified building structure under an aircraft impact is discussed through a numerical structural analysis and an analytical fragility assessment. Sequences of the impact scenario are shown in a developed event tree, with uncertainties considered in the impact analysis and failure probabilities calculated. To evaluate the influence of parameters relevant to design safety, risks are estimated for three specification levels of cask and storage facility structures. The proposed assessment procedure includes the determination of the loading parameters, reference impact scenario, structural response analyses of facility walls, cask containment, and fuel assemblies, and a radiological consequence analysis with dose-risk estimation. The risk results for the proposed scenario in this study are expected to be small relative to those of design basis accidents for best-estimated conservative values. The importance of this framework is seen in its flexibility to evaluate the capability of the facility to withstand an aircraft impact and in its ability to anticipate potential realistic risks; the framework also provides insight into epistemic uncertainty in the available data and into the sensitivity of the design parameters for future research.

• 대한수의학회지
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• 제42권2호
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• pp.163-170
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• 2002

The relationship between level of milk composition and conditions of ovary and uterus were analyzed in Holstein cows at seven farms participating in a reproductive herd health management program. Milk data were taken from 503 early lactating cows between 30 and 60 days in milk with reproductive examination with ultrasonography from september 1999 to August 2000. Milk fat, protein and solid-not-fat concentration in the herds were $3.70{\pm}1.08%$, $2.97{\pm}0.35$, and $8.41{\pm}0.61%$, respectively. The reproductive disorder relative to normal cows had higher risk in the cows that the level of protein was lower than 2.70%. Also, the higher milk fat than 4.50% were associated with a higher risks in the uterine disease and follicular cysts. Therefore, the cows with the fat to protein ratio of > 1.30 had higher risks for reproductive disorder such as cystic ovarian diseases, inactive ovaries and endometritis. These results indicated that cows diagnosed with reproductive disorder were energy deficient prior to reproductive disorder diagnosis. Consequently, milk fat and protein analyses may be used serve as a monitoring tool for condition of ovary and uterus in early lactating cows

• 대한지역사회영양학회지
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• 제21권4호
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• pp.354-365
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• 2016

Objectives: Studies that reported the association between diet quality/nutritional intake status and mortality have rarely used long-term follow-up data in Asian countries, including Korea. This study investigated the association between the risk of mortality (all-cause and cause-specific) and the diet quality/nutritional intake status using follow-up 12-year mortality data from a nationally representative sample of South Koreans. Methods: 8,941 individuals who participated in 1998 and 2001 Korea Health and Nutrition Examination Surveys were linked to mortality data from death certificates. Of those individuals, 1,083 (12.1%) had died as of December, 2012. Cox proportional hazard models were used to estimate the relative risks of mortality according to the level of diet quality and intakes of major nutrients. Indicators for diet quality index and nutritional intake status were assessed using MAR (mean adequacy ratio) and energy and protein intake level compared with the 2010 Korean DRI. Results: Higher diet quality/nutritional intake status were associated with lower mortality; the mortality risk (95% confidence interval) from all-cause of lowest MAR group vs highest was 1.66 (1.27 to 2.18) among ${\geq}30$ year old, and 1.98 (1.36 to 2.86) among 30~64 year old individuals. Those with below 75% of energy and protein intake of Korean DRI had higher mortality risks of all-cause mortality compared to the reference group. Diet quality/nutritional intake status was inversely associated with mortality from cardiovascular diseases and cancer. Conclusions: Poor Diet quality/nutritional intake status were associated with a higher risk of mortality from all-cause and mortality from cardiovascular diseases and cancer among South Korean adults.

• Journal of Yeungnam Medical Science
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• 제41권1호
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• pp.39-44
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• 2024

