• 정보처리학회논문지B
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• 제19B권4호
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• pp.231-236
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• 2012

소비자 행동이론에 따르면 사람의 성향은 향상초점과 예방초점이라는 두 가지 조절초점 유형으로 나누어지며, 이 두 가지 성향은 다양한 영역에 있어서 소비자의 의사결정에 많은 영향을 미치는 것으로 알려져 있다. 본 연구에서는 개인화 추천에서 Cold Start 문제의 최소화 및 추천 알고리즘 성능 개선을 위하여 조절초점이론을 적용한다. 이를 위하여, 웹쇼핑 로그로부터 소비자 별 행동변수, 정보탐색활동성 지수를 추출하고 이를 활용한 소비자 조절초점성향 분류 방법을 제안한다. 본 연구는 사회과학/IT 융합 연구로서 소비자행동 이론의 시스템화 가능성을 입증하였다는 점에 있어서 의의를 지니며, 향후 다양한 분야의 이론들을 적용한 IT 서비스에 대한 연구로 확장하고자 한다.

• 산경연구논집
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• 제10권5호
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• pp.49-58
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• 2019

Purpose - Consumer behaviors or decision-making process has been changing recently as the consumer environment, including mobile everyday life, has changed. In view of this changing consumer smart environment, this study aims to investigate structural relation about the influence omni-channel propensity and regulatory focus on consideration set formation. Research design, data, and methodology - In order to proceed with this study, we review previous studies and setting hypotheses. The hypothesis was verified through a survey that was conducted for university students with experience in purchasing in less than three months. With reference to previous studies, operational definition was made for the questionnaire design. From 2018 Nov. to 2019 Feb. Survey was conducted on the panel consumers who purchase item within that period. 315 collected survey data were used to verify hypotheses except the data that had incorrect values. This data were used for SPSS/AMOS for confirm hypothesis which developed by researcher. Results - The results of this study are as follows. First, Consumers were considering a more heterogeneous alternatives if they were more omni-channel propensity in the process of forming consideration set. Second, Consumers were more conscious of the price if they were more omni-channel propensity Third, Consumers were considering a more newness alternatives if they were more omni-channel propensity in the process of forming consideration set. Meanwhile, The results of the study on regulatory focus and consideration set relationships are as follows. Consumers were considering a more heterogeneous alternatives if they were more promotion focus tendency in the process of forming consideration set. Second, Prevention focus tendency were more conscious of the price in the process of considering alternatives. Third, Consumers were considering a more newness alternatives if they were more promotion focus tendency. Conclusions - Depending on the changing consumer environment, the omni-channel propensity was shown to influence the formation of the consideration set. Also, Regulatory focus of consumers significantly influence to formation of consideration set. this study also contributes to the development of the theory as well as the practical approach with understanding consumer decision process on smart(mobile) environment.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2265-2268
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• 2013

Several lines of evidence indicate that cancer is a multistep process. To survey the mechanisms involving gene alteration and miRNAs in adrenocortical cancer, we focused on transcriptional factors as a point of penetration to build a regulatory network. We derived three level networks: differentially expressed; related; and global. A topology network ws then set up for development of adrenocortical cancer. In this network, we found that some pathways with differentially expressed elements (genetic and miRNA) showed some self-adaption relations, such as EGFR. The differentially expressed elements partially uncovered mechanistic changes for adrenocortical cancer which should guide medical researchers to further achieve pertinent research.

• BMB Reports
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• 제50권11호
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• pp.554-559
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• 2017

MicroRNAs (miRNAs) are ~22nt-long single-stranded RNA molecules that form a RNA-induced silencing complex with Argonaute (AGO) protein to post-transcriptionally downregulate their target messenger RNAs (mRNAs). To understand the regulatory mechanisms of miRNA, discovering the underlying functional rules for how miRNAs recognize and repress their target mRNAs is of utmost importance. To determine functional miRNA targeting rules, previous studies extensively utilized various methods including high-throughput biochemical assays and bioinformatics analyses. However, targeting rules reported in one study often fail to be reproduced in other studies and therefore the general rules for functional miRNA targeting remain elusive. In this review, we evaluate previously-reported miRNA targeting rules and discuss the biological impact of the functional miRNAs on gene-regulatory networks as well as the future direction of miRNA targeting research.

• BMB Reports
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• 제28권4호
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• pp.368-373
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• 1995

The upstream regulatory region (URR) of bovine papillomavirus type 1 (BPV) contains promoters and a conditional transcriptional enhancer that is trans-activated by the viral E2 protein. After deleting the 5' and 3' ends of BPV URR, BamHI linkers were inserted into several positions of BPV URR without causing an addition or a deletion of URR sequences. Most linker scanning mutations did not show any effects on the transcription of P7940 and P89 promoters in BPV URR. However, several mutants showed reduced transcriptional activities. Based on our results we found that the AP-2 and Sp1 binding sites were important for basal level transcription of BPV URR in the absence of the E2 protein and that the CTF/NF-1 site is dispensable for E2 transactivation of BPV URR transcription.

• Journal of Dairy Science and Biotechnology
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• 제14권1호
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• pp.17-31
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• 1996

This study was to investigate current regulatory status of nutrition labeling in advanced countries, such as US and Japan. In US, the mandatory and voluntary components and the order in which they must appear are total calories, total fat, cholesterol, sodium, potassium, total carbohydrate, protein vitamin and iron. The amount of each nutrient must be reported on the basis of the serving size except vitamines and minerals. In Japan, new regulatation on nutrition labeling was made in 1995. For nutrition labeling on processed food, a standard must be appeared and it is mandatory. The union of Europe and Codex also newly regulated on nutrition labeling. It is time to make new regulation on nutrition labeling for being advanced country.

• 한국식품과학회지
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• 제9권4호
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• pp.295-305
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• 1977

근원성유로 부터 근수축조절단백질들을 추출정제하고 저장중의 변화를 연구하여 다음과 같은 결과를 얻었다. 1. ${\alpha}-actinin$은 그 분자형(分子形)이나 생물활성(生物活性)에 아무런 변화도 일으키지 않았다. 2. 근육저장중에 근원섬유의 troponin-troponin complex의 함량은 감소되고 있으며 troponin-tropomyosin complex의 troponin함유비(含有比)는 낮아지고 있다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.427-430
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• 2005

Studies on cellular pathways and networks are now one of the most actively researched topics in all fields of biomedicine ranging from developmental biology to etiology. Many databases have been developed and quantitative simulation models have been proposed. One of the eventual goals of pathway/network studies is to integrate different types of pathway/network models and databases to simulate overall cellular responses. A bottleneck to this goal is modeling gene expression since the mechanism of this process is not yet fully unveiled. We are developing a small scale computer program called CiRMU (Cis-Regulatory Machinery Unit model) for describing, viewing, analyzing, and modeling the process of gene expression. A prototype system is being designed and implemented for analyzing functions of nuclear receptors.

• Bioinformatics and Biosystems
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• 제2권2호
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• pp.52-57
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• 2007

The computational discovery of transcription factor binding site is one of the important tools in the genetic and genomic analysis. Rough prediction of gene regulation network and finding possible co-regulated genes are typical applications of the technique. Countless motif-discovery algorithms have been proposed for the past years. However, there is no dominant algorithm yet. Each algorithm does not give enough accuracy without extensive information. In this paper, we explore the possibility of combining multiple algorithms for the one integrated result in order to improve the performance and the convenience of researchers. Moreover, we apply new high order information that is reorganized from the set of basis predictions to the final prediction.

• Genomics & Informatics
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• 제18권3호
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• pp.26.1-26.6
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• 2020

Single-cell RNA sequencing (scRNA-seq) has been widely applied to provide insights into the cell-by-cell expression difference in a given bulk sample. Accordingly, numerous analysis methods have been developed. As it involves simultaneous analyses of many cell and genes, efficiency of the methods is crucial. The conventional cell type annotation method is laborious and subjective. Here we propose a semi-automatic method that calculates a normalized score for each cell type based on user-supplied cell type-specific marker gene list. The method was applied to a publicly available scRNA-seq data of mouse cardiac non-myocyte cell pool. Annotating the 35 t-stochastic neighbor embedding clusters into 12 cell types was straightforward, and its accuracy was evaluated by constructing co-expression network for each cell type. Gene Ontology analysis was congruent with the annotated cell type and the corollary regulatory network analysis showed upstream transcription factors that have well supported literature evidences. The source code is available as an R script upon request.