• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2125-2129
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• 2016

Background: Stomach cancer is an aggressive malignancy that is difficult to detect at an early stage and therefore is characterized by poor survival rates. Over the last two decades, there has been no report of gastric cancer survival in Khon Kaen province, Thailand. The aim of this retrospective cohort study was to provide up-to-date information about the survival of gastric cancer patients in this province. Materials and Methods: Data from Khon Kaen population-based cancer registry, Faculty of Medicine, Khon Kaen University were newly obtained on 650 patients who were diagnosed with stomach cancer during the period 1 January, 2000 to 31 December, 2012. These were then followed up until death or the end of the study (31 December 2014). We calculated the observed survival with the actuarial life table method, and relative survival, defined as the ratio of observed survival in the group of the stomach cancer patients to the expected survival in the entire Thai population from the estimated generation life tables for Thailand of five-year birth cohorts from 1900 - 2000. Results: The 5 year observed and 5 year relative survival rates were 17.2 % (95% CI: 13.54-21.14) and 18.2 % (95% CI: 14.3-22.4), respectively. The highest 5 year relative survival rates were demonstrated among patients aged 45-65, with stage I or II lesions, with adenocarcinomas, with a body of stomach location, well differentiated and receiving surgery and/or chemotherapy. Conclusions: The observed and relative survival rates were close to each other. Our findings provide basic information beneficial to development of an effective treatment system and appropriately improved population-based cancer registration.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5853-5858
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• 2015

Background: The survival rate reflecting prognosis of breast cancer patients is usually estimated based on crude survival methods such as observed and cause-specific. In situations where data are based on population-cancer registries, this method may produce biased estimations. This study therefore aimed to estimate the net survival of breast cancer based on relative survival. Materials and Methods: Data for 622 breast cancer patients diagnosed at the Iran Cancer Institute during 1990-95 and tracked till the end of 2000 were analyzed. For estimation of relative survival, Ederer's second method and SAS (9.1) and STATA (11) software were used. Results: Threeyear relative survivals of 85%, 90%, 80% and 67% were observed for age groups 15-44, 55-59, 60-74, and 75+years-old, respectively. A relative survival of approximately one was observed for two subsequent years for age-group 45-59 years-old. A value greater than one for two subsequent years of follow-up was observed in the age-group 60-74 years-old. Conclusions: Tracking the diagnosis of breast cancer, the relative survival decreases as we go to higher age-groups. It is also perceived that through follow-up, relative survival first decreased and then increased a little. The statistical cure point is acceptable for age group 45-59 years-old while for age-groups 15-44 and 60-74 years old is a sign of low quality data for some follow-up intervals.

• 한국수학사학회지
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• 제16권2호
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• pp.103-116
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• 2003

Now we have faced to two fundamental population problems: The one is over-population problem in proportion to the nation's total area, 99,434 $km^2$, and the other is unbalanced population distributions in the provincial districts of administration (16th local governments). For example, the population density of Seoul city is 16,335 persons, and the nations population density of South Korea is 464 persons for 1 km$^2$. At the first part of this study, we introduced the origins and historical back grounds of Formal Demorgraphy. And the second part, we suggest some useful indicators of urbanization of rural populations in terms of Gini's Coefficients of Concentration. As the result, we can show that the ecological Gini's Coefficients of Concentration, during the periods covered by this study, have been increasing extraordinary: 0.349, 0.433, 0.532, 0.581, 0.633 and 0.626 in 1970, 1980, 1985, 1990, 1995, 2000 A.D. respectively. However, the trend of urbanization (concentration of population) of Korean population has been the relative equilibrium state of 0.63 from 1995 to 2000 A.D.

• 약학회지
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• 제43권2호
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• pp.278-284
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• 1999

This study deals with the biological changes in mice after ${\gamma}-irradiated$. Four weeks old BALA/c mice were irradiated with 6.5Gy of ${\gamma}-ray$ on the fifth day after oral administration of radioprotectants such as ascorbic acid, tocopherol and cysteine. Control group was irradiated with 6.5Gy without pre-administration of radioprotectors. Blood cells and sperm cells were counted and body, testis and spleen were weighed 3 days after irradiation. And also liver antioxidant activity and range of spleen immune cells were measured. Differences in most biological parameters were not clearly distinguished between experimental groups. However, the relative spleen weight, the relative testis weight and the population size of spleen immune cells such as T helper cells, B cells and macrophages measured by means of FACS showed significant difference between irradiated and radioprotectant administered group. It is concluded that the relative spleen weight, the relative testis weight and the population size of spleen immune cells are easy and useful parameters for assessing the effect of radioprotective substances and for quantifying biological damage of radiation, as well.

