• 대한두경부종양학회지
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• 제23권2호
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• pp.138-141
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• 2007

Objectives : Well differentiated thyroid carcinoma(WDTC) has relatively good prognosis. But recurrence is associated with increased morbidity and mortality, and always results in reoperation. So it is important to evaluate the risk factors relative to the recurrence. The aim of this study is to evaluate the risk factors of recurrence. Materials and Method : Two hundred seventeen patients who had undergone thyroidectomy and proved as WDTC from January 1999 to December 2004 was included in the study. We reviewed patient-related and tumorrelated factors respectively and analyzed the correlation with tumor recurrence. Results : Fourteen patients from two hundreds seventeen had recurred. Recurrence rate was 6.5%, and average interval of recurrence was 28 month. Male, age over 45, multiple mass, and advanced TMN stage patient group show higher recurrence rate, but no statistical significance. However, the recurrence rate of lymph node metastasis, tumor size>1.5cm, and extracapsular invasion group were statistically high. Conclusion : Lymph node metastasis, tumor size and extracapsular invasion are significant risk factors related to the recurrence of WDTC.

• 정보학연구
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• 제5권1호
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• pp.99-111
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• 2002

원 영상에 근접한 색채 재현을 위한 선형 변환을 이용한 영상의 컬러 보정은 컬러 공간의 비 선형성으로 인해 색의 왜곡 현상이라는 문제가 발생하게 된다. 이러한 문제를 극복하기 위해 선형 이론인 임의의 평면상에 주어진 자료점들로 구성되는 베지어 곡선이 사용되어 왔다. 그러나, 이 베지어 곡선은 자료점의 개수에 따라 차수가 증가하게 되므로 수치적 계산상의 많은 제약을 받게 된다. 본 논문에서는 각 구간에서나 전체 구간에서의 차수가 3차이면서 베지어 곡선의 특성을 갖는 "3중첩 구간적 베지어 3차 곡선"(TPBC Curve; Triplicated Piecewise Bezier Cubic Curve)를 이용하였다. 이에 따른, TPBC-곡선과 20차 베지어 곡선을 이용하였을 때와 비교하여 컬러 보정 시 발생하는 왜곡 현상, 그리고 좁은 영역의 컬러 보정으로 인한 작업량의 증가를 감소시킨 결과를 보여주고자 한다. 보여주고자 한다.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2006년도 추계학술대회
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• pp.80-86
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• 2006

Bioequivalence is a term in pharmacokinetics used to access the expected in vivo biological equivalence of two proprietary preparations of a drug. Bioequivalence studies are usually performed for generic drugs. Two pharmaceutical products are bioequivalent if they are pharmaceutically equivalent and their bioavailabilioes after administration in the same molar dose are similar. Bioequivalence is usually accessed by single dose in vivo studies in healthy volunteers and the reference product is usually the innovator product that is marketed. Regulatory definition of bioequivalence is based on the statistical analysis of thebioavailability of the reference and test product. In general, two products are evaluated as bioequivalent if the 90% confidence interval of the relative mean Cmaxand AUC of the test to reference product are within 80.00% to 125.00% in the fasting state. Key process in bioequivalence study is development and validation of bioanalytical method, determination of the drug concentration in the biosamples (usually plasma or serum) obtained from volunteers, calculation of the pharmacokinetic parameters and statistical analysis of the pharmacokinetic parameters. Although current guidelines and regulations do not require the bioequivalence studies to be done under good laboratory practice (CLP), the issues to perform the bioequivalence studies under GLP environment is emerged both from the regulatory and industry side. GLP perspectives of bioequivalence studiesare needed to be discussed in respect to achieve quality assurance in bioequivalence studies.

