• Nuclear Engineering and Technology
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• 제51권8호
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• pp.2034-2041
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• 2019

Public acceptance has become the most critical question for sustainable development of nuclear energy in recent decades. Many researches concentrated on risk and benefit perception, which were deemed as the most influential factors of Public Acceptance of Nuclear Energy (PANE). But few researches focused on psychological factors including regulatory focus. Therefore, this paper aimed to explore the moderating effect of regulatory focus on PANE based on Regulatory Focus Theory in order to find ways to increase/decrease PANE. An Internet-based survey had been carried out in China nationwide. The results indicated that trust in government was positively related to PANE and this relationship was mediated by risk and benefit perception. In addition, the strength of the associations between risk and benefit perception and PANE were moderated by regulatory focus, consisting of prevention focus and promotion focus. Prevention focus strengthened the negative relationship between risk perception and PANE, while promotion focus weakened. Moreover, promotion focus weakened the positive relationship between benefit perception and PANE, but no significant moderating effect of prevention focus was founded on the relationship between benefit perception and PANE. Some policy implications were also proposed on the basis of above-mentioned findings.

• Journal of Microbiology and Biotechnology
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• 제10권2호
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• pp.169-175
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• 2000

The filamentous soil bacterium Streptomyces coelicolor is known to produce four distinct antibiotics. The simultaneous global regulation for the biosynthesis of those four antibiotics was previously confirmed by absA and absB mutations that blocked all four antibiotics' biosynthesis without influencing their morphological differentiation. To study the complex regulatory cascade that controls the secondary metabolism in Streptomyces, a new abs-like mutation was characterized. namely absR, which is slightly leaky on a complete R2YE medium, yet tight on a minimal medium. A genetic analysis of the absR locus indicated that it is located at 10 o'clock on the genetic map, near the site of absA. A cloned copy of the absA gene that encoded bacterial two-component regulatory kinases did not restore antibiotic biosyntheis to the absR mutant. Accordingly, it is proposed that absR is another abs-type mutation which is less tight than the previously identified absA or absB mutations income medium conditions, and can be used to characterize another global regulatory gene for secondary metabolete formation in S. coelicolor.

• 대한의생명과학회지
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• 제20권3호
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• pp.147-155
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• 2014

It has well studied that immune cells are strongly related to tumor progression and tumor suppression. To identify the difference of immune cell between tumor bearing mice and normal mice, we examined systemically the immune cell of CT26 tumor bearing mice on 21 days after tumor cell administration. As previously reported, CD4+ and CD8+ T cells population of tumor bearing mice significantly decreased 38% and 30% on day 21 compared to that of normal mice, respectively. All subpopulation of CD4 and CD8+ T cell significantly decreased, except CD49b+ T cell subpopulation. But, myeloid cell population ($CD11b^{high}$ and all Gr-1+ subpopulation) of tumor bearing mice significantly increased on day 21. Especially, all subpopulation of CD11b+Gr-1+ cell of tumor bearing mice significantly increased on day 21. Also, Foxp3+$CD25^{high}$ CD4 T cell (regulatory T cells) population significantly increased on day 21. These results suggest that tumor can induce the decline of T lymphocyte and the expansion of myeloid cells and regulatory T cells, and provide the basic information for the study of tumor immunology.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3677-3683
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• 2015

Abnormally expressed microRNAs (miRNAs) and genes have been found to play key roles in esophageal squamous cell carcinoma (ESCC), but little is known about the underlying mechanisms. The aim of this paper was to assess inter-relationships and the regulatory mechanisms of ESCC through a network-based approach. We built three regulatory networks: an abnormally expressed network, a related network and a global network. Unlike previous examples, containing information only on genes or miRNAs, the prime focus was on relationships. It is worth noting that abnormally expressed network emerged as a fault map of ESCC. Theoretically, ESCC might be treated and prevented by correcting the included errors. In addition, the predicted transcription factors (TFs) obtained by the P-match method also warrant further study. Our results may further guide gene therapy researchers in the study of ESCC.

