• 헤리티지:역사와 과학
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• 제41권1호
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• pp.21-33
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• 2008

충청지역의 다양한 유적의 소토(燒土)에서 구한 34점의 고고지자기 측정데이터를 통해 충청지역의 고고지자기 변동 양상을 살펴보고, 더 나아가 국내에서의 지자기의 지역적인 차이에 대해 검토해 보았다. 충청지역의 고고지자기 측정데이터는 거리상으로 차이가 있는 일본의 고고지자기 변동과의 비교에서 보면, 전체적인 변동 모습은 비슷하나 A.D. 300년경에서는 편각이 동쪽으로 10도 이상 치우치는 현저한 차이를 보이고, 그 이외 시기에서는 복각이 다소 깊어지고 편각이 서쪽으로 약간씩 치우치는 지자기의 지역적인 차이가 확인되었다. 이러한 양상은 우리나라 전체의 고고지자기 변동 양상과 큰 차이가 없으며, 충청지역 데이터와의 직접 비교에서도 국내에서는 서력기원전시기와 기원후 시기 모두 뚜렷한 지자기의 지역차는 확인되지 않았다. 앞으로 더 많은 고고지자기 측정 데이터가 증가하고 다양한 시기의 데이터가 채워지면 더욱 명확해 지겠지만, 충청지역 유적의 고고지자기 측정결과를 통해 볼 때, 지자기의 지역적인 차이에 의해 발생하는 고고지자기 측정연대의 오차와 같은 문제점은 우리나라 내에서는 크게 걱정하지 않아도 될 듯하다. 게다가 시료의 채취와 측정에서 신뢰가 가능한 측정데이터를 구하기 위하여 많은 노력들을 하고 있기 때문에, 고고지자기 측정결과에서 추정연대의 오차문제 뿐만 아니라 데이터의 신뢰도의 측면에서도 문제가 없을 것이라 생각된다.

• 한국임상약학회지
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• 제28권2호
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• pp.146-153
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• 2018

Objective: Multi-regional clinical trials have been widely used for accelerating global drug development by multinational pharmaceutical companies. In this study, we aimed to review and analyze the international trends in regulations and guidelines on multi-regional clinical trials by regulatory authorities and international organizations, such as International Conference on Harmonisation, for referring to policies, including development of domestic guidelines for multi-regional clinical trials. Methods: The policies, regulations, and guidelines published by the US Food and Drug Administration, European Medicines Agency, Pharmaceuticals and Medical Devices Agency (Japan), and China Food and Drug Administration were searched, and the International Conference on Harmonisation E17 draft guideline was reviewed. Results: The regulatory authorities in developed countries have developed and implemented regulations and guidelines on multi-regional clinical trials to promote simultaneous global drug development and evaluate the regional differences in drug safety and efficacy. International Conference on Harmonisation developed the draft guideline for planning/designing of multi-regional clinical trials in 2016, which recommends the general principles for strategy-related issues and design of multi-regional clinical trials, and for protocol-related issues, such as consideration of regional variability, subject selection, dose selection, endpoints, comparators, overall sample size, allocation to regions, collecting information on efficacy and safety, and statistical analysis. Conclusion: It is important to understand the international regulatory requirements for designing and planning of multi-regional clinical trials for global drug development. Moreover, it is necessary to prepare multi-regional clinical trial guidelines in accordance with the Korean regulation for clinical trials and drug administration.

• Journal of Preventive Medicine and Public Health
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• 제43권2호
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• pp.174-184
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• 2010

Objectives: This study shows the issues that should be considered when applying standardized rates using Community Health Survey(CHS) data. Methods: We analyzed 2008 CHS data. In order to obtain the reliability of standardized rates, we calculated z-score and rank correlation coefficients between direct standardized rate and indirect standardized rate for 31 major indices. Especially, we assessed the change of correlations according to population composition (age and sex), and characteristics of the index. We used Mantel-Haenszel chi-square to quantify the difference of population composition. Results: Among 31 major indices, 29 indices' z-score and rank correlation coefficients were over 0.9. However, regions with larger differences in population composition showed lower reliability. Low reliability was also observed for the indices specific to subgroups with small denominator such as 'permanent lesion from stroke', and the index with large regional variations in age-related differences such as 'obtaining health examinations'. Conclusions: Standardized rates may have low reliability, if comparison is made between areas with extremely large differences in population composition, or for indicies with large regional variations in age-related differences. Therefore, the special features of standardized rates should be considered when health state are compared among areas.