• 한국산업보건학회지
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• 제26권4호
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• pp.445-453
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• 2016

Objectives: The objective of this study is to assess relative safety level of the decompression tables in Ministry of Employment and Labor Public Notice No. 2014-28 in comparison with overseas decompression tables. Methods: Decompression tables in the Public Notice No. 2014-28 were compared with examples from Japan, the USA, Canada, and France in terms of ascent rate, surface intervals after exceptional exposures, oxygen decompression and allowable partial pressure, depth limits in air diving, no-decompression limits, and decompression time and methods. Results: Public Notice No. 2014-28 does not include air diving depth limits, exceptional exposure limits, mandatory surface intervals after exceptional exposures, oxygen decompression, and surface decompression schedules. Its decompression time was found to be the shortest among the five decompression tables. Conclusions: Public Notice No. 2014-28 has the lowest safety level in comparison with overseas decompression tables. Deck decompression chambers are not applicable due to no regulations on surface interval and oxygen use in the chamber for decompression.

• Clinics in Shoulder and Elbow
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• 제19권2호
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• pp.110-116
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• 2016

Background: Arthroscopic surgical repair is a better intervention than non-operative (conservative) treatment for patients with shoulder dislocations. This systematic review determined the numbers-needed-to-treat (NNT) and relative risk reduction (RRR) associated with arthroscopic surgical repair versus non-operative treatment in reducing recurrence rates among patients with first-time traumatic anterior shoulder dislocations. Methods: We searched Google Scholar, MEDLINE, SPORTDiscus, and CINAHL from inception in 2015. All articles had to compare arthroscopic surgical repair and non-operative treatment and be written in English. We used the total number of subjects and the number of recurrent dislocations within each treatment to calculate the NNT and RRR for each study and the pooled data. Results: Six articles were selected and all clearly demonstrated that the arthroscopic surgical repair was more effective than non-operative treatment in reducing the recurrence episodes. The pooled NNT was 1.76 (95% confidence interval [CI]=NNT to benefit 1.50-2.13) and the pooled RRR was 86.0% (95% CI=77.0%-92.0%) among individuals who underwent arthroscopic repair. The average follow-up time was 56 months. Conclusions: A Strength of Recommendation Taxonomy level of evidence of 1 with a grade A recommendation supports the use of arthroscopic surgical repair over non-operative treatment in prevention of first-time traumatic anterior shoulder dislocations. We suggest that sports medicine practitioners consider the patients' age, occupation, and physical activity level when making a clinical decision.

• KSBB Journal
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• 제32권1호
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• pp.54-62
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• 2017

This study aimed to estimate the measurement uncertainty related to determination of hyaluronic acid used as a dietary supplement by high-performance liquid chromatography. According to the guidelines of the Association of Official Analytical Chemists, the analytical processes for determination of hyaluronic acid were performed. And the measurement uncertainty obtained during the analytical processes were expressed in accordance with mathematical/ statistical guidances of GUM (Guide to the Expression of Uncertainty in Measurement) & EURACHEM (Focus for Analytical Chemistry in Europe) for the analytical operations. For the uncertainty in measurement produced based on this analytical method, the expanded uncertainty was calculated by using the relative standard uncertainty between analytical results and sources of uncertainty in measurement (sample weight, final volume, extraction volume, standard solution, matrix and instrument etc). In the results of 95% confidence interval, it was calculated that the uncertainty in measurement was $57.75{\pm}8.76{\mu}g/kg$ (k=2.0). Therefore, it showed that the measurement uncertainty obtained by this analytical method influences on 15.2% of the contents of hyaluronic acid as the analytical results.

• 약학회지
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• 제55권1호
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• pp.22-31
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• 2011