• 대한의생명과학회지
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• 제26권4호
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• pp.256-266
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• 2020

Carboxypeptidase D (CPD) is a zinc-dependent protease, which is highly expressed in macrophages, and is thought to participate in inflammatory processes. In the present study, we investigated the possible regulatory effect of all-trans retinoic acid (ATRA), which is an active form of vitamin A and plays a critical regulatory role in both the innate and adaptive immunity, on CPD expression and secretion in human monocytic THP-1 cells. CPD mRNA expression first increased, from a concentration as low as 10 nM ATRA to a maximum level of expression, at 1 μM. ATRA enhanced intracellular CPD expression in a time- and concentration-dependent manner but did not affect cell surface CPD expression. Interestingly, 9-cis-RA did not affect CPD expression. Additionally, an experiment with RAR/RXR selective agonist or antagonists demonstrated that ATRA-induced enhancement of CPD expression was RAR/RXR dependent. ATRA also enhanced CPD secretion from THP-1 cells; however, this enhancement was RAR/RXR-independent. The anti-inflammatory agent dexamethasone reversed ATRA-induced enhancement of CPD expression and secretion. Our results suggest ATRA exerts regulatory effects on expression and secretion of CPD in human monocytes, and ATRA-induced CPD secretion may be associated with inflammatory response.

• 감성과학
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• 제13권4호
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• pp.669-676
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• 2010

조절부합은 개인의 조절초점 성향과 평가 및 판단 전략이 지닌 조절초점이 서로 일치할 때 일어난다. 본 연구에서는 평가 및 의사결정의 영역이 유발하는 조절초점과 개인의 조절초점간의 부합이 평가에 영향을 미칠 것이라고 가정하고, 향상적 영역으로는 제품 디자인 평가를, 예방적 영역으로는 도덕적 평가를 사용하여 조절부합 효과를 알아보았다. 향상초점과 관련된 영역인 미적 제품에 대한 평가 과제를 사용한 실험 1에서는 향상초점인 사람들이 예방초점인 사람들에 비해 긍정적인 것은 더 긍정적으로, 부정적인 것은 더 부정적으로 평가하였다, F(1, 95) = 4.87, p < .05. 반면 금지와 규범적인 도덕 상황을 사용한 실험 2에서는 금지적 상황에서만 예방초점인 사람들이 향상초점인 사람들에 비해 도덕적으로 옳지 않은 결정에 대해서는 더 비 도덕적인 것으로 평가하였다, F(1, 139) 4.14, p < .05. 반면 규범적 상황에 대한 평가에서는 이러한 조절부합 효과가 나타나지 않았다. 이러한 연구결과는 평가 및 의사결정 영역과 관련해서도 조절부합이 나타날 수 있음을 보여준다.

• 유통과학연구
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• 제12권2호
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• pp.39-47
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• 2014

Purpose - The ultimate goal of a franchise system comes from its win-win strategy. Agency theory uses goal incongruity to examine complex contracting problems between buyers and suppliers. Goal incongruity within a contractual relationship can be defined as the agent's desire not to cooperate. It is the degree to which the contractual terms do not satisfy the agent's goals. The greater the goal incongruity between the agent and the contract, the more likely it is that the agent will meet the terms of the contract. Thus, goal incongruity between buyers and suppliers has close relationships with both behavioral and financial performance. This study tries to examine these relationships in the franchise context using a model including related variables, such as regulatory foci, financial performance, and opportunism, to explain the reasons that not all franchisees perform their best. In particular, the study examines the effects of goal incongruity on regulatory focus, and the effects of regulatory focus on performance and opportunism. In short, the objective is to determine goal incongruity's effect on regulatory foci, and the effect of regulatory focus on performance and opportunism. Research design, data, and methodology - This study used data collected from the franchisee managers of 104 franchisors in South Korea. The franchisors include more than 10 franchisees, the majority of whom have been in business for more than five years. The study also surveyed 104 franchisees, matched with their franchisors for the sake of a dyadic approach. The study used regression analysis to test the hypotheses. Results - H1 and H2 predicted that goal incongruity would decrease promotion focus and increase prevention focus. Supporting H1, the result indicates goal incongruity had a positive effect on promotion focus. However, H2 was not supported. Goal incongruity had no significant effect on prevention focus (β = -.375, t = -4.331 and β = -.145, t = -1.950, respectively). H3 and H4 predicted that promotion focus would increase financial performance and decrease opportunism. Supporting these hypotheses, the results indicate that promotion focus had a positive effect on financial performance and a negative effect on opportunism (β = .771, t = 7.899 and β = -.765, t = -6.778, respectively). H5 and H6 predicted that prevention focus would decrease financial performance and increase opportunism. However, the results do not support these hypotheses. The results indicate that prevention focus had no effects on opportunism or financial performance (β = -.130, t = -1.070 and β = .090, t = .641, respectively). Overall, the evidence generally supported the hypotheses. Conclusion - Goal incongruity between a franchisor and a franchisee increases the franchisee's financial performance and opportunism, and the relationship is mediated by promotion focus. Interestingly, however, prevention focus has no mediating effect between goal incongruity and performance. Even though no significant relation exists between goal incongruity and prevention focus, the results have two implications. First, decreasing goal incongruity can improve financial performance and suppress franchisee opportunism. Second, the relationship between goal incongruity and performance affects promotion-focused franchisees.

