• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2018년도 춘계 학술논문 발표대회
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• pp.318-319
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• 2018

Protective coatings at nuclear power plants should be designed to withstand exposure to ambient conditions during normal operation or design-basis accidents. However, there was a change in the perception of the protective coating to the revision of the Regulatory Guidelines by the NRC in July 2000. In other words, maintenance guidelines have been strengthened in order to minimize the clogging of the cooling water system due to the substances in the containment building. Therefore, KHNP, the contractor and operator of the nuclear power plant, plans to develop the coating system for nuclear power plants in accordance with the regulation, and plans to develop its own coating expert.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2007년도 추계학술대회
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• pp.425-432
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• 2007

In the policy management of the safety&health, the environment and the quality, the documentation of the management system is required in every international regulatory guides. In case of 3 level classification of the system documents, it generally will be identified such name as the manual, the procedure and the job instruction. Each document has the unique role and usage though, the job instructions, especially, would be developed to support the practical job worker. So, the job instructions should be reflect the latest know-how of the job-handling methods. And that, it should be used at any times by the practical job worker. This study is planned to survey the actual usage status of the job instructions of the domestic enterprises, and tried to suggest the effective way of maintaining the documents.

• 한국환경교육학회지:환경교육
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• 제14권1호
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• pp.43-55
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• 2001

The purpose of this study was to review the current status and problems of the national qualification system in the Environmental field focusing on deficiencies of the regulatory system and qualities of environmental professional including the Environmental control Professional Engineer, Environmental Engineer, Environmental Industrial Engineer and Environmental field. An overview of the environmental field, its current status, domestic qualification items and training conditions in environment-related areas, laws of environmental field, and data of the job analysis were reviewed. The concrete and extensive development plans for the qualification system of the Environmental field are as follows: First of all, a job analysis should be made of on the introduction of new systems or policy modification to reflect technical changes and national policies about the environmental field in the qualification exam. Second, it is essential to prepare policies that are suitable for the qualification system in the Environmental field and that improve its effectiveness. Third, the appropriate policy measures should be taken in order to elevate the social standing of Environmental field qualification holders.

• Asia pacific journal of information systems
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• 제31권3호
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• pp.433-447
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• 2021

The purpose of this paper is to shed light on the current status of Industry 4.0 policies in India and provide holistic policy recommendations in the transition towards Industry 4.0. The study was conducted based on the content-centric review of written policy documents like policy memoranda (memos), green papers and white papers, policy briefs, policy reports, opinion pieces, and newspaper and academic publications on Industry 4.0. India lacks infrastructure, regulatory framework, architectural reference model, incentives, skills, and standard roadmap towards Industry 4.0. The current policy status and policy recommendations presented in this study can serve as a great asset for academicians, policymakers, and practitioners to prepare a holistic roadmap for Industry 4.0 policy implementation. The study is first to assess India's current policy status and compare with Germany towards Industry 4.0. Besides, it is expected to assist government policymakers in formulating tangible policy outputs and strategic roadmaps.

• 한국환경과학회지
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• 제23권7호
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• pp.1277-1287
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• 2014

As concerns have been raised about health effects of children's products containing hazardous chemicals on children, the Korea Ministry of Environment announced 135 environmental hazardous substances in children's products (EHSCP) which were subject to risk assessment. Therefore, it is necessary to identify the current status of EHSCP for management due to their various exposure routes and types. In this study, we investigated the exposure assessment of EHSCP as well as relevant policies implemented in domestic and foreign countries. Domestic and foreign cases of detection of EHSCP were reviewed in the literature and websites of related agencies. Due to the lack of reference values for child-specific toxicity of EHSCP, those for adults and regulatory status of EHSCP were also investigated and reviewed with literature. The related agencies of foreign countries provided 13 child-specific reference doses (RfDs), 76 RfDs, and 42 reference concentrations as toxicity reference values of the EHSCP. Among substances investigated in the studies to assess exposure of hazardous substances in children's products by the Korea Ministry of Environment, 23 substances were included in 135 EHSCP. The same studies identified 9 substances which were excluded from the 135 EHSCP. For regulatory status for hazardous substances in children's products, 44 substances (32.6 %) and 84 substances (62.2 %) of 135 EHSCP were under regulation in Korea and foreign countries, respectively. In the present study, we found that a list of 135 EHSCP should be revised to ensure children's safety.