• Journal of Information Science Theory and Practice
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• 제4권1호
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• pp.30-48
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• 2016

The study tested a hybrid model with constructs drawn from the Technology Acceptance Model (TAM) and Diffusion of Innovation (DOI) theory in order to examine the moderating effect of productivity and relative advantage (RA) on perceived usefulness (PU) vis-à-vis electronic information resources (EIR) adoption in private university libraries in Ogun and Osun States of Nigeria. The descriptive research design was adopted in the study. The population consisted of 61 (55.0%) librarians and 50 (45.0%) library officers (totaling 116—100%) in Babcock University, Bells University, Covenant University, Bowen University, Oduduwa University, and Redeemer's University. Purposive sampling procedure was adopted after which total enumeration was used since the total population is small. The questionnaire was used for data collection. Of the 116 copies of the questionnaire administered, 111 (95.7%) were found usable. The instrument was structured based on a 4-point Likert agreement scale of Strongly Agree, Agree, Disagree, and Strongly Disagree. Data were analyzed using descriptive statistics like tables of frequency counts and percentage. The findings revealed that productivity and relative advantage are significant moderators of perceived usefulness of EIR adoption in private university libraries in Ogun and Osun States, Nigeria.

• 한국환경보건학회지
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• 제49권6호
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• pp.362-371
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• 2023

Background: PM_2.5 pollution has been a persistent problem in South Korea, with concentrations consistently exceeding World Health Organization (WHO) guidelines. The aging of the population in the country further exacerbates the health impacts of PM_2.5 since older adults are more susceptible to the adverse effects of air pollution. Objectives: This study aims to evaluate how the health impact (premature death) due to long-term exposure to PM_2.5 in South Korea could change in the future according to the trend of change in the country's population structure. Methods: The study employs a relative risk function, which accounts for age-specific relative risks, to assess the changes in premature deaths by age and region at the average annual PM_2.5 concentration for 2022 and at PM_2.5 concentration improvement levels. Premature deaths were estimated using the Global Exposure Mortality Model (GEMM). Results: The findings indicate that the increase in premature deaths resulting from the projected population structure changes up to 2050 would significantly outweigh the health benefits (reduction in premature deaths) compared to 2012. This is primarily attributed to the rising number of premature deaths among the elderly due to population aging. Furthermore, the study suggests that the effectiveness of the current domestic PM_2.5 standard would be halved by 2050 due to the increasing impact of population aging on PM_2.5-related mortality. Conclusions: The study highlights the importance of considering trends in population structure when evaluating the health benefits of air pollution reduction measures. By comparing and evaluating the health benefits in reflection of changes in population structure to the predicted PM_2.5 concentration improvements at the provincial level, a more comprehensive assessment of regional air quality management strategies can be achieved.

• Genomics & Informatics
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• 제18권3호
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• pp.27.1-27.12
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• 2020

The prevalence of early-onset type 2 diabetes (EOT2D) is increasing in Asian countries. Genome-wide association studies performed in European and various other populations have identified associations of numerous variants with type 2 diabetes in adults. However, the genetic component of EOT2D which is still unexplored could have similarities with late-onset type 2 diabetes. Here in the present study we aim to identify the association of variants with EOT2D in South Indian population. Twenty-five variants from 18 gene loci were genotyped in 1,188 EOT2D and 1,183 normal glucose tolerant subjects using the MassARRAY technology. We confirm the association of the HHEX variant rs1111875 with EOT2D in this South Indian population and also the association of CDKN2A/2B (rs7020996) and TCF7L2 (rs4506565) with EOT2D. Logistic regression analyses of the TCF7L2 variant rs4506565(A/T), showed that the heterozygous and homozygous carriers for allele 'T' have odds ratios of 1.47 (95% confidence interval [CI], 1.17 to 1.83; p = 0.001) and 1.65 (95% CI, 1.18 to 2.28; p = 0.006) respectively, relative to AA homozygote. For the HHEX variant rs1111875 (T/C), heterozygous and homozygous carriers for allele 'C' have odds ratios of 1.13 (95% CI, 0.91 to 1.42; p = 0.27) and 1.58 (95% CI, 1.17 to 2.12; p = 0.003) respectively, relative to the TT homozygote. For CDKN2A/2B variant rs7020996, the heterozygous and homozygous carriers of allele 'C' were protective with odds ratios of 0.65 (95% CI, 0.51 to 0.83; p = 0.0004) and 0.62 (95% CI, 0.27 to 1.39; p = 0.24) respectively, relative to TT homozygote. This is the first study to report on the association of HHEX variant rs1111875 with EOT2D in this population.