• 한국문헌정보학회지
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• 제41권2호
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• pp.111-133
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• 2007

인터넷 상의 불법 유해 정보의 존재는 규제 당국뿐만 아니라 공공도서관과 학교를 비롯하여, 인터넷 서비스를 제공하는 모든 공공정보자원에서 큰 고민거리가 되어온 지 오래다. 특히 현대 정보사회에서 정보자원의 조직과 정보의 공개, 제공 및 이용서비스를 주 임무로 하고 있는 공공도서관의 경우 도서관 이용자들에 대한 인터넷 서비스의 제공은 필수적이라 할 수 있다는 측면에서 인터넷 정보를 둘러싼 규제 환경의 변화는 공공도서관 서비스 전반에 직접적인 영향을 미칠 수 있다. 1990년대 중반부터 본격화된 인터넷 정보에 대한 규제는 인터넷의 고유한 매체특성으로 인하여 법제도적 규제와 함께 기술적 규제 방식이 적극적으로 활용되어 왔다. 그러나 기술적 규제 방식 또한 각 나라마다. 매우 다양한 모습으로 발전하여 왔고, 더욱이 도서관 등과 같은 공공정보자원에서의 기술 규제는 표현의 자유와 알권리, 정보접근원의 침해라는 비판을 받아왔다. 이 글은 인터넷 규제와 표현의 자유에 대한 이론적 논의들로 시작하여, 인터넷에 대한 기술적 규제 방식으로 폭넓게 활용되고 있는 필터링 소프트웨어의 기술적 측면을 살피고, 인터넷 필터링을 중심으로 한 각국의 규제 양상을 비교 분석한다. 이를 통해 공공정보자원에서의 인터넷 필터링을 둘러싼 문제들에 대해 비판적으로 논의하고자 한다.

• 한국전자파학회논문지
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• 제30권6호
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• pp.427-437
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• 2019

2019년 1월 과학기술정보통신부는 2019년부터 2023년까지의 제3차 전파진흥기본계획을 발표하였고, 그 핵심은 시장기반 전파제도를 도입하고, 수평적 규제체계를 수립하는 것이다. 다소 늦은 감은 있으나 이러한 전파제도의 개혁은 매우 합리적이고 체계적인 것으로 세계적으로 전례가 드문 획기적인 입법적 진보라고 평가할 수 있다. 이러한 시장기반 전파제도와 수평적 규제체계를 완성하기 위해서는 유상의 면허대가와 일정한 이용기간을 전제로 한 단일한 주파수 면허제를 도입하여야 한다. 이를 통해 유한한 전파자원의 효율적 배분을 실현할 수 있게 될 것이다. 또한 주파수 면허의 생애주기적 체계를 전파법에 잘 반영시켜 법률 조문화하는 입법적인 노력이 요구된다.

• Asian-Australasian Journal of Animal Sciences
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• 제16권11호
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• pp.1690-1694
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• 2003

The large and rapid changes of glucose utilization in lactating mammary tissue in response to changes in nutritional state must be largely related by external signal of insulin. This also must be related with the quantity and composition of the diet in vivo. To characterize the mode of growth factors and gut regulatory peptides with insulin, in vitro experiment was conducted with HC11 cells. All the growth factor alone and the combinations of growth factors significantly (p<0.05) increased in glucose uptake. Insulin, EGF and IGF-1 exhibited a stimulation of glucose uptake for at least 24 h. Furthermore, the highest (p<0.05) synergistic effect was shown in EGF plus IGF-1 and the second synergistic effect in insulin plus EGF while no synergistic effect was found between insulin and IGF-1. However, the gut regulatory peptides neither potentiated nor inhibited the action of insulin on glucose uptake. Although growth factors did not modulates glucose uptake via increasing the rate of translation of the GLUT1 protein, RT-PCR analysis indicated that the growth factors significantly (p<0.05) increased the expression of GLUT1. The growth factors are therefore shown to be capable of modulating glucose uptake by transcription level with insulin in HC 11 cells.