This systematic review was conducted to assess the clinical effect of ocular fluoroquinolones used for the treatment of bacterial conjunctivitis. A literature search for randomized controlled clinical trials registered up to January 2010 based on PubMed database, using the following search terms: conjunctivitis and fluoroquinolones (besifloxacin, moxifloxacin, gatifloxacin, levofloxacin, lomefloxacin, ciprofloxacin and ofloxacin) were performed. Pooled data on the clinical resolution and bacterial eradication rates derived from selected 16 studies were reported as the relative risk (RR) and 95% confidence interval (95% CI) compared with placebo. Early clinical resolution and microbiological eradication rates in placebo were 28% and 62% respectively. Fluoroquinolones were significantly effective comparing to placebo: early RR 1.94 (95% CI 1.60~2.34) and late RR 1.30 (1.19~1.43) in clinical resolution rates, and early RR 1.75 (1.58~1.94) and late RR 1.28 (1.18~1.39) in microbiological eradication rates. Besifloxacin, ciprofloaxain and moxifloxacin in clinical resolution, and besifloxacin and levofloxacin in microbiological eradication showed higher RRs than pooled overall fluoroquinolones' RRs. New quinolones had higher antibacterial potencies for all pathogens isolated from bacterial conjunctivitis and resistant isolates than old generation quinolones. In conclusion, ocular 7 fluoroquinolones were all effective than placebo for bacterial conjunctivitis and there were differences between quinolones in early and late clinical resolutions and microbiological eradications, and no differences in safety comparing to placebo.

• 대한가정학회지
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• 제36권3호
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• pp.131-144
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• 1998

This study attempts to analyze the propensity for conspicuous consumption of the adolescent consumers and related variables such as socio-economic variables, consumer experience, materialism and consumption-oriented attitudes to provide a basis for the development of consumer education program. The survey of this research was conducted by means of self admistered questionnaire with 788 adolescent consumers attending middle and high school located in Ulsan. The results of this research were as follows: 1) The average level of the propensity for conspicuous consumption was a little high median point. This implies that consumer education is necessary for the adolescent consumer in order to reduce the level of conspicuous consumption. 2) The adolescent consumers' propensity for conspicuous consumption varies significantly according to the socio-economic variables such as sex, grade, the allowance interval, the amount of allowance, the mother's education and the subjective level of household consumption. 3) The propensity for conspicuous consumption is positively correlated with materialism and the consumption-oriented attitudes. The consumer experience is positively correlated with materialism and not significantly correlated with the propensity for conspicuous consumption and the consumption-oriented attitudes. Materialism is positively correlated with the consumption-oriented attitudes. 4) According to the results of the regression analysis examining the influences of variables affecting the propensity for conspicuous consumption, the relative importance of the variables are in the order of; materialism, the consumption-oriented attitudes, sex and the amount of allowance. These independent variables explains 49.3% of the total variance about the propensity for conspicuous consumption.

• 한국환경복원기술학회지
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• 제15권1호
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• pp.63-71
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• 2012

To investigate the air temperature difference between windward and leeward side at high-rise building area, the air temperature and relative humidity data were observed for 10 minute interval from July 9, 2011 to November 30, 2011. The observed data were compared, analyzed and examined to illustrate air temperature between windward side (H Apartment) and Leeward side (W Apartment). The diurnal and seasonal variation of air temperature difference between windward and leeward site were also investigated. After the analysis, the overheat of windward side by $0.4^{\circ}C$ irrespective short distance of two observation positions. It was also lower than those of surrounding air temperature observing stations. It is mainly due to the air temperature decreasing effects of leeward side of high rise buildings.

• Safety and Health at Work
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• 제8권4호
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• pp.402-406
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• 2017

Transit workers constitute a blue-collar occupational group that have elevated smoking rates relative to other sectors of employed adults in the United States. This study analyzed cross-sectional tobacco survey data from 935 workers (60% African American; 37% female) employed at an urban public transit agency in California. Prevalence of current and former smoking was 20.3% and 20.6%, respectively. Younger workers were less likely than older workers to be current or former smokers. Having a complete home smoking ban was associated with decreased likelihood of being a smoker [odds ratio (OR) = 0.04, 95% confidence interval (CI) = 0.01-0.17], as were neutral views about whether it is easy for a smoker to take a smoking break during their shift (OR = 0.50, 95% CI 0.28-0.88). Current smoking among the sample is > 50% higher than the adult statewide prevalence. Potential points of intervention identified in this study include perceived ease of worksite smoking breaks and establishing home smoking bans. Tailored cessation efforts focusing on older transit workers more likely to smoke are needed to reduce tobacco-related disparities in this workforce.