Background: Medication-related osteonecrosis of the jaw (MRONJ) is a significant concern, particularly among patients taking bisphosphonates (BPs), denosumab, and selective estrogen receptor modulators (SERMs) for osteoporosis. Despite the known risks, large-scale cohort studies examining the incidence and severity of MRONJ are lacking. We aimed to ascertain the incidence and risk of MRONJ among these patients, whom we stratified by age groups, medication types, and duration of use. Methods: We utilized data from the National Health Insurance Service's sample cohort database, focusing on patients aged 40 years and above diagnosed with osteoporosis. The patients were divided into three groups: those prescribed BPs only, those prescribed SERMs only, and those prescribed both. Results: The overall incidence rate of MRONJ was 0.17%. A significantly higher incidence rate was observed among those taking osteoporosis medications, particularly among females with a relative risk of 4.99 (95% confidence interval, 3.21-7.74). The SERM group also had an incidence rate comparable to that of the BP group. Severity was assessed based on the invasiveness of the treatment methods, with 71.3% undergoing invasive treatment in the medication group. Conclusion: This study provides valuable insights into the incidence and severity of MRONJ among a large cohort of patients with osteoporosis. It underscores the need for comprehensive guidance on MRONJ risks across different medication groups and sets the stage for future research focusing on specific populations and treatment outcomes.

• 한국산학기술학회논문지
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• 제19권7호
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• pp.88-94
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• 2018

국내외 현수교량 주케이블의 경우, 부식을 방지하기 위해 송기시스템을 통하여 주케이블 내부 상대습도를 보통 $40%{\pm}5%$ 이하로 유지하고 있다. 국내 주케이블 송기시스템이 설치된 현수교량의 위치는 모두 지리적으로 온난다습한 기후에 노출되는 빈도가 높은 해안지역이며, 특히나 우리나라의 해안지역은 각 계절의 온도차 및 일교차가 크기 때문에 강재 부식에 더욱 열악한 조건이다. 본 연구에서는 지역별 환경분석을 수행함으로써 보편적으로 사용하고 있는 송기시스템의 가동기준 40%가 아닌 좀 더 효율적인 지역별 송기시스템 가동 기준을 수립하는데 기초자료로 활용하고자 하였다. 최근 국내에 가장 큰 영향을 끼친 태풍 BOLAVEN(2012)과 CHABA(2016) 기간의 상대습도 분포, 분석 기간(2012~2016) 중 내습한 모든 태풍의 기간을 제외한 여름철과 겨울철의 상대습도 분포, 기온과 연계한 겨울철 상대습도 분포 분석을 통해 지역별로 송기시스템 가동기준을 차별화하는 것에 대한 근거를 마련할 수 있었다. 미래 기후변화로 인한 해수면 온도 상승 및 강수량 증가의 영향을 고려할 때 더욱더 객관적인 지역별 송기시스템 가동기준이 필요할 것으로 판단되며, 이는 추후 현수교 주케이블의 송기시스템 가동에 대한 경제적 효율성을 높일 수 있을 것으로 사료된다.

• 경영정보학연구
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• 제20권3호
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• pp.51-71
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• 2018

많은 정보보호 분야 연구들은 인식을 높여야 할 필요성을 밝히고 있다. 그러나 정보보호에 대한 인식이 상당한 수준으로 높아졌음에도 실제 보호행동은 최근까지 그에 미치지 못하고 있다. 이에 인식수준과는 별개로 정보보호 의사결정에 심리적 요인이 작용할 것으로 가정하고 정보보호에 대한 인식에 차이가 없는 실험상황에서 심리적 거리감과 낙관편향에 따른 차이를 확인하고 정보보호 행동에 대한 영향을 확인하고자 하였다. 연구결과 모바일 기기 사용자의 확률적 거리감에 따라 정보보호 위험의 지각에 차이가 있었으며, 사회적 거리감에 따라 상대적 낙관성의 정도에 차이가 있었다. 이를 바탕으로 상대적 낙관성을 개념화하고 정보보호 행동의도와의 관계를 분석한 결과 자신과 가까운 사람과 비교해 더 낙관적이라 생각했을 때 정보보호 위험의 수준을 낮게 평가하고 확률적 거리감에 따라 영향력이 달라짐을 확인했다. 본 연구는 방법론적 측면에서 의미 있는 시도를 하였고, 정보보호와 관련한 행동에 있어 심리적 요인을 고려함으로써 실질적 위험지각에 영향을 미치는 상대적 낙관성의 범위를 좁혔다는 데 의의가 있다. 정보보호를 위한 의사결정 과정에 다각도로 접근할 필요성을 실증적으로 규명함으로써 궁극적으로 정보기술 사용자의 정보보호 수준 향상과 정보자산의 보호에 기여할 것으로 기대한다.