• 응용통계연구
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• 제28권3호
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• pp.477-483
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• 2015

본 연구에서는 계속조사에서 과거의 조사결과에서 얻은 추정값의 상대표준오차를 이용한 표본크기 결정 문제에 대하여 실제 사업체 조사자료를 활용하여 살펴보았다. 통계청 사업체 조사결과 중 건설업을 모집단으로 이용하여 표본크기를 500에서 3,000까지 500씩 증가시켜가면서 표본을 1,000개씩 단순임의추출 또는 층화추출하여 추출된 각 표본으로부터 상대표준오차들의 사분위수를 계산하였다. 그리고 이들 값들을 토대로 계속조사에서 시점 (t-1)에서의 상대표준오차를 이용한 시점 t에서의 표본크기를 추출법에 따라 구하였다. 그 결과 단순임의추출의 경우는 층화추출의 경우보다 시점 (t-1)에서의 상대표준오차들의 크기에 따라 표본크기가 매우 크게 차이가 나타남을 알 수 있었으며, 층화추출의 경우도 어떻게 층화를 하느냐에 따라 표본크기에 차이가 있을 수 있음을 알 수 있었다. 따라서 계속 조사에서 과거의 조사결과에서 얻은 추정값의 상대표준오차를 이용한 표본크기 식을 활용하는데 있어서 세심한 주의가 필요함을 확인할 수 있었다.

• 응용통계연구
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• 제16권1호
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• pp.1-14
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• 2003

본 연구에서는 현행 경제활동인구조사 체계에 근거하여 대영역 내의 시군구 단위 행정자치구역들에 대한 실업통계들을 생산할 수 있는 소지역 추정법이 제안된다. 고려된 소지역 추정량들은 합성 추정량, 복합추정량과 같은 설계기반 간접 추정량들이며 이러한 추정량들에 대한 평균제곱오차 추정식이 경제활동인구조사 체계 하에서 산정되어 시군구 단위 소지역 추정값들에 대한 정확도의 측도로써 활용된다. 2000년 12월 충북지역의 경제활동인구조사 자료로부터 이 지역 내의 10개 시군구 단위 행정자치구역들에 대한 실업자 총계 및 잭나이프 평균제곱오차가 본 연구에서 제시된 추정절차에 의해 추정된다. 시군구 단위 실업자 총계 추정값들의 신뢰성은 이들 추정값들의 상대편향(Relative Bias)과 상대오차제곱근(Relative Root Mean Square Error)에 의해 평가된다. 현행 한국 경제활동인구조사체계 하에서 복합추정량이 다른 추정량들에 비해 매우 안정적임을 밝힌다.

• Fisheries and Aquatic Sciences
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• 제15권1호
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• pp.57-62
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• 2012

Interspecific relationship between a euryhaline rotifer Brachionus rotundiformis and a cyclopoid copepod Apocyclops borneoensis was investigated in the laboratory culture. In a mixed culture of B. rotundiformis and A. borneoensis, population growth of B. rotundiformis was suppressed from day 10, while growth in a monoculture population continuously increased throughout the experimental period. However, the population growth of A. borneoensis in the mixed culture did not markedly differ from that in a monoculture population. Suppression of B. rotundiformis growth coincided with a decrease in the numbers of both non-egg-bearing and egg-bearing females, and increasing resting egg formation. Growth of A. borneoensis was not affected by the presence of the rotifer. However, relative growth index of ovisac bearing females in the mixed culture was 1.62 times higher than that in the monoculture. Presence of the copepod did not greatly reduce the food available to the rotifer population. The rotifer B. rotundiformis responded in a unique way, to stresses such as physical damage (filtering by A. borneoensis) with the production of many resting eggs to increase its chances of survival.