• 제목/요약/키워드: Regulatory Status

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Quality Assurance Experience in Korea

  • 이종찬
    • 비파괴검사학회지
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    • 제4권1호
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    • pp.23-29
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    • 1984
  • This paper describes the evolution of quality assurance in Korea from it's total reliance on foreign contractors to the present status of conducting all QA functions independently. A brief status of the Republic of Korea Regulatory Bodies, licensing precess, codes and standards, and the quality organization of the Korea Electric Power Corporation are also included.

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Inferring Relative Activity between Pathway and Downstream Genes to Classify Melanoma Cancer Progression

  • Jung, In-Kyung;Lee, Jung-Sul;Choi, Chul-Hee;Kim, Dong-Sup
    • Interdisciplinary Bio Central
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    • 제3권1호
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    • pp.5.1-5.5
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    • 2011
  • Introduction: Many signal transduction pathways mediate cell's behavior by regulating expression level of involved genes. Abnormal behavior indicates loss of regulatory potential of pathways, and this can be attributed to loss of expression regulation of downstream genes. Therefore, function of pathways should be assessed by activity of a pathway itself and relative activity between a pathway and downstream genes, simultaneously. Results and Discussion: In this study, we suggested a new method to assess pathway's function by introducing concept of 'responsiveness'. The responsiveness was defined as a relative activity between a pathway itself and its downstream genes. The expression level of a downstream gene as a function of an upstream pathway activation characterizes disease status. In this aspect, by using the responsiveness we predicted potential progress in cancer development. We applied our method to predict primary and metastatic status of melanoma cancer. The result shows that the responsiveness-based approach achieves better performance than using gene or pathway information alone. The mean of ROC scores in the responsiveness-based approach was 0.90 for GSE7553 data set, increased more than 40% compared to a gene-based method. Moreover, identifying the abnormal regulatory patterns between pathway and its downstream genes provided more biologically interpretable information compared to gene or pathway based approaches.

Development and strengthening of the nuclear and radiation safety infrastructure for nuclear power program of Bangladesh

  • Islam, Md. Shafiqul;Faisal, Shafiqul Islam;Khan, Sadia
    • Nuclear Engineering and Technology
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    • 제53권5호
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    • pp.1705-1716
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    • 2021
  • Bangladesh, as a newcomer country, is expecting to start her nuclear power journey by 2022. Due to evident reasons, newcomer nuclear countries face several key challenges concerning the development of national nuclear safety infrastructure. The paper investigates the status of the 7 key safety infrastructure issues out of the 19 and readiness of the supportive organizations, laboratories, and workforces following the International Atomic energy Agency's status evaluation guide at milestone 3 and foreign countries' practice. Much progress has been achieved at phase 3 regarding the establishments of a few Acts, a regulator, and an operator. However, comprehensive regulatory frameworks, skilled workforces, establishments of a few supportive organizations, and laboratories for managing environmental radioactivity, radiological accidents, and radioactive wastes are yet to ready. Several suggestions are made for establishing and expediting radiation monitoring laboratories, a radiological emergency management center, a radioactive waste management company, and technical support organizations for the safety infrastructure. To avoid perceived risks, policymakers and competent authorities need to emphasize creating an optimized safety infrastructure before commissioning and operating the 1st nuclear power plant safely, securely, and cost-sustainably.

The humidifier disinfectant case and the legislative challenges of the 20th Congress

  • Park, Taehyun
    • Environmental Analysis Health and Toxicology
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    • 제31권
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    • pp.15.1-15.6
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    • 2016
  • A number of absurdities surrounding the humidifier disinfectant (HD) incident may have occurred because 1) a judicial system operates on the underlying false assumption that the involved parties are equals in knowledge, information and resource mobilization capabilities, regardless of respective real status as company or individual; 2) there is a lack of a system that mandates a company to prevent and actively manage possible catastrophes; 3) the regulatory scheme makes companies believe that as long as they are complying with the existing regulations, they have satisfied all of their responsibilities. I believe that this issue is an opportunity to bring about changes in the judicial redress system, the system of internal management of manufacturers, and the regulatory system of the government. The following regulation amendments are needed to move towards the changes stated above. First, legislation relating to victim relief that is applicable to the HD incident must be established. Second, a risk management system must be formed within the manufacturing company and to this end an institutional environment for the system must be established within regulatory framework. Furthermore, legislation must be passed that could punish companies themselves that have caused severe damage to individuals because they had failed to take necessary actions to avoid foreseeable harm. Finally, the framework of regulation must be changed so that the company, who has the necessary information regarding the product and the component chemicals used in the product, must self-directed experiment and assessment of the safety of their own products.

나노물질 안전관리 동향 및 제도 도입에 관한 고찰 (Safety Management System on Nanomaterials with a Regulatory Scheme)

  • 김선아;김호정;홍용석
    • 환경정책연구
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    • 제12권3호
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    • pp.49-71
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    • 2013
  • 독성, 환경 노출 및 인체에 대한 위해성 유해성 등 안전성에 대한 문제점을 가지고 있는 나노물질의 확인 및 안전성 확보의 요구가 점차 높아지고 있다. 나노물질은 화학물질로 이용될 뿐만 아니라 소비자가 이용하는 제품으로 범 분야에 걸쳐 활용되기 때문에, 보다 효과적인 나노물질의 안전관리 제도화를 위해서는 각국의 정책사례를 규제 강도별, 나노 적용분야별, 규제대상 종류별로 구분하여 정책 동향을 파악하는 것이 중요하다. 나노물질의 잠재적 위험성을 최소화시키기 위해서는 사전예방원칙을 적용한 제도의 구축 또한 필요하다. 더불어 국내 실정에 적합한 정책 수립을 목표로 하고, 국제 흐름에 선제적, 능동적으로 대응할 수 있는 방안도 함께 고려해야 한다.