• The Plant Pathology Journal
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• 제28권3호
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• pp.259-269
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• 2012

Protein phosphatase 2A (PP2A), a family of serine/threonine protein phosphatases, plays an important role in balancing the phosphorylation status of cellular proteins for regulating diverse biological functions in eukaryotic organisms. Despite intensive studies in mammals, limited information on its role is available in filamentous fungi. Here, we investigated the functional roles of genes for a putative B' delta regulatory subunit (FgPP2AR) and a catalytic subunit (FgPP2AC) of PP2A in a filamentous ascomycete, Fusarium graminearum. Molecular characterization of an insertional mutant of this plant pathogenic fungus allowed us to identify the roles of FgPP2AR. Targeted gene replacement and complementation analyses demonstrated that the deletion of FgPP2AR, which was constitutively expressed in all growth stages, caused drastic changes in hyphal growth, conidia morphology/germination, gene expression for mycotoxin production, sexual development and pathogenicity. In particular, overproduction of aberrant cylindrical-shaped conidia is suggestive of arthroconidial induction in the ${\Delta}FgPP2AR$ strain, which has never been described in F. graminearum. In contrast, the ${\Delta}FgPP2AC$ strain was not significantly different from its wild-type progenitor in conidiation, trichothecene gene expression, and pathogenicity; however, it showed reduced hyphal growth and no perithecial formation. The double-deletion ${\Delta}FgPP2AR;{\Delta}FgPP2AC$ strain had more severe defects than single-deletion strains in all examined phenotypes. Taken together, our results indicate that both the putative regulatory and catalytic subunits of PP2A are involved in various cellular processes for fungal development in F. graminearum.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2027-2030
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• 2016

Objective: To investigate the effect of peripheral blood CD4 + CD25 + regulatory T cell on postoperative immunotherapy in patients with renal carcinoma. Methods: 38 patients with renal cell carcinoma were recruited, and 20 patients from the operation group purely underwent the radical nephrectomy therapy, 18 patients from the combined group successively underwent the radical nephrectomy therapy and IFN-${\alpha}$ adjuvant immunotherapy. Additionally, 12 healthy subjects were recruited in the same period of time and regarded as the control group. Flow cytometry was used to detect CD4 +, CD8 +, CD4 + CD25+ T lymphocyte subset content and the ratio of all parts in the pre-operative period, in the first post-operative week and in the third post-operative month, compare and analyze its variation trend. Results: The CD4+CD25+ T lymphocyte subset content of individual renal carcinoma patients was significantly higher than that of the control group, also increases with the progression in the tumor stage (P<0.05). The post-operative CD4 + CD25+T lymphocytes of individual operation group and combined group patients showed different degrees of increment, but the increment of the combined group was significantly lower than that of the operation group (P<0.05). For the combined group patients with less pre-operative CD4 + CD25+T lymphocytes, their levels would increase after the immunotherapy, while the pre-operative patients with more CD4 + CD25+ T lymphocytes were the opposite situation. Conclusion: The detection of peripheral blood CD4+CD25+ regulatory T lymphocyte subset can reflect the anti-tumor immune status of renal cell carcinoma patient body. It can contribute to predict the prognosis of immunotherapy and provide reference for the choice of renal carcinoma post-operative adjuvant immunotherapy.

• Parasites, Hosts and Diseases
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• 제50권4호
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• pp.385-390
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• 2012

