• Journal of agriculture & life science
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• v.50 no.2
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• pp.151-160
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• 2016

Inflammatory cytokines play a major role in osteoclastogenesis, leading to the bone resorption that is frequently associated with osteoporosis. Sulforaphane, isolated from the Broccoli(Brassica oleracea var. italia) florets, inhibits the production of inflamatory cytokine. In the present study, we determined inhibitory effect of sulforaphane on Receptor activator of nuclear factor κB ligand(RANKL)-induced osteoclast formation. Sulforaphane inhibited the expression of osteoclast marker genes, such as tartrate-resistant acid phosphatase(TRAP), cathepsin K, matrix metalloproteinase 9(MMP-9), and calcitonin receptor in RANKL-induced RAW 264.7 macrophage. Also, sluforaphane inhibited the expression of osteoclast protein, such as TRAP, MMP-9, tumor necrosis factor receptor-associated factor 6(TRAF6) and transcription factor nuclease factor of activated T cells(NFAT)c1. Sulforaphane inhibited RANKL-induced activiation of nuclear factor kappaB(NF-kappaB) by suppression RANKL-mediated NF-kappaB transcriptional acitivation. We are confirmed that sulforaphane inhibits not only transcriptional activity of NF-kappaB but also expressions of the osteoclastogenesis factors(TRAP, cathepsin K, MMP-9, calcitonin, TRAF6) and trranscription factor NFATc1.

• International Journal of Computer Science & Network Security
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• v.21 no.1
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• pp.201-206
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• 2021

The significance of high-quality development and green total factor productivity has attracted widespread attention and research, while few studies on green total factor productivity that considers the use of water resources have been conducted in the context of water shortages and water stress. In this study, the green total factor productivity of water use from 2005 to 2015 in mainland China is evaluated based on the global Malmquist-Luenberger productivity index. Results show that: (1) China's green total factor productivity of water use has been improving since 2005 with an annual global Malmquist-Luenberger productivity index of 1.0104. (2) At the regional level, the eastern zone in mainland China owns the highest green total factor productivity of water use, while that in the intermediate zone ranks last. (3) The green total factor productivity of water use in the southern region (1.0113) significantly higher than that in the northern region (1.0095), and also higher than the national average level in the same period. BPC index has been the most important incluencing factor of green total factor productivity of water use at both national level and regional level since 2011.

• Journal of Korean Society of Transportation
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• v.33 no.3
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• pp.223-236
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• 2015

This study dealt with regional characteristics in car insurance for reduction of traffic accidents. The objective was to establish scientifically the verification procedure in the application of regional auto insurance rate. To specify the objective, this study conducts the correlation analysis between factors which are various in each local traffic environment and the loss ratio in automobile insurance. Also, this provides a correlation and a modal in loss ratio, classifying human factors in locality in major cause result from traffic accident. Based on the results, this brings up the problems with applying a uniform criterion for automobile insurance rate although various factors have effect on traffic accidents in locality. Therefore, what stands out most from this study is that a policy on automobile insurance applied to regional factor should be introduced.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.2426-2441
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• 2008

This research is analyzed by the operation frequency of Regional Railroad and the Load Factor on the level of each service based on the Regional railroad ticket sales data on the 2007 fiscal year. Because the Regional Railroad passenger's satisfaction is sensitive of the transportation demand alteration, this research analyzed LOS. In addition to, analyzed the LOS will affect driving patterns of the Regional Railroad.

• Journal of the Korean Association of Geographic Information Studies
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• v.15 no.3
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• pp.13-22
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• 2012

The spatial structure analysis using the existing space syntax has a weakness only to apply the road factor. Hence, it is necessary to perform a new spatial structure analysis considering the regional characteristics factor as well as the road factor. The purpose of this study is to propose a modified spatial structure analysis which adopts road and regional characteristics factors using the existing space syntax and GIS and then to apply it to the spatial structure analysis of the urbanized areas in Hapdeok town. For the new analysis, the experts' survey has been conducted to derive the spatial structure factors of the area and their relative weights. Specifically, it drew the road factor as well as the regional characteristics factors such as road, district, land value, and building density. This study shows that the existing spatial structure analysis considering only the road factor does not reflect the actual spatial structure but the modified spatial structure analysis considering the road factor and the regional characteristics factors more accurately analyzes the spatial structure of Hapdeok town. Hapdeok is not an area where road networks were developed along main development axis and its centrality was changed, but an area where road networks were developed by effectiveness and equity and its centrality was changed by downtown decline. The towns like Hapdeok is more suitable for applying the modified spatial structure analysis method considering the regional characteristics factors. Further research is required for selecting characteristics factors and appropriate parameters in the modified spatial structure analysis. Further case studies await in other cities for conducting its verification.