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건설업체 자율안전관리 능력제고 방안 (Improving Self-control Safety & Management Ability of Construction Contractors)

  • 이송;손기상;최원일;오태상;채점식
    • 한국안전학회지
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    • 제15권4호
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    • pp.112-118
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    • 2000
  • This paper is resulted from the research to activate Self-control Safety Management system that adopted to improve an assessment system for Hazard Prevention Plan. And members of company, university and research institute have jointly participated in the research. First, it is investigated that introduced background and processing method with existing practical data & materials references in order to understand what domestic Self-control Safety Management system will be available for. And general construction company at site have their ability to assess Hazard Prevention Plan by mailing questionnaire to on thousand site, visits, and interviews. Also, It is investigated how much they have the assessment ability. It is selected to do a questionnaire survey for the status of self-regulatory safety assessment ability of the designated self-regulatory companies in order to produce and enhance the self-regulatory assessment ability and the necessity of Self-control Safety Management system. Finally, it is selected to do a questionnaire survey for fixing and the enhance Self-control Safety Management system of general construction contractors.

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관리대상 화학물질의 지정 및 관리체계 차등화를 통한 효율적 대학 연구실 관리에 대한 연구 (A Study on the Efficient Management of University Laboratories through Differential Designation of Chemical Substances and Classification of Management System)

  • 김덕한;김민선;이익모
    • 대한안전경영과학회지
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    • 제24권4호
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    • pp.61-70
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    • 2022
  • In spite of lab safety act for over 10 years, over 100 safety accidents in the laboratory have been constantly occurring. The ideal safety management system is to prevent accidents by differential classifying and managing laboratory regulatory materials according to the risk level. In order to approach this system, in-depth interviews with safety managers were first conducted to identify the current status of safety management in domestic university laboratories. And then through comparative analysis of safety management systems in domestic and foreign laboratories, a new regulatory substance classification standard based on the analysis of the hazards and the classification of risk grades, and a safety management system are proposed. From this study, it will contribute to the creation of a safe laboratory environment by differential classification and management laboratory regulatory materials based on the risk level.

서비스기업 종사원의 심리적 주인의식과 소비자만족에 관한 연구 (A Study on Relationship Between Psychological Ownership & Customer Satisfaction in Service Enterprise Employees)

  • 이정림;김형길;김재균
    • 유통과학연구
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    • 제14권3호
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    • pp.93-101
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    • 2016
  • Purpose - Due to the heavy reliance on the human dependence, several factors such as attitude, behavior, emotional status and the quality of the service by the employees have been a decisive effect on the existence of a business in service industry. This study made use of the cases from the beauty salons in Korea, and tried to find out the meaningful results with following purposes. The purpose of this study is to find out the effects of psychological ownership with focusing on the employees in service industry. Therefore, this study is based on the literature reviews in the fields of psychological ownership, regulatory focus, and customer satisfaction. In particular, this study focuses on the regulatory focus with two parts. The two parts are composed of the promotion focus and prevention focus. Also, the relationship between the regulatory focus on employee and customer satisfaction was identified through empirical study. Mediating effects of regulatory focus were also studied, that is, the regulatory focus was on the relationship between psychological ownership and customer satisfaction. In conclusion, practical and intellectual implications were discussed for the growth and development in service industry. Research design, data & methodology - The survey for this study was conducted from November 15th to December 15th in 2015. The same amount of survey was given to both, the service providers and customers. For both of them, such as the service providers and customers, 260 questionnaires were distributed to them in total. After excluding the missing and unreliable responses for the exact analysis and process, 250 responses were collected and used in the research analysis. This study conducted a survey questionnaires, and the confirmatory analysis was used for the reliability and validity in this study. SPSS & AMOS programs were used for the analysis. Results - The first variable that was looked at from this study is the psychological ownership. The psychological ownership had positive effects on the performance both in improving focus and prevention focus. It indicates that this study supports the results from the previous studies. Second, the effects on the performance in improving focus and prevention focus for customer satisfaction were studied. As a result, the performance in improving focus had positive effect on customer satisfaction, but prevention focus did not have any positive effect. Third, this study looked at the mediating effect of regulatory focus on the relationship between the psychological ownership and the customer satisfaction, and only partly, they had positive effects on customer satisfaction. Conclusions - The results of this study showed that the psychological ownership has positive effects on regulatory focus both in performance improving focus and prevention focus. However, the mediating effects had partial positive effects on customer satisfaction and these results indicate that the service enterprises should focus on the employees' psychological ownership in order to maximize the customers' satisfaction.

In vivo action of RNA G-quadruplex in phloem development

  • Cho, Hyunwoo;Cho, Hyun Seob;Hwang, Ildoo
    • BMB Reports
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    • 제51권11호
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    • pp.547-548
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    • 2018
  • Phloem network integrates cellular energy status into post-embryonic growth, and development by tight regulation of carbon allocation. Phloem development involves complicated coordination of cell fate determination, cell division, and terminal differentiation into sieve elements (SEs), functional conduit. All of these processes must be tightly coordinated, for optimization of systemic connection between source supplies and sink demands throughout plant life cycle, that has substantial impact on crop productivity. Despite its pivotal role, surprisingly, regulatory mechanisms underlying phloem development have just begun to be explored, and we recently identified a novel translational regulatory network involving RNA G-quadruplex and a zinc-finger protein, JULGI, for phloem development. From this perspective, we further discuss the role of RNA G-quadruplex on post-transcriptional control of phloem regulators, as a potential interface integrating spatial information for asymmetric cell division, and phloem development.