In order to know the effect of pre-existing Trichinella spiralis infection on experimentally induced intestinal inflammation and immune responses, we induced colitis in T. spiralis-infected mice and observed the severity of colitis and the levels of Th1, Th2, and regulatory cytokines and recruitment of $CD4^+CD25^+Foxp3^+$ T (regulatory T; $T_{reg}$) cells. Female C57BL/6 mice were infected with 250 muscle larvae; after 4 weeks, induction of experimental colitis was performed using 3% dextran sulfate sodium (DSS). During the induction period, we observed severity of colitis, including weight loss and status of stool, and evaluated the disease activity index (DAI). A significantly low DAI and degree of weight loss were observed in infected mice, compared with uninfected mice. In addition, colon length in infected mice was not contracted, compared with uninfected mice. We also observed a significant increase in production of pro-inflammatory cytokines, IL-6 and IFN-${\gamma}$, in spleen lymphocytes treated with DSS; however, such an increase was not observed in infected mice treated with DSS. Of particular interest, production of regulatory cytokines, IL-10 and transforming growth factor (TGF)-${\beta}$, in spleen lymphocytes showed a significant increase in mice infected with T. spiralis. A similar result was observed in mesenteric lymph nodes (MLN). Subsets of the population of $T_{reg}$ cells in MLN and spleen showed significant increases in mice infected with T. spiralis. In conclusion, T. spiralis infection can inhibit the DSS-induced colitis in mice by enhancing the regulatory cytokine and $T_{reg}$ cells recruitment.

• 해양환경안전학회지
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• 제27권6호
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• pp.737-743
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• 2021

본 논문에서는 해양산업시설 현황과 규제법규 체계, 그리고 이들 시설의 위험유해물질 배출실태 등을 분석하고, 이에 따른 규제체계의 개선방향을 제시하였다. 분석결과 2020년말 현재, 해양환경관리법의 적용을 받는 해양산업시설은 약 1천1백여개소에 이르는 것으로 파악되고 있다. 이들 해양산업시설로부터 배출되어 해양유입 가능성이 높은 위험유해물질은 190여종으로 추정되며, 이중 해양유입의 가능성이 가장 높은 물질은 수계로 배출되는 것으로 파악된 20여종으로 추정된다. 그러나 관련 법규정의 미비로 인하여, 배출되는 물질이 예외적 배출물질에 해당하는지 여부를 명확히 판단하기가 어려워, 현장에서의 효과적인 규제집행에 어려움을 겪고 있는 실정이다. 이에 해양환경관리법의 예외적 배출기준과 해당 물질의 종류에 대해 명확히 규정해야 하며, 예외적 배출물질을 무엇으로 할 것인지를 결정할 선정체계와 물질의 위해성 평가체계, 그리고 관련 위험유해물질의 배출정보수집 및 모니터링체계를 명확히 해야 한다.

• 법제연구
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• 제44호
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• pp.63-101
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• 2013

이 글에서는 먼저 경쟁과 다양성이 미디어 정책의 구체적인 수단을 규정한 방송관련법이 추구하는 주된 목적이 된다는 것을 전제로 하여 각각의 개념과 구성요소 그리고 그 제도적 구현의 모습을 살펴보고, 특정분야의 경쟁법으로서의 방송관련법에서는 경쟁 목적이 차별성 요인을 갖는 한편 다양성 가치도 특수성을 갖는다는 논의를 전개한다. 다음으로 경쟁과 다양성 가치를 조화롭게 실현하기 위해서는 방송시장 특유의 구조적 규제수단을 포함하는 특별한 경쟁규칙이 필요하다고 전제하면서, 방송관련법상 경쟁 목적 규제와 다양성 목적 규제에 대하여 개선되어야 할 방향을 다음과 같이 제시한다. 첫째, 경쟁 목적 규제의 개선 방안이다. 사전적인 상태적 규제로서의 시청점유율 규제와 사후적인 행위규제로서의 금지행위 규제는 다양성 가치를 추구하면서도 원인적 규제를 대체하는 데 중요한 역할을 할 수 있다. 이를 위하여 공정거래법의 위법성 판단방식을 유추하여 다양성 관련 요소를 금지행위의 위법성 판단기준의 고려요소로 하는 방식을 구체적으로 개발할 필요가 있다. 둘째, 다양성 목적 규제의 개선 방안이다. 이는 규제 목적의 설정, 대체가능한 규제수단의 식별, 규제 목적에 맞는 규제수단과 규제수준의 선택이라는 3가지 관점에서 검토될 수 있다. 이러한 관점에서 다양성 가치가 단순한 수사적 도구에 그치지 않고 평가 및 분석 도구로 사용될 수 있는 제도적 수단 위주로 규제 틀을 개선하는 한편, 경쟁과 같은 경제적 목적과의 조화를 고려할 때 불합리해 보이는 규제에 대하여는 이를 유지할 것인가 또는 어느 정도로 유지할 것인가를 신중하게 재검토해야 한다.