• 한국의류학회지
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• 제26권1호
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• pp.168-178
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• 2002

This study is aimed at investigating and comparing the differences in the uniform of nurses according to regions and hospital size in Korea. This study takes two large regions as its survey area; one is Seoul, Incheon and Gyeonggi Province, and the other is Daejon and Chungcheong Province. The hospital size is divided into general hospitals and neighborhood hospitals. The survey was conducted among the nurses working in 12 randomly-selected hospitals and its statistical results are analysed firm 818 respondents'questionnaires. The results are divided into 3 categories as follows; 1) Results of analysis of survey on the uniform of nurses : Nurses usually wear two-piece suits and more than half of the hospitals choose a white-color pattern. And the nurse's uniform with color varying according to their position and ward is considered to be desirable; 2) Analysis on regional differences : In the case of Daejon and Chungcheong Province, there is a relatively high ratio of respondents who answered questions with 'high percentage of young nurses', 'position differentiation by means of different design and fabric according to ward'. In case of Seoul, Incheon and Gyeonggi Province, questions with 'use of a patterned textile in nurses'uniform', 'ready-made size system'are higher; 3) Analysis of the differences in accordance with hospital size : In the case of general hospitals, there is relatively a high ratio of respondents who answered questions with 'use of different design and fabric according to a nurse's position', 'use of patterns in nurses'uniform'. In the case of neighborhood hospitals, there is a high ratio of respondents with'use of classical one-piece or two-piece type wear', 'ready-made type size system', 'obligatory use off nurse's cap'.

• 한국의류학회지
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• 제40권3호
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• pp.456-464
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• 2016

A new combat uniform is improved for added combat safety with various functions such as survivability, battle conformity and a camouflage performance system. Camouflage performance is an important factor in terms of combat survivability since it makes identification difficult and provide security. The combat uniform is worn under extreme conditions (exposure to ultraviolet light, sweat and friction) and an excellent color fastness to repeated washing is required. In this study, we investigated the color management, durability and discoloration of new combat uniform fabric with a digital pattern for camouflage performance to provide preliminary color management data. We examined color differences between standard fabric and mass-produced combat uniform fabrics, color differences between each military supply contract firm and color changes in combat uniforms after 60 washing cycles. The slight color differences between standard fabric and mass-produced combat uniform fabrics were tolerable under quality criteria of Republic of Korea Ministry of National Defense. However, the differences between the military supply contract firms were recognizable to the naked eye and increased with repeated washing. Continuous research on color fastness under repeated washing and color management is required to standardize reliability from each military supply contract firm for the daytime performance of a combat uniform's camouflage.

• 한국환경과학회지
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• 제31권9호
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• pp.743-755
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• 2022

This study aims to review the differences in urban regeneration independently implemented by the government (Ministry of Land, Infrastructure, and Transport, MOLIT) and Seoul based on related laws and ordinances, and to draw out the implications of Korean urban regeneration's directions. The results are as follows. First, Seoul has constantly responded to the revision of the Urban Regeneration Act by adjusting and specifying the contents of ordinances, and especially, there have been efforts to enhance regional characteristics suitably for the circumstances of Seoul. Second, in the urban regeneration of Seoul, the budgets including the matching ratio of national and local subsidies shall be changed according to the standards of the MOLIT in changing designating places after the selection of the urban regeneration by the ministry, and this procedure and these implementation methods cause confusion to Seoul and local governments. Third, there were differences in the results of comparing the budgets and support methods of the "Gaggum Housing Project" of Seoul and "New Deal Housing Repair Project" of the MOLIT, which caused conflicts due to the differences in the project implementation and support standards, and the arbitrary interpretation of the guidelines. Although the urban regeneration greatly contributed to the revelation and conservation of regional characteristics, it might be necessary to establish systems that can enhance citizens' awareness and compensate the efficient contents needed for each region in the future.

• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 2001년도 The Asia-Pacific Conference on Reproductive Biology and Environmental Sciences
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• pp.81-84
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• 2001

• 한국양식학회:학술대회논문집
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• 한국양식학회 2003년도 추계학술발표대회 논문요약집
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• pp.134-135
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• 2003

The geographic expansion of the toxic dinoflagellates genus Alexandrium has been shown to be world wide ranging. The members of the genus Alexandrium ocnstituted of 20-30 species did not show substantial differences in their morphology, which is mostly referred in the 'tamarensis species complex', except some species. Though rDNA sequences variations are very few and pseudogene types are so diverse that it is difficult to use them as the specific markers. In this study, we outlined Korean and Japanese A, tamarense and A. catenella regional isolates by phylogenetic analysis inferred from no cutting alignments of LSU rDNA D1-D2 and SSU rDNA sequences to group these regional isolates. The results were compared to RFLP patterns of PCR products targeted chloroplast DNA. Lastly screening of highly repeated microsatellite DNA which is frequently used for population analysis in eukaryotes was conducted. A. catenella regional strains identified by the sequencing of rDNA D1-D2 domain were divided into at least 3 groups of type E, CMC and Chinese type, divergence root may not be deep comparing with that of A. tamarense whose pseudogenes are very variable. Results of RFLP pattern and the phylogeny of the unknown gene targeting chloroplast showed that Korean and Japanese A. catenella regional isolates were divided into 3 types: Korean, Japanese and the third CMC types. Population-specific PCR amplification with Japanese A. catenella type-specific PCR primers was useful method for population analysis of A. catenella. Various types of satellite sequences such as 5 nucleotides repeats were obtained from A. tamarense and A. catenella. The 5 nucleotides repeats were primed at the both 3'and 5' ends, and these repeats were prominent as longer repeated motifs. This repeated DNA was intercalated as internal sequences containing various types subrepeats. It is expected that these satellite DNA would be a useful molecular population marker through detail comparison among Alexandrium regional isolates to trace their transferring pathway and to prevent their human-associated their regional extents.

• 지역연구
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• 제31권3호
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• pp.55-77
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• 2015

이 연구의 목적은 수도권 시군구별 입지요인이 제조업 기업들의 생애주기에 미치는 영향을 실증분석 하는 것이다. 한 기업도 가구와 마찬가지로 일련의 생애주기를 갖는다. 기업의 생애주기를 선행연구에서는 기업통계(firmography)로 정의하고 있으며, 이를 생성, 성장, 쇠퇴, 소멸의 단계로 구분하였다. 이 연구에서도 기업의 생애주기 단계를 동일하게 적용하였으며, 제조업 기업들을 대상으로 경공업과 중공업, 첨단제조업으로 구분하여 분석하였다. 수도권 시군구별 입지요인은 도시규모와 교통접근성, 사회 경제특성, 수도권 권역구분으로 구분하여 총 12개의 입지요인을 독립변수로 적용하였다. 분석결과, 경공업과 중공업, 첨단제조업 기업별로 기업의 생애주기에 미치는 유의미한 입지요인이 차이가 있었으며, 입지계수 또한 각각 다르게 나타났다. 이 연구결과는 기업유치를 통해 일자리를 늘리려는 지자체에서 신규기업의 생성뿐만 아니라 기존 기업의 성장을 도모하는 정책을 수립하는데 있어서 중요한 기초자료가 될 수 있을 것으로 기대된다.

• 한국산학기술학회논문지
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• 제11권10호
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• pp.3779-3788
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• 2010

본 연구는 지역전략산업과 연계되어 추진되고 있는 중소기업 산업인력 양성 정책의 효율화방안을 제시하고자 한다. 특히 산업인력부문의 공급측면과 수요측면을 동시에 접근함으로써 실무적.정책적 시사점을 파악하고자 하였다. 공급측면에 대해서는 지역산업인력 종사자 현황 및 전략산업별 인력공급현황, 지역전략산업 내 인력양성사업을 다루었다. 수요측면에 대해서는 지역전략산업진흥사업에 참여하고 있는 201개의 중소기업을 대상으로 인력수급현황과 산업인력 양성에 관한 기업수요에 대하여 설문조사를 실시하였다. 연구결과 전략산업별 기업수요의 특성이 다르게 나타나고 있어 전략산업별 차별적인 정책방향과 효율성 개선을 위한 시사점을 찾을 수 있었다. 이러한 결과들은 중앙정부의 산업인력 정책기조와 지역산업 현장의 기업수요를 반영하여 산업인력정책의 효율성을 증대하기 위한 시사점이 될 것이다.