• Fashion & Textile Research Journal
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• v.5 no.4
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• pp.379-388
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• 2003

The purpose of this study was to compare the somatometric characteristics obtained from the factor scores of both upper and lower body by regional differences. The sample group was drawn from boys at the ages 7 to 12 living in Pusan and Kyungsangnam-do. Data from each boy comprised 57 anthropometric measurements and 11 photographic measurements. The study reached following conclusions. 1. According to the result of factor analysis, five indicative factor's were obtained from the upper body measurements and four indicative factors were obtained from the lower body measurements. 2. According to the comparision of factor scores on measurements of the upper body between Pusan and Kyungsangnam-do, there were differences in all five factors. Boys in Pusan had higher stature, bigger frame, more protruded chest and shoulder blades, more sloping curve along with the backbone, more protruded belly, narrower and sloping shoulders than boys in Kyungsangnam-do. 4. According to the comparision of factor scores on measurements of the lower body between Pusan and Kyungsangnam-do, there were differences in factor 1 and factor 4. Boys in Pusan had bigger frame and flatter hip than boys in Kyungsangnam-do.

• Journal of the Korean Institute of Landscape Architecture
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• v.39 no.2
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• pp.10-17
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• 2011

The paradigm of the use and management of natural resources is changing. Wise use of natural resources can be achieved by enhancing their conservation value and, at the same time, taking them as an opportunity for regional development. It leads to an idea of pursuing regional development by making good use of natural resources. In this paper, natural resources were classified as living species resources, ecosystem and landscape resources, and non-living resources. The resources were divided into 27 detailed analysis indices. The administrative boundaries of 165 municipalities in Korea were defined as spatial analysis units. Finally, a spatial database of natural resources was built. To classify the regional types, we conducted factor analyses with a detailed index of natural resources and a cluster analysis with the factor value. As the result of the factor analysis, six factors have been deduced as follows: forest resources, landscape resources, coastal ecology resources, inland water resources, landform resources, and ecology visit resources. In addition, the cluster analyses were conducted for the points of the factors drawn. The final classification consists of nine groups, and appropriate methods for each regional development have been suggested. Results of this study will contribute to providing fundamental materials for site selection and objective-setting for regional development policies and planning in consideration of natural resources.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4725-4732
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• 2012

Aim: The incidence of stomach cancer in Mizoram is highest in India. We have conducted a population based matched case-control study to identify environmental and genetic risk factors in this geographical area. Methods: A total of 102 histologically confirmed stomach cancer cases and 204 matched healthy population controls were recruited. GSTM1 and GSTT1 genotypes were determined by PCR and H. pylori infections were determined by ELISA. Results: Tobacco-smoking was found to be an important risk factor for high incidence of stomach cancer in Mizoram. Meiziol (local cigarette) smoking was a more important risk factor than other tobacco related habits. Cigarette, tuibur (tobacco smoke infused water) and betel nut consumption synergistically increased the risk of stomach cancer. Polymorphisms of GSTM1 and GSTT1 genes were not found to be directly associated with stomach cancer in Mizoram. However, they appeared to be effect modifiers. Persons habituated with tobacco smoking and/or tuibur habit had increased risk of stomach cancer if they carried the GSTM1 null genotype and GSTT1 non-null genotype. Conclusion: Tobacco smoking, especially meiziol is the important risk factor for stomach cancer in Mizoram. GSTM1 and GSTT1 genes modify the effect of tobacco habits. This study is a first step in understanding the epidemiology of stomach cancer in Mizoram, India.

• Journal of Korean Society on Water Environment
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• v.32 no.1
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• pp.89-97
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• 2016

Digital Elevation Models (DEMs) have been used to represent the effects of topography on soil erosion. A DEM of 30 m resolution is frequently used in hydrology and soil erosion studies because the National Water Management Information System (WAMIS) provides a 30 m resolution DEM at national scale on its web site. However, the Ministry of Environment recommends the use of a DEM with 10 m resolution for evaluation of soil erosion due to the fact that soil erosion estimation is to some degree affected by the spatial resolution of DEM. In this regard, a DEM with 5 m resolution was resampled for 10 × 10 m, 20 × 20 m, 30 × 30 m, 50 × 50 m, 70 × 70 m, and 100 × 100 m resolutions, respectively. USLE LS factors and soil erosion values were evaluated using these datasets. Use of a DEM with at least 30 m resolution provided reasonable LS factors and soil erosion values at a watershed.

• Journal of Korean Society on Water Environment
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• v.31 no.3
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• pp.241-252
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• 2015

Runoff behaviors by five bias correction methods were analyzed, which were Change Factor methods using past observed and estimated data by the estimation scenario with average annual calibration factor (CF_Y) or with average monthly calibration factor (CF_M), Quantile Mapping methods using past observed and estimated data considering cumulative distribution function for entire estimated data period (QM_E) or for dry and rainy season (QM_P), and Integrated method of CF_M+QM_E(CQ). The peak flow by CF_M and QM_P were twice as large as the measured peak flow, it was concluded that QM_P method has large uncertainty in monthly runoff estimation since the maximum precipitation by QM_P provided much difference to the other methods. The CQ method provided the precipitation amount, distribution, and frequency of the smallest differences to the observed data, compared to the other four methods. And the CQ method provided the rainfall-runoff behavior corresponding to the carbon dioxide emission scenario of SRES A1B. Climate change scenario with bias correction still contained uncertainty in accurate climate data generation. Therefore it is required to consider the trend of observed precipitation and the characteristics of bias correction methods so that the generated precipitation can be used properly in water resource management plan establishment.