• BMB Reports
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• 제49권11호
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• pp.598-606
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• 2016

ARF is an alternative reading frame product of the INK4a/ARF locus, inactivated in numerous human cancers. ARF is a key regulator of cellular senescence, an irreversible cell growth arrest that suppresses tumor cell growth. It functions by sequestering MDM2 (a p53 E3 ligase) in the nucleolus, thus activating p53. Besides MDM2, ARF has numerous other interacting partners that induce either cellular senescence or apoptosis in a p53-independent manner. This further complicates the dynamics of the ARF network. Expression of ARF is frequently disrupted in human cancers, mainly due to epigenetic and transcriptional regulation. Vigorous studies on various transcription factors that either positively or negatively regulate ARF transcription have been carried out. However, recent focus on posttranslational modifications, particularly ubiquitination, indicates wider dynamic controls of ARF than previously known. In this review, we discuss the role and dynamic regulation of ARF in senescence and cancer.

• 한국정보통신학회논문지
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• 제8권5호
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• pp.1068-1073
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• 2004

전원장치의 소형화 핵심기술인 반도체 스위칭 기술을 이용하여 5 V/500 mA급 트랜스리스형 파워모듈(transless type power module)을 설계하였다. 파워 모들은 강압형 chopper 방식을 이용하였으며, 스위칭회로, 제어회로, 전압검출회로, 그리고 정전압 회로 등으로 구성되어 었다. 본 연구에서 설계한 스위칭 파워모듈은 0.2 V의 load regulation, 0.1 V의 line regulation, 85 mVp-p의 output ripple 전압, 64.7 kHz의 스위칭 주파수, 최대 58% 정도의 효율을 나타내었으며, 신뢰성 및 EMC 평가항목을 만족하였다.

• 한국마린엔지니어링학회:학술대회논문집
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• 한국마린엔지니어링학회 2011년도 후기공동학술대회 논문집
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• pp.114-116
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• 2011

By 33 CFR 154.828 regulation, a liquid seal must be installed on the inlet to vapor destruction unit in vapor control system. However, install and maintenance of liquid seal are subject to many problems in ship environment. Therefore, US Coastguard, which is the governing body of the regulation, have prepared another clause in the regulation for the exemption from previous clauses. In this paper, relevent regulation is reviewed, together with the requirements for exemption from liquid seal installation. A previous example case is also studied to propose how safety assessment for the alternative safety devices replacing liquid seal should be performed.

• BMB Reports
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• 제46권6호
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• pp.289-294
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• 2013

To maintain cellular homeostasis against the demands of the extracellular environment, a precise regulation of kinases and phosphatases is essential. In cell cycle regulation mechanisms, activation of the cyclin-dependent kinase (CDK1) and cyclin B complex (CDK1:cyclin B) causes a remarkable change in protein phosphorylation. Activation of CDK1:cyclin B is regulated by two auto-amplification loops-CDK1:cyclin B activates Cdc25, its own activating phosphatase, and inhibits Wee1, its own inhibiting kinase. Recent biological evidence has revealed that the inhibition of its counteracting phosphatase activity also occurs, and it is parallel to CDK1:cyclin B activation during mitosis. Phosphatase regulation of mitotic kinases and their substrates is essential to ensure that the progression of the cell cycle is ordered. Outlining how the mutual control of kinases and phosphatases governs the localization and timing of cell division will give us a new understanding about cell cycle regulation.

• Journal of Power Electronics
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• 제9권4호
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• pp.526-534
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• 2009

This paper introduces the electronic ballast for high pressure sodium (HPS) lamps which provides power regulation during the whole lamp life without using a closed-loop power control system, in spite of large variations of lamp characteristics resulting from lamp aging. The structure of the electronic ballast and the parameters of HPS lamps are described. A mathematical model for the ballast is developed and used for the design and analysis of the ballast. A design procedure is presented to design the ballast which provides intrinsic power regulation over the whole lamp life. To improve the technical specifications of the ballast, the practical and standard constraints are considered in the design. According to the design procedure, an electronic ballast for 250-W HPS lamps is designed. All theoretical analyses are verified with the help of a semi-industrial experimental setup. The results validate that the designed ballast provides power regulation during the whole lamp life.

• International Journal of Computer Science & Network Security
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• 제22권11호
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• pp.236-240
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• 2022

The main purpose of the study is to analyze the key aspects of state regulation of the hotel and restaurant complex in the system of tourism development and the national economy. The effectiveness of the regulation of the hotel and restaurant complex in the system of development of tourism and the national economy largely depends on the presence of an effective central executive body that would take care of the problems of the development of the industry, the quality and perfection of legal support, a strategic view of programming the development of the industry within the state and regions, as well as administrative mechanisms of public administration, which fully ensure control over the activities of economic entities and the quality of the services they provide. Based on the results of the study, key aspects of state regulation of the hotel and restaurant complex in the system of tourism development and the national economy were identified.

• 의료법학
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• 제12권2호
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• pp.317-338
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• 2011

The World Health Organization (WHO) tries to accomplish the goal of 'smoke free society', and developed countries regard the nicotine as an addictive drug. In order to better protect human health, all parties are required to adopt and implement effective legislative, executive, administrative or other measures for tobacco control in accordance with Article 4 the Framework Convention on Tobacco Control (FCTC). In order to achieve the objective of the FCTC and its protocols and to implement its provisions, Korea need to take an attention on the U.S. Family Smoking Prevention And Tobacco Control Act of 2009 and Final Rule. It is need to integrate and centralize of tobacco safety administration and smoking prevention for the national health promotion.

• 한국콘텐츠학회논문지
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• 제18권3호
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• pp.499-508
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• 2018

이 연구는 경찰공무원을 대상으로 우리나라에서 최초로 회복탄력성을 측정하고, 조직몰입에 미치는 영향을 검증하여 경찰조직을 대상으로 한 실증적 연구의 방향성을 제시하는데 목적이 있다. 회복탄력성에 대한 선행연구의 분석을 통해서 회복탄력성의 발전과정과 하위 개념들을 정리하고, 경찰공무원의 회복탄력성이 조직몰입과 어떤 관계가 있는지를 분석하고자 하였다. 따라서 회복탄력성의 하위 개념을 자기조절능력(감정조절력, 원인분석력, 충동통제력), 대인관계능력(자아확장력, 소통능력, 공감능력), 긍정성(감사하기, 생활만족, 낙관성)으로 나누어 독립변수로, 조직몰입(감정몰입, 지속몰입, 규범몰입)을 종속변수로 사용하여 분석모형을 설정하였다. 분석결과 회복탄력성이 조직몰입에 미치는 영향을 생활만족>원인분석력>소통능력>공감능력>감사하기>충동통제력 순으로 모두 감정몰입에 정(+)적인 영향을 미치고, 생활만족>낙관성>감정조절력>소통능력>원인분석력 순으로 지속몰입에 정(+)적인 영향을 미치며, 자아확장력>공감능력>낙관성>생활만족>충동통제력>원인분석력 순으로 모두 규범몰입에 정(+)적인 영향을 미치는 것으로 나타났다.

• 한방안이비인후피부과학회지
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• 제23권2호
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• pp.109-124
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• 2010

Objectives : The aim of this study is to investigate the antiallergic effects of YTT on allergic rhinitis by regulation of peroxisome proliferator-activated receptor gamma (PPAR-$\gamma$). Methods : The thirty rats were divided into three groups : normal group, control (allergic rhinitis elicited) group, sample (Yeotaectonggi-tang treated after allergic rhinitis elicitation) group. To induce allergic rhinitis in control group and sample group, rats were sensitized intraperitoneally with 0.1% ovalbumin(OVA) solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin(OVA) solution 3 times at intervals of 2 days. After that time rats in sample group were oral administration treated by YTT for 7days. The change of the amounts of eosinophil, substance P, MIP-2, PPAR-$\gamma$, IL-4, iNOS were observed in each group. we used the statistical method of ANOVA test(p<0.05). Results : The number of eosinophil in sample group noticeably decreased than control group. And the decrease of substance P and MIP-2 positive reaction were observed in mucosa. YTT inhibited IL-4 and iNOS production, mucus secretion, activation of mast cells and fibrosis remodeling by regulation of PPAR-$\gamma$ activation. Conclusion : According to the above results, it is considered that YTT mitigated mucosa damage on the mice model with allergic rhinitis by regulation of PPAR-$\gamma$.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6245-6248
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• 2013

Aims: To study effects of down-regulation of pituitary tumor-transforming gene (PTTG) on proliferation and metastasis ability of the SCL-1 cutaneous squamous cell carcinoma (CSCC) cell line and explore related mechanisms. Methods: SCL-1 cells were divided into 3 groups (untreated, siRNA control and PTTG siRNA). Cell proliferation assays were performed using a CCK-8 kit and proliferation and metastasis ability were analyzed using Boyden chambers. In addition, expression of MMP-2 and MMP-9 was detected by r-time qPCR and Western blotting. Results: Down-regulation of PTTG could markedly inhibit cell proliferation in SCL-1 cells, compared to untreated and control siRNA groups (P < 0.05). Real-time qPCR demonstrated that expression levels of PTTG, MMP-2 and MMP-9 in the PTTG siRNA group were 0.8%, 23.2% and 21.3% of untreated levels. Western blotting revealed that expression of PTTG, MMP-2 and MMP-9 proteins in the PTTG siRNA group was obviously down-regulated. The numbers of migrating cells ($51.38{\pm}4.71$) in the PTTG siRNA group was obviously lower than that in untreated group ($131.33{\pm}6.12$) and the control siRNA group ($127.72{\pm}5.20$) (P < 0.05), suggesting that decrease of proliferation and metastasis ability mediated by PTTG knock-down may be closely correlated with down-regulation of MMP-2 and MMP-9 expression. Conclusion: Inhibition of PTTG expression may be a new target for therapy of CSCC.