• Title/Summary/Keyword: Regulatory Science

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Quality Evaluation of Commercial Salted and Fermented Anchoby Sauce (시판 멸치액젓의 품질평가 방법에 관한 연구)

  • 김재현;류기형;안현주;이경행;이현자;변명우
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.29 no.5
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    • pp.837-842
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    • 2000
  • Commercially distributed salted and fermented anchovy sauces in Korea were purchased from six different companies. Microbiological, chemical, rheological and sensory analyses were carried out to evaluate the quality and safety and to provide basic information of the products. The salinity of every product was lower than of regulatory standard. All samples tested had acceptable in moisture content and pH. However, wide range of amino nitrogen (AN), volatile basic nitrogen(AN), volatile basic nitrogen (VBN), and trimethylamine (TMA) contents were observed. One product among tested had lower level of AN than regulatory standard. Pathogenic microorganisms were also detected from the samples, therefore sanitation procedure will be needed to ensure safety. From the results, AN, VBN, and viscosity were highly correlated to sensory scores, suggesting that these values can utilized as a standard method to evaluate quality of the salted and fermented anchovy sauce.

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Informational and Methodological Approach to Ensuring the Economic Security of the State in the Banking Sphere

  • Shemayeva, Luidmila;Hladkykh, Dmytro;Mihus, Iryna;Onofriichuk, Andrii;Onofriichuk, Vitalii
    • International Journal of Computer Science & Network Security
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    • v.21 no.12spc
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    • pp.477-482
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    • 2021
  • The existing approaches to ensuring the banking security of the state do not take into account the peculiarities of the banking system in the rapid development of the information economy (increasing uncertainty, imbalance and nonlinearity of processes in the banking system under the influence of innovation, institutions, information asymmetry, etc.). A methodological approach to determining the synergetic effect in the implementation of the regulatory influence of the state on the development of innovation processes related to informatization in the banking system, based on the use of differential equations and modelling the sensitivity of innovation processes related to informatization in the banking system, to the regulatory influence of the state to prevent the deployment of risks and threats to economic security of the state in this area has been suggested in the present article.

Comparison of TNF-Mediated Glucose Catabolism between the TNF-Sensitive and -Resistant Cell Lines

  • Kim, Yeon-Hyang;Park, Bok-Ryun;Cheong, Hee-Sun;Kwon, Oh-Hwan;Kim, Dae-Que;Kim, Soung-Soo
    • BMB Reports
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    • v.32 no.2
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    • pp.140-146
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    • 1999
  • When murine fibrosarcoma L929 cells, a TNF-sensitive cell line, were treated with recombinant human tumor necrosis factor-$\alpha$ (rhTNF-$\alpha$), the activities of glycolytic regulatory enzymes and lactate dehydrogenase increased up to 100-150% compared to the control L929 cells after TNF treatment. By using various metabolic inhibitors and activators, it was found that cAMP-dependent protein kinase is responsible for the increase of activities of the glycolytic enzymes. The activities of glycolytic regulatory enzymes and lactate dehydrogenase of TNF-resistant A549 cells, a human lung carcinoma cell line, did not increase significantly compared to TNF-sensitive L929 cells upon TNF treatment. In contrast, the pyruvate carboxylase activities of A549 cells, but not L929 cells, increased up to 30~40% after TNF treatment. The data suggest that pyruvate carboxylase activity may contribute to the compensation of energy loss mediated by TNF treatment in TNF-resistant A549 cells.

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Effect of Low Doses of Genistein and Equol on Protein Expression Profile in MCF-7 Cells

  • Kim, Jang-Hoon;Lim, Hyun-Ae;Lee, Jeong-Soon;Sung, Mi-Kyung;Kim, Young-Kyoon;Yu, Ri-Na;Kim, Jong-Sang
    • Food Science and Biotechnology
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    • v.14 no.6
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    • pp.854-859
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    • 2005
  • Although action modes of equol and genistein have been extensively studied, their precise roles in tumor cells remain elusive. To address possible effects of these compounds on protein expression in mammary tumor cells, proteins modulated in MCF-7 mammary tumor cells when incubated in absence and presence of 10 uM equol or genistein were identified through 2-dimensional gel electrophoresis, MALDI-TOF MS/MS, and NCBInr database search using Mascot software. Most proteins differentially expressed in MCF-7 cells after treatment with 10 uM genistein or equol were identified as being the same. Exposure to both compounds caused decreased cellular expression of RNA-binding protein regulatory subunit and oncogene DJ1 tubulin beta-1 chain, and increased expression of heterogeneous ribonucleoproteins F and L, KH-type splicing regulatory protein, and translation elongation factor EF-Tu precursor. Genistein and equol at dose used in this study showed common action mechanism.

A Critical Analysis on Capital Market Developments in India: Pre and Post Liberalization Period

  • Potluri, Rajasekhara Mouly;Pasha, Shaik Abdul Majeeb;Challa, Siva kumar;Challagundla, Srilakshmi
    • Journal of Distribution Science
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    • v.12 no.10
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    • pp.5-9
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    • 2014
  • Purpose - This paper aims to critically examine capital market developments in India before and after liberalization. Research design, data, and methodology - The paper examines the Indian capital market from its inception to the latest developments related to both primary and secondary markets, and also discusses recent initiatives of capital markets to enhance the expected level of services to the investor community. It also sheds light on the regulatory framework for investor protection. Results - The study further highlights the future roadmap for the radical development of the Indian capital market. The paper identifies the various initial obstacles and intricacies that affect the smooth functioning of the Indian capital markets. Hence, the paper articulates that these concerns should be addressed by the regulatory authorities and at the policy level at the earliest for further strengthening the capital markets in the interests of the economy in general and retail investors in particular. Conclusion - This is a topic of utmost contemporary importance to worldwide national economies, and calls for novel methods and techniques in dealing effectively with the menace facing capital markets.

Hepatitis B Virus X Protein Stimulates Virus Replication Via DNA Methylation of the C-1619 in Covalently Closed Circular DNA

  • Lee, Hyehyeon;Jeong, Hyerin;Lee, Sun Young;Kim, Soo Shin;Jang, Kyung Lib
    • Molecules and Cells
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    • v.42 no.1
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    • pp.67-78
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    • 2019
  • Methylation of HBV cccDNA has been detected in vivo and in vitro; however, the mechanism and its effects on HBV replication remain unclear. HBx derived from a 1.2-mer HBV replicon upregulated protein levels and enzyme activities of DNA methyltransferase 1 (DNMT1), 3a, and 3b, resulting in methylation of the negative regulatory region (NRE) in cccDNA, while none of these effects were observed with an HBx-null mutant. The HBx-positive HBV cccDNA expressed higher levels of HBc and produced about 4-fold higher levels of HBV particles than those from the HBx-null counterpart. For these effects, HBx interrupted the action of NRE binding protein via methylation of the C-1619 within NRE, resulting in activation of the core promoter. Treatment with 5-Aza-2′dC or DNMT1 knock-down drastically impaired the ability of HBx to activate the core promoter and stimulate HBV replication in 1.2-mer HBV replicon and in vitro infection systems, indicating the positive role of HBx-mediated cccDNA methylation in